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1UAW
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BU of 1uaw by Molmil
Solution structure of the N-terminal RNA-binding domain of mouse Musashi1
Descriptor: mouse-musashi-1
Authors:Miyanoiri, Y, Kobayashi, H, Watanabe, M, Ikeda, T, Nagata, T, Okano, H, Uesugi, S, Katahira, M.
Deposit date:2003-03-24
Release date:2004-03-24
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Origin of higher affinity to RNA of the N-terminal RNA-binding domain than that of the C-terminal one of a mouse neural protein, musashi1, as revealed by comparison of their structures, modes of interaction, surface electrostatic potentials, and backbone dynamics
J.Biol.Chem., 278, 2003
2KIA
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BU of 2kia by Molmil
Solution structure of Myosin VI C-terminal cargo-binding domain
Descriptor: Myosin-VI
Authors:Feng, W, Yu, C, Wei, Z, Miyanoiri, Y, Zhang, M.
Deposit date:2009-04-29
Release date:2009-09-29
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Myosin VI undergoes cargo-mediated dimerization
Cell(Cambridge,Mass.), 138, 2009
3WIY
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BU of 3wiy by Molmil
Crystal structure of Mcl-1 in complex with compound 10
Descriptor: 7-(4-{[(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrophenyl)sulfonyl]carbamoyl}-2-methylphenyl)-3-[3-(naphthalen-1-yloxy)propyl]pyrazolo[1,5-a]pyridine-2-carboxylic acid, Induced myeloid leukemia cell differentiation protein Mcl-1
Authors:Sogabe, S, Igaki, S, Hayano, Y.
Deposit date:2013-09-26
Release date:2013-11-27
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Discovery of potent Mcl-1/Bcl-xL dual inhibitors by using a hybridization strategy based on structural analysis of target proteins.
J.Med.Chem., 56, 2013
1IQT
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BU of 1iqt by Molmil
Solution structure of the C-terminal RNA-binding domain of heterogeneous nuclear ribonucleoprotein D0 (AUF1)
Descriptor: heterogeneous nuclear ribonucleoprotein D0
Authors:Katahira, M, Miyanoiri, Y, Enokizono, Y, Matsuda, G, Nagata, T, Ishikawa, F, Uesugi, S.
Deposit date:2001-08-01
Release date:2002-08-07
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Structure of the C-terminal RNA-binding domain of hnRNP D0 (AUF1), its interactions with RNA and DNA, and change in backbone dynamics upon complex formation with DNA.
J.Mol.Biol., 311, 2001
3WIZ
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BU of 3wiz by Molmil
Crystal structure of Bcl-xL in complex with compound 10
Descriptor: 7-(4-{[(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrophenyl)sulfonyl]carbamoyl}-2-methylphenyl)-3-[3-(naphthalen-1-yloxy)propyl]pyrazolo[1,5-a]pyridine-2-carboxylic acid, Bcl-2-like protein 1, PHOSPHATE ION
Authors:Sogabe, S, Igaki, S, Hayano, Y.
Deposit date:2013-09-26
Release date:2013-11-27
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Discovery of potent Mcl-1/Bcl-xL dual inhibitors by using a hybridization strategy based on structural analysis of target proteins.
J.Med.Chem., 56, 2013
3WIX
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BU of 3wix by Molmil
Crystal structure of Mcl-1 in complex with compound 4
Descriptor: 7-(4-carboxyphenyl)-3-[3-(naphthalen-1-yloxy)propyl]pyrazolo[1,5-a]pyridine-2-carboxylic acid, Induced myeloid leukemia cell differentiation protein Mcl-1
Authors:Sogabe, S, Igaki, S, Hayano, Y.
Deposit date:2013-09-26
Release date:2013-11-27
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery of potent Mcl-1/Bcl-xL dual inhibitors by using a hybridization strategy based on structural analysis of target proteins.
J.Med.Chem., 56, 2013
7E0D
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BU of 7e0d by Molmil
Structure of L-glutamate oxidase R305E mutant in complex with L-arginine
Descriptor: ARGININE, FLAVIN-ADENINE DINUCLEOTIDE, L-glutamate oxidase
Authors:Ito, N, Matsuo, S, Inagaki, K, Imada, K.
Deposit date:2021-01-27
Release date:2021-04-07
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A new l-arginine oxidase engineered from l-glutamate oxidase.
Protein Sci., 30, 2021
7E0C
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BU of 7e0c by Molmil
Structure of L-glutamate oxidase R305E mutant
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, L-glutamate oxidase
Authors:Ito, N, Matsuo, S, Inagaki, K, Imada, K.
Deposit date:2021-01-27
Release date:2021-04-07
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:A new l-arginine oxidase engineered from l-glutamate oxidase.
Protein Sci., 30, 2021
6L9C
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BU of 6l9c by Molmil
Neutron structure of copper amine oxidase from Arthrobacter glibiformis at pD 7.4
Descriptor: COPPER (II) ION, Phenylethylamine oxidase, SODIUM ION
Authors:Murakawa, T, Kurihara, K, Shoji, M, Shibazaki, C, Sunami, T, Tamada, T, Yano, N, Yamada, T, Kusaka, K, Suzuki, M, Shigeta, Y, Kuroki, R, Hayashi, H, Yano, Y, Tanizawa, K, Adachi, M, Okajima, T.
Deposit date:2019-11-08
Release date:2020-04-29
Last modified:2023-11-22
Method:NEUTRON DIFFRACTION (1.14 Å), X-RAY DIFFRACTION
Cite:Neutron crystallography of copper amine oxidase reveals keto/enolate interconversion of the quinone cofactor and unusual proton sharing.
Proc.Natl.Acad.Sci.USA, 117, 2020
1F3P
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BU of 1f3p by Molmil
FERREDOXIN REDUCTASE (BPHA4)-NADH COMPLEX
Descriptor: FERREDOXIN REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Senda, T, Yamada, T, Sakurai, N, Kubota, M, Nishizaki, T, Masai, E, Fukuda, M, Mitsuidagger, Y.
Deposit date:2000-06-06
Release date:2001-06-06
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of NADH-dependent ferredoxin reductase component in biphenyl dioxygenase.
J.Mol.Biol., 304, 2000
8K9O
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BU of 8k9o by Molmil
Crystal structure of Cyanobacteriochrome RcaE GAF domain in Pg state
Descriptor: PHYCOCYANOBILIN, histidine kinase
Authors:Nagae, T, Hirose, Y, Mishima, M.
Deposit date:2023-08-01
Release date:2024-05-15
Last modified:2024-06-26
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Green/red light-sensing mechanism in the chromatic acclimation photosensor.
Sci Adv, 10, 2024
7SQO
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BU of 7sqo by Molmil
Structure of the orexin-2 receptor(OX2R) bound to TAK-925, Gi and scFv16
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
Authors:McGrath, A.P, Kang, Y, Flinspach, M.
Deposit date:2021-11-05
Release date:2022-05-25
Last modified:2022-07-06
Method:ELECTRON MICROSCOPY (3.17 Å)
Cite:Molecular mechanism of the wake-promoting agent TAK-925.
Nat Commun, 13, 2022
2JMW
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BU of 2jmw by Molmil
Structure of DNA-Binding Domain of Arabidopsis GT-1
Descriptor: DNA binding protein GT-1
Authors:Nagata, T, Niyada, E, Noto, K, Ikeda, Y, Yamamoto, Y, Uesugi, S, Murata, J, Hiratsuka, K, Katahira, M.
Deposit date:2006-12-11
Release date:2007-12-11
Last modified:2023-12-20
Method:SOLUTION NMR
Cite:Solution structures of the trihelix DNA-binding domains of the wild-type and a phosphomimetic mutant of Arabidopsis GT-1: mechanism for an increase in DNA-binding affinity through phosphorylation.
Proteins, 78, 2010
7SR8
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BU of 7sr8 by Molmil
Molecular mechanism of the the wake-promoting agent TAK-925
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Hypocretin receptor type 2, ...
Authors:Yin, J, Chapman, K, Lian, P, De Brabander, J.K, Rosenbaum, D.M.
Deposit date:2021-11-08
Release date:2022-06-08
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Molecular mechanism of the wake-promoting agent TAK-925.
Nat Commun, 13, 2022
3H8D
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BU of 3h8d by Molmil
Crystal structure of Myosin VI in complex with Dab2 peptide
Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, CHLORIDE ION, Disabled homolog 2, ...
Authors:Yu, C, Feng, W, Wei, Z, Zhang, M.
Deposit date:2009-04-29
Release date:2009-09-29
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Myosin VI undergoes cargo-mediated dimerization
Cell(Cambridge,Mass.), 138, 2009
1X0F
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BU of 1x0f by Molmil
Complex structure of the C-terminal RNA-binding domain of hnRNP D(AUF1) with telomeric DNA
Descriptor: 5'-D(P*TP*AP*GP*G)-3', Heterogeneous nuclear ribonucleoprotein D0
Authors:Enokizono, Y, Konishi, Y, Nagata, K, Ouhashi, K, Uesugi, S, Ishikawa, F, Katahira, M.
Deposit date:2005-03-22
Release date:2005-04-05
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Structure of hnRNP D complexed with single-stranded telomere DNA and unfolding of the quadruplex by heterogeneous nuclear ribonucleoprotein D.
J.Biol.Chem., 280, 2005
1WTB
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BU of 1wtb by Molmil
Complex structure of the C-terminal RNA-binding domain of hnRNP D (AUF1) with telomere DNA
Descriptor: 5'-D(P*TP*AP*GP*G)-3', Heterogeneous nuclear ribonucleoprotein D0
Authors:Enokizono, Y, Konishi, Y, Nagata, K, Ouhashi, K, Uesugi, S, Ishikawa, F, Katahira, M.
Deposit date:2004-11-22
Release date:2005-04-05
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Structure of hnRNP D complexed with single-stranded telomere DNA and unfolding of the quadruplex by heterogeneous nuclear ribonucleoprotein D
J.Biol.Chem., 280, 2005
5B4O
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BU of 5b4o by Molmil
Crystal structure of Macrophage Migration Inhibitory Factor in complex with BTZO-14
Descriptor: 1,2-ETHANEDIOL, 2-pyridin-3-yl-1,3-benzothiazin-4-one, Macrophage migration inhibitory factor, ...
Authors:Oki, H, Igaki, S, Moriya, Y, Hayano, Y, Habuka, N.
Deposit date:2016-04-07
Release date:2016-04-20
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:BTZO-1, a cardioprotective agent, reveals that macrophage migration inhibitory factor regulates ARE-mediated gene expression
Chem. Biol., 17, 2010
2EBI
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BU of 2ebi by Molmil
Arabidopsis GT-1 DNA-binding domain with T133D phosphomimetic mutation
Descriptor: DNA binding protein GT-1
Authors:Nagata, T, Noto, K, Niyada, E, Ikeda, Y, Yamamoto, Y, Uesugi, S, Murata, J, Hiratsuka, K, Katahira, M.
Deposit date:2007-02-08
Release date:2008-02-19
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Solution structures of the trihelix DNA-binding domains of the wild-type and a phosphomimetic mutant of Arabidopsis GT-1: mechanism for an increase in DNA-binding affinity through phosphorylation.
Proteins, 78, 2010
7CKV
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BU of 7ckv by Molmil
Crystal structure of Cyanobacteriochrome GAF domain in Pr state
Descriptor: MAGNESIUM ION, PHYCOCYANOBILIN, RcaE
Authors:Nagae, T, Koizumi, T, Hirose, Y, Mishima, M.
Deposit date:2020-07-19
Release date:2021-05-05
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Structural basis of the protochromic green/red photocycle of the chromatic acclimation sensor RcaE.
Proc.Natl.Acad.Sci.USA, 118, 2021
3VVI
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BU of 3vvi by Molmil
Crystal structure of the coiled-coil domain of the transient receptor potential channel from Gibberella zeae (TRPGz)
Descriptor: ACETATE ION, Non selective cation channel homologous to TRP channel
Authors:Ihara, M, Yamashita, A.
Deposit date:2012-07-25
Release date:2013-04-10
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Molecular bases of multimodal regulation of a fungal transient receptor potential (TRP) channel
J.Biol.Chem., 288, 2013
3WYM
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BU of 3wym by Molmil
Crystal structure of the catalytic domain of PDE10A complexed with 1-(2-fluoro-4-(1H-pyrazol-1-yl)phenyl)-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one
Descriptor: 1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one, MAGNESIUM ION, ZINC ION, ...
Authors:Oki, H, Hayano, Y.
Deposit date:2014-09-01
Release date:2014-11-19
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of 1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (TAK-063), a highly potent, selective, and orally active phosphodiesterase 10A (PDE10A) inhibitor.
J.Med.Chem., 57, 2014
3WYK
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BU of 3wyk by Molmil
Crystal structure of the catalytic domain of PDE10A complexed with 3-(1-phenyl-1H-pyrazol-5-yl)-1-(3-(trifluoromethyl)phenyl)pyridazin-4(1H)-one
Descriptor: 3-(1-phenyl-1H-pyrazol-5-yl)-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one, MAGNESIUM ION, ZINC ION, ...
Authors:Oki, H, Hayano, Y.
Deposit date:2014-09-01
Release date:2014-11-19
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Discovery of 1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (TAK-063), a highly potent, selective, and orally active phosphodiesterase 10A (PDE10A) inhibitor.
J.Med.Chem., 57, 2014
3WYL
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BU of 3wyl by Molmil
Crystal structure of the catalytic domain of PDE10A complexed with 5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)-1-(3-(trifluoromethyl)phenyl)pyridazin-4(1H)-one
Descriptor: 5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one, MAGNESIUM ION, ZINC ION, ...
Authors:Oki, H, Hayano, Y.
Deposit date:2014-09-01
Release date:2014-11-19
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Discovery of 1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (TAK-063), a highly potent, selective, and orally active phosphodiesterase 10A (PDE10A) inhibitor.
J.Med.Chem., 57, 2014
8HN3
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BU of 8hn3 by Molmil
Soluble domain of cytochrome c-556 from Chlorobaculum tepidum
Descriptor: ACETATE ION, Cytochrome c-556, GLYCEROL, ...
Authors:Kishimoto, H, Azai, C, Yamamoto, T, Mutoh, R, Nakaniwa, T, Tanaka, H, Kurisu, G, Oh-oka, H.
Deposit date:2022-12-07
Release date:2023-07-05
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Soluble domains of cytochrome c-556 and Rieske iron-sulfur protein from Chlorobaculum tepidum: Crystal structures and interaction analysis.
Curr Res Struct Biol, 5, 2023

 

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