3GDX

Dna polymerase beta with a gapped DND substrate and dTMP(CF2)PP

Summary for 3GDX

• Entry DOI: 10.2210/pdb3gdx/pdb
• Related: 2FMS
• Descriptor: DNA polymerase beta, 5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3', ... (9 entities in total)
• Functional Keywords: nucloetidyl transferase, dna polymerase, dna damage, dna repair, dna replication, dna synthesis, dna-binding, dna-directed dna polymerase, lyase, magnesium, metal-binding, nucleotidyltransferase, nucleus, polymorphism, sodium, transferase, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus: P06746
• Total number of polymer chains: 4
• Total formula weight: 47314.28

Authors

Wilson, S.H.,Batra, V.K.,Pedersen, L.C. (deposition date: 2009-02-24, release date: 2009-05-05, Last modification date: 2023-09-06)

• Primary citation: Upton, T.G.,Kashemirov, B.A.,McKenna, C.E.,Goodman, M.F.,Prakash, G.K.,Kultyshev, R.,Batra, V.K.,Shock, D.D.,Pedersen, L.C.,Beard, W.A.,Wilson, S.H.; Alpha,beta-difluoromethylene deoxynucleoside 5'-triphosphates: a convenient synthesis of useful probes for DNA polymerase beta structure and function; Org.Lett., 11:1883-1886, 2009; PubMed: 19351147; DOI: 10.1021/ol701755k

Experimental method

X-RAY DIFFRACTION (2.2 Å)