Author results

6S5W
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STRUCTURE OF RIB DOMAIN 'RIB LONG' FROM LACTOBACILLUS ACIDOPHILUS
Descriptor:Surface protein, SULFATE ION, SODIUM ION
Authors:Griffiths, S.C., Cooper, R.E.M., Whelan, F., Whittingham, J.L., Bateman, A., Potts, J.R.
Deposit date:2019-07-02
Release date:2019-12-11
Last modified:2019-12-18
Method:X-RAY DIFFRACTION (1.07 Å)
Cite:Defining the remarkable structural malleability of a bacterial surface protein Rib domain implicated in infection.
Proc.Natl.Acad.Sci.USA, 2019
1G7A
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1.2 A STRUCTURE OF T3R3 HUMAN INSULIN AT 100 K
Descriptor:INSULIN A-CHAIN, INSULIN B-CHAIN, ZINC ION, ...
Authors:Smith, G.D., Pangborn, W.A., Blessing, R.H.
Deposit date:2000-11-09
Release date:2001-08-03
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Phase changes in T(3)R(3)(f) human insulin: temperature or pressure induced?
Acta Crystallogr.,Sect.D, 57, 2001
6SX1
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STRUCTURE OF RIB STANDARD, A RIB DOMAIN FROM LACTOBACILLUS ACIDOPHILUS
Descriptor:Surface protein
Authors:Cooper, R.E.M., Griffiths, S.C., Turkenburg, J.P., Bateman, A., Potts, J.R.
Deposit date:2019-09-24
Release date:2019-12-18
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Defining the remarkable structural malleability of a bacterial surface protein Rib domain implicated in infection.
Proc.Natl.Acad.Sci.USA, 2019
1G7B
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1.3 A STRUCTURE OF T3R3 HUMAN INSULIN AT 100 K
Descriptor:INSULIN A-CHAIN, INSULIN B-CHAIN, ZINC ION, ...
Authors:Smith, G.D., Pangborn, W.A., Blessing, R.H.
Deposit date:2000-11-09
Release date:2001-08-03
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Phase changes in T(3)R(3)(f) human insulin: temperature or pressure induced?
Acta Crystallogr.,Sect.D, 57, 2001
1PID
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BOVINE DESPENTAPEPTIDE INSULIN
Descriptor:DESPENTAPEPTIDE INSULIN
Authors:Holden, P.H., Papiz, M., Dodson, G.G.
Deposit date:1995-11-22
Release date:1996-12-07
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:A model of insulin fibrils derived from the x-ray crystal structure of a monomeric insulin (despentapeptide insulin).
Proteins, 27, 1997
2J5G
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THE NATIVE STRUCTURE OF A BETA-DIKETONE HYDROLASE FROM THE CYANOBACTERIUM ANABAENA SP. PCC 7120
Descriptor:ALR4455 PROTEIN, SULFATE ION
Authors:Bennett, J.P., Whittingham, J.L., Brzozowski, A.M., Leonard, P.M., Grogan, G.
Deposit date:2006-09-18
Release date:2007-01-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Structural Characterisation of a Beta Diketone Hydrolase from the Cyanobacterium Anabaena Sp. Pcc 7120 in Native and Product Bound Forms, a Coenzyme A-Independent Member of the Crotonase Suprafamily
Biochemistry, 46, 2007
1ZNI
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INSULIN
Descriptor:INSULIN, ZINC ION, CHLORIDE ION
Authors:Turkenburg, M.G.W., Whittingham, J.L., Dodson, G.G., Dodson, E.J., Xiao, B., Bentley, G.A.
Deposit date:1997-09-23
Release date:1998-01-28
Last modified:2018-07-04
Method:X-RAY DIFFRACTION (1.498 Å)
Cite:Structure of insulin in 4-zinc insulin.
Nature, 261, 1976
1ZEH
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STRUCTURE OF INSULIN
Descriptor:INSULIN, M-CRESOL, ZINC ION, ...
Authors:Whittingham, J.L., Edwards, E.J., Antson, A.A., Clarkson, J.M., Dodson, G.G.
Deposit date:1998-05-01
Release date:1998-12-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Interactions of phenol and m-cresol in the insulin hexamer, and their effect on the association properties of B28 pro --> Asp insulin analogues.
Biochemistry, 37, 1998
2YOG
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PLASMODIUM FALCIPARUM THYMIDYLATE KINASE IN COMPLEX WITH A (THIO)UREA- ALPHA-DEOXYTHYMIDINE INHIBITOR
Descriptor:THYMIDYLATE KINASE, 1-[4-chloranyl-3-(trifluoromethyl)phenyl]-3-[[(2R,3S)-5-[5-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]-3-oxidanyl-oxolan-2-yl]methyl]thiourea
Authors:Huaqing, C., Carrero-Lerida, J., Silva, A.P.G., Whittingham, J.L., Brannigan, J.A., Ruiz-Perez, L.M., Read, K.D., Wilson, K.S., Gonzalez-Pacanowska, D., Gilbert, I.H.
Deposit date:2012-10-24
Release date:2013-07-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Synthesis and Evaluation of Alpha-Thymidine Analogues as Novel Antimalarials.
J.Med.Chem., 55, 2012
2J5S
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STRUCTURAL OF ABDH, A BETA-DIKETONE HYDROLASE FROM THE CYANOBACTERIUM ANABAENA SP. PCC 7120 BOUND TO (S)-3-OXOCYCLOHEXYL ACETIC ACID
Descriptor:BETA-DIKETONE HYDROLASE, (S)-CYCLOHEXANONE-2-ACETATE, NICKEL (II) ION
Authors:Bennett, J.P., Whittingham, J.L., Brzozowski, A.M., Leonard, P.M., Grogan, G.
Deposit date:2006-09-19
Release date:2007-01-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Structural Characterisation of a Beta Diketone Hydrolase from the Cyanobacterium Anabaena Sp. Pcc 7120 in Native and Product Bound Forms, a Coenzyme A-Independent Member of the Crotonase Suprafamily
Biochemistry, 46, 2007
1UZ9
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CRYSTALLOGRAPHIC AND SOLUTION STUDIES OF N-LITHOCHOLYL INSULIN: A NEW GENERATION OF PROLONGED-ACTING INSULINS.
Descriptor:INSULIN, M-CRESOL, (2S)-2-AMINO-6-({(4R)-4-[(10R,13S)-10,13-DIMETHYL-3-OXOHEXADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-17-YL]PENTANOYL}AMINO)HEXANOIC ACID, ...
Authors:Whittingham, J.L., Jonassen, I., Havelund, S., Roberts, S.M., Dodson, E.J., Verma, C.S., Wilkinson, A.J., Dodson, G.G.
Deposit date:2004-03-08
Release date:2005-03-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystallographic and Solution Studies of N-Lithocholyl Insulin: A New Generation of Prolonged-Acting Human Insulins
Biochemistry, 43, 2004
1ZEG
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STRUCTURE OF B28 ASP INSULIN IN COMPLEX WITH PHENOL
Descriptor:INSULIN, PHENOL, ZINC ION, ...
Authors:Whittingham, J.L., Edwards, E.J., Antson, A.A., Clarkson, J.M., Dodson, G.G.
Deposit date:1998-05-01
Release date:1998-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Interactions of phenol and m-cresol in the insulin hexamer, and their effect on the association properties of B28 pro --> Asp insulin analogues.
Biochemistry, 37, 1998
2YOH
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PLASMODIUM FALCIPARUM THYMIDYLATE KINASE IN COMPLEX WITH A UREA-ALPHA- DEOXYTHYMIDINE INHIBITOR
Descriptor:THYMIDYLATE KINASE, 1-[[(2R,3S,5S)-5-[5-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]-3-oxidanyl-oxolan-2-yl]methyl]-3-(4-nitrophenyl)urea
Authors:Huaqing, C., Carrero-Lerida, J., Silva, A.P.G., Whittingham, J.L., Brannigan, J.A., Ruiz-Perez, L.M., Read, K.D., Wilson, K.S., Gonzalez-Pacanowska, D., Gilbert, I.H.
Deposit date:2012-10-24
Release date:2013-07-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Synthesis and Evaluation of Alpha-Thymidine Analogues as Novel Antimalarials.
J.Med.Chem., 55, 2012
1GUJ
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INSULIN AT PH 2: STRUCTURAL ANALYSIS OF THE CONDITIONS PROMOTING INSULIN FIBRE FORMATION.
Descriptor:INSULIN, SULFATE ION
Authors:Whittingham, J.L., Scott, D.J., Chance, K., Wilson, A., Finch, J., Brange, J., Dodson, G.G.
Deposit date:2002-01-28
Release date:2002-03-08
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Insulin at Ph2: Structural Analysis of the Conditions Promoting Insulin Fibre Formation
J.Mol.Biol., 318, 2002
3T64
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5'-DIPHENYL NUCLEOSIDE INHIBITORS OF PLASMODIUM FALCIPARUM DUTPASE
Descriptor:Deoxyuridine 5'-triphosphate nucleotidohydrolase, putative, 5'-(BENZHYDRYLAMINO)-2',5'-DIDEOXYURIDINE, ...
Authors:Hampton, S.E., Baragana, B., Schipani, A., Bosch-Navarrete, C., Musso-Buendia, A., Recio, E., Kaiser, M., Whittingham, J.L., Roberts, S.M., Shevtsov, M., Brannigan, J.A., Kahnberg, P., Brun, R., Wilson, K.S., Gonzalez-Pacanowska, D., Johansson, N.G., Gilbert, I.H.
Deposit date:2011-07-28
Release date:2012-08-29
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Design, synthesis, and evaluation of 5'-diphenyl nucleoside analogues as inhibitors of the Plasmodium falciparum dUTPase.
Chemmedchem, 6, 2011
6S5X
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STRUCTURE OF RIBR, THE MOST N-TERMINAL RIB DOMAIN FROM GROUP B STREPTOCOCCUS SPECIES STREPTOCOCCUS AGALACTIAE
Descriptor:Group B streptococcal R4 surface protein, SODIUM ION
Authors:Whelan, F., Turkenburg, J.P., Griffiths, S.C., Bateman, A., Potts, J.R.
Deposit date:2019-07-02
Release date:2019-12-11
Last modified:2019-12-18
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Defining the remarkable structural malleability of a bacterial surface protein Rib domain implicated in infection.
Proc.Natl.Acad.Sci.USA, 2019
1RWE
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ENHANCING THE ACTIVITY OF INSULIN AT RECEPTOR EDGE: CRYSTAL STRUCTURE AND PHOTO-CROSS-LINKING OF A8 ANALOGUES
Descriptor:insulin, Insulin, ZINC ION, ...
Authors:Wan, Z., Xu, B., Chu, Y.C., Li, B., Nakagawa, S.H., Qu, Y., Hu, S.Q., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2003-12-16
Release date:2005-02-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Enhancing the activity of insulin at the receptor interface: crystal structure and photo-cross-linking of A8 analogues.
Biochemistry, 43, 2004
1XDA
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STRUCTURE OF INSULIN
Descriptor:FATTY ACID ACYLATED INSULIN, PHENOL, ZINC ION, ...
Authors:Whittingham, J.L., Havelund, S., Jonassen, I.
Deposit date:1996-12-18
Release date:1997-07-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of a prolonged-acting insulin with albumin-binding properties.
Biochemistry, 36, 1997
2CEU
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DESPENTAPEPTIDE INSULIN IN ACETIC ACID (PH 2)
Descriptor:INSULIN, SULFATE ION
Authors:Whittingham, J.L., Zhang, Y., Zakova, L., Dodson, E.J., Turkenburg, J.P., Brange, J., Dodson, G.G.
Deposit date:2006-02-10
Release date:2006-03-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:I222 Crystal Form of Despentapeptide (B26-B30) Insulin Provides New Insights Into the Properties of Monomeric Insulin.
Acta Crystallogr.,Sect.D, 62, 2006
2TCI
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X-RAY CRYSTALLOGRAPHIC STUDIES ON HEXAMERIC INSULINS IN THE PRESENCE OF HELIX-STABILIZING AGENTS, THIOCYANATE, METHYLPARABEN AND PHENOL
Descriptor:THIOCYANATE INSULIN, THIOCYANATE ION, ZINC ION
Authors:Whittingham, J.L., Dodson, E.J., Moody, P.C.E., Dodson, G.G.
Deposit date:1995-09-13
Release date:1996-01-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:X-ray crystallographic studies on hexameric insulins in the presence of helix-stabilizing agents, thiocyanate, methylparaben, and phenol.
Biochemistry, 34, 1995
3T70
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5'-DIPHENYL NUCLEOSIDE INHIBITORS OF PLASMODIUM FALCIPARUM DUTPASE
Descriptor:Deoxyuridine 5'-triphosphate nucleotidohydrolase, putative, PEPTIDE GLY-HIS-GLY, ...
Authors:Hampton, S.E., Baragana, B., Schipani, A., Bosch-Navarrete, C., Musso-Buendia, A., Recio, E., Kaiser, M., Whittingham, J.L., Roberts, S.M., Shevtsov, M., Brannigan, J.A., Kahnberg, P., Brun, R., Wilson, K.S., Gonzalez-Pacanowska, D., Johansson, N.G., Gilbert, I.H.
Deposit date:2011-07-29
Release date:2012-08-29
Last modified:2019-10-09
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Design, synthesis, and evaluation of 5'-diphenyl nucleoside analogues as inhibitors of the Plasmodium falciparum dUTPase.
Chemmedchem, 6, 2011
5AEO
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VIRULENCE-ASSOCIATED PROTEIN VAPG FROM THE INTRACELLULAR PATHOGEN RHODOCOCCUS EQUI
Descriptor:R. EQUI VAPG PROTEIN, POTASSIUM ION
Authors:Okoko, T., Blagova, E.V., Whittingham, J.L., Dover, L.G., Wilkinson, A.J.
Deposit date:2015-01-07
Release date:2015-03-25
Last modified:2015-08-05
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Characterisation of the Virulence-Associated Protein Vapg from the Horse Pathogen Rhodococcus Equi.
Vet.Microbiol., 179, 2015
6S5Z
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STRUCTURE OF RIB R28N FROM STREPTOCOCCUS PYOGENES
Descriptor:Surface protein R28, SODIUM ION
Authors:Whelan, F., Griffiths, S.C., Whittingham, J.L., Bateman, A., Potts, J.R.
Deposit date:2019-07-02
Release date:2019-12-11
Last modified:2019-12-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Defining the remarkable structural malleability of a bacterial surface protein Rib domain implicated in infection.
Proc.Natl.Acad.Sci.USA, 2019
2YOF
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PLASMODIUM FALCIPARUM THYMIDYLATE KINASE IN COMPLEX WITH A (THIO)UREA- BETA-DEOXYTHYMIDINE INHIBITOR
Descriptor:THYMIDYLATE KINASE, 1-[4-chloranyl-3-(trifluoromethyl)phenyl]-3-[[(2R,3S)-5-[5-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]-3-oxidanyl-oxolan-2-yl]methyl]thiourea, ACETATE ION, ...
Authors:Huaqing, C., Carrero-Lerida, J., Silva, A.P.G., Whittingham, J.L., Brannigan, J.A., Ruiz-Perez, L.M., Read, K.D., Wilson, K.S., Gonzalez-Pacanowska, D., Gilbert, I.H.
Deposit date:2012-10-24
Release date:2013-07-24
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Synthesis and Evaluation of Alpha-Thymidine Analogues as Novel Antimalarials.
J.Med.Chem., 55, 2012
2WWF
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PLASMODIUM FALCIPARUM THYMIDYLATE KINASE IN COMPLEX WITH TMP AND ADP
Descriptor:THYMIDILATE KINASE, PUTATIVE, THYMIDINE-5'-PHOSPHATE, ...
Authors:Whittingham, J.L., Carrero-Lerida, J., Brannigan, J.A., Ruiz-Perez, L.M., Silva, A.P.G., Fogg, M.J., Wilkinson, A.J., Gilbert, I.H., Wilson, K.S., Gonzalez-Pacanowska, D.
Deposit date:2009-10-23
Release date:2010-04-21
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Structural Basis for the Efficient Phosphorylation of Aztmp and Dgmp by Plasmodium Falciparum Type I Thymidylate Kinase.
Biochem.J., 428, 2010
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