Author results

6IQT
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CRYSTAL STRUCTURE OF CAGV, A VIRB8 HOMOLOG OF T4SS FROM HELICOBACTER PYLORI STRAIN 26695
Descriptor:Cag pathogenicity island protein (Cag10)
Authors:Wu, X., Zhao, Y., Sun, L., Jiang, M., Wang, Q., Wang, Q., Yang, W., Wu, Y.
Deposit date:2018-11-08
Release date:2019-11-13
Method:X-RAY DIFFRACTION (1.922 Å)
Cite:Crystal Structure confirmation of a novel homodimer mechanism in VirB8 family by CagV of T4SS from Helicobacter pylori Strain 26695
To Be Published
1CKA
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STRUCTURAL BASIS FOR THE SPECIFIC INTERACTION OF LYSINE-CONTAINING PROLINE-RICH PEPTIDES WITH THE N-TERMINAL SH3 DOMAIN OF C-CRK
Descriptor:C-CRK N-TERMINAL SH3 DOMAIN, C3G PEPTIDE (PRO-PRO-PRO-ALA-LEU-PRO-PRO-LYS-LYS-ARG)
Authors:Wu, X., Kuriyan, J.
Deposit date:1995-01-24
Release date:1995-05-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural basis for the specific interaction of lysine-containing proline-rich peptides with the N-terminal SH3 domain of c-Crk.
Structure, 3, 1995
1CKB
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STRUCTURAL BASIS FOR THE SPECIFIC INTERACTION OF LYSINE-CONTAINING PROLINE-RICH PEPTIDES WITH THE N-TERMINAL SH3 DOMAIN OF C-CRK
Descriptor:C-CRK N-TERMINAL SH3 DOMAIN, SOS PEPTIDE (PRO-PRO-PRO-VAL-PRO-PRO-ARG-ARG-ARG-ARG)
Authors:Wu, X., Kuriyan, J.
Deposit date:1995-01-24
Release date:1995-05-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for the specific interaction of lysine-containing proline-rich peptides with the N-terminal SH3 domain of c-Crk.
Structure, 3, 1995
3JU5
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CRYSTAL STRUCTURE OF DIMERIC ARGININE KINASE AT 1.75-A RESOLUTION
Descriptor:Arginine kinase, MAGNESIUM ION
Authors:Wu, X., Ye, S., Guo, S., Yan, W., Bartlam, M., Rao, Z.
Deposit date:2009-09-14
Release date:2009-09-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural basis for a reciprocating mechanism of negative cooperativity in dimeric phosphagen kinase activity
Faseb J., 24, 2010
3JU6
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CRYSTAL STRUCTURE OF DIMERIC ARGININE KINASE IN COMPLEX WITH AMPPNP AND ARGININE
Descriptor:Arginine kinase, ARGININE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Wu, X., Ye, S., Guo, S., Yan, W., Bartlam, M., Rao, Z.
Deposit date:2009-09-14
Release date:2009-09-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structural basis for a reciprocating mechanism of negative cooperativity in dimeric phosphagen kinase activity
Faseb J., 24, 2010
4A4Q
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STEREOSELECTIVE SYNTHESIS, X-RAY ANALYSIS, AND BIOLOGICAL EVALUATION OF A NEW CLASS OF LACTAM BASED HIV-1 PROTEASE INHIBITORS
Descriptor:PROTEASE, methyl [(2S)-1-{2-(2-{(3R,4S)-3-benzyl-4-hydroxy-1-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-2-oxopyrrolidin-3-yl}ethyl)-2-[4-(pyridin-4-yl)benzyl]hydrazinyl}-3,3-dimethyl-1-oxobutan-2-yl]carbamate
Authors:Wu, X., Ohrngren, P., Joshi, A.A., Trejos, A., Persson, M., Arvela, R.K., Wallberg, H., Vrang, L., Rosenquist, A., Samuelsson, B., Unge, J., Larhed, M.
Deposit date:2011-10-19
Release date:2012-11-07
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Synthesis, X-Ray Analysis, and Biological Evaluation of a New Class of Stereopure Lactam-Based HIV-1 Protease Inhibitors.
J.Med.Chem., 55, 2012
4A6B
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STEREOSELECTIVE SYNTHESIS, X-RAY ANALYSIS, AND BIOLOGICAL EVALUATION OF A NEW CLASS OF LACTAM BASED HIV-1 PROTEASE INHIBITORS
Descriptor:POL PROTEIN, METHYL ((S)-1-(2-([1,1'-BIPHENYL]-4-YLMETHYL)-2-(3-((3S,4S)-3-BENZYL-4-HYDROXY-1-((1S,2R)-2-HYDROXY-2,3-DIHYDRO-1H-INDEN-1-YL)-2-OXOPYRROLIDIN-3-YL)PROPYL)HYDRAZINYL)-3,3-DIMETHYL-1-OXOBUTAN-2-YL)CARBAMATE
Authors:Wu, X., Ohrngren, P., Joshi, A.A., Trejos, A., Persson, M., Unge, J., Arvela, R.K., Wallberg, H., Vrang, L., Rosenquist, A., Samuelsson, B.B., Unge, J., Larhed, M.
Deposit date:2011-11-01
Release date:2012-05-09
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Synthesis, X-Ray Analysis, and Biological Evaluation of a New Class of Stereopure Lactam-Based HIV-1 Protease Inhibitors.
J.Med.Chem., 55, 2012
4A6C
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STEREOSELECTIVE SYNTHESIS, X-RAY ANALYSIS, AND BIOLOGICAL EVALUATION OF A NEW CLASS OF LACTAM BASED HIV-1 PROTEASE INHIBITORS
Descriptor:POL PROTEIN, METHYL ((S)-1-(2-(3-((3S,4S)-3-BENZYL-4-HYDROXY-1-((1S,2R)-2-HYDROXY-2,3-DIHYDRO-1H-INDEN-1-YL)-2-OXOPYRROLIDIN-3-YL)PROPYL)-2-(4-(PYRIDIN-4-YL)BENZYL)HYDRAZINYL)-3,3-DIMETHYL-1-OXOBUTAN-2-YL)CARBAMATE
Authors:Wu, X., Ohrngren, P., Joshi, A.A., Trejos, A., Persson, M., Unge, J., Arvela, R.K., Wallberg, H., Vrang, L., Rosenquist, A., Samuelsson, B.B., Unge, J., Larhed, M.
Deposit date:2011-11-01
Release date:2012-05-09
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Synthesis, X-Ray Analysis, and Biological Evaluation of a New Class of Stereopure Lactam-Based HIV-1 Protease Inhibitors.
J.Med.Chem., 55, 2012
4FZ8
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CRYSTAL STRUCTURE OF C11 FAB, AN ADCC MEDIATING ANTI-HIV-1 ANTIBODY.
Descriptor:FAB heavy chain of human ANTI-HIV-1 ENV ANTIBODY C11, FAB light chain of human ANTI-HIV-1 ENV ANTIBODY C11, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Wu, X., Tolbert, W.D., Pazgier, M.
Deposit date:2012-07-06
Release date:2013-07-10
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:Crystal structure of C11 Fab, an ADCC mediating anti-HIV-1 antibody.
To be Published
4JXM
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CRYSTAL STRUCTURE OF RRP9 WD40 REPEATS
Descriptor:U3 small nucleolar RNA-interacting protein 2, UNKNOWN ATOM OR ION
Authors:Wu, X., Tempel, W., Xu, C., El Bakkouri, M., He, H., Seitova, A., Li, Y., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2013-03-28
Release date:2013-04-17
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Crystal structure of RRP9 WD40 repeats
To be Published
4N5A
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CRYSTAL STRUCTURE OF EFR3
Descriptor:Protein EFR3
Authors:Wu, X., Chi, R.J., Baskin, J.M., Lucast, L., Burd, C.G., De Camilli, P., Reinisch, K.M.
Deposit date:2013-10-09
Release date:2014-01-22
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (3.204 Å)
Cite:Structural insights into assembly and regulation of the plasma membrane phosphatidylinositol 4-kinase complex.
Dev.Cell, 28, 2014
4N5C
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CRYSTAL STRUCTURE OF YPP1
Descriptor:Cargo-transport protein YPP1
Authors:Wu, X., Chi, R.J., Baskin, J.M., Lucast, L., Burd, C.G., De Camilli, P., Reinisch, K.M.
Deposit date:2013-10-09
Release date:2014-01-22
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Structural insights into assembly and regulation of the plasma membrane phosphatidylinositol 4-kinase complex.
Dev.Cell, 28, 2014
5YIU
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CAULOBACTER CRESCENTUS GCRA DNA-BINDING DOMAIN (DBD)
Descriptor:Cell cycle regulatory protein GcrA
Authors:Wu, X., Zhang, Y.
Deposit date:2017-10-06
Release date:2018-03-21
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Structural insights into the unique mechanism of transcription activation by Caulobacter crescentus GcrA.
Nucleic Acids Res., 46, 2018
5YIV
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CAULOBACTER CRESCENTUS GCRA DNA-BINDING DOMAIN(DBD) IN COMPLEX WITH METHYLATED DSDNA(CRYSTAL FORM 1)
Descriptor:Cell cycle regulatory protein GcrA, DNA (5'-D(*CP*CP*TP*GP*(6MA)P*TP*TP*CP*G)-3'), DNA (5'-D(*CP*CP*GP*(6MA)P*AP*TP*CP*AP*G)-3')
Authors:Wu, X., Zhang, Y.
Deposit date:2017-10-06
Release date:2018-03-21
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.914 Å)
Cite:Structural insights into the unique mechanism of transcription activation by Caulobacter crescentus GcrA.
Nucleic Acids Res., 46, 2018
5YIW
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CAULOBACTER CRESCENTUS GCRA DNA-BINDING DOMAIN (DBD) IN COMPLEX WITH METHYLATED DSDNA (CRYSTAL FORM 2)
Descriptor:Cell cycle regulatory protein GcrA, DNA (5'-D(*CP*CP*CP*TP*GP*(6MA)P*TP*TP*CP*GP*C)-3'), DNA (5'-D(P*GP*CP*GP*(6MA)P*AP*TP*CP*AP*GP*G)-3'), ...
Authors:Wu, X., Zhang, Y.
Deposit date:2017-10-06
Release date:2018-03-21
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.551 Å)
Cite:Structural insights into the unique mechanism of transcription activation by Caulobacter crescentus GcrA.
Nucleic Acids Res., 46, 2018
5YIX
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CAULOBACTER CRESCENTUS GCRA SIGMA-INTERACTING DOMAIN (SID) IN COMPLEX WITH DOMAIN 2 OF SIGMA 70
Descriptor:RNA polymerase sigma factor RpoD, Cell cycle regulatory protein GcrA, (R,R)-2,3-BUTANEDIOL, ...
Authors:Wu, X., Zhang, Y.
Deposit date:2017-10-06
Release date:2018-03-21
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.302 Å)
Cite:Structural insights into the unique mechanism of transcription activation by Caulobacter crescentus GcrA.
Nucleic Acids Res., 46, 2018
5Z7I
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CAULOBACTER CRESCENTUS GCRA DNA-BINDING DOMAIN(DBD)IN COMPLEX WITH UNMETHYLATED DSDNA
Descriptor:Cell cycle regulatory protein GcrA, DNA (5'-D(*CP*CP*CP*TP*GP*AP*TP*TP*CP*GP*C*)-3'), DNA (5'-D(P*GP*CP*GP*AP*AP*TP*CP*AP*GP*G)-3'), ...
Authors:Wu, X., Zhang, Y.
Deposit date:2018-01-29
Release date:2018-03-21
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.601 Å)
Cite:Structural insights into the unique mechanism of transcription activation by Caulobacter crescentus GcrA.
Nucleic Acids Res., 46, 2018
6ND1
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CRYOEM STRUCTURE OF THE SEC COMPLEX FROM YEAST
Descriptor:Protein transport protein SEC61, Protein translocation protein SEC63, Protein transport protein SSS1, ...
Authors:Wu, X., Cabanos, C., Rapoport, T.A.
Deposit date:2018-12-13
Release date:2019-01-09
Last modified:2019-02-20
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structure of the post-translational protein translocation machinery of the ER membrane.
Nature, 566, 2019
3TPX
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CRYSTAL STRUCTURE OF HUMAN MDM2 IN COMPLEX WITH A TRIFLUOROMETHYLATED D-PEPTIDE INHIBITOR
Descriptor:E3 ubiquitin-protein ligase Mdm2, D-peptide inhibitor DPMI-delta, SULFATE ION, ...
Authors:Wu, X., Pazgier, M.
Deposit date:2011-09-08
Release date:2012-06-20
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:An Ultrahigh Affinity d-Peptide Antagonist Of MDM2.
J.Med.Chem., 55, 2012
4DU0
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CRYSTAL STRUCTURE OF HUMAN ALPHA-DEFENSIN 1, HNP1 (G17A MUTANT)
Descriptor:Neutrophil defensin 1, GLYCEROL, CHLORIDE ION
Authors:Wu, X., Lu, W., Pazgier, M.
Deposit date:2012-02-21
Release date:2012-04-11
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Invariant gly residue is important for alpha-defensin folding, dimerization, and function: a case study of the human neutrophil alpha-defensin HNP1
J.Biol.Chem., 287, 2012
1ZY6
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MEMBRANE-BOUND DIMER STRUCTURE OF PROTEGRIN-1 (PG-1), A BETA-HAIRPIN ANTIMICROBIAL PEPTIDE IN LIPID BILAYERS FROM ROTATIONAL-ECHO DOUBLE-RESONANCE SOLID-STATE NMR
Descriptor:Protegrin 1
Authors:Wu, X., Mani, R., Tang, M., Buffy, J.J., Waring, A.J., Sherman, M.A., Hong, M.
Deposit date:2005-06-09
Release date:2006-06-13
Last modified:2011-07-13
Method:SOLID-STATE NMR
Cite:Membrane-Bound Dimer Structure of a beta-Hairpin Antimicrobial Peptide from Rotational-Echo Double-Resonance Solid-State NMR.
Biochemistry, 45, 2006
2BEL
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STRUCTURE OF HUMAN 11-BETA-HYDROXYSTEROID DEHYDROGENASE IN COMPLEX WITH NADP AND CARBENOXOLONE
Descriptor:CORTICOSTEROID 11-BETA-DEHYDROGENASE ISOZYME 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, CARBENOXOLONE, ...
Authors:Kavanagh, K., Wu, X., Svensson, S., Elleby, B., von Delft, F., Debreczeni, J.E., Sharma, S., Bray, J., Edwards, A., Arrowsmith, C., Sundstrom, M., Abrahmsen, L., Oppermann, U.
Deposit date:2004-11-25
Release date:2004-12-06
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:The High Resolution Structures of Human, Murine and Guinea Pig 11-Beta-Hydroxysteroid Dehydrogenase Type 1 Reveal Critical Differences in Active Site Architecture
To be Published
2C2N
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STRUCTURE OF HUMAN MITOCHONDRIAL MALONYLTRANSFERASE
Descriptor:MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE, SULFATE ION, 3,6,9,12,15-PENTAOXAHEPTADECAN-1-OL, ...
Authors:Wu, X., Bunkoczi, G., Smee, C., Arrowsmith, C., Sundstrom, M., Weigelt, J., Edwards, A., von Delft, F., Oppermann, U.
Deposit date:2005-09-29
Release date:2006-01-18
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural Basis for Different Specificities of Acyltransferases Associated with the Human Cytosolic and Mitochondrial Fatty Acid Synthases.
Chem.Biol., 16, 2009
3TNM
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CRYSTAL STRUCTURE OF A32 FAB, AN ADCC MEDIATING ANTI-HIV-1 ANTIBODY
Descriptor:Fab heavy chain of human anti-HIV-1 Env antibody A32, Fab light chain of human anti-HIV-1 Env antibody A32, ACETATE ION, ...
Authors:Wu, X., Pazgier, M.
Deposit date:2011-09-01
Release date:2012-09-26
Last modified:2015-10-14
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Diverse specificity and effector function among human antibodies to HIV-1 envelope glycoprotein epitopes exposed by CD4 binding.
Proc.Natl.Acad.Sci.USA, 110, 2013
3TNN
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CRYSTAL STRUCTURE OF N5-I5 FAB, AN ADCC MEDIATING AND NON-NEUTRALIZING CD4I ANTI-HIV- 1 ANTIBODY.
Descriptor:Fab heavy chain of ADCC and non-neutralizing anti-HIV-1 antibody N5-i5, Fab light chain of ADCC and non-neutralizing anti-HIV-1 antibody N5-i5, SULFATE ION, ...
Authors:Wu, X., Pazgier, M.
Deposit date:2011-09-01
Release date:2012-09-26
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of N5-i5 Fab, an ADCC and non-neutralizing anti-HIV-1 antibody
To be Published