Author results

6OAL
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STRUCTURE OF HUMAN PARG COMPLEXED WITH JA2120
Descriptor:Poly(ADP-ribose) glycohydrolase, 1,3-dimethyl-8-{[2-(morpholin-4-yl)ethyl]sulfanyl}-3,7-dihydro-1H-purine-2,6-dione
Authors:Brosey, C.A., Ahmed, Z., Warden, S., Tainer, J.A.
Deposit date:2019-03-16
Release date:2020-03-18
Last modified:2020-05-27
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Nat Commun, 10, 2019
6OAK
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STRUCTURE OF HUMAN PARG COMPLEXED WITH JA2131
Descriptor:Poly(ADP-ribose) glycohydrolase, (8S)-1,3-dimethyl-8-{[2-(morpholin-4-yl)ethyl]sulfanyl}-6-sulfanylidene-1,3,6,7,8,9-hexahydro-2H-purin-2-one
Authors:Brosey, C.A., Ahmed, Z., Warden, S., Tainer, J.A.
Deposit date:2019-03-16
Release date:2020-03-18
Last modified:2020-05-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Nat Commun, 10, 2019
6OA3
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STRUCTURE OF HUMAN PARG COMPLEXED WITH JA2131
Descriptor:Poly(ADP-ribose) glycohydrolase, (8S)-1,3-dimethyl-8-{[2-(morpholin-4-yl)ethyl]sulfanyl}-6-sulfanylidene-1,3,6,7,8,9-hexahydro-2H-purin-2-one
Authors:Stegeman, R.A., Jones, D.E., Ellenberger, T., Kim, I.K., Tainer, J.A.
Deposit date:2019-03-15
Release date:2019-12-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Nat Commun, 10, 2019
6OA1
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STRUCTURE OF HUMAN PARG COMPLEXED WITH JA2120
Descriptor:Poly(ADP-ribose) glycohydrolase, 1,3-dimethyl-8-{[2-(morpholin-4-yl)ethyl]sulfanyl}-3,7-dihydro-1H-purine-2,6-dione
Authors:Stegeman, R.A., Jones, D.E., Ellenberger, T., Kim, I.K., Tainer, J.A.
Deposit date:2019-03-15
Release date:2019-12-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Nat Commun, 10, 2019
6OA0
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STRUCTURE OF HUMAN PARG COMPLEXED WITH JA2-9
Descriptor:Poly(ADP-ribose) glycohydrolase, 4-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)butanoic acid
Authors:Stegeman, R.A., Jones, D.E., Ellenberger, T., Kim, I.K., Tainer, J.A.
Deposit date:2019-03-15
Release date:2019-12-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Nat Commun, 10, 2019
6O9Y
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STRUCTURE OF HUMAN PARG COMPLEXED WITH JA2-8
Descriptor:Poly(ADP-ribose) glycohydrolase, 7-[(2S)-2-hydroxy-3-(morpholin-4-yl)propyl]-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione
Authors:Stegeman, R.A., Jones, D.E., Ellenberger, T., Kim, I.K., Tainer, J.A.
Deposit date:2019-03-15
Release date:2019-12-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Nat Commun, 10, 2019
6O9X
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STRUCTURE OF HUMAN PARG COMPLEXED WITH JA2-4
Descriptor:Poly(ADP-ribose) glycohydrolase, 1,3-dimethyl-8-{[2-(pyrrolidin-1-yl)ethyl]sulfanyl}-6-sulfanylidene-1,3,6,9-tetrahydro-2H-purin-2-one
Authors:Stegeman, R.A., Jones, D.E., Ellenberger, T., Kim, I.K., Tainer, J.A.
Deposit date:2019-03-15
Release date:2019-12-25
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Nat Commun, 10, 2019
6N6B
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THE COMPLEX CRYSTAL STRUCTURE OF NEURAMINIDASE FROM A/MINNESOTA/11/2010 WITH B10 ANTIBODY.
Descriptor:Neuraminidase, B10 antibody Heavy Chain Fab, B10 antibody Light Chain Fab, ...
Authors:Yang, H., Stevens, J.
Deposit date:2018-11-26
Release date:2019-07-03
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The neuraminidase of A(H3N2) influenza viruses circulating since 2016 is antigenically distinct from the A/Hong Kong/4801/2014 vaccine strain.
Nat Microbiol, 4, 2019
6DDV
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CRYSTAL STRUCTURE ANALYSIS OF THE EPITOPE OF AN ANTI-MICA ANTIBODY
Descriptor:Anti-MICA Fab fragment heavy chain clone 6E1, MHC class I chain-related protein A, Anti-MICA Fab fragment light chain clone 6E1
Authors:Matsumoto, M.L.
Deposit date:2018-05-10
Release date:2018-10-24
Last modified:2019-01-23
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:High-resolution glycosylation site-engineering method identifies MICA epitope critical for shedding inhibition activity of anti-MICA antibodies.
MAbs, 11, 2019
6DDR
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CRYSTAL STRUCTURE ANALYSIS OF THE EPITOPE OF AN ANTI-MICA ANTIBODY
Descriptor:Anti-MICA Fab fragment light chain clone 13A9, Anti-MICA Fab fragment heavy chain clone 13A9, MHC class I polypeptide-related sequence A, ...
Authors:Matsumoto, M.L.
Deposit date:2018-05-10
Release date:2018-10-24
Last modified:2019-01-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:High-resolution glycosylation site-engineering method identifies MICA epitope critical for shedding inhibition activity of anti-MICA antibodies.
MAbs, 11, 2019
6DDM
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CRYSTAL STRUCTURE ANALYSIS OF THE EPITOPE OF AN ANTI-MICA ANTIBODY
Descriptor:Anti-MICA Fab fragment light chain clone 1D5, MHC class I polypeptide-related sequence A, Anti-MICA Fab fragment heavy chain clone 1D5
Authors:Matsumoto, M.L.
Deposit date:2018-05-10
Release date:2018-10-24
Last modified:2019-01-23
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:High-resolution glycosylation site-engineering method identifies MICA epitope critical for shedding inhibition activity of anti-MICA antibodies.
MAbs, 11, 2019
5YU9
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CRYSTAL STRUCTURE OF EGFR 696-1022 T790M IN COMPLEX WITH IBRUTINIB
Descriptor:Epidermal growth factor receptor, 1-{(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one, CHLORIDE ION
Authors:Yan, X.E., Yun, C.H.
Deposit date:2017-11-21
Release date:2017-12-27
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Ibrutinib targets mutant-EGFR kinase with a distinct binding conformation.
Oncotarget, 7, 2016
5V8A
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CRYSTAL STRUCTURE OF INFLUENZA A VIRUS MATRIX PROTEIN M1 (NLS-88R, PH 7.3)
Descriptor:Matrix protein 1
Authors:Musayev, F.N., Safo, M.K., Desai, U.R., Xie, H., Mosier, P.D., Zhou, Q., Chiang, M.-J., Kosikova, M.
Deposit date:2017-03-21
Release date:2017-04-19
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (3 Å)
Cite:Maintaining pH-dependent conformational flexibility of M1 is critical for efficient influenza A virus replication.
Emerg Microbes Infect, 6, 2017
5V7S
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CRYSTAL STRUCTURE OF INFLUENZA A VIRUS MATRIX PROTEIN M1 (NLS-88E, PH 6.2)
Descriptor:Matrix protein 1, PHOSPHATE ION
Authors:Musayev, F.N., Safo, M.K., Althufairi, B., Desai, U.R., Xie, H., Mosier, P.D., Chiang, M.-J., Zhou, Q.
Deposit date:2017-03-20
Release date:2017-04-12
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Maintaining pH-dependent conformational flexibility of M1 is critical for efficient influenza A virus replication.
Emerg Microbes Infect, 6, 2017
5V7B
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CRYSTAL STRUCTURE OF INFLUENZA A VIRUS MATRIX PROTEIN M1 (NLS-88E)
Descriptor:Matrix protein 1
Authors:Musayev, F.N., Safo, M.K., Desai, U.R., Xie, H., Mosier, P.D., Chiang, M.-J.
Deposit date:2017-03-20
Release date:2017-04-12
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Maintaining pH-dependent conformational flexibility of M1 is critical for efficient influenza A virus replication.
Emerg Microbes Infect, 6, 2017
5V6G
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CRYSTAL STRUCTURE OF INFLUENZA A VIRUS MATRIX PROTEIN M1(NLS-88R)
Descriptor:Matrix protein 1
Authors:Musayev, F.N., Safo, M.K., Desai, U.R., Xie, H., Mosier, P.D., Chiang, M.-J.
Deposit date:2017-03-16
Release date:2017-04-12
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Maintaining pH-dependent conformational flexibility of M1 is critical for efficient influenza A virus replication.
Emerg Microbes Infect, 6, 2017
5GSD
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CRYSTAL STRUCTURE OF LMP2 PEPTIDE FROM EBV IN COMPLEX WITH HLA-A*11:01
Descriptor:HLA class I histocompatibility antigen, A-11 alpha chain, Beta-2-microglobulin, ...
Authors:Tadwal, V.S., Xiao, Z., Ren, E.C.
Deposit date:2016-08-15
Release date:2017-08-09
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Dual non-contiguous peptide occupancy of HLA class I evoke antiviral human CD8 T cell response and form neo-epitopes with self-antigens
Sci Rep, 7, 2017
5GRG
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CRYSTAL STRUCTURE OF DUAL PEPTIDE FROM EBV IN COMPLEX WITH HLA-A*11:01
Descriptor:HLA class I histocompatibility antigen, A-11 alpha chain, Beta-2-microglobulin, ...
Authors:Tadwal, V.S., Xiao, Z., Ren, E.C.
Deposit date:2016-08-11
Release date:2017-08-09
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Dual non-contiguous peptide occupancy of HLA class I evoke antiviral human CD8 T cell response and form neo-epitopes with self-antigens
Sci Rep, 7, 2017
5GRD
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CRYSTAL STRUCTURE OF 10-MER PEPTIDE FROM EBV IN COMPLEX WITH HLA-A1101.
Descriptor:HLA class I histocompatibility antigen, A-11 alpha chain, Beta-2-microglobulin, ...
Authors:Tadwal, V.S., Xiao, Z., Ren, E.C.
Deposit date:2016-08-10
Release date:2017-08-09
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Dual non-contiguous peptide occupancy of HLA class I evoke antiviral human CD8 T cell response and form neo-epitopes with self-antigens
Sci Rep, 7, 2017
4ZSE
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CRYSTAL STRUCTURE OF EGFR 696-1022 T790M/V948R, CRYSTAL FORM II
Descriptor:Epidermal growth factor receptor, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ...
Authors:Yan, X.E., Yun, C.H.
Deposit date:2015-05-13
Release date:2016-06-15
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Ibrutinib Selectively and Irreversibly Targets EGFR-mutant non-Small Cell Lung Cancer Cells
To Be Published
4J01
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CRYSTAL STRUCTURE OF FISCHERELLA TRANSCRIPTION FACTOR HETR COMPLEXED WITH 29MER DNA TARGET
Descriptor:Transcription Factor HetR, DNA (29-MER), SULFATE ION
Authors:Kim, Y., Joachimiak, G., Gornicki, P., Joachimiak, A., MCSG, Midwest Center for Structural Genomics (MCSG)
Deposit date:2013-01-30
Release date:2013-03-27
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.246 Å)
Cite:Structures of complexes comprised of Fischerella transcription factor HetR with Anabaena DNA targets.
Proc.Natl.Acad.Sci.USA, 110, 2013
4J00
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CRYSTAL STRUCTURE OF FISCHERELLA TRANSCRIPTION FACTOR HETR COMPLEXED WITH 24MER DNA TARGET
Descriptor:Transcription Factor HetR, DNA (5'-D(*TP*GP*GP*TP*GP*AP*GP*GP*GP*GP*TP*TP*AP*AP*AP*CP*CP*CP*CP*TP*CP*AP*CP*C)-3'), MAGNESIUM ION
Authors:Kim, Y., Joachimiak, G., Gornicki, P., Joachimiak, A., MCSG, Midwest Center for Structural Genomics (MCSG)
Deposit date:2013-01-30
Release date:2013-03-27
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.004 Å)
Cite:Structures of complexes comprised of Fischerella transcription factor HetR with Anabaena DNA targets.
Proc.Natl.Acad.Sci.USA, 110, 2013
4IZZ
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CRYSTAL STRUCTURE OF FISCHERELLA TRANSCRIPTION FACTOR HETR COMPLEXED WITH 21MER DNA TARGET
Descriptor:Transcription Factor HetR, DNA (5'-D(*GP*TP*GP*AP*GP*GP*GP*GP*TP*TP*AP*AP*AP*CP*CP*CP*CP*TP*CP*AP*C)-3'), SULFATE ION, ...
Authors:Kim, Y., Joachimiak, G., Gornicki, P., Joachimiak, A., MCSG, Midwest Center for Structural Genomics (MCSG)
Deposit date:2013-01-30
Release date:2013-03-27
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.502 Å)
Cite:Structures of complexes comprised of Fischerella transcription factor HetR with Anabaena DNA targets.
Proc.Natl.Acad.Sci.USA, 110, 2013
3QOE
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CRYSTAL STRUCTURE OF HETEROCYST DIFFERENTIATION PROTEIN, HETR FROM FISCHERELLA MV11
Descriptor:Heterocyst differentiation protein
Authors:Kim, Y., Joachimiak, G., Gornicki, P., Joachimiak, A., Midwest Center for Structural Genomics (MCSG)
Deposit date:2011-02-09
Release date:2011-04-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.004 Å)
Cite:Structure of transcription factor HetR required for heterocyst differentiation in cyanobacteria.
Proc.Natl.Acad.Sci.USA, 108, 2011
3QOD
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CRYSTAL STRUCTURE OF HETEROCYST DIFFERENTIATION PROTEIN, HETR FROM FISCHERELLA MV11
Descriptor:Heterocyst differentiation protein
Authors:Kim, Y., Joachimiak, G., Gornicki, P., Joachimiak, A., Midwest Center for Structural Genomics (MCSG)
Deposit date:2011-02-09
Release date:2011-04-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.38 Å)
Cite:Structure of transcription factor HetR required for heterocyst differentiation in cyanobacteria.
Proc.Natl.Acad.Sci.USA, 108, 2011
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