2Z60
Crystal Structure of the T315I Mutant of Abl kinase bound with PPY-A
Summary for 2Z60
Entry DOI | 10.2210/pdb2z60/pdb |
Related | 2QOH |
Descriptor | Proto-oncogene tyrosine-protein kinase ABL1, 5-[3-(2-METHOXYPHENYL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-N,N-DIMETHYLPYRIDINE-3-CARBOXAMIDE (3 entities in total) |
Functional Keywords | abl, kinase, mutant, t315i, alternative splicing, atp-binding, cell adhesion, chromosomal rearrangement, cytoplasm, cytoskeleton, lipoprotein, magnesium, manganese, metal-binding, myristate, nucleotide-binding, nucleus, phosphorylation, proto-oncogene, sh2 domain, sh3 domain, transferase |
Biological source | Mus musculus (house mouse) |
Cellular location | Cytoplasm, cytoskeleton: P00520 |
Total number of polymer chains | 1 |
Total formula weight | 33626.44 |
Authors | Zhou, T.,Dalgarno, D.,Zhu, X. (deposition date: 2007-07-21, release date: 2007-09-18, Last modification date: 2023-11-01) |
Primary citation | Zhou, T.,Parillon, L.,Li, F.,Wang, Y.,Keats, J.,Lamore, S.,Xu, Q.,Shakespeare, W.,Dalgarno, D.,Zhu, X. Crystal Structure of the T315I Mutant of Abl Kinase Chem.Biol.Drug Des., 70:171-181, 2007 Cited by PubMed: 17718712DOI: 10.1111/j.1747-0285.2007.00556.x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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