1LKN | |
4N1Z | | CRYSTAL STRUCTURE OF HUMAN FARNESYL DIPHOSPHATE SYNTHASE IN COMPLEX WITH BPH-1222 | | Descriptor: | Farnesyl pyrophosphate synthase, PHOSPHATE ION, MAGNESIUM ION, ... | | Authors: | Liu, Y.L., Xia, Y., Zhang, Y., Verma, I., Oldfield, E. | | Deposit date: | 2013-10-04 | | Release date: | 2014-12-10 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | A combination therapy for KRAS-driven lung adenocarcinomas using lipophilic bisphosphonates and rapamycin.
Sci Transl Med, 6, 2014
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5GNV | | STRUCTURE OF PSD-95/MAP1A COMPLEX REVEALS UNIQUE TARGET RECOGNITION MODE OF MAGUK GK DOMAIN | | Descriptor: | Disks large homolog 4, Microtubule-associated protein 1A, SULFATE ION | | Authors: | Shang, Y., Xia, Y., Zhu, R., Zhu, J. | | Deposit date: | 2016-07-25 | | Release date: | 2017-08-02 | | Last modified: | 2017-11-01 | | Method: | X-RAY DIFFRACTION (2.596 Å) | | Cite: | Structure of the PSD-95/MAP1A complex reveals a unique target recognition mode of the MAGUK GK domain
Biochem. J., 474, 2017
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4LQT | | 1.10A RESOLUTION CRYSTAL STRUCTURE OF A SUPERFOLDER GREEN FLUORESCENT PROTEIN (W57A) MUTANT | | Descriptor: | Green fluorescent protein, 1,2-ETHANEDIOL | | Authors: | Lovell, S., Xia, Y., Vo, B., Battaile, K.P., Egan, C., Karanicolas, J. | | Deposit date: | 2013-07-19 | | Release date: | 2013-12-18 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (1.1 Å) | | Cite: | The designability of protein switches by chemical rescue of structure: mechanisms of inactivation and reactivation.
J.Am.Chem.Soc., 135, 2013
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4LQU | | 1.60A RESOLUTION CRYSTAL STRUCTURE OF A SUPERFOLDER GREEN FLUORESCENT PROTEIN (W57G) MUTANT | | Descriptor: | Green fluorescent protein | | Authors: | Lovell, S., Xia, Y., Vo, B., Battaile, K.P., Egan, C., Karanicolas, J. | | Deposit date: | 2013-07-19 | | Release date: | 2013-12-18 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | The designability of protein switches by chemical rescue of structure: mechanisms of inactivation and reactivation.
J.Am.Chem.Soc., 135, 2013
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5SXY | |
1IAX | | CRYSTAL STRUCTURE OF ACC SYNTHASE COMPLEXED WITH PLP | | Descriptor: | 1-AMINOCYCLOPROPANE-1-CARBOXYLATE SYNTHASE 2, SULFATE ION, PYRIDOXAL-5'-PHOSPHATE | | Authors: | Huai, Q., Xia, Y., Chen, Y., Callahan, B., Li, N., Ke, H. | | Deposit date: | 2001-03-24 | | Release date: | 2001-04-04 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Crystal structures of 1-aminocyclopropane-1-carboxylate (ACC) synthase in complex with aminoethoxyvinylglycine and pyridoxal-5'-phosphate provide new insight into catalytic mechanisms
J.Biol.Chem., 276, 2001
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1IAY | | CRYSTAL STRUCTURE OF ACC SYNTHASE COMPLEXED WITH COFACTOR PLP AND INHIBITOR AVG | | Descriptor: | 1-AMINOCYCLOPROPANE-1-CARBOXYLATE SYNTHASE 2, PYRIDOXAL-5'-PHOSPHATE, 2-AMINO-4-(2-AMINO-ETHOXY)-BUTYRIC ACID | | Authors: | Huai, Q., Xia, Y., Chen, Y., Callahan, B., Li, N., Ke, H. | | Deposit date: | 2001-03-24 | | Release date: | 2001-04-04 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Crystal structures of 1-aminocyclopropane-1-carboxylate (ACC) synthase in complex with aminoethoxyvinylglycine and pyridoxal-5'-phosphate provide new insight into catalytic mechanisms
J.Biol.Chem., 276, 2001
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3WP0 | | CRYSTAL STRUCTURE OF DLG GK IN COMPLEX WITH A PHOSPHOR-LGL2 PEPTIDE | | Descriptor: | Disks large homolog 4, Lethal(2) giant larvae protein homolog 2, GLYCEROL | | Authors: | Zhu, J., Shang, Y., Wan, Q., Xia, Y., Chen, J., Du, Q., Zhang, M. | | Deposit date: | 2014-01-08 | | Release date: | 2014-03-19 | | Last modified: | 2014-04-30 | | Method: | X-RAY DIFFRACTION (2.039 Å) | | Cite: | Phosphorylation-dependent interaction between tumor suppressors Dlg and Lgl
Cell Res., 24, 2014
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3WP1 | | PHOSPHORYLATION-DEPENDENT INTERACTION BETWEEN TUMOR SUPPRESSORS DLG AND LGL | | Descriptor: | Disks large homolog 4, Lethal(2) giant larvae protein homolog 2, SULFATE ION | | Authors: | Zhu, J., Shang, Y., Wan, Q., Xia, Y., Chen, J., Du, Q., Zhang, M. | | Deposit date: | 2014-01-08 | | Release date: | 2014-03-19 | | Last modified: | 2014-04-30 | | Method: | X-RAY DIFFRACTION (2.804 Å) | | Cite: | Phosphorylation-dependent interaction between tumor suppressors Dlg and Lgl
Cell Res., 24, 2014
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5KSI | | CRYSTAL STRUCTURE OF DEOXYGENATED HEMOGLOBIN IN COMPLEX WITH SPHINGOSINE PHOSPHATE AND 2,3-BISPHOSPHOGLYCERATE | | Descriptor: | Hemoglobin subunit alpha, Hemoglobin subunit beta, PROTOPORPHYRIN IX CONTAINING FE, ... | | Authors: | Ahmed, M.H., Safo, M.K., Xia, Y. | | Deposit date: | 2016-07-08 | | Release date: | 2017-07-26 | | Last modified: | 2017-12-06 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural and Functional Insight of Sphingosine 1-Phosphate-Mediated Pathogenic Metabolic Reprogramming in Sickle Cell Disease.
Sci Rep, 7, 2017
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5KSJ | | CRYSTAL STRUCTURE OF DEOXYGENATED HEMOGLOBIN IN COMPLEX WITH SPHINGOSINE PHOSPHATE | | Descriptor: | Hemoglobin subunit alpha, Hemoglobin subunit beta, PROTOPORPHYRIN IX CONTAINING FE, ... | | Authors: | Ahmed, M.H., Safo, M.K., Xia, Y. | | Deposit date: | 2016-07-08 | | Release date: | 2017-07-26 | | Last modified: | 2017-12-06 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural and Functional Insight of Sphingosine 1-Phosphate-Mediated Pathogenic Metabolic Reprogramming in Sickle Cell Disease.
Sci Rep, 7, 2017
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2N9B | |
2HEM | | NMR STRUCTURE AND MG2+ BINDING OF AN RNA SEGMENT THAT UNDERLIES THE L7/L12 STALK IN THE E.COLI 50S RIBOSOMAL SUBUNIT. | | Descriptor: | 5'-R(P*GP*GP*GP*AP*AP*GP*GP*CP*GP*CP*UP*UP*CP*GP*GP*CP*GP*UP*CP*GP*GP*CP*CP*C)-3' | | Authors: | Zhao, Q., Nagaswamy, U., Lee, H., Xia, Y., Gao, X., Fox, G. | | Deposit date: | 2006-06-21 | | Release date: | 2006-09-12 | | Last modified: | 2011-07-13 | | Method: | SOLUTION NMR | | Cite: | NMR structure and Mg2+ binding of an RNA segment that underlies the L7/L12 stalk in the E.coli 50S ribosomal subunit
Nucleic Acids Res., 33, 2005
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2MZ0 | |
4A4R | | UNAC TETRALOOPS: TO WHAT EXTENT CAN THEY MIMIC GNRA TETRALOOPS | | Descriptor: | 5'-R(*GMP*GP*AP*CP*CP*CP*GP*GP*CP*UP*AP*AP*CP*GP *CP*UP*GP*GP*GP*UP*CP*C)-3' | | Authors: | Zhao, Q., Huang, H., Nagaswamy, U., Xia, Y., Gao, X., Fox, G. | | Deposit date: | 2011-10-20 | | Release date: | 2012-05-30 | | Method: | SOLUTION NMR | | Cite: | Unac Tetraloops: To What Extent Can They Mimic Gnra Tetraloops
Biopolymers, 97, 2012
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4A4S | | UNAC TETRALOOPS: TO WHAT EXTENT CAN THEY MIMIC GNRA TETRALOOPS | | Descriptor: | 5'-R(*GP*GP*AP*CP*CP*CP*GP*GP*CP*UP*CP*AP*CP*GP *CP*UP*GP*GP*GP*UP*CP*C)-3' | | Authors: | Zhao, Q., Huang, H., Nagaswamy, U., Xia, Y., Gao, X., Fox, G. | | Deposit date: | 2011-10-20 | | Release date: | 2012-05-30 | | Last modified: | 2017-04-19 | | Method: | SOLUTION NMR | | Cite: | Unac Tetraloops: To What Extent Can They Mimic Gnra Tetraloops
Biopolymers, 97, 2012
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4A4T | | UNAC TETRALOOPS: TO WHAT EXTENT CAN THEY MIMIC GNRA TETRALOOPS | | Descriptor: | 5'-R(*GP*GP*AP*CP*CP*CP*GP*GP*CP*UP*UP*AP*CP*GP *CP*UP*GP*GP*GP*UP*CP*C)-3' | | Authors: | Zhao, Q., Huang, H., Nagaswamy, U., Xia, Y., Gao, X., Fox, G. | | Deposit date: | 2011-10-20 | | Release date: | 2012-05-30 | | Last modified: | 2017-04-19 | | Method: | SOLUTION NMR | | Cite: | Unac Tetraloops: To What Extent Can They Mimic Gnra Tetraloops
Biopolymers, 97, 2012
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4A4U | | UNAC TETRALOOPS: TO WHAT EXTENT CAN THEY MIMIC GNRA TETRALOOPS | | Descriptor: | 5'-R(*GP*GP*AP*CP*CP*CP*GP*GP*CP*UP*GP*AP*CP*GP *CP*UP*GP*GP*GP*UP*CP*C)-3' | | Authors: | Zhao, Q., Huang, H., Nagaswamy, U., Xia, Y., Gao, X., Fox, G. | | Deposit date: | 2011-10-20 | | Release date: | 2012-05-30 | | Last modified: | 2017-04-19 | | Method: | SOLUTION NMR | | Cite: | Unac Tetraloops: To What Extent Can They Mimic Gnra Tetraloops
Biopolymers, 97, 2012
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4I0U | | IMPROVED STRUCTURE OF THERMOTOGA MARITIMA CORA AT 2.7 A RESOLUTION | | Descriptor: | Magnesium transport protein CorA, MAGNESIUM ION, CHLORIDE ION, ... | | Authors: | Nordin, N., Guskov, A., Phua, T., Sahaf, N., Xia, Y., Lu, S.Y., Eshaghi, H., Eshaghi, S. | | Deposit date: | 2012-11-19 | | Release date: | 2013-03-06 | | Last modified: | 2014-09-10 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Exploring the structure and function of Thermotoga maritima CorA reveals the mechanism of gating and ion selectivity in Co2+/Mg2+ transport.
Biochem.J., 451, 2013
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4OR2 | | HUMAN CLASS C G PROTEIN-COUPLED METABOTROPIC GLUTAMATE RECEPTOR 1 IN COMPLEX WITH A NEGATIVE ALLOSTERIC MODULATOR | | Descriptor: | Soluble cytochrome b562, Metabotropic glutamate receptor 1, 4-fluoro-N-methyl-N-{4-[6-(propan-2-ylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl}benzamide, ... | | Authors: | Wu, H., Wang, C., Gregory, K.J., Han, G.W., Cho, H.P., Xia, Y., Niswender, C.M., Katritch, V., Cherezov, V., Conn, P.J., Stevens, R.C., GPCR Network (GPCR) | | Deposit date: | 2014-02-10 | | Release date: | 2014-03-19 | | Last modified: | 2017-11-22 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator
Science, 344, 2014
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5YGI | |
5VRL | | CRYSTAL STRUCTURE OF THE INHA FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH AN12855, EBSI 4333. | | Descriptor: | Enoyl-[acyl-carrier-protein] reductase [NADH], (~{N}~{E})-~{N}-[[2-[[2-ethylsulfonyl-1,1-bis(oxidanyl)-3,4-dihydro-2,3,1$l^{4}-benzodiazaborinin-7-yl]oxy]-5-(trifluoromethyl)phenyl]methylidene]hydroxylamine | | Authors: | Abendroth, J., Edwards, T.E., Lorimer, D. | | Deposit date: | 2017-05-11 | | Release date: | 2018-05-16 | | Last modified: | 2018-12-05 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Discovery of a cofactor-independent inhibitor ofMycobacterium tuberculosisInhA.
Life Sci Alliance, 1, 2018
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5VRM | | CRYSTAL STRUCTURE OF THE INHA FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH AN12855, EBSI 4333. | | Descriptor: | Enoyl-[acyl-carrier-protein] reductase [NADH], [[(2~{R},3~{S},4~{R},5~{R})-5-(3-aminocarbonylpyridin-1-ium-1-yl)-3-oxidanyl-4-[[1-oxidanyl-6-[4-(trifluoromethyl)phenoxy]-3~{H}-2,1$l^{4}-benzoxaborol-1-yl]oxy]oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate | | Authors: | Abendroth, J., Edwards, T.E., Lorimer, D. | | Deposit date: | 2017-05-11 | | Release date: | 2018-05-16 | | Last modified: | 2018-12-05 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Discovery of a cofactor-independent inhibitor ofMycobacterium tuberculosisInhA.
Life Sci Alliance, 1, 2018
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5VRN | | CRYSTAL STRUCTURE OF THE INHA FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH AN12855, EBSI 4333. | | Descriptor: | Enoyl-[acyl-carrier-protein] reductase [NADH], [[(2~{R},3~{S},4~{R},5~{R})-5-(3-aminocarbonylpyridin-1-ium-1-yl)-4-[[5-[4-cyano-2-[(~{E})-hydroxyiminomethyl]phenoxy]-1-oxidanyl-3~{H}-2,1$l^{4}-benzoxaborol-1-yl]oxy]-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate | | Authors: | Abendroth, J., Edwards, T.E., Lorimer, D. | | Deposit date: | 2017-05-11 | | Release date: | 2018-05-16 | | Last modified: | 2018-12-05 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Discovery of a cofactor-independent inhibitor ofMycobacterium tuberculosisInhA.
Life Sci Alliance, 1, 2018
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