2QOH

Crystal Structure of Abl kinase bound with PPY-A

Summary for 2QOH

• Entry DOI: 10.2210/pdb2qoh/pdb
• Related: 2Z60
• Descriptor: Proto-oncogene tyrosine-protein kinase ABL1, 5-[3-(2-METHOXYPHENYL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-N,N-DIMETHYLPYRIDINE-3-CARBOXAMIDE (3 entities in total)
• Functional Keywords: abl, kinase, inhibitor, transferase
• Biological source: Mus musculus (house mouse)
• Cellular location: Cytoplasm, cytoskeleton: P00520
• Total number of polymer chains: 2
• Total formula weight: 67228.77

Authors

Zhou, T.,Dalgarno, D.,Zhu, X. (deposition date: 2007-07-20, release date: 2007-09-18, Last modification date: 2023-10-25)

• Primary citation: Zhou, T.,Parillon, L.,Li, F.,Wang, Y.,Keats, J.,Lamore, S.,Xu, Q.,Shakespeare, W.,Dalgarno, D.,Zhu, X.; Crystal Structure of the T315I Mutant of Abl Kinase; Chem.Biol.Drug Des., 70:171-181, 2007; PubMed: 17718712; DOI: 10.1111/j.1747-0285.2007.00556.x

Experimental method

X-RAY DIFFRACTION (1.95 Å)