4GRT

HUMAN GLUTATHIONE REDUCTASE A34E, R37W MUTANT, MIXED DISULFIDE BETWEEN TRYPANOTHIONE AND THE ENZYME

Summary for 4GRT

DescriptorGLUTATHIONE REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, BIS(GAMMA-GLUTAMYL-CYSTEINYL-GLYCINYL)SPERMIDINE (3 entities in total)
Functional Keywordsoxidoreductase, flavoenzyme, mixed disulfide
Biological sourceHomo sapiens (human)
Cellular locationIsoform Mitochondrial: Mitochondrion. Isoform Cytoplasmic: Cytoplasm P00390
Total number of polymer chains1
Total molecular weight51574.89
Authors
Stoll, V.S.,Simpson, S.J.,Krauth-Siegel, R.L.,Walsh, C.T.,Pai, E.F. (deposition date: 1997-02-12, release date: 1997-08-12, Last modification date: 2011-07-13)
Primary citation
Stoll, V.S.,Simpson, S.J.,Krauth-Siegel, R.L.,Walsh, C.T.,Pai, E.F.
Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity.
Biochemistry, 36:6437-6447, 1997
PubMed: 9174360 (PDB entries with the same primary citation)
DOI: 10.1021/bi963074p
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.8 Å)
?

Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers182.4%12.5%0MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report