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1UXY
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MURB MUTANT WITH SER 229 REPLACED BY ALA, COMPLEX WITH ENOLPYRUVYL-UDP-N-ACETYLGLUCOSAMINE
Descriptor:URIDINE DIPHOSPHO-N-ACETYLENOLPYRUVYLGLUCOSAMINE REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, URIDINE-DIPHOSPHATE-2(N-ACETYLGLUCOSAMINYL) BUTYRIC ACID
Authors:Benson, T.E., Walsh, C.T., Hogle, J.M.
Deposit date:1996-11-08
Release date:1997-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:X-ray crystal structures of the S229A mutant and wild-type MurB in the presence of the substrate enolpyruvyl-UDP-N-acetylglucosamine at 1.8-A resolution.
Biochemistry, 36, 1997
1MBB
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OXIDOREDUCTASE
Descriptor:URIDINE DIPHOSPHO-N-ACETYLENOLPYRUVYLGLUCOSAMINE REDUCTASE, URIDINE-DIPHOSPHATE-3(N-ACETYLGLUCOSAMINYL)BUTYRIC ACID, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Benson, T.E., Lees, W.J., Walsh, C.T., Hogle, J.M.
Deposit date:1995-11-07
Release date:1996-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:(E)-enolbutyryl-UDP-N-acetylglucosamine as a mechanistic probe of UDP-N-acetylenolpyruvylglucosamine reductase (MurB).
Biochemistry, 35, 1996
1MBT
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OXIDOREDUCTASE
Descriptor:URIDINE DIPHOSPHO-N-ACETYLENOLPYRUVYLGLUCOSAMINE REDUCTASE, SULFATE ION, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Benson, T.E., Walsh, C.T., Hogle, J.M.
Deposit date:1995-11-28
Release date:1996-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:The structure of the substrate-free form of MurB, an essential enzyme for the synthesis of bacterial cell walls.
Structure, 4, 1996
2MBR
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MURB WILD TYPE, COMPLEX WITH ENOLPYRUVYL-UDP-N-ACETYLGLUCOSAMINE
Descriptor:URIDINE DIPHOSPHO-N-ACETYLENOLPYRUVYLGLUCOSAMINE REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, URIDINE-DIPHOSPHATE-2(N-ACETYLGLUCOSAMINYL) BUTYRIC ACID
Authors:Benson, T.E., Walsh, C.T., Hogle, J.M.
Deposit date:1996-11-08
Release date:1997-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:X-ray crystal structures of the S229A mutant and wild-type MurB in the presence of the substrate enolpyruvyl-UDP-N-acetylglucosamine at 1.8-A resolution.
Biochemistry, 36, 1997
1EHI
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D-ALANINE:D-LACTATE LIGASE (LMDDL2) OF VANCOMYCIN-RESISTANT LEUCONOSTOC MESENTEROIDES
Descriptor:D-ALANINE:D-LACTATE LIGASE, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Kuzin, A.P., Sun, T., Jorczak-Baillass, J., Healy, V.L., Walsh, C.T., Knox, J.R.
Deposit date:2000-02-21
Release date:2000-05-23
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Enzymes of vancomycin resistance: the structure of D-alanine-D-lactate ligase of naturally resistant Leuconostoc mesenteroides.
Structure Fold.Des., 8, 2000
1CSA
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THE MUTANT E.COLI F112W CYCLOPHILIN BINDS CYCLOSPORIN A IN NEARLY IDENTICAL CONFORMATION AS HUMAN CYCLOPHILIN
Descriptor:CYCLOSPORIN A
Authors:Fejzo, J., Walsh, C.T., Wagner, G.
Deposit date:1992-02-24
Release date:1994-04-30
Last modified:2012-12-12
Method:SOLUTION NMR
Cite:The Mutant Escherichia Coli F112W Cyclophilin Binds Cyclosporin a in Nearly Identical Conformation as Human Cyclophilin.
Biochemistry, 33, 1994
1GRT
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HUMAN GLUTATHIONE REDUCTASE A34E/R37W MUTANT
Descriptor:GLUTATHIONE REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Stoll, V.S., Simpson, S.J., Krauth-Siegel, R.L., Walsh, C.T., Pai, E.F.
Deposit date:1996-12-17
Release date:1997-06-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity.
Biochemistry, 36, 1997
2C0Z
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THE 1.6 A RESOLUTION CRYSTAL STRUCTURE OF NOVW: A 4-KETO-6-DEOXY SUGAR EPIMERASE FROM THE NOVOBIOCIN BIOSYNTHETIC GENE CLUSTER OF STREPTOMYCES SPHEROIDES
Descriptor:NOVW, SULFATE ION, 1,2-ETHANEDIOL
Authors:Jakimowicz, P., Tello, M., Freel-Meyers, C.L., Walsh, C.T., Buttner, M.J., Field, R.A., Lawson, D.M.
Deposit date:2005-09-09
Release date:2006-01-25
Last modified:2014-03-12
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The 1.6 A Resolution Crystal Structure of Novw: A 4-Keto-6-Deoxy Sugar Epimerase from the Novobiocin Biosynthetic Gene Cluster of Streptomyces Spheroides
Proteins, 63, 2006
2GRT
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HUMAN GLUTATHIONE REDUCTASE A34E, R37W MUTANT, OXIDIZED GLUTATHIONE COMPLEX
Descriptor:GLUTATHIONE REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, OXIDIZED GLUTATHIONE DISULFIDE
Authors:Stoll, V.S., Simpson, S.J., Krauth-Siegel, R.L., Walsh, C.T., Pai, E.F.
Deposit date:1997-02-12
Release date:1997-08-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity.
Biochemistry, 36, 1997
2WK1
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STRUCTURE OF THE O-METHYLTRANSFERASE NOVP
Descriptor:NOVP, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ...
Authors:Gomez Garcia, I., Stevenson, C.E.M., Uson, I., Freel Meyers, C.L., Walsh, C.T., Lawson, D.M.
Deposit date:2009-06-03
Release date:2009-12-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:The Crystal Structure of the Novobiocin Biosynthetic Enzyme Novp: The First Representative Structure for the Tylf O-Methyltransferase Superfamily.
J.Mol.Biol., 395, 2010
4GRT
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HUMAN GLUTATHIONE REDUCTASE A34E, R37W MUTANT, MIXED DISULFIDE BETWEEN TRYPANOTHIONE AND THE ENZYME
Descriptor:GLUTATHIONE REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, BIS(GAMMA-GLUTAMYL-CYSTEINYL-GLYCINYL)SPERMIDINE
Authors:Stoll, V.S., Simpson, S.J., Krauth-Siegel, R.L., Walsh, C.T., Pai, E.F.
Deposit date:1997-02-12
Release date:1997-08-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity.
Biochemistry, 36, 1997
5GRT
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HUMAN GLUTATHIONE REDUCTASE A34E, R37W MUTANT, GLUTATHIONYLSPERMIDINE COMPLEX
Descriptor:GLUTATHIONE REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, GLUTATHIONYLSPERMIDINE DISULFIDE
Authors:Stoll, V.S., Simpson, S.J., Krauth-Siegel, R.L., Walsh, C.T., Pai, E.F.
Deposit date:1997-02-12
Release date:1997-08-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity.
Biochemistry, 36, 1997
1IIR
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CRYSTAL STRUCTURE OF UDP-GLUCOSYLTRANSFERASE GTFB
Descriptor:glycosyltransferase GtfB, SULFATE ION, MAGNESIUM ION
Authors:Mulichak, A.M., Losey, H.C., Walsh, C.T., Garavito, R.M.
Deposit date:2001-04-24
Release date:2001-07-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of the UDP-glucosyltransferase GtfB that modifies the heptapeptide aglycone in the biosynthesis of vancomycin group antibiotics.
Structure, 9, 2001
1JMK
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STRUCTURAL BASIS FOR THE CYCLIZATION OF THE LIPOPEPTIDE ANTIBIOTIC SURFACTIN BY THE THIOESTERASE DOMAIN SRFTE
Descriptor:Surfactin Synthetase, SULFATE ION
Authors:Bruner, S.D., Weber, T., Kohli, R.M., Schwarzer, D., Marahiel, M.A., Walsh, C.T., Stubbs, M.T.
Deposit date:2001-07-18
Release date:2002-03-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Structural basis for the cyclization of the lipopeptide antibiotic surfactin by the thioesterase domain SrfTE.
Structure, 10, 2002
1L5A
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CRYSTAL STRUCTURE OF VIBH, AN NRPS CONDENSATION ENZYME
Descriptor:amide synthase
Authors:Keating, T.A., Marshall, C.G., Walsh, C.T., Keating, A.E.
Deposit date:2002-03-06
Release date:2002-06-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:The structure of VibH represents nonribosomal peptide synthetase condensation, cyclization and epimerization domains.
Nat.Struct.Biol., 9, 2002
1PN3
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CRYSTAL STRUCTURE OF TDP-EPI-VANCOSAMINYLTRANSFERASE GTFA IN COMPLEXES WITH TDP AND THE ACCEPTOR SUBSTRATE DVV.
Descriptor:GLYCOSYLTRANSFERASE GTFA, DESVANCOSAMINYL VANCOMYCIN, THYMIDINE-5'-DIPHOSPHATE, ...
Authors:Mulichak, A.M., Losey, H.C., Lu, W., Wawrzak, Z., Walsh, C.T., Garavito, R.M.
Deposit date:2003-06-12
Release date:2003-08-12
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of the Tdp-Epi-Vancosaminyltransferase Gtfa from the Chloroeremomycin Biosynthetic Pathway.
Proc.Natl.Acad.Sci.USA, 100, 2003
1PNV
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CRYSTAL STRUCTURE OF TDP-EPI-VANCOSAMINYLTRANSFERASE GTFA IN COMPLEXES WITH TDP AND VANCOMYCIN
Descriptor:GLYCOSYLTRANSFERASE GTFA, VANCOMYCIN, THYMIDINE-5'-DIPHOSPHATE, ...
Authors:Mulichak, A.M., Losey, H.C., Lu, W., Wawrzak, Z., Walsh, C.T., Garavito, R.M.
Deposit date:2003-06-13
Release date:2003-08-12
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of the Tdp-Epi-Vancosaminyltransferase Gtfa from the Chloroeremomycin Biosynthetic Pathway.
Proc.Natl.Acad.Sci.USA, 100, 2003
1RRV
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X-RAY CRYSTAL STRUCTURE OF TDP-VANCOSAMINYLTRANSFERASE GTFD AS A COMPLEX WITH TDP AND THE NATURAL SUBSTRATE, DESVANCOSAMINYL VANCOMYCIN.
Descriptor:GLYCOSYLTRANSFERASE GTFD, DESVANCOSAMINYL VANCOMYCIN, POTASSIUM ION, ...
Authors:Mulichak, A.M., Lu, W., Losey, H.C., Walsh, C.T., Garavito, R.M.
Deposit date:2003-12-09
Release date:2004-05-18
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of Vancosaminyltransferase Gtfd from the Vancomycin Biosynthetic Pathway: Interactions with Acceptor and Nucleotide Ligands
Biochemistry, 43, 2004
2GZR
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ENTEROBACTIN AND SALMOCHELIN HYDROLASE IROE
Descriptor:IroE protein
Authors:Larsen, N.A., Walsh, C.T.
Deposit date:2006-05-11
Release date:2006-09-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Characterization of Enterobactin Hydrolase IroE.
Biochemistry, 45, 2006
2GZS
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ENTEROBACTIN HYDOLASE IROE COMPLEX WITH DFP
Descriptor:IroE protein, DIISOPROPYL PHOSPHONATE
Authors:Larsen, N.A., Walsh, C.T.
Deposit date:2006-05-12
Release date:2006-09-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural Characterization of Enterobactin Hydrolase IroE.
Biochemistry, 45, 2006
2ISJ
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BLUB BOUND TO OXIDIZED FMN
Descriptor:BluB, FLAVIN MONONUCLEOTIDE
Authors:Larsen, N.A., Taga, M.E., Howard-Jones, A.R., Walsh, C.T., Walker, G.C.
Deposit date:2006-10-17
Release date:2007-03-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:BluB cannibalizes flavin to form the lower ligand of vitamin B12.
Nature, 446, 2007
2ISK
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BLUB BOUND TO FLAVIN ANION (CHARGE TRANSFER COMPLEX)
Descriptor:BluB, 1-DEOXY-1-(7,8-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-2H-BENZO[G]PTERIDIN-1-ID-10(5H)-YL)-5-O-PHOSPHONATO-D-RIBITOL
Authors:Larsen, N.A., Taga, M.E., Howard-Jones, A.R., Walsh, C.T., Walker, G.C.
Deposit date:2006-10-17
Release date:2007-03-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:BluB cannibalizes flavin to form the lower ligand of vitamin B12.
Nature, 446, 2007
2ISL
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BLUB BOUND TO REDUCED FLAVIN (FMNH2) AND MOLECULAR OXYGEN. (CLEAR CRYSTAL FORM)
Descriptor:BluB, 1-DEOXY-1-(7,8-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-2H-BENZO[G]PTERIDIN-1-ID-10(5H)-YL)-5-O-PHOSPHONATO-D-RIBITOL, OXYGEN MOLECULE
Authors:Larsen, N.A., Taga, M.E., Howard-Jones, A.R., Walsh, C.T., Walker, G.C.
Deposit date:2006-10-17
Release date:2007-03-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:BluB cannibalizes flavin to form the lower ligand of vitamin B12.
Nature, 446, 2007
2K2Q
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COMPLEX STRUCTURE OF THE EXTERNAL THIOESTERASE OF THE SURFACTIN-SYNTHETASE WITH A CARRIER DOMAIN
Descriptor:Tyrocidine synthetase 3 (Tyrocidine synthetase III), Surfactin synthetase thioesterase subunit
Authors:Koglin, A., Lohr, F., Bernhard, F., Rogov, V.V., Frueh, D.P., Strieter, E.R., Mofid, M.R., Guntert, P., Wagner, G., Walsh, C.T., Marahiel, M.A., Dotsch, V.
Deposit date:2008-04-10
Release date:2008-12-09
Last modified:2018-01-24
Method:SOLUTION NMR
Cite:Structural basis for the selectivity of the external thioesterase of the surfactin synthetase.
Nature, 454, 2008
2LIU
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NMR STRUCTURE OF HOLO-ACPI DOMAIN FROM CURA MODULE FROM LYNGBYA MAJUSCULA
Descriptor:CurA
Authors:Busche, A.E., Gottstein, D., Hein, C., Ripin, N., Pader, I., Tufar, P., Eisman, E.B., Gu, L., Walsh, C.T., Loehr, F., Sherman, D.H., Guntert, P., Dotsch, V.
Deposit date:2011-09-01
Release date:2011-12-14
Last modified:2012-03-14
Method:SOLUTION NMR
Cite:Characterization of Molecular Interactions between ACP and Halogenase Domains in the Curacin A Polyketide Synthase.
Acs Chem.Biol., 7, 2012