Author results

3GDX
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DNA POLYMERASE BETA WITH A GAPPED DND SUBSTRATE AND DTMP(CF2)PP
Descriptor:DNA polymerase beta, 5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3', ...
Authors:Wilson, S.H., Batra, V.K., Pedersen, L.C.
Deposit date:2009-02-24
Release date:2009-05-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Alpha,beta-difluoromethylene deoxynucleoside 5'-triphosphates: a convenient synthesis of useful probes for DNA polymerase beta structure and function
Org.Lett., 11, 2009
5TZV
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BINARY COMPLEX CRYSTAL STRUCTURE OF DNA POLYMERASE BETA WITH G:T MISMATCH AT THE PRIMER TERMINUS
Descriptor:DNA polymerase beta, DNA (5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*T)-3'), ...
Authors:Wilson, S.H., Batra, V.K.
Deposit date:2016-11-22
Release date:2016-12-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of DNA Polymerase Mispaired DNA Termini Transitioning to Pre-catalytic Complexes Support an Induced-Fit Fidelity Mechanism.
Structure, 24, 2016
1BPX
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DNA POLYMERASE BETA/DNA COMPLEX
Descriptor:DNA (5'-D(*CP*CP*GP*AP*CP*GP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), DNA (5'-D(*GP*TP*CP*GP*G)-3'), ...
Authors:Sawaya, M.R., Prasad, R., Wilson, S.H., Kraut, J., Pelletier, H.
Deposit date:1997-04-11
Release date:1997-06-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structures of human DNA polymerase beta complexed with gapped and nicked DNA: evidence for an induced fit mechanism.
Biochemistry, 36, 1997
1BPY
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HUMAN DNA POLYMERASE BETA COMPLEXED WITH GAPPED DNA AND DDCTP
Descriptor:DNA (5'-D(*CP*CP*GP*AP*CP*GP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*DOC)-3'), DNA (5'-D(*GP*TP*CP*GP*G)-3'), ...
Authors:Sawaya, M.R., Pelletier, H., Prasad, R., Wilson, S.H., Kraut, J.
Deposit date:1997-04-15
Release date:1997-06-16
Last modified:2017-02-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of human DNA polymerase beta complexed with gapped and nicked DNA: evidence for an induced fit mechanism.
Biochemistry, 36, 1997
1BPZ
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HUMAN DNA POLYMERASE BETA COMPLEXED WITH NICKED DNA
Descriptor:DNA (5'-D(*CP*CP*GP*AP*CP*CP*AP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*G)-3'), DNA (5'-D(*GP*TP*CP*GP*G)-3'), ...
Authors:Sawaya, M.R., Prasad, R., Wilson, S.H., Kraut, J., Pelletier, H.
Deposit date:1997-04-14
Release date:1997-06-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structures of human DNA polymerase beta complexed with gapped and nicked DNA: evidence for an induced fit mechanism.
Biochemistry, 36, 1997
1BPB
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CRYSTAL STRUCTURE OF RAT DNA POLYMERASE BETA: EVIDENCE FOR A COMMON POLYMERASE MECHANISM
Descriptor:DNA POLYMERASE BETA
Authors:Sawaya, M.R., Pelletier, H., Kumar, A., Wilson, S.H., Kraut, J.
Deposit date:1994-04-12
Release date:1994-06-22
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of rat DNA polymerase beta: evidence for a common polymerase mechanism.
Science, 264, 1994
1BPD
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CRYSTAL STRUCTURE OF RAT DNA POLYMERASE BETA: EVIDENCE FOR A COMMON POLYMERASE MECHANISM
Descriptor:DNA POLYMERASE BETA, PHOSPHATE ION
Authors:Sawaya, M.R., Pelletier, H., Kumar, A., Wilson, S.H., Kraut, J.
Deposit date:1994-04-12
Release date:1994-06-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Crystal structure of rat DNA polymerase beta: evidence for a common polymerase mechanism.
Science, 264, 1994
1DK2
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REFINED SOLUTION STRUCTURE OF THE N-TERMINAL DOMAIN OF DNA POLYMERASE BETA
Descriptor:DNA POLYMERASE BETA
Authors:Maciejewski, M.W., Prasad, R., Liu, D.-J., Wilson, S.H., Mullen, G.P.
Deposit date:1999-12-06
Release date:2000-02-14
Last modified:2017-02-01
Method:SOLUTION NMR
Cite:Backbone dynamics and refined solution structure of the N-terminal domain of DNA polymerase beta. Correlation with DNA binding and dRP lyase activity.
J.Mol.Biol., 296, 2000
1DK3
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REFINED SOLUTION STRUCTURE OF THE N-TERMINAL DOMAIN OF DNA POLYMERASE BETA
Descriptor:DNA POLYMERASE BETA
Authors:Maciejewski, M.W., Prasad, R., Liu, D.-J., Wilson, S.H., Mullen, G.P.
Deposit date:1999-12-06
Release date:2000-02-14
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Backbone dynamics and refined solution structure of the N-terminal domain of DNA polymerase beta. Correlation with DNA binding and dRP lyase activity.
J.Mol.Biol., 296, 2000
2BPC
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CRYSTAL STRUCTURE OF RAT DNA POLYMERASE BETA: EVIDENCE FOR A COMMON POLYMERASE MECHANISM
Descriptor:DNA POLYMERASE BETA, MANGANESE (II) ION
Authors:Sawaya, M.R., Pelletier, H., Kumar, A., Wilson, S.H., Kraut, J.
Deposit date:1994-07-08
Release date:1994-08-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of rat DNA polymerase beta: evidence for a common polymerase mechanism.
Science, 264, 1994
1BNO
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NMR SOLUTION STRUCTURE OF THE N-TERMINAL DOMAIN OF DNA POLYMERASE BETA, MINIMIZED AVERAGE STRUCTURE
Descriptor:DNA POLYMERASE BETA
Authors:Liu, D.-J., Prasad, R., Wilson, S.H., Derose, E.F., Mullen, G.P.
Deposit date:1996-04-25
Release date:1996-12-07
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Three-dimensional solution structure of the N-terminal domain of DNA polymerase beta and mapping of the ssDNA interaction interface.
Biochemistry, 35, 1996
1BNP
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NMR SOLUTION STRUCTURE OF THE N-TERMINAL DOMAIN OF DNA POLYMERASE BETA, 55 STRUCTURES
Descriptor:DNA POLYMERASE BETA
Authors:Liu, D.-J., Prasad, R., Wilson, S.H., Derose, E.F., Mullen, G.P.
Deposit date:1996-04-25
Release date:1996-12-07
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Three-dimensional solution structure of the N-terminal domain of DNA polymerase beta and mapping of the ssDNA interaction interface.
Biochemistry, 35, 1996
1BPE
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CRYSTAL STRUCTURE OF RAT DNA POLYMERASE BETA; EVIDENCE FOR A COMMON POLYMERASE MECHANISM
Descriptor:DNA POLYMERASE BETA, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
Authors:Sawaya, M.R., Pelletier, H., Kumar, A., Wilson, S.H., Kraut, J.
Deposit date:1994-04-12
Release date:1994-07-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of rat DNA polymerase beta: evidence for a common polymerase mechanism.
Science, 264, 1994
2BPF
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STRUCTURES OF TERNARY COMPLEXES OF RAT DNA POLYMERASE BETA, A DNA TEMPLATE-PRIMER, AND DDCTP
Descriptor:DNA (5'-D(*GP*GP*GP*CP*GP*CP*CP*G)-3'), DNA (5'-D(*CP*GP*GP*CP*GP*CP*C)-3'), PROTEIN (DNA POLYMERASE BETA (E.C.2.7.7.7)), ...
Authors:Pelletier, H., Sawaya, M.R., Kumar, A., Wilson, S.H., Kraut, J.
Deposit date:1994-05-19
Release date:1994-12-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structures of ternary complexes of rat DNA polymerase beta, a DNA template-primer, and ddCTP.
Science, 264, 1994
2BPG
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STRUCTURES OF TERNARY COMPLEXES OF RAT DNA POLYMERASE BETA, A DNA TEMPLATE-PRIMER, AND DDCTP
Descriptor:DNA (5'-D(*GP*GP*GP*CP*GP*CP*CP*G)-3'), DNA (5'-D(*CP*GP*GP*CP*GP*CP*C)-3'), DNA POLYMERASE BETA, ...
Authors:Pelletier, H., Sawaya, M.R., Kumar, A., Wilson, S.H., Kraut, J.
Deposit date:1994-05-19
Release date:1994-08-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structures of ternary complexes of rat DNA polymerase beta, a DNA template-primer, and ddCTP.
Science, 264, 1994
6BEM
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TERNARY COMPLEX CRYSTAL STRUCTURE OF DNA POLYMERASE BETA WITH S-ISOMER OF BETA-GAMMA-CHCL-DCTP
Descriptor:Template strand, Primer Strand, Downstream Primer Strand, ...
Authors:Batra, V.K., Wilson, S.H.
Deposit date:2017-10-25
Release date:2018-10-31
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Mapping Functional Substrate-Enzyme Interactions in the pol beta Active Site through Chemical Biology: Structural Responses to Acidity Modification of Incoming dNTPs.
Biochemistry, 57, 2018
1MQ2
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HUMAN DNA POLYMERASE BETA COMPLEXED WITH GAPPED DNA CONTAINING AN 8-OXO-7,8-DIHYDRO-GUANINE AND DAMP
Descriptor:5'-D(*CP*CP*GP*AP*CP*(8OG)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(2DA))-3', 5'-D(P*GP*TP*CP*GP*G)-3', ...
Authors:Krahn, J.M., Beard, W.A., Miller, H., Grollman, A.P., Wilson, S.H.
Deposit date:2002-09-13
Release date:2003-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of DNA Polymerase beta with the Mutagenic DNA Lesion 8-oxodeoxyguanine Reveals Structural Insights into its Coding Potential
Structure, 11, 2003
1MQ3
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HUMAN DNA POLYMERASE BETA COMPLEXED WITH GAPPED DNA CONTAINING AN 8-OXO-7,8-DIHYDRO-GUANINE TEMPLATE PAIRED WITH DCTP
Descriptor:5'-D(*CP*CP*GP*AP*CP*(8OG)P*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3', 5'-D(P*GP*TP*CP*GP*G)-3', ...
Authors:Krahn, J.M., Beard, W.A., Miller, H., Grollman, A.P., Wilson, S.H.
Deposit date:2002-09-13
Release date:2003-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of DNA Polymerase beta with the Mutagenic DNA Lesion 8-oxodeoxyguanine Reveals Structural Insights into its Coding Potential
Structure, 11, 2003
1TV9
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HUMAN DNA POLYMERASE BETA COMPLEXED WITH NICKED DNA CONTAINING A MISMATCHED TEMPLATE ADENINE AND INCOMING CYTIDINE
Descriptor:5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*CP*C)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ...
Authors:Krahn, J.M., Beard, W.M., Wilson, S.H.
Deposit date:2004-06-29
Release date:2004-11-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:STRUCTURAL INSIGHTS INTO DNA POLYMERASE BETA DETERRENTS FOR MISINCORPORATION SUPPORT OF AN INDUCED-FIT MECHANISM FOR FIDELITY
Structure, 12, 2004
1TVA
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HUMAN DNA POLYMERASE BETA COMPLEXED WITH NICKED DNA CONTAINING A MISMATCHED TEMPLATE THYMIDINE AND INCOMING CYTIDINE
Descriptor:5'-D(*CP*CP*GP*AP*CP*TP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*CP*C)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ...
Authors:Krahn, J.M., Beard, W.A., Wilson, S.H.
Deposit date:2004-06-29
Release date:2004-11-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural insights into DNA polymerase Beta deterrents for misincorporation support an induced-fit mechanism for fidelity
Structure, 12, 2004
1ZJM
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HUMAN DNA POLYMERASE BETA COMPLEXED WITH DNA CONTAINING AN A-A MISMATCHED PRIMER TERMINUS
Descriptor:d(*CP*CP*GP*AP*CP*CP*AP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ...
Authors:Batra, V.K., Beard, W.A., Shock, D.D., Pedersen, L.C., Wilson, S.H.
Deposit date:2005-04-29
Release date:2005-08-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Nucleotide-induced DNA polymerase active site motions accommodating a mutagenic DNA intermediate.
STRUCTURE, 13, 2005
1ZJN
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HUMAN DNA POLYMERASE BETA COMPLEXED WITH DNA CONTAINING AN A-A MISMATCHED PRIMER TERMINUS WITH DGTP
Descriptor:d(*CP*CP*GP*AP*CP*CP*AP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ...
Authors:Batra, V.K., Beard, W.A., Shock, D.D., Pedersen, L.C., Wilson, S.H.
Deposit date:2005-04-29
Release date:2005-08-16
Last modified:2016-11-30
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Nucleotide-induced DNA polymerase active site motions accommodating a mutagenic DNA intermediate.
STRUCTURE, 13, 2005
2FMP
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DNA POLYMERASE BETA WITH A TERMINATED GAPPED DNA SUBSTRATE AND DDCTP WITH SODIUM IN THE CATALYTIC SITE
Descriptor:5'-D(*CP*CP*GP*AP*CP*GP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3', 5'-D(P*GP*TP*CP*GP*G)-3', ...
Authors:Batra, V.K., Beard, W.A., Shock, D.D., Krahn, J.M., Pedersen, L.C., Wilson, S.H.
Deposit date:2006-01-09
Release date:2006-04-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Magnesium-induced assembly of a complete DNA polymerase catalytic complex.
Structure, 14, 2006
2FMQ
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SODIUM IN ACTIVE SITE OF DNA POLYMERASE BETA
Descriptor:5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ...
Authors:Batra, V.K., Beard, W.A., Shock, D.D., Krahn, J.M., Pedersen, L.C., Wilson, S.H.
Deposit date:2006-01-09
Release date:2006-04-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Magnesium-induced assembly of a complete DNA polymerase catalytic complex.
Structure, 14, 2006
2FMS
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DNA POLYMERASE BETA WITH A GAPPED DNA SUBSTRATE AND DUMPNPP WITH MAGNESIUM IN THE CATALYTIC SITE
Descriptor:5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ...
Authors:Batra, V.K., Beard, W.A., Shock, D.D., Krahn, J.M., Pedersen, L.C., Wilson, S.H.
Deposit date:2006-01-09
Release date:2006-04-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Magnesium-induced assembly of a complete DNA polymerase catalytic complex.
Structure, 14, 2006