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6CBX
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CRYSTAL STRUCTURE OF HUMAN SET AND MYND DOMAIN CONTAINING PROTEIN 2 WITH MTF1497
Descriptor:N-lysine methyltransferase SMYD2, ZINC ION, [3-(4-amino-6-methyl-1H-imidazo[4,5-c]pyridin-1-yl)azetidin-1-yl][1-({1-[(1R)-cyclohept-2-en-1-yl]piperidin-4-yl}methyl)-1H-pyrrol-3-yl]methanone, ...
Authors:ZENG, H., DONG, A., Hutchinson, A., Seitova, A., TATLOCK, J., KUMPF, R., OWEN, A., TAYLOR, A., Casimiro-Garcia, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., BROWN, P.J., WU, H., Structural Genomics Consortium (SGC)
Deposit date:2018-02-05
Release date:2018-03-14
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Crystal structure of human SET and MYND Domain Containing protein 2 with MTF1497
to be published
6CBY
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CRYSTAL STRUCTURE OF HUMAN SET AND MYND DOMAIN CONTAINING PROTEIN 2 WITH MTF9975
Descriptor:N-lysine methyltransferase SMYD2, ZINC ION, [3-(4-amino-6-methyl-1H-imidazo[4,5-c]pyridin-1-yl)-3-methylazetidin-1-yl][1-({1-[(1R)-cyclohept-2-en-1-yl]piperidin-4-yl}methyl)-1H-pyrrol-3-yl]methanone
Authors:ZENG, H., DONG, A., Hutchinson, A., Seitova, A., TATLOCK, J., KUMPF, R., OWEN, A., TAYLOR, A., Casimiro-Garcia, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., BROWN, P.J., WU, H., Structural Genomics Consortium (SGC)
Deposit date:2018-02-05
Release date:2018-03-14
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Crystal structure of human SET and MYND Domain Containing protein 2 with MTF9975
to be published
1IDG
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THE NMR SOLUTION STRUCTURE OF THE COMPLEX FORMED BETWEEN ALPHA-BUNGAROTOXIN AND AN 18MER COGNATE PEPTIDE
Descriptor:ALPHA-BUNGAROTOXIN, ACETYLCHOLINE RECEPTOR PROTEIN, ALPHA CHAIN
Authors:Zeng, H., Moise, L., Grant, M.A., Hawrot, E.
Deposit date:2001-04-04
Release date:2001-04-25
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The solution structure of the complex formed between alpha-bungarotoxin and an 18-mer cognate peptide derived from the alpha 1 subunit of the nicotinic acetylcholine receptor from Torpedo californica.
J.Biol.Chem., 276, 2001
1IDH
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THE NMR SOLUTION STRUCTURE OF THE COMPLEX FORMED BETWEEN ALPHA-BUNGAROTOXIN AND AN 18MER COGNATE PEPTIDE
Descriptor:ALPHA-BUNGAROTOXIN, ACETYLCHOLINE RECEPTOR PROTEIN, ALPHA CHAIN
Authors:Zeng, H., Moise, L., Grant, M.A., Hawrot, E.
Deposit date:2001-04-04
Release date:2001-04-25
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The solution structure of the complex formed between alpha-bungarotoxin and an 18-mer cognate peptide derived from the alpha 1 subunit of the nicotinic acetylcholine receptor from Torpedo californica.
J.Biol.Chem., 276, 2001
1IDI
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THE NMR SOLUTION STRUCTURE OF ALPHA-BUNGAROTOXIN
Descriptor:ALPHA-BUNGAROTOXIN
Authors:Zeng, H., Moise, L., Grant, M.A., Hawrot, E.
Deposit date:2001-04-04
Release date:2001-04-25
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The solution structure of the complex formed between alpha-bungarotoxin and an 18-mer cognate peptide derived from the alpha 1 subunit of the nicotinic acetylcholine receptor from Torpedo californica.
J.Biol.Chem., 276, 2001
1IDL
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THE NMR SOLUTION STRUCTURE OF ALPHA-BUNGAROTOXIN
Descriptor:ALPHA-BUNGAROTOXIN
Authors:Zeng, H., Moise, L., Grant, M.A., Hawrot, E.
Deposit date:2001-04-04
Release date:2001-04-25
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The solution structure of the complex formed between alpha-bungarotoxin and an 18-mer cognate peptide derived from the alpha 1 subunit of the nicotinic acetylcholine receptor from Torpedo californica.
J.Biol.Chem., 276, 2001
1LXG
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SOLUTION STRUCTURE OF ALPHA-COBRATOXIN COMPLEXED WITH A COGNATE PEPTIDE (STRUCTURE ENSEMBLE)
Descriptor:Long neurotoxin 1, Acetylcholine receptor protein, alpha chain
Authors:Zeng, H., Hawrot, E.
Deposit date:2002-06-05
Release date:2002-11-20
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:NMR-based Binding Screen and Structural Analysis of the Complex Formed between alpha-Cobratoxin and an 18-mer Cognate Peptide Derived from the alpha1 Subunit of the Nicotinic Acetylcholine Receptor from Torpedo californica
J.Biol.Chem., 277, 2002
1LXH
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SOLUTION STRUCTURE OF ALPHA-COBRATOXIN COMPLEXED WITH A COGNATE PEPTIDE (MINIMIZED AVERAGE STRUCTURE)
Descriptor:LONG NEUROTOXIN 1, ACETYLCHOLINE RECEPTOR PROTEIN, ALPHA CHAIN
Authors:Zeng, H., Hawrot, E.
Deposit date:2002-06-05
Release date:2002-11-20
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:NMR-based Binding Screen and Structural Analysis of the Complex Formed between alpha-Cobratoxin and an 18-mer Cognate Peptide Derived from the alpha1 Subunit of the Nicotinic Acetylcholine Receptor from Torpedo californica
J.Biol.Chem., 277, 2002
5YTC
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LARGE FRAGMENT OF DNA POLYMERASE I FROM THERMUS AQUATICUS IN A CLOSED TERNARY COMPLEX WITH THE UNNATURAL BASE M-FC PAIR WITH DATP IN THE ACTIVE SITE
Descriptor:DNA polymerase I, thermostable, DNA (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*(DOC)P*(DOC))-3'), ...
Authors:Zeng, H., Mondal, M., Song, R.Y., Zhang, J., Xia, B., Yi, C.Q.
Deposit date:2017-11-17
Release date:2018-11-21
Last modified:2019-01-02
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Unnatural Cytosine Bases Recognized as Thymines by DNA Polymerases by the Formation of the Watson-Crick Geometry.
Angew. Chem. Int. Ed. Engl., 58, 2019
5YTD
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LARGE FRAGMENT OF DNA POLYMERASE I FROM THERMUS AQUATICUS IN A CLOSED TERNARY COMPLEX WITH THE NATURAL BASE PAIR 5FC:DGTP
Descriptor:DNA polymerase I, thermostable, DNA (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*(DOC))-3'), ...
Authors:Zeng, H., Mondal, M., Song, R.Y., Zhang, J., Xia, B., Gao, Y.Q., Yi, C.Q.
Deposit date:2017-11-17
Release date:2018-11-21
Last modified:2019-01-02
Method:X-RAY DIFFRACTION (2 Å)
Cite:Unnatural Cytosine Bases Recognized as Thymines by DNA Polymerases by the Formation of the Watson-Crick Geometry.
Angew. Chem. Int. Ed. Engl., 58, 2019
5YTE
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LARGE FRAGMENT OF DNA POLYMERASE I FROM THERMUS AQUATICUS IN A CLOSED TERNARY COMPLEX WITH WITH NATURAL DT:DATP BASE PAIR
Descriptor:DNA polymerase I, thermostable, DNA (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*(DOC))-3'), ...
Authors:Zeng, H., Mondal, M., Song, R.Y., Zhang, J., Xia, B., Gao, Y.Q., Yi, C.Q.
Deposit date:2017-11-17
Release date:2018-11-21
Last modified:2019-01-02
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Unnatural Cytosine Bases Recognized as Thymines by DNA Polymerases by the Formation of the Watson-Crick Geometry.
Angew. Chem. Int. Ed. Engl., 58, 2019
5YTF
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STRUCTURE OF LARGE FRAGMENT OF DNA POLYMERASE I FROM THERMUS AQUATICUS HOST-GUEST COMPLEX WITH THE UNNATURAL BASE M-FC PAIR WITH DA
Descriptor:DNA polymerase I, thermostable, DNA (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*(DOC))-3'), ...
Authors:Zeng, H., Mondal, M., Song, R.Y., Zhang, J., Xia, B., Gao, Y.Q., Yi, C.Q.
Deposit date:2017-11-17
Release date:2018-11-21
Last modified:2019-01-02
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Unnatural Cytosine Bases Recognized as Thymines by DNA Polymerases by the Formation of the Watson-Crick Geometry.
Angew. Chem. Int. Ed. Engl., 58, 2019
5YTG
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STRUCTURE OF LARGE FRAGMENT OF DNA POLYMERASE I FROM THERMUS AQUATICUS HOST-GUEST COMPLEX WITH THE UNNATURAL BASE I-FC PAIR WITH DA
Descriptor:DNA polymerase I, thermostable, DNA (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*(DOC))-3'), ...
Authors:Zeng, H., Mondal, M., Song, R.Y., Zhang, J., Xia, B., Gao, Y.Q., Yi, C.Q.
Deposit date:2017-11-17
Release date:2018-11-21
Last modified:2019-01-02
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Unnatural Cytosine Bases Recognized as Thymines by DNA Polymerases by the Formation of the Watson-Crick Geometry.
Angew. Chem. Int. Ed. Engl., 58, 2019
5YTH
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STRUCTURE OF LARGE FRAGMENT OF DNA POLYMERASE I FROM THERMUS AQUATICUS HOST-GUEST COMPLEX WITH THE UNNATURAL BASE M-FC PAIR WITH DG
Descriptor:DNA polymerase I, thermostable, DNA (5'-D(*GP*AP*CP*CP*GP*CP*GP*GP*CP*GP*CP*(DOC))-3'), ...
Authors:Zeng, H., Mondal, M., Song, R.Y., Zhang, J., Xia, B., Gao, Y.Q., Yi, C.Q.
Deposit date:2017-11-17
Release date:2018-11-21
Last modified:2019-01-02
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Unnatural Cytosine Bases Recognized as Thymines by DNA Polymerases by the Formation of the Watson-Crick Geometry.
Angew. Chem. Int. Ed. Engl., 58, 2019
5Z3N
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STRUCTURE OF LARGE FRAGMENT OF DNA POLYMERASE I FROM THERMUS AQUATICUS HOST-GUEST COMPLEX WITH THE UNNATURAL BASE 5FC PAIR WITH DA
Descriptor:DNA polymerase I, thermostable, DNA (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*(DOC))-3'), ...
Authors:Zeng, H., Mondal, M., Song, R.Y., Zhang, J., Xia, B., Gao, Y.Q., Yi, C.Q.
Deposit date:2018-01-08
Release date:2018-11-21
Last modified:2019-01-02
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Unnatural Cytosine Bases Recognized as Thymines by DNA Polymerases by the Formation of the Watson-Crick Geometry.
Angew. Chem. Int. Ed. Engl., 58, 2019
4QPP
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THE CRYSTAL STRUCTURE OF HUMAN HMT1 HNRNP METHYLTRANSFERASE-LIKE PROTEIN 6 IN COMPLEX WITH COMPOUND DS-421 (2-{4-[3-CHLORO-2-(2-METHOXYPHENYL)-1H-INDOL-5-YL]PIPERIDIN-1-YL}-N-METHYLETHANAMINE
Descriptor:Protein arginine N-methyltransferase 6, POLY-UNK, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Dong, A., Zeng, H., Smil, D., Walker, J.R., He, H., Eram, M., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Vedadi, M., Brown, P.J., Wu, H., Structural Genomics Consortium (SGC)
Deposit date:2014-06-24
Release date:2014-08-20
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:The Crystal Structure of Human HMT1 hnRNP methyltransferase-like protein 6 in complex with compound DS-421
To be Published
4YVD
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CRYTSAL STRUCTURE OF HUMAN PLEIOTROPIC REGULATOR 1 (PRL1)
Descriptor:Pleiotropic regulator 1, SODIUM ION, CHLORIDE ION, ...
Authors:Dong, A., Zeng, H., Xu, C., Tempel, W., Li, Y., He, H., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Min, J., Wu, H., Structural Genomics Consortium (SGC)
Deposit date:2015-03-19
Release date:2015-04-15
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crytsal structure of human Pleiotropic Regulator 1 (PRL1).
to be published
3CKK
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CRYSTAL STRUCTURE OF HUMAN METHYLTRANSFERASE-LIKE PROTEIN 1
Descriptor:tRNA (guanine-N(7)-)-methyltransferase, S-ADENOSYLMETHIONINE, GLYCEROL
Authors:Dong, A., Zeng, H., Dobrovetsky, E., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Min, J., Plotnikov, A.N., Wu, H., Structural Genomics Consortium (SGC)
Deposit date:2008-03-16
Release date:2008-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structure of human methyltransferase-like protein 1.
To be Published
3DAL
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METHYLTRANSFERASE DOMAIN OF HUMAN PR DOMAIN-CONTAINING PROTEIN 1
Descriptor:PR domain zinc finger protein 1
Authors:Amaya, M.F., Zeng, H., Antoshenko, T., Dong, A., Loppnau, P., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Min, J., Plotnikov, A.N., Wu, H., Structural Genomics Consortium (SGC)
Deposit date:2008-05-29
Release date:2008-08-12
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The crystal structure of methyltransferase domain of human PR domain-containing protein 1
To be Published
3DB5
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CRYSTAL STRUCTURE OF METHYLTRANSFERASE DOMAIN OF HUMAN PR DOMAIN-CONTAINING PROTEIN 4
Descriptor:PR domain zinc finger protein 4
Authors:Amaya, M.F., Zeng, H., Loppnau, P., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Min, J., Plotnikov, A.N., Wu, H., Structural Genomics Consortium (SGC)
Deposit date:2008-05-30
Release date:2008-08-12
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:The crystal structure of methyltransferase domain of human PR domain-containing protein 4.
To be Published
3EP0
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METHYLTRANSFERASE DOMAIN OF HUMAN PR DOMAIN-CONTAINING PROTEIN 12
Descriptor:PR domain zinc finger protein 12
Authors:Amaya, M.F., Zeng, H., Loppnau, P., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Botchkarev, A., Min, J., Plotnikov, A.N., Wu, H., Structural Genomics Consortium (SGC)
Deposit date:2008-09-29
Release date:2008-11-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The crystal structure of methyltransferase domain of human PR Domain-containing protein 12.
To be Published
3EPP
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CRYSTAL STRUCTURE OF MRNA CAP GUANINE-N7 METHYLTRANSFERASE (RNMT) IN COMPLEX WITH SINEFUNGIN
Descriptor:mRNA cap guanine-N7 methyltransferase, SINEFUNGIN
Authors:Amaya, M.F., Zeng, H., Loppnau, P., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Botchkarev, A., Min, J., Plotnikov, A.N., Wu, H., Structural Genomics Consortium (SGC)
Deposit date:2008-09-29
Release date:2008-10-21
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Crystal structure of mRNA cap guanine-N7 methyltransferase (RNMT) in complex with sinefungin.
To be Published
3FLG
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THE PWWP DOMAIN OF HUMAN DNA (CYTOSINE-5-)-METHYLTRANSFERASE 3 BETA
Descriptor:DNA (cytosine-5)-methyltransferase 3B
Authors:Amaya, M.F., Zeng, H., MacKenzie, F., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Botchkarev, A., Min, J., Wu, H., Structural Genomics Consortium (SGC)
Deposit date:2008-12-18
Release date:2009-03-31
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of the PWWP domain of Human DNA (cytosine-5-)-methyltransferase 3 beta
To be Published
3QBY
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CRYSTAL STRUCTURE OF THE PWWP DOMAIN OF HUMAN HEPATOMA-DERIVED GROWTH FACTOR 2
Descriptor:Hepatoma-derived growth factor-related protein 2, H4K20me3 Histone H4 Peptide, UNKNOWN ATOM OR ION, ...
Authors:Zeng, H., Tempel, W., Amaya, M.F., Adams-Cioaba, M.A., Mackenzie, F., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Min, J., Wu, H., Structural Genomics Consortium (SGC)
Deposit date:2011-01-14
Release date:2011-02-09
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural and Histone Binding Ability Characterizations of Human PWWP Domains.
Plos One, 6, 2011
3QJ6
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THE CRYSTAL STRUCTURE OF PWWP DOMAIN OF HUMAN HEPATOMA-DERIVED GROWTH FACTOR 2 IN COMPLEX WITH H3K79ME3 PEPTIDE
Descriptor:Hepatoma-derived growth factor-related protein 2, H3K79me3, SULFATE ION, ...
Authors:Zeng, H., Amaya, M.F., Tempel, W., Walker, J.R., Mackenzie, F., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Min, J., Wu, H., Structural Genomics Consortium (SGC)
Deposit date:2011-01-28
Release date:2011-02-23
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and Histone Binding Ability Characterizations of Human PWWP Domains.
Plos One, 6, 2011