3KFA
Structural analysis of DFG-in and DFG-out dual Src-Abl inhibitors sharing a common vinyl purine template
Summary for 3KFA
Entry DOI | 10.2210/pdb3kfa/pdb |
Related | 3KF4 |
Descriptor | Tyrosine-protein kinase ABL1, 3-{(E)-2-[6-(cyclopropylamino)-9H-purin-9-yl]ethenyl}-4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]benzamide (3 entities in total) |
Functional Keywords | abl, cml, drug resistance, inhibitor, atp-binding, kinase, nucleotide-binding, oncogene, tyrosine-protein kinase, transferase |
Biological source | Mus musculus (mouse) |
Cellular location | Cytoplasm, cytoskeleton: P00520 |
Total number of polymer chains | 2 |
Total formula weight | 67601.04 |
Authors | Zhou, T. (deposition date: 2009-10-27, release date: 2009-12-22, Last modification date: 2023-09-06) |
Primary citation | Zhou, T.,Commodore, L.,Huang, W.S.,Wang, Y.,Sawyer, T.K.,Shakespeare, W.C.,Clackson, T.,Zhu, X.,Dalgarno, D.C. Structural analysis of DFG-in and DFG-out dual Src-Abl inhibitors sharing a common vinyl purine template. Chem.Biol.Drug Des., 75:18-28, 2010 Cited by PubMed: 19895503DOI: 10.1111/j.1747-0285.2009.00905.x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.22 Å) |
Structure validation
Download full validation report