Author results

2AZX
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CHARGED AND UNCHARGED TRNAS ADOPT DISTINCT CONFORMATIONS WHEN COMPLEXED WITH HUMAN TRYPTOPHANYL-TRNA SYNTHETASE
Descriptor:72-MER, Tryptophanyl-tRNA synthetase, SULFATE ION, ...
Authors:Yang, X.L., Otero, F.J., Ewalt, K.L., Liu, J., Swairjo, M.A., Kohrer, C., RajBhandary, U.L., Skene, R.J., McRee, D.E., Schimmel, P.
Deposit date:2005-09-12
Release date:2006-08-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Two conformations of a crystalline human tRNA synthetase-tRNA complex: implications for protein synthesis.
Embo J., 25, 2006
4XEO
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CRYSTAL STRUCTURE OF HUMAN ALARS CATALYTIC DOMAIN WITH R329H MUTATION
Descriptor:Alanine--tRNA ligase, cytoplasmic, '5'-O-(N-(L-ALANYL)-SULFAMOYL)ADENOSINE, ...
Authors:Zhou, H., He, W., Yang, X.L.
Deposit date:2014-12-24
Release date:2015-12-30
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Crystal structure of human AlaRS catalytic domain with R329H mutation
To Be Published
2ZT5
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CRYSTAL STRUCTURE OF HUMAN GLYCYL-TRNA SYNTHETASE (GLYRS) IN COMPLEX WITH AP4A (COCRYSTALLIZED WITH ATP)
Descriptor:Glycyl-tRNA synthetase, BIS(ADENOSINE)-5'-TETRAPHOSPHATE
Authors:Guo, R.T., Yang, X.L., Schimmel, P.
Deposit date:2008-09-19
Release date:2009-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures and biochemical analyses suggest unique mechanism and role for human GlyRS in Ap4A homeostasis
To be Published
2ZT6
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CRYSTAL STRUCTURE OF HUMAN GLYCYL-TRNA SYNTHETASE (GLYRS) IN COMPLEX WITH AMPCPP
Descriptor:Glycyl-tRNA synthetase, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER
Authors:Guo, R.T., Yang, X.L., Schimmel, P.
Deposit date:2008-09-19
Release date:2009-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.08 Å)
Cite:Crystal structures and biochemical analyses suggest unique mechanism and role for human GlyRS in Ap4A homeostasis
To be Published
2ZT7
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CRYSTAL STRUCTURE OF HUMAN GLYCYL-TRNA SYNTHETASE (GLYRS) IN COMPLEX WITH GLYCINE AND ATP
Descriptor:Glycyl-tRNA synthetase, GLYCINE, ADENOSINE-5'-TRIPHOSPHATE
Authors:Guo, R.T., Yang, X.L., Schimmel, P.
Deposit date:2008-09-19
Release date:2009-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structures and biochemical analyses suggest unique mechanism and role for human GlyRS in Ap4A homeostasis
To be Published
2ZT8
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CRYSTAL STRUCTURE OF HUMAN GLYCYL-TRNA SYNTHETASE (GLYRS) IN COMPLEX WITH GLY-AMP ANALOG
Descriptor:Glycyl-tRNA synthetase, [(2S,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (aminoacetyl)sulfamate
Authors:Guo, R.T., Yang, X.L., Schimmel, P.
Deposit date:2008-09-19
Release date:2009-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Crystal structures and biochemical analyses suggest unique mechanism and role for human GlyRS in Ap4A homeostasis
To be Published
2ZXF
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CRYSTAL STRUCTURE OF HUMAN GLYCYL-TRNA SYNTHETASE (GLYRS) IN COMPLEX WITH AP4A (COCRYSTALLIZED WITH AP4A)
Descriptor:Glycyl-tRNA synthetase, BIS(ADENOSINE)-5'-TETRAPHOSPHATE
Authors:Guo, R.T., Yang, X.L., Schimmel, P.
Deposit date:2008-12-23
Release date:2009-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Crystal structures and biochemical analyses suggest unique mechanism and role for human GlyRS in Ap4A homeostasis
To be Published
3BJU
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CRYSTAL STRUCTURE OF TETRAMERIC FORM OF HUMAN LYSYL-TRNA SYNTHETASE
Descriptor:Lysyl-tRNA synthetase, CALCIUM ION, LYSINE, ...
Authors:Guo, M., Yang, X.L., Schimmel, P.
Deposit date:2007-12-04
Release date:2008-02-05
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Crystal structure of tetrameric form of human lysyl-tRNA synthetase: Implications for multisynthetase complex formation
Proc.Natl.Acad.Sci.Usa, 105, 2008
3G98
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CRYSTAL STRUCTURE OF THE C-ALA DOMAIN FROM AQUIFEX AEOLICUS ALANYL-TRNA SYNTHETASE
Descriptor:Alanyl-tRNA synthetase
Authors:Guo, M., Yang, X.L., Schimmel, P.
Deposit date:2009-02-13
Release date:2009-10-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:The C-Ala domain brings together editing and aminoacylation functions on one tRNA.
Science, 325, 2009
4HVC
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CRYSTAL STRUCTURE OF HUMAN PROLYL-TRNA SYNTHETASE IN COMPLEX WITH HALOFUGINONE AND ATP ANALOGUE
Descriptor:Bifunctional glutamate/proline--tRNA ligase, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, ...
Authors:Zhou, H., Sun, L., Yang, X.L., Schimmel, P.
Deposit date:2012-11-06
Release date:2013-01-02
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase.
Nature, 494, 2012
4XEM
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CRYSTAL STRUCTURE OF WILD TYPE HUMAN ALARS CATALYTIC DOMAIN
Descriptor:Alanine--tRNA ligase, cytoplasmic, '5'-O-(N-(L-ALANYL)-SULFAMOYL)ADENOSINE, ...
Authors:Zhou, H., He, W., Yang, X.L.
Deposit date:2014-12-24
Release date:2016-02-17
Method:X-RAY DIFFRACTION (1.278 Å)
Cite:Crystal structure of wild type human AlaRS catalytic domain
To Be Published
5HWL
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HUMAN GLUTATHIONE S-TRANSFERASE MU2 COMPLEXED WITH BDEA, MONOCLINIC CRYSTAL FORM
Descriptor:Glutathione S-transferase Mu 2, GLUTATHIONE, N,N'-(butane-1,4-diyl)bis{2-[2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetamide}
Authors:Zhang, X., Wei, J., Wu, S., Zhang, H.P., Luo, M., Yang, X.L., Liao, F., Wang, D.Q.
Deposit date:2016-01-29
Release date:2017-11-08
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Human glutathione s-transferase Mu2 complexed with BDEA, monoclinic crystal form
To Be Published
5THH
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CRYSTAL STRUCTURE OF A HUMAN TYROSYL-TRNA SYNTHETASE MUTANT
Descriptor:Tyrosine--tRNA ligase, cytoplasmic, TYROSINE
Authors:Blocquel, D., Yang, X.L.
Deposit date:2016-09-29
Release date:2017-05-17
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.959 Å)
Cite:Alternative stable conformation capable of protein misinteraction links tRNA synthetase to peripheral neuropathy.
Nucleic Acids Res., 45, 2017
5THL
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CRYSTAL STRUCTURE OF THE HUMAN TYROSYL-TRNA SYNTHETASE MUTANT G41R
Descriptor:Tyrosine--tRNA ligase, cytoplasmic
Authors:Blocquel, D., Sajish, M., Yang, X.L.
Deposit date:2016-09-29
Release date:2017-06-07
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Alternative stable conformation capable of protein misinteraction links tRNA synthetase to peripheral neuropathy.
Nucleic Acids Res., 45, 2017
5W6M
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CRYSTAL STRUCTURE OF THE HUMAN HISTIDYL-TRNA SYNTHETASE MUTANT D175E
Descriptor:Histidine--tRNA ligase, cytoplasmic
Authors:Blocquel, D., Yang, X.L.
Deposit date:2017-06-16
Release date:2018-06-20
Method:X-RAY DIFFRACTION (3.696 Å)
Cite:Crystal structure of the human histidyl-tRNA synthetase mutant D175E
To Be Published
1B0S
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BINDING OF AR-1-144, A TRI-IMIDAZOLE DNA MINOR GROOVE BINDER, TO CCGG SEQUENCE ANALYZED BY NMR SPECTROSCOPY
Descriptor:DNA (5'-D(*GP*AP*AP*CP*CP*GP*GP*TP*TP*C)-3'), (2-{[4-({4-[(4-FORMYLAMINO-1-METHYL-1H-IMIDAZOLE-2-CARBONYL)-AMINO]-1-METHYL-1H-IMIDAZOLE-2-CARBONYL}-AMINO)-1-METHYL-1H-IMIDAZOLE-2-CARBONYL]-AMINO}-ETHYL)-DIMETHYL-AMMONIUM
Authors:Yang, X.-L., Kaenzig, C., Lee, M., Wang, A.H.-J.
Deposit date:1998-11-12
Release date:1999-08-31
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Binding of AR-1-144, a tri-imidazole DNA minor groove binder, to CCGG sequence analyzed by NMR spectroscopy.
Eur.J.Biochem., 263, 1999
1BE5
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STRUCTURAL STUDIES OF A STABLE PARALLEL-STRANDED DNA DUPLEX INCORPORATING ISOGUANINE:CYTOSINE AND ISOCYTOSINE:GUANINE BASE PAIRS BY NMR, MINIMIZED AVERAGE STRUCTURE
Descriptor:DNA DUPLEX (TGCACGGACT)
Authors:Yang, X.-L., Sugiyama, H., Ikeda, S., Saito, I., Wang, A.H.-J.
Deposit date:1998-05-19
Release date:1998-08-12
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural studies of a stable parallel-stranded DNA duplex incorporating isoguanine:cytosine and isocytosine:guanine basepairs by nuclear magnetic resonance spectroscopy.
Biophys.J., 75, 1998
1FD5
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BINDING OF A MACROCYCLIC BISACRIDINE AND AMETANTRONE TO CGTACG INVOLVES SIMILAR UNUSUAL INTERCALATION PLATFORMS (BISACRIDINE COMPLEX)
Descriptor:DNA (5'-D(*CP*GP*TP*AP*CP*G)-3'), COBALT (II) ION, MACROCYCLIC-BIS-9-AMINO-ACRIDINE, ...
Authors:Yang, X.-L., Robinson, H., Gao, Y.-G., Wang, A.H.-J.
Deposit date:2000-07-19
Release date:2000-08-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Binding of a macrocyclic bisacridine and ametantrone to CGTACG involves similar unusual intercalation platforms.
Biochemistry, 39, 2000
1FDG
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BINDING OF A MACROCYCLIC BISACRIDINE AND AMETANTRONE TO CGTACG INVOLVES SIMILAR UNUSUAL INTERCALATION PLATFORMS (AMETANTRONE COMPLEX)
Descriptor:DNA (5'-D(*CP*GP*TP*AP*CP*G)-3'), COBALT (II) ION, 1,4-BIS-[2-(2-HYDROXY-ETHYLAMINO)-ETHYLAMINO]-ANTHRAQUINONE, ...
Authors:Yang, X.-L., Robinson, H., Gao, Y.-G., Wang, A.H.-J.
Deposit date:2000-07-20
Release date:2000-08-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Binding of a macrocyclic bisacridine and ametantrone to CGTACG involves similar unusual intercalation platforms.
Biochemistry, 39, 2000
3VBB
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CRYSTAL STRUCTURE OF SERYL-TRNA SYNTHETASE FROM HUMAN AT 2.9 ANGSTROMS
Descriptor:Seryl-tRNA synthetase, cytoplasmic, MAGNESIUM ION, ...
Authors:Xu, X.L., Yang, X.-L.
Deposit date:2012-01-02
Release date:2012-02-29
Last modified:2012-03-21
Method:X-RAY DIFFRACTION (2.891 Å)
Cite:Unique domain appended to vertebrate tRNA synthetase is essential for vascular development.
Nat Commun, 3, 2012
6AJF
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CRYSTAL STRUCTURE OF MYCOLIC ACID TRANSPORTER MMPL3 FROM MYCOBACTERIUM SMEGMATIS
Descriptor:Drug exporters of the RND superfamily-like protein,Endolysin, (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID, alpha-D-glucopyranosyl 6-O-dodecyl-alpha-D-glucopyranoside
Authors:Zhang, B., Li, J., Yang, X.L., Wu, L.J., Yang, H.T., Rao, Z.H.
Deposit date:2018-08-27
Release date:2018-12-26
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.698 Å)
Cite:Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target.
Cell, 176, 2019
6AJG
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CRYSTAL STRUCTURE OF MYCOLIC ACID TRANSPORTER MMPL3 FROM MYCOBACTERIUM SMEGMATIS COMPLEXED WITH SQ109
Descriptor:Drug exporters of the RND superfamily-like protein,Endolysin, N-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-N'-[(1R,3S,5R,7R)-tricyclo[3.3.1.1~3,7~]dec-2-yl]ethane-1,2-diamine, DODECYL-BETA-D-MALTOSIDE, ...
Authors:Zhang, B., Li, J., Yang, X.L., Wu, L.J., Yang, H.T., Rao, Z.H.
Deposit date:2018-08-27
Release date:2018-12-26
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.604 Å)
Cite:Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target.
Cell, 176, 2019
6AJH
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CRYSTAL STRUCTURE OF MYCOLIC ACID TRANSPORTER MMPL3 FROM MYCOBACTERIUM SMEGMATIS COMPLEXED WITH AU1235
Descriptor:Drug exporters of the RND superfamily-like protein,Endolysin, 1-(2-adamantyl)-3-[2,3,4-tris(fluoranyl)phenyl]urea, alpha-D-glucopyranosyl 6-O-dodecyl-alpha-D-glucopyranoside, ...
Authors:Zhang, B., Li, J., Yang, X.L., Wu, L.J., Yang, H.T., Rao, Z.H.
Deposit date:2018-08-27
Release date:2018-12-26
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.818 Å)
Cite:Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target.
Cell, 176, 2019
6AJI
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CRYSTAL STRUCTURE OF MYCOLIC ACID TRANSPORTER MMPL3 FROM MYCOBACTERIUM SMEGMATIS COMPLEXED WITH RIMONABANT
Descriptor:Drug exporters of the RND superfamily-like protein,Endolysin, 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide, alpha-D-glucopyranosyl 6-O-dodecyl-alpha-D-glucopyranoside, ...
Authors:Zhang, B., Li, J., Yang, X.L., Wu, L.J., Yang, H.T., Rao, Z.H.
Deposit date:2018-08-27
Release date:2018-12-26
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target.
Cell, 176, 2019
6AJJ
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CRYSTAL STRUCTURE OF MYCOLIC ACID TRANSPORTER MMPL3 FROM MYCOBACTERIUM SMEGMATIS COMPLEXED WITH ICA38
Descriptor:Drug exporters of the RND superfamily-like protein,Endolysin, (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID, alpha-D-glucopyranosyl 6-O-dodecyl-alpha-D-glucopyranoside, ...
Authors:Zhang, B., Li, J., Yang, X.L., Wu, L.J., Yang, H.T., Rao, Z.H.
Deposit date:2018-08-27
Release date:2018-12-26
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.794 Å)
Cite:Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target.
Cell, 176, 2019
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