4Q9N
| Crystal structure of Chlamydia trachomatis enoyl-ACP reductase (FabI) in complex with NADH and AFN-1252 | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Enoyl-[acyl-carrier-protein] reductase [NADH], N-methyl-N-[(3-methyl-1-benzofuran-2-yl)methyl]-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)propanamide | Authors: | Yao, J, Abdelrahman, Y, Robertson, R.M, Cox, J.V, Belland, R.J, White, S.W, Rock, C.O. | Deposit date: | 2014-05-01 | Release date: | 2014-06-25 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.795 Å) | Cite: | Type II Fatty Acid Synthesis Is Essential for the Replication of Chlamydia trachomatis. J.Biol.Chem., 289, 2014
|
|
5WYH
| Crystal structure of RidL(1-200) complexed with VPS29 | Descriptor: | GLYCEROL, Interaptin, Vacuolar protein sorting-associated protein 29 | Authors: | Yao, J, Sun, Q, Jia, D. | Deposit date: | 2017-01-13 | Release date: | 2018-01-24 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.46 Å) | Cite: | Mechanism of inhibition of retromer transport by the bacterial effector RidL. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
|
|
7CRU
| hnRNPK NLS in complex with Importin alpha 1 (KPNA2) | Descriptor: | ACETATE ION, GLYCEROL, Heterogeneous nuclear ribonucleoprotein K, ... | Authors: | Yao, J, Sun, Q. | Deposit date: | 2020-08-14 | Release date: | 2021-11-17 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Nuclear import receptors and hnRNPK mediates nuclear import and stress granule localization of SIRLOIN. Cell.Mol.Life Sci., 78, 2021
|
|
7CRE
| |
4LMQ
| Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12 | Descriptor: | Stromal cell-derived factor 1, hu30D8 Fab heavy chain, hu30D8 Fab light chain | Authors: | Zhong, Z, Wang, J, Li, B, Xiang, H, Ultsch, M, Coons, M, Wong, T, Chiang, N.Y, Clark, S, Clark, R, Quintana, L, Gribling, P, Suto, E, Barck, K, Corpuz, R, Yao, J, Takkar, R, Lee, W.P, Damico-Beyer, L.A, Carano, R.D, Adams, C, Kelley, R.F, Wang, W, Ferrara, N. | Deposit date: | 2013-07-10 | Release date: | 2013-08-14 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2.773 Å) | Cite: | Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12. Clin.Cancer Res., 19, 2013
|
|
6DD5
| Crystal Structure of the Cas6 Domain of Marinomonas mediterranea MMB-1 Cas6-RT-Cas1 Fusion Protein | Descriptor: | GLYCEROL, MMB-1 Cas6 Fused to Maltose Binding Protein,CRISPR-associated endonuclease Cas1, SULFATE ION, ... | Authors: | Stamos, J.L, Mohr, G, Silas, S, Makarova, K.S, Markham, L.M, Yao, J, Lucas-Elio, P, Sanchez-Amat, A, Fire, A.Z, Koonin, E.V, Lambowitz, A.M. | Deposit date: | 2018-05-09 | Release date: | 2018-10-17 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | A Reverse Transcriptase-Cas1 Fusion Protein Contains a Cas6 Domain Required for Both CRISPR RNA Biogenesis and RNA Spacer Acquisition. Mol. Cell, 72, 2018
|
|
5KYM
| Crystal Structure of the 1-acyl-sn-glycerophosphate (LPA) acyltransferase, PlsC, from Thermotoga maritima | Descriptor: | 1-HEPTADECANOYL-2-TRIDECANOYL-3-GLYCEROL-PHOSPHONYL CHOLINE, 1-acyl-sn-glycerol-3-phosphate acyltransferase, DODECYL-BETA-D-MALTOSIDE, ... | Authors: | Robertson, R.M, Yao, J, Gajewski, S, Kumar, G, Martin, E.W, Rock, C.O, White, S.W. | Deposit date: | 2016-07-21 | Release date: | 2017-07-26 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | A two-helix motif positions the lysophosphatidic acid acyltransferase active site for catalysis within the membrane bilayer. Nat. Struct. Mol. Biol., 24, 2017
|
|
6LG2
| VanR bound to Vanillate | Descriptor: | 4-HYDROXY-3-METHOXYBENZOATE, Predicted transcriptional regulators | Authors: | He, Y, Bharath, S.R, Song, H. | Deposit date: | 2019-12-04 | Release date: | 2020-02-12 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Developing a highly efficient hydroxytyrosol whole-cell catalyst by de-bottlenecking rate-limiting steps. Nat Commun, 11, 2020
|
|
6M6U
| Crystal structure the toxin-antitoxin MntA-HpeT mutant-D39ED41E | Descriptor: | Toxin-antitoxin system antitoxin MntA family, Toxin-antitoxin system toxin HepN family | Authors: | Ouyang, S.Y, Zhen, X.K. | Deposit date: | 2020-03-16 | Release date: | 2020-09-30 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.349 Å) | Cite: | Novel polyadenylylation-dependent neutralization mechanism of the HEPN/MNT toxin/antitoxin system. Nucleic Acids Res., 48, 2020
|
|
6M6W
| Crystal structure the toxin-antitoxin MntA-HpeT mutant-Y104A | Descriptor: | Toxin-antitoxin system antidote Mnt family, Toxin-antitoxin system toxin HepN family | Authors: | Ouyang, S.Y, Zhen, X.K. | Deposit date: | 2020-03-16 | Release date: | 2020-09-30 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.611 Å) | Cite: | Novel polyadenylylation-dependent neutralization mechanism of the HEPN/MNT toxin/antitoxin system. Nucleic Acids Res., 48, 2020
|
|
6M6V
| Crystal structure the toxin-antitoxin MntA-HepT | Descriptor: | RNA (5'-R(P*AP*AP*A)-3'), Toxin-antitoxin system antidote Mnt family, Toxin-antitoxin system toxin HepN family | Authors: | Ouyang, S.Y, Zhen, X.K. | Deposit date: | 2020-03-16 | Release date: | 2020-09-30 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.08 Å) | Cite: | Novel polyadenylylation-dependent neutralization mechanism of the HEPN/MNT toxin/antitoxin system. Nucleic Acids Res., 48, 2020
|
|
7BXO
| Crystal structure of the toxin-antitoxin with AMP-PNP | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Toxin-antitoxin system antidote Mnt family, ... | Authors: | Ouyang, S.Y, Zhen, X.K. | Deposit date: | 2020-04-20 | Release date: | 2020-09-30 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.77 Å) | Cite: | Novel polyadenylylation-dependent neutralization mechanism of the HEPN/MNT toxin/antitoxin system. Nucleic Acids Res., 48, 2020
|
|
7AER
| Rebuilt and re-refined PDB entry 5yep: tri-AMPylated Shewanella oneidensis HEPN toxin in complex with MNT antitoxin | Descriptor: | ADENOSINE MONOPHOSPHATE, Toxin-antitoxin system antidote Mnt family, Toxin-antitoxin system toxin HepN family | Authors: | Tamulaitiene, G, Sasnauskas, G, Songailiene, I, Juozapaitis, J, Siksnys, V. | Deposit date: | 2020-09-18 | Release date: | 2020-12-30 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | HEPN-MNT Toxin-Antitoxin System: The HEPN Ribonuclease Is Neutralized by OligoAMPylation. Mol.Cell, 80, 2020
|
|
6VLX
| Crystal structure of FabI from Alistipes finegoldii | Descriptor: | Enoyl-[acyl-carrier-protein] reductase [NADH], GLYCEROL | Authors: | Radka, C.D, Seetharaman, J, Rock, C.O. | Deposit date: | 2020-01-27 | Release date: | 2020-04-29 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | The genome of a Bacteroidetes inhabitant of the human gut encodes a structurally distinct enoyl-acyl carrier protein reductase (FabI). J.Biol.Chem., 295, 2020
|
|
6VLY
| Crystal structure of FabI-NADH complex from Alistipes finegoldii | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, CHLORIDE ION, Enoyl-[acyl-carrier-protein] reductase [NADH], ... | Authors: | Radka, C.D, Seetharaman, J, Rock, C.O. | Deposit date: | 2020-01-27 | Release date: | 2020-04-29 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | The genome of a Bacteroidetes inhabitant of the human gut encodes a structurally distinct enoyl-acyl carrier protein reductase (FabI). J.Biol.Chem., 295, 2020
|
|
6IP1
| alpha-SNAP-SNARE subcomplex in the whole 20S complex | Descriptor: | Alpha-soluble NSF attachment protein, Synaptosomal-associated protein 25, Syntaxin-1A, ... | Authors: | Huang, X, Sun, S, Wang, X, Fan, F, Zhou, Q, Sui, S.F. | Deposit date: | 2018-11-01 | Release date: | 2019-04-24 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Mechanistic insights into the SNARE complex disassembly. Sci Adv, 5, 2019
|
|
7YQE
| |
6IP2
| NSF-D1D2 part in the whole 20S complex | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Vesicle-fusing ATPase | Authors: | Huang, X, Sun, S, Wang, X, Fan, F, Zhou, Q, Sui, S.F. | Deposit date: | 2018-11-01 | Release date: | 2019-04-24 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Mechanistic insights into the SNARE complex disassembly. Sci Adv, 5, 2019
|
|
7F65
| Bacetrial Cocaine Esterase with mutations T172R/G173Q/V116K/S117A/A51L, bound to benzoic acid | Descriptor: | BENZOIC ACID, Cocaine esterase, SULFATE ION | Authors: | Ouyang, P.F, Zhang, Y, Tong, J. | Deposit date: | 2021-06-24 | Release date: | 2021-09-15 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.202 Å) | Cite: | Computational Design and Crystal Structure of a Highly Efficient Benzoylecgonine Hydrolase. Angew.Chem.Int.Ed.Engl., 60, 2021
|
|
3KRY
| Crystal structure of MMP-13 in complex with SC-78080 | Descriptor: | 1-(2-methoxyethyl)-N-oxo-4-({4-[4-(trifluoromethoxy)phenoxy]phenyl}sulfonyl)piperidine-4-carboxamide, CALCIUM ION, Collagenase 3, ... | Authors: | Kiefer, J.R, Williams, J.M, Becker, D.P. | Deposit date: | 2009-11-19 | Release date: | 2010-10-06 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Orally-active MMP-1 sparing alpha-tetrahydropyranyl and alpha-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease J.Med.Chem., 53, 2010
|
|
4WVO
| An engineered PYR1 mandipropamid receptor in complex with mandipropamid and HAB1 | Descriptor: | (2S)-2-(4-chlorophenyl)-N-{2-[3-methoxy-4-(prop-2-yn-1-yloxy)phenyl]ethyl}-2-(prop-2-yn-1-yloxy)ethanamide, Abscisic acid receptor PYR1, MAGNESIUM ION, ... | Authors: | Peterson, F.C, Volkman, B.F, Cutler, S.R. | Deposit date: | 2014-11-06 | Release date: | 2015-02-11 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.251 Å) | Cite: | Agrochemical control of plant water use using engineered abscisic acid receptors. Nature, 520, 2015
|
|
4RQW
| Crystal structure of Myc3 N-terminal JAZ-binding domain [44-238] from Arabidopsis | Descriptor: | CALCIUM ION, Transcription factor MYC3 | Authors: | Ke, J, Zhang, F, Zhou, X.E, Brunzelle, J, Zhou, M, Xu, H.E, Melcher, K, He, S.Y. | Deposit date: | 2014-11-05 | Release date: | 2015-08-12 | Last modified: | 2015-09-16 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural basis of JAZ repression of MYC transcription factors in jasmonate signalling. Nature, 525, 2015
|
|
4RRU
| Myc3 N-terminal JAZ-binding domain[5-242] from arabidopsis | Descriptor: | CALCIUM ION, Transcription factor MYC3 | Authors: | Ke, J, Zhang, F, Zhou, X.E, Brunzelle, J.S, Zhou, M, Xu, H.E, Melcher, K, He, S.Y. | Deposit date: | 2014-11-06 | Release date: | 2015-08-12 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural basis of JAZ repression of MYC transcription factors in jasmonate signalling. Nature, 525, 2015
|
|
4RS9
| Structure of Myc3 N-terminal JAZ-binding domain [44-238] in complex with Jas motif of JAZ9 | Descriptor: | Protein TIFY 7, Transcription factor MYC3 | Authors: | Ke, J, Zhang, F, Zhou, X.E, Brunzelle, J.S, Zhou, M, Xu, H.E, Melcher, K, He, S.Y. | Deposit date: | 2014-11-07 | Release date: | 2015-08-12 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural basis of JAZ repression of MYC transcription factors in jasmonate signalling. Nature, 525, 2015
|
|
8T2I
| Negative stain EM assembly of MYC, JAZ, and NINJA complex | Descriptor: | AFP homolog 2, Maltose/maltodextrin-binding periplasmic protein, Protein TIFY 10A, ... | Authors: | Zhou, X.E, Zhang, Y, Zhou, Y, He, Q, Cao, X, Kariapper, L, Suino-Powell, K, Zhu, Y, Zhang, F, Karsten, M. | Deposit date: | 2023-06-06 | Release date: | 2023-06-28 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (10.4 Å) | Cite: | Assembly of JAZ-JAZ and JAZ-NINJA complexes in jasmonate signaling. Plant Commun., 4, 2023
|
|