6VK0

CryoEM structure of Hrd1-Usa1/Der1/Hrd3 of the flipped topology

Summary for 6VK0

Entry DOI	10.2210/pdb6vk0/pdb
EMDB information	21220 21221 21222
Descriptor	U1 SNP1-associating protein 1, Degradation in the endoplasmic reticulum protein 1, ERAD-associated E3 ubiquitin-protein ligase component HRD3, ... (4 entities in total)
Functional Keywords	retro-translocation, erad, protein degradation, ubiquitination, protein transport
Biological source	Saccharomyces cerevisiae (Baker's yeast) More
Total number of polymer chains	4
Total formula weight	208233.89
Authors	Wu, X.,Rapoport, T.A. (deposition date: 2020-01-18, release date: 2020-04-29, Last modification date: 2024-03-06)
Primary citation	Wu, X.,Siggel, M.,Ovchinnikov, S.,Mi, W.,Svetlov, V.,Nudler, E.,Liao, M.,Hummer, G.,Rapoport, T.A. Structural basis of ER-associated protein degradation mediated by the Hrd1 ubiquitin ligase complex. Science, 368:-, 2020 Cited by PubMed: 32327568 DOI: 10.1126/science.aaz2449 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4.1 Å)

Structure validation