4B11

Plasmodium vivax N-myristoyltransferase with a bound benzofuran inhibitor (compound 13)

Summary for 4B11

• Entry DOI: 10.2210/pdb4b11/pdb
• Related: 4A95 4B10 4B12 4B13 4B14
• Descriptor: GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, 3-methyl-N-(naphthalen-1-ylmethyl)-4-piperidin-4-yloxy-1-benzofuran-2-carboxamide, 2-oxopentadecyl-CoA, ... (8 entities in total)
• Functional Keywords: transferase, myristoyltransferase, malaria, drug design
• Biological source: PLASMODIUM VIVAX
• Total number of polymer chains: 3
• Total formula weight: 139997.21

Authors

Yu, Z.,Brannigan, J.A.,Moss, D.K.,Brzozowski, A.M.,Wilkinson, A.J.,Holder, A.A.,Tate, E.W.,Leatherbarrow, R.J. (deposition date: 2012-07-06, release date: 2012-10-17, Last modification date: 2023-12-20)

• Primary citation: Yu, Z.,Brannigan, J.A.,Moss, D.K.,Brzozowski, A.M.,Wilkinson, A.J.,Holder, A.A.,Tate, E.W.,Leatherbarrow, R.J.; Design and Synthesis of Inhibitors of Plasmodium Falciparum N-Myristoyltransferase, a Promising Target for Anti-Malarial Drug Discovery.; J.Med.Chem., 55:8879-, 2012; PubMed: 23035716; DOI: 10.1021/JM301160H

Experimental method

X-RAY DIFFRACTION (1.59 Å)