2GTD | | CRYSTAL STRUCTURE OF A TYPE III PANTOTHENATE KINASE: INSIGHT INTO THE CATALYSIS OF AN ESSENTIAL COENZYME A BIOSYNTHETIC ENZYME UNIVERSALLY DISTRIBUTED IN BACTERIA | | Descriptor: | Type III Pantothenate Kinase | | Authors: | Yang, K., Eyobo, Y., Brand, A.L., Martynowski, D., Tomchick, D. | | Deposit date: | 2006-04-27 | | Release date: | 2006-08-01 | | Last modified: | 2017-10-18 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal Structure of a Type III Pantothenate Kinase: Insight into the Mechanism of an Essential Coenzyme A Biosynthetic Enzyme Universally Distributed in Bacteria.
J.Bacteriol., 188, 2006
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3BEX | | TYPE III PANTOTHENATE KINASE FROM THERMOTOGA MARITIMA COMPLEXED WITH PANTOTHENATE | | Descriptor: | Type III pantothenate kinase, PHOSPHATE ION, PANTOTHENOIC ACID | | Authors: | Yang, K., Huerta, C., Strauss, E., Zhang, H. | | Deposit date: | 2007-11-20 | | Release date: | 2008-06-24 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.51 Å) | | Cite: | Structural basis for substrate binding and the catalytic mechanism of type III pantothenate kinase.
Biochemistry, 47, 2008
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3BF1 | | TYPE III PANTOTHENATE KINASE FROM THERMOTOGA MARITIMA COMPLEXED WITH PANTOTHENATE AND ADP | | Descriptor: | Type III pantothenate kinase, ADENOSINE-5'-DIPHOSPHATE, PANTOTHENOIC ACID | | Authors: | Yang, K., Huerta, C., Strauss, E., Zhang, H. | | Deposit date: | 2007-11-20 | | Release date: | 2008-06-24 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural basis for substrate binding and the catalytic mechanism of type III pantothenate kinase.
Biochemistry, 47, 2008
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3BF3 | | TYPE III PANTOTHENATE KINASE FROM THERMOTOGA MARITIMA COMPLEXED WITH PRODUCT PHOSPHOPANTOTHENATE | | Descriptor: | Type III pantothenate kinase, MAGNESIUM ION, N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanine | | Authors: | Yang, K., Huerta, C., Strauss, E., Zhang, H. | | Deposit date: | 2007-11-20 | | Release date: | 2008-06-24 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.63 Å) | | Cite: | Structural basis for substrate binding and the catalytic mechanism of type III pantothenate kinase.
Biochemistry, 47, 2008
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3E66 | | CRYSTAL STRUCTURE OF THE BETA-FINGER DOMAIN OF YEAST PRP8 | | Descriptor: | PRP8 | | Authors: | Yang, K., Zhang, L., Xu, T., Heroux, A., Zhao, R. | | Deposit date: | 2008-08-14 | | Release date: | 2008-10-14 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Crystal structure of the beta-finger domain of Prp8 reveals analogy to ribosomal proteins.
Proc.Natl.Acad.Sci.Usa, 105, 2008
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5HQP | | CRYSTAL STRUCTURE OF THE ERP44-PEROXIREDOXIN 4 COMPLEX | | Descriptor: | Peroxiredoxin-4, Endoplasmic reticulum resident protein 44 | | Authors: | Yang, K., Li, D.F., Wang, X., Wang, C.C. | | Deposit date: | 2016-01-22 | | Release date: | 2016-10-12 | | Last modified: | 2016-11-16 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal Structure of the ERp44-Peroxiredoxin 4 Complex Reveals the Molecular Mechanisms of Thiol-Mediated Protein Retention.
Structure, 24, 2016
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5V7Q | | CRYO-EM STRUCTURE OF THE LARGE RIBOSOMAL SUBUNIT FROM MYCOBACTERIUM TUBERCULOSIS BOUND WITH A POTENT LINEZOLID ANALOG | | Descriptor: | 50S ribosomal protein L32, 50S ribosomal protein L33, 50S ribosomal protein L34, ... | | Authors: | Yang, K., Chang, J.-Y., Cui, Z., Zhang, J. | | Deposit date: | 2017-03-20 | | Release date: | 2017-09-20 | | Last modified: | 2017-11-01 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Structural insights into species-specific features of the ribosome from the human pathogen Mycobacterium tuberculosis.
Nucleic Acids Res., 45, 2017
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5V93 | | CRYO-EM STRUCTURE OF THE 70S RIBOSOME FROM MYCOBACTERIUM TUBERCULOSIS BOUND WITH CAPREOMYCIN | | Descriptor: | 50S ribosomal protein L32, 50S ribosomal protein L33, 50S ribosomal protein L34, ... | | Authors: | Yang, K., Chang, J.-Y., Cui, Z., Li, X., Meng, R., Duan, L., Thongchol, J., Jakana, J., Huwe, C., Sacchettini, J., Zhang, J. | | Deposit date: | 2017-03-22 | | Release date: | 2017-09-20 | | Last modified: | 2017-11-01 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Structural insights into species-specific features of the ribosome from the human pathogen Mycobacterium tuberculosis.
Nucleic Acids Res., 45, 2017
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6DMX | | HBZ56 IN COMPLEX WITH KIX AND C-MYB | | Descriptor: | BZIP factor, Transcriptional activator Myb, CREB-binding protein | | Authors: | Yang, K., Wright, P.E., Stanfield, R.L. | | Deposit date: | 2018-06-05 | | Release date: | 2018-09-19 | | Last modified: | 2018-10-17 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural basis for cooperative regulation of KIX-mediated transcription pathways by the HTLV-1 HBZ activation domain.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6DNQ | | HBZ77 IN COMPLEX WITH KIX AND C-MYB | | Descriptor: | BZIP factor, Transcriptional activator Myb, CREB-binding protein, ... | | Authors: | Yang, K., Wright, P.E., Stanfield, R.L. | | Deposit date: | 2018-06-07 | | Release date: | 2018-09-19 | | Last modified: | 2018-10-17 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Structural basis for cooperative regulation of KIX-mediated transcription pathways by the HTLV-1 HBZ activation domain.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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5Z0R | | STRUCTURAL INSIGHT INTO THE ZIKA VIRUS CAPSID ENCAPSULATING THE VIRAL GENOME | | Descriptor: | Extracellular solute-binding protein family 1,viral genome protein, MALTOSE | | Authors: | Li, T., Zhao, Q., Yang, X., Chen, C., Yang, K., Wu, C., Zhang, T., Duan, Y., Xue, X., Mi, K., Ji, X., Wang, Z., Yang, H. | | Deposit date: | 2017-12-20 | | Release date: | 2018-04-11 | | Last modified: | 2018-05-02 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Structural insight into the Zika virus capsid encapsulating the viral genome.
Cell Res., 28, 2018
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5Z0V | | STRUCTURAL INSIGHT INTO THE ZIKA VIRUS CAPSID ENCAPSULATING THE VIRAL GENOME | | Descriptor: | Extracellular solute-binding protein family 1,viral genome protein, MALTOSE | | Authors: | Li, T., Zhao, Q., Yang, X., Chen, C., Yang, K., Wu, C., Zhang, T., Duan, Y., Xue, X., Mi, K., Ji, X., Wang, Z., Yang, H. | | Deposit date: | 2017-12-21 | | Release date: | 2018-04-11 | | Last modified: | 2018-05-02 | | Method: | X-RAY DIFFRACTION (2.913 Å) | | Cite: | Structural insight into the Zika virus capsid encapsulating the viral genome.
Cell Res., 28, 2018
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1WNO | | CRYSTAL STRUCTURE OF A NATIVE CHITINASE FROM ASPERGILLUS FUMIGATUS YJ-407 | | Descriptor: | Chitinase, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, SULFATE ION, ... | | Authors: | Hu, H., Wang, G., Yang, H., Zhou, J., Mo, L., Yang, K., Jin, C., Jin, C., Rao, Z. | | Deposit date: | 2004-08-07 | | Release date: | 2005-03-15 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal structure of a native chitinase from Aspergillus fumigatus YJ-407
To be Published
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5JMT | | CRYSTAL STRUCTURE OF ZIKA VIRUS NS3 HELICASE | | Descriptor: | NS3 helicase | | Authors: | Tian, H., Ji, X., Yang, X., Xie, W., Yang, K., Chen, C., Wu, C., Chi, H., Mu, Z., Wang, Z., Yang, H. | | Deposit date: | 2016-04-29 | | Release date: | 2016-05-25 | | Last modified: | 2017-09-27 | | Method: | X-RAY DIFFRACTION (1.796 Å) | | Cite: | The crystal structure of Zika virus helicase: basis for antiviral drug design
Protein Cell, 7, 2016
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1WOF | | CRYSTAL STRUCTURE OF SARS-COV MPRO IN COMPLEX WITH AN INHIBITOR N1 | | Descriptor: | 3C-like proteinase, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]-L-ALANYL-L-VALYL-N~1~-((1S)-4-ETHOXY-4-OXO-1-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE | | Authors: | Yang, H., Bartlam, M., Xue, X., Yang, K., Liang, W., Rao, Z. | | Deposit date: | 2004-08-18 | | Release date: | 2005-08-30 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases.
Plos Biol., 3, 2005
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2AMD | | CRYSTAL STRUCTURE OF SARS_COV MPRO IN COMPLEX WITH AN INHIBITOR N9 | | Descriptor: | 3C-like proteinase, N-(3-FUROYL)-D-VALYL-L-VALYL-N~1~-((1R,2Z)-4-ETHOXY-4-OXO-1-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-D-LEUCINAMIDE | | Authors: | Yang, H., Xue, X., Yang, K., Zhao, Q., Bartlam, M., Rao, Z. | | Deposit date: | 2005-08-09 | | Release date: | 2005-09-13 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases.
Plos Biol., 3, 2005
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2AMP | | CRYSTAL STRUCTURE OF PORCINE TRANSMISSIBLE GASTROENTERITIS VIRUS MPRO IN COMPLEX WITH AN INHIBITOR N1 | | Descriptor: | 3C-like proteinase, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]-L-ALANYL-L-VALYL-N~1~-((1S)-4-ETHOXY-4-OXO-1-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE | | Authors: | Yang, H., Xue, X., Yang, K., Zhao, Q., Bartlam, M., Rao, Z. | | Deposit date: | 2005-08-10 | | Release date: | 2005-09-13 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases.
Plos Biol., 3, 2005
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2AMQ | | CRYSTAL STRUCTURE OF SARS_COV MPRO IN COMPLEX WITH AN INHIBITOR N3 | | Descriptor: | 3C-like proteinase, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE | | Authors: | Yang, H., Xue, X., Yang, K., Zhao, Q., Bartlam, M., Rao, Z. | | Deposit date: | 2005-08-10 | | Release date: | 2005-09-13 | | Last modified: | 2015-12-09 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases.
Plos Biol., 3, 2005
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2D2D | | CRYSTAL STRUCTURE OF SARS-COV MPRO IN COMPLEX WITH AN INHIBITOR I2 | | Descriptor: | 3C-like proteinase, ETHYL (2E,4S)-4-[((2R)-2-{[N-(TERT-BUTOXYCARBONYL)-L-VALYL]AMINO}-2-PHENYLETHANOYL)AMINO]-5-[(3S)-2-OXOPYRROLIDIN-3-YL]PENT-2-ENOATE | | Authors: | Yang, H., Bartlam, M., Xue, X., Yang, K., Liang, W., Ding, Y., Rao, Z. | | Deposit date: | 2005-09-08 | | Release date: | 2005-09-20 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases.
Plos Biol., 3, 2005
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5EU8 | | STRUCTURE OF FIPV MAIN PROTEASE IN COMPLEX WITH DUAL INHIBITORS | | Descriptor: | main protease, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE, ZINC ION, ... | | Authors: | Wang, F., Chen, C., Liu, X., Yang, K., Xu, X., Yang, H. | | Deposit date: | 2015-11-18 | | Release date: | 2015-12-30 | | Last modified: | 2016-02-10 | | Method: | X-RAY DIFFRACTION (2.447 Å) | | Cite: | Crystal Structure of Feline Infectious Peritonitis Virus Main Protease in Complex with Synergetic Dual Inhibitors
J.Virol., 90, 2015
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5GWY | | STRUCTURE OF MAIN PROTEASE FROM HUMAN CORONAVIRUS NL63: INSIGHTS FOR WIDE SPECTRUM ANTI-CORONAVIRUS DRUG DESIGN | | Descriptor: | main protease, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE | | Authors: | Wang, F., Chen, C., Tan, W., Yang, K., Yang, H. | | Deposit date: | 2016-09-14 | | Release date: | 2017-09-20 | | Last modified: | 2019-04-03 | | Method: | X-RAY DIFFRACTION (2.852 Å) | | Cite: | Structure of Main Protease from Human Coronavirus NL63: Insights for Wide Spectrum Anti-Coronavirus Drug Design.
Sci Rep, 6, 2016
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5GWZ | | THE STRUCTURE OF PORCINE EPIDEMIC DIARRHEA VIRUS MAIN PROTEASE IN COMPLEX WITH AN INHIBITOR | | Descriptor: | PEDV main protease, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE | | Authors: | Wang, F., Chen, C., Yang, K., Liu, X., Liu, H., Xu, Y., Chen, X., Liu, X., Cai, Y., Yang, H. | | Deposit date: | 2016-09-14 | | Release date: | 2017-03-29 | | Last modified: | 2017-04-26 | | Method: | X-RAY DIFFRACTION (2.444 Å) | | Cite: | Michael Acceptor-Based Peptidomimetic Inhibitor of Main Protease from Porcine Epidemic Diarrhea Virus
J. Med. Chem., 60, 2017
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5GXJ | | ZIKA VIRUS NS2B-NS3 PROTEASE | | Descriptor: | FLAVIVIRUS_NS2B,LINKER,Peptidase S7 | | Authors: | Yang, H., Chen, X., Ji, X., Xiong, Y., Yang, K. | | Deposit date: | 2016-09-18 | | Release date: | 2017-05-03 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Viral protease activation mechanism
To Be Published
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5X8Y | | A MUTATION IDENTIFIED IN NEONATAL MICROCEPHALY DESTABILIZES ZIKA VIRUS NS1 ASSEMBLY IN VITRO | | Descriptor: | ZIKV NS1 | | Authors: | Wang, D., Chen, C., Liu, S., Zhou, H., Yang, K., Zhao, Q., Ji, X., Chen, C., Xie, W., Wang, Z., Mi, L.Z., Yang, H. | | Deposit date: | 2017-03-03 | | Release date: | 2017-05-17 | | Method: | X-RAY DIFFRACTION (2.817 Å) | | Cite: | A Mutation Identified in Neonatal Microcephaly Destabilizes Zika Virus NS1 Assembly in Vitro
Sci Rep, 7, 2017
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3V3E | | CRYSTAL STRUCTURE OF THE HUMAN NUR77 LIGAND-BINDING DOMAIN | | Descriptor: | Nuclear receptor subfamily 4 group A member 1, GLYCEROL | | Authors: | Zhang, Q., Shi, C., Yang, K., Chen, Y., Zhan, Y., Wu, Q., Lin, T. | | Deposit date: | 2011-12-13 | | Release date: | 2012-09-26 | | Last modified: | 2013-07-10 | | Method: | X-RAY DIFFRACTION (2.06 Å) | | Cite: | The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK
Nat.Chem.Biol., 8, 2012
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