Author results

3QX3
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HUMAN TOPOISOMERASE IIBETA IN COMPLEX WITH DNA AND ETOPOSIDE
Descriptor:DNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ...
Authors:Wu, C.C., Li, T.K., Farh, L., Lin, L.Y., Lin, T.S., Yu, Y.J., Yen, T.J., Chiang, C.W., Chan, N.L.
Deposit date:2011-03-01
Release date:2011-07-06
Last modified:2012-01-25
Method:X-RAY DIFFRACTION (2.162 Å)
Cite:Structural basis of type II topoisomerase inhibition by the anticancer drug etoposide
Science, 333, 2011
4G0U
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HUMAN TOPOISOMERASE IIBETA IN COMPLEX WITH DNA AND AMSACRINE
Descriptor:DNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ...
Authors:Wu, C.C., Li, T.K., Li, Y.C., Chan, N.L.
Deposit date:2012-07-10
Release date:2013-07-17
Last modified:2014-03-12
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs
Nucleic Acids Res., 41, 2013
4G0V
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HUMAN TOPOISOMERASE IIBETA IN COMPLEX WITH DNA AND MITOXANTRONE
Descriptor:DNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ...
Authors:Wu, C.C., Li, T.K., Li, Y.C., Chan, N.L.
Deposit date:2012-07-10
Release date:2013-07-17
Last modified:2014-03-12
Method:X-RAY DIFFRACTION (2.548 Å)
Cite:On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs
Nucleic Acids Res., 41, 2013
4G0W
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HUMAN TOPOISOMERASE IIBETA IN COMPLEX WITH DNA AND AMETANTRONE
Descriptor:DNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ...
Authors:Wu, C.C., Li, T.K., Li, Y.C., Chan, N.L.
Deposit date:2012-07-10
Release date:2013-07-17
Last modified:2014-03-12
Method:X-RAY DIFFRACTION (2.696 Å)
Cite:On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs
Nucleic Acids Res., 41, 2013
4J3N
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HUMAN TOPOISOMERASE IIBETA IN COMPLEX WITH DNA
Descriptor:DNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ...
Authors:Wu, C.C., Li, T.K., Li, Y.C., Chan, N.L.
Deposit date:2013-02-06
Release date:2013-10-02
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs
Nucleic Acids Res., 41, 2013
5ZKI
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HUMAN EXOG-H140A IN COMPLEX WITH DUPLEX DNA
Descriptor:Nuclease EXOG, mitochondrial, DNA (5'-D(*CP*GP*GP*GP*AP*TP*AP*TP*CP*CP*CP*G)-3'), ...
Authors:Wu, C.C., Lin, J.L.J., Yuan, H.S.
Deposit date:2018-03-24
Release date:2019-04-03
Last modified:2019-06-19
Method:X-RAY DIFFRACTION (2.321 Å)
Cite:A unique exonuclease ExoG cleaves between RNA and DNA in mitochondrial DNA replication.
Nucleic Acids Res., 47, 2019
5ZKJ
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HUMAN EXOG-H140A IN COMPLEX WITH RNA/DNA HYBRID DUPLEX
Descriptor:Nuclease EXOG, mitochondrial, RNA (5'-R(P*CP*GP*GP*GP*AP*UP*GP*UP*CP*AP*CP*G)-3'), ...
Authors:Wu, C.C., Lin, J.L.J., Yuan, H.S.
Deposit date:2018-03-24
Release date:2019-04-03
Last modified:2019-06-19
Method:X-RAY DIFFRACTION (2.798 Å)
Cite:A unique exonuclease ExoG cleaves between RNA and DNA in mitochondrial DNA replication.
Nucleic Acids Res., 47, 2019
6IID
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HUMAN EXOG-H140A IN COMPLEX WITH RNA-DNA CHIMERIC DUPLEX
Descriptor:Nuclease EXOG, mitochondrial, DNA/RNA (5'-R(P*CP*GP*GP*GP*A)-D(P*T)-R(P*G)-D(P*T)-R(P*CP*AP*CP*G)-3'), ...
Authors:Wu, C.C., Lin, J.L.J., Yuan, H.S.
Deposit date:2018-10-04
Release date:2019-04-03
Last modified:2019-06-19
Method:X-RAY DIFFRACTION (2.986 Å)
Cite:A unique exonuclease ExoG cleaves between RNA and DNA in mitochondrial DNA replication.
Nucleic Acids Res., 47, 2019
4M23
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CRYSTAL STRUCTURE OF NON-HEME IRON OXYGENASE ORFP
Descriptor:L-arginine beta-hydroxylase
Authors:Chang, C.Y., Liu, Y.C., Lyu, S.Y., Wu, C.C., Li, T.L.
Deposit date:2013-08-05
Release date:2014-06-18
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms.
Angew.Chem.Int.Ed.Engl., 53, 2014
4M25
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CRYSTAL STRUCTURE OF NON-HEME IRON OXYGENASE ORFP IN COMPLEX WITH FE AND ALPHA-KETOGLUTARIC ACID
Descriptor:L-arginine beta-hydroxylase, FE (III) ION, 2-OXOGLUTARIC ACID
Authors:Chang, C.Y., Liu, Y.C., Lyu, S.Y., Wu, C.C., Li, T.L.
Deposit date:2013-08-05
Release date:2014-06-25
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms.
Angew.Chem.Int.Ed.Engl., 53, 2014
4M26
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CRYSTAL STRUCTURE OF NON-HEME IRON OXYGENASE ORFP IN COMPLEX WITH FE, SUCCINATE, AND (3S)-HYDROXY-L-ARG
Descriptor:L-arginine beta-hydroxylase, FE (III) ION, 2-OXOGLUTARIC ACID, ...
Authors:Chang, C.Y., Liu, Y.C., Lyu, S.Y., Wu, C.C., Li, T.L.
Deposit date:2013-08-05
Release date:2014-06-25
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms.
Angew.Chem.Int.Ed.Engl., 53, 2014
4M27
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CRYSTAL STRUCTURE OF NON-HEME IRON OXYGENASE ORFP IN COMPLEX WITH FE AND L-ARG
Descriptor:L-arginine beta-hydroxylase, FE (III) ION, ARGININE, ...
Authors:Chang, C.Y., Liu, Y.C., Lyu, S.Y., Wu, C.C., Li, T.L.
Deposit date:2013-08-05
Release date:2014-06-25
Last modified:2018-07-18
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms.
Angew.Chem.Int.Ed.Engl., 53, 2014
4M2C
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CRYSTAL STRUCTURE OF NON-HEME IRON OXYGENASE ORFP IN COMPLEX WITH FE AND D-ARG
Descriptor:L-arginine beta-hydroxylase, FE (III) ION, D-ARGININE
Authors:Chang, C.Y., Liu, Y.C., Lyu, S.Y., Wu, C.C., Li, T.L.
Deposit date:2013-08-05
Release date:2014-06-25
Last modified:2018-07-18
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms.
Angew.Chem.Int.Ed.Engl., 53, 2014
4M2E
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CRYSTAL STRUCTURE OF NON-HEME IRON OXYGENASE ORFP IN COMPLEX WITH FE AND L-HOMOARGININE
Descriptor:L-arginine beta-hydroxylase, L-HOMOARGININE, FE (III) ION
Authors:Chang, C.Y., Liu, Y.C., Lyu, S.Y., Wu, C.C., Li, T.L.
Deposit date:2013-08-05
Release date:2014-06-25
Last modified:2018-07-18
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms.
Angew.Chem.Int.Ed.Engl., 53, 2014
4M2F
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CRYSTAL STRUCTURE OF NON-HEME IRON OXYGENASE ORFP IN COMPLEX WITH FE AND L-CANAVANINE
Descriptor:L-arginine beta-hydroxylase, FE (III) ION, L-CANAVANINE
Authors:Chang, C.Y., Liu, Y.C., Lyu, S.Y., Wu, C.C., Li, T.L.
Deposit date:2013-08-05
Release date:2014-06-25
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms.
Angew.Chem.Int.Ed.Engl., 53, 2014
4M2G
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CRYSTAL STRUCTURE OF NON-HEME IRON OXYGENASE ORFP IN COMPLEX WITH FE, SUCCINATE, AND (3R,4R)-DIHYDROXY-L-ARG
Descriptor:L-arginine beta-hydroxylase, FE (III) ION, SUCCINIC ACID, ...
Authors:Chang, C.Y., Liu, Y.C., Lyu, S.Y., Wu, C.C., Li, T.L.
Deposit date:2013-08-05
Release date:2014-06-25
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms.
Angew.Chem.Int.Ed.Engl., 53, 2014
4M2I
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CRYSTAL STRUCTURE OF NON-HEME IRON OXYGENASE ORFP IN COMPLEX WITH FE
Descriptor:L-arginine beta-hydroxylase, FE (III) ION
Authors:Chang, C.Y., Liu, Y.C., Lyu, S.Y., Wu, C.C., Li, T.L.
Deposit date:2013-08-05
Release date:2014-06-25
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms.
Angew.Chem.Int.Ed.Engl., 53, 2014
4M2J
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CRYSTAL STRUCTURE OF PLP-DEPENDENT CYCLASE ORFR IN COMPLEX WITH AU
Descriptor:Aminotransferase, PYRIDOXAL-5'-PHOSPHATE, GOLD ION
Authors:Chang, C.Y., Liu, Y.C., Lyu, S.Y., Wu, C.C., Li, T.L.
Deposit date:2013-08-05
Release date:2014-06-18
Last modified:2018-07-18
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms.
Angew.Chem.Int.Ed.Engl., 53, 2014
4M2K
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CRYSTAL STRUCTURE OF PLP-DEPENDENT CYCLASE ORFR IN COMPLEX WITH PLP
Descriptor:Aminotransferase, PYRIDOXAL-5'-PHOSPHATE
Authors:Chang, C.Y., Liu, Y.C., Lyu, S.Y., Wu, C.C., Li, T.L.
Deposit date:2013-08-05
Release date:2014-06-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms.
Angew.Chem.Int.Ed.Engl., 53, 2014
4M2M
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CRYSTAL STRUCTURE OF PLP-DEPENDENT CYCLASE ORFR IN COMPLEX WITH PLP-L-ARG
Descriptor:Aminotransferase, PYRIDOXAL-5'-PHOSPHATE, ARGININE
Authors:Chang, C.Y., Liu, Y.C., Lyu, S.Y., Wu, C.C., Li, T.L.
Deposit date:2013-08-05
Release date:2014-06-18
Last modified:2018-07-18
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms.
Angew.Chem.Int.Ed.Engl., 53, 2014
4NE0
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CRYSTAL STRUCTURE OF NON-HEME IRON OXYGENASE ORFP D157A MUTANT IN COMPLEX WITH (3S)-HYDROXY-L-ARG
Descriptor:L-arginine beta-hydroxylase, FE (III) ION, SUCCINIC ACID, ...
Authors:Chang, C.Y., Liu, Y.C., Lyu, S.Y., Wu, C.C., Li, T.L.
Deposit date:2013-10-28
Release date:2014-06-18
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms
Angew.Chem.Int.Ed.Engl., 53, 2014
5GWI
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STRUCTURE OF A HUMAN TOPOISOMERASE IIBETA FRAGMENT IN COMPLEX WITH DNA AND E7873R
Descriptor:DNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ...
Authors:Wang, Y.R., Chen, S.F., Wu, C.C., Chan, N.L.
Deposit date:2016-09-12
Release date:2017-08-23
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (2.737 Å)
Cite:Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry
Nucleic Acids Res., 45, 2017
5GWJ
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STRUCTURE OF A HUMAN TOPOISOMERASE IIBETA FRAGMENT IN COMPLEX WITH DNA AND E7873S
Descriptor:DNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ...
Authors:Wang, Y.R., Chen, S.F., Wu, C.C., Chan, N.L.
Deposit date:2016-09-12
Release date:2017-08-23
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (2.566 Å)
Cite:Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry
Nucleic Acids Res., 45, 2017
5GWK
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HUMAN TOPOISOMERASE IIALPHA IN COMPLEX WITH DNA AND ETOPOSIDE
Descriptor:DNA topoisomerase 2-alpha, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ...
Authors:Wang, Y.R., Wu, C.C., Chan, N.L.
Deposit date:2016-09-12
Release date:2017-08-23
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3.152 Å)
Cite:Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry
Nucleic Acids Res., 45, 2017
5ZRF
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CRYSTAL STRUCTURE OF HUMAN TOPOISOMERASE II BETA IN COMPLEX WITH 5-IODOURIDINE-CONTAINING-DNA AND ETOPOSIDE IN SPACE GROUP P21
Descriptor:DNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA/RNA (5'-R(P*(IU))-D(P*GP*CP*AP*GP*C)-R(P*(IU))-D(P*CP*GP*GP*C)-R(P*(IU))-3'), ...
Authors:Chen, S.F., Wang, Y.R., Wu, C.C., Chan, N.L.
Deposit date:2018-04-24
Release date:2018-08-08
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate.
Nat Commun, 9, 2018
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