4UFW
| Plasmodium vivax N-myristoyltransferase in complex with a pyridyl inhibitor (compound 22) | Descriptor: | 2-oxopentadecyl-CoA, 4-chloranyl-N-[2-(3-methoxyphenyl)ethanimidoyl]-2-piperidin-4-yloxy-benzamide, CHLORIDE ION, ... | Authors: | Yu, Z, Brannigan, J.A, Rangachari, K, Heal, W.P, Wilkinson, A.J, Holder, A.A, Tate, E.W, Leatherbarrow, R.J. | Deposit date: | 2015-03-19 | Release date: | 2016-02-03 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Discovery of Pyridyl-Based Inhibitors of Plasmodium Falciparum N-Myristoyltransferase Medchemcomm, 6, 2015
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4UFX
| Plasmodium vivax N-myristoyltransferase in complex with a pyridyl inhibitor (compound 19) | Descriptor: | 2-oxopentadecyl-CoA, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | Authors: | Yu, Z, Brannigan, J.A, Rangachari, K, Heal, W.P, Wilkinson, A.J, Holder, A.A, Tate, E.W, Leatherbarrow, R.J. | Deposit date: | 2015-03-19 | Release date: | 2016-02-03 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.49 Å) | Cite: | Discovery of Pyridyl-Based Inhibitors of Plasmodium Falciparum N-Myristoyltransferase Medchemcomm, 6, 2015
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4UFV
| Plasmodium vivax N-myristoyltransferase in complex with a pyridyl inhibitor (compound 18) | Descriptor: | 2-oxopentadecyl-CoA, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | Authors: | Yu, Z, Brannigan, J.A, Rangachari, K, Heal, W.P, Wilkinson, A.J, Holder, A.A, Tate, E.W, Leatherbarrow, R.J. | Deposit date: | 2015-03-19 | Release date: | 2016-02-03 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Discovery of Pyridyl-Based Inhibitors of Plasmodium Falciparum N-Myristoyltransferase Medchemcomm, 6, 2015
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6UTG
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4B14
| Plasmodium vivax N-myristoyltransferase with a bound benzofuran inhibitor (compound 26) | Descriptor: | 2-oxopentadecyl-CoA, 3-methoxybenzyl 3-methyl-4-(piperidin-4-yloxy)-1-benzofuran-2-carboxylate, CHLORIDE ION, ... | Authors: | Yu, Z, Brannigan, J.A, Moss, D.K, Brzozowski, A.M, Wilkinson, A.J, Holder, A.A, Tate, E.W, Leatherbarrow, R.J. | Deposit date: | 2012-07-06 | Release date: | 2012-10-17 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Design and Synthesis of Inhibitors of Plasmodium Falciparum N-Myristoyltransferase, a Promising Target for Anti-Malarial Drug Discovery. J.Med.Chem., 55, 2012
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4B11
| Plasmodium vivax N-myristoyltransferase with a bound benzofuran inhibitor (compound 13) | Descriptor: | 2-oxopentadecyl-CoA, 3-methyl-N-(naphthalen-1-ylmethyl)-4-piperidin-4-yloxy-1-benzofuran-2-carboxamide, CHLORIDE ION, ... | Authors: | Yu, Z, Brannigan, J.A, Moss, D.K, Brzozowski, A.M, Wilkinson, A.J, Holder, A.A, Tate, E.W, Leatherbarrow, R.J. | Deposit date: | 2012-07-06 | Release date: | 2012-10-17 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | Design and Synthesis of Inhibitors of Plasmodium Falciparum N-Myristoyltransferase, a Promising Target for Anti-Malarial Drug Discovery. J.Med.Chem., 55, 2012
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4B10
| Plasmodium vivax N-myristoyltransferase with a non-hydrolysable co- factor | Descriptor: | 2-oxopentadecyl-CoA, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | Authors: | Yu, Z, Brannigan, J.A, Moss, D.K, Brzozowski, A.M, Wilkinson, A.J, Holder, A.A, Tate, E.W, Leatherbarrow, R.J. | Deposit date: | 2012-07-06 | Release date: | 2012-10-17 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | Design and Synthesis of Inhibitors of Plasmodium Falciparum N-Myristoyltransferase, a Promising Target for Anti-Malarial Drug Discovery. J.Med.Chem., 55, 2012
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4B13
| Plasmodium vivax N-myristoyltransferase with a bound benzofuran inhibitor (compound 25) | Descriptor: | 2-oxopentadecyl-CoA, 4-{[2-(3-benzyl-1,2,4-oxadiazol-5-yl)-3-methyl-1-benzofuran-4-yl]oxy}piperidine, CHLORIDE ION, ... | Authors: | Yu, Z, Brannigan, J.A, Moss, D.K, Brzozowski, A.M, Wilkinson, A.J, Holder, A.A, Tate, E.W, Leatherbarrow, R.J. | Deposit date: | 2012-07-06 | Release date: | 2012-10-17 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Design and Synthesis of Inhibitors of Plasmodium Falciparum N-Myristoyltransferase, a Promising Target for Antimalarial Drug Discovery. J.Med.Chem., 55, 2012
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4B12
| Plasmodium vivax N-myristoyltransferase with a bound benzofuran inhibitor (compound 23) | Descriptor: | 1-[3-methyl-4-(piperidin-4-yloxy)-1-benzofuran-2-yl]-3-phenylpropan-1-one, 2-oxopentadecyl-CoA, CHLORIDE ION, ... | Authors: | Yu, Z, Brannigan, J.A, Moss, D.K, Brzozowski, A.M, Wilkinson, A.J, Holder, A.A, Tate, E.W, Leatherbarrow, R.J. | Deposit date: | 2012-07-06 | Release date: | 2012-10-17 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Design and Synthesis of Inhibitors of Plasmodium Falciparum N-Myristoyltransferase, a Promising Target for Anti-Malarial Drug Discovery. J.Med.Chem., 55, 2012
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2OQ2
| Crystal structure of yeast PAPS reductase with PAP, a product complex | Descriptor: | ADENOSINE-3'-5'-DIPHOSPHATE, Phosphoadenosine phosphosulfate reductase | Authors: | Yu, Z, Fisher, A.J. | Deposit date: | 2007-01-31 | Release date: | 2008-01-15 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of Saccharomyces cerevisiae 3'-phosphoadenosine-5'-phosphosulfate reductase complexed with adenosine 3',5'-bisphosphate. Biochemistry, 47, 2008
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2GKS
| Crystal Structure of the Bi-functional ATP Sulfurylase-APS Kinase from Aquifex aeolicus, a Chemolithotrophic Thermophile | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Bifunctional SAT/APS kinase | Authors: | Yu, Z, MacRea, I.J, Lansdon, E.B, Segel, I.H, Fisher, A.J. | Deposit date: | 2006-04-03 | Release date: | 2007-03-06 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Crystal structure of the bifunctional ATP sulfurylase-APS kinase from the chemolithotrophic thermophile Aquifex aeolicus. J.Mol.Biol., 365, 2007
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4OWP
| Crystal structure of rpn11 in a heterodimer complex with rpn8, representing the active portion of the proteasome lid. | Descriptor: | 26S proteasome regulatory subunit RPN11, 26S proteasome regulatory subunit RPN8, ZINC ION | Authors: | Yu, Z, Mansour, W, Nakasone, M.A, Glickman, M.H, Dvir, H. | Deposit date: | 2014-02-03 | Release date: | 2015-08-05 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Crystal structure of rpn11 in a heterodimer complex with rpn8, representing the active portion of the proteasome lid.In preparation. To Be Published
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8D52
| Parathyroid hormone 1 receptor extracellular domain complexed with a peptide ligand containing (2-naphthyl)-beta-3-homoalanine | Descriptor: | 1,2-ETHANEDIOL, PTHrP[1-36], Parathyroid hormone/parathyroid hormone-related peptide receptor, ... | Authors: | Yu, Z, Kreitler, D.F, Gellman, S.H. | Deposit date: | 2022-06-03 | Release date: | 2023-06-14 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | Harnessing Aromatic-Histidine Interactions through Synergistic Backbone Extension and Side Chain Modification. Angew.Chem.Int.Ed.Engl., 62, 2023
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8D51
| Parathyroid hormone 1 receptor extracellular domain complexed with a peptide ligand containing beta-3-homotryptophan | Descriptor: | 1,2-ETHANEDIOL, PTHrP[1-36], Parathyroid hormone/parathyroid hormone-related peptide receptor, ... | Authors: | Yu, Z, Kreitler, D.F, Gellman, S.H. | Deposit date: | 2022-06-03 | Release date: | 2023-06-14 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Harnessing Aromatic-Histidine Interactions through Synergistic Backbone Extension and Side Chain Modification. Angew.Chem.Int.Ed.Engl., 62, 2023
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8H1C
| Cryo-EM structure of Oryza sativa plastid glycyl-tRNA synthetase in complex with two tRNAs (one in tRNA binding state and the other in tRNA locked state) | Descriptor: | Glycine--tRNA ligase, tRNA(gly) (74-MER) | Authors: | Yu, Z, Wu, Z, Li, Y, Lu, G, Lin, J. | Deposit date: | 2022-10-02 | Release date: | 2023-04-26 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Structural basis of a two-step tRNA recognition mechanism for plastid glycyl-tRNA synthetase. Nucleic Acids Res., 51, 2023
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7TZO
| The apo structure of human mTORC2 complex | Descriptor: | Rapamycin-insensitive companion of mTOR, Serine/threonine-protein kinase mTOR, Target of rapamycin complex 2 subunit MAPKAP1, ... | Authors: | Yu, Z, Chen, J, Pearce, D. | Deposit date: | 2022-02-16 | Release date: | 2023-01-11 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.28 Å) | Cite: | Interactions between mTORC2 core subunits Rictor and mSin1 dictate selective and context-dependent phosphorylation of substrate kinases SGK1 and Akt. J.Biol.Chem., 298, 2022
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7XK0
| Cryo-EM strucrture of Oryza sativa plastid glycyl-tRNA synthetase in complex with tRNA (tRNA locked state) | Descriptor: | Glycine--tRNA ligase, tRNA(gly) | Authors: | Yu, Z, Wu, Z, Li, Y, Lu, G, Lin, J. | Deposit date: | 2022-04-19 | Release date: | 2023-05-03 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.59 Å) | Cite: | Structural basis of a two-step tRNA recognition mechanism for plastid glycyl-tRNA synthetase. Nucleic Acids Res., 51, 2023
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7XJZ
| Cryo-EM strucrture of Oryza sativa plastid glycyl-tRNA synthetase in complex with tRNA (tRNA binding state) | Descriptor: | Glycine--tRNA ligase, tRNA(gly) | Authors: | Yu, Z, Wu, Z, Li, Y, Lu, G, Lin, J. | Deposit date: | 2022-04-19 | Release date: | 2023-05-03 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structural basis of a two-step tRNA recognition mechanism for plastid glycyl-tRNA synthetase. Nucleic Acids Res., 51, 2023
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7XJY
| Cryo-EM structure of Oryza sativa plastid glycyl-tRNA synthetase (apo form) | Descriptor: | Glycine--tRNA ligase | Authors: | Yu, Z, Wu, Z, Li, Y, Lu, G, Lin, J. | Deposit date: | 2022-04-19 | Release date: | 2023-05-03 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural basis of a two-step tRNA recognition mechanism for plastid glycyl-tRNA synthetase. Nucleic Acids Res., 51, 2023
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7XK1
| Cryo-EM structure of Oryza sativa plastid glycyl-tRNA synthetase in complex with two tRNAs (both in tRNA binding states) | Descriptor: | Glycine--tRNA ligase, tRNA(gly) | Authors: | Yu, Z, Wu, Z, Li, Y, Lu, G, Lin, J. | Deposit date: | 2022-04-19 | Release date: | 2023-05-03 | Last modified: | 2023-05-24 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Structural basis of a two-step tRNA recognition mechanism for plastid glycyl-tRNA synthetase. Nucleic Acids Res., 51, 2023
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6UTH
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6UTJ
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6UTI
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6UTF
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7L99
| Crystal structure of BRDT bromodomain 2 in complex with CDD-1302 | Descriptor: | Bromodomain testis-specific protein, N-[3-(acetylamino)-4-methylphenyl]-3-(4-amino-2-methylphenyl)-1-methyl-1H-indazole-5-carboxamide, O-(O-(2-AMINOPROPYL)-O'-(2-METHOXYETHYL)POLYPROPYLENE GLYCOL 500) | Authors: | Sharma, R, Yu, Z, Ku, A.F, Anglin, J.L, Ucisik, M.N, Faver, J.C, Sankaran, B, Kim, C, Matzuk, M.M. | Deposit date: | 2021-01-03 | Release date: | 2021-06-30 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Discovery and characterization of bromodomain 2-specific inhibitors of BRDT. Proc.Natl.Acad.Sci.USA, 118, 2021
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