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5GRT
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BU of 5grt by Molmil
HUMAN GLUTATHIONE REDUCTASE A34E, R37W MUTANT, GLUTATHIONYLSPERMIDINE COMPLEX
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, GLUTATHIONE REDUCTASE, GLUTATHIONYLSPERMIDINE DISULFIDE
Authors:Stoll, V.S, Simpson, S.J, Krauth-Siegel, R.L, Walsh, C.T, Pai, E.F.
Deposit date:1997-02-12
Release date:1997-08-12
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity.
Biochemistry, 36, 1997
1UXY
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BU of 1uxy by Molmil
MURB MUTANT WITH SER 229 REPLACED BY ALA, COMPLEX WITH ENOLPYRUVYL-UDP-N-ACETYLGLUCOSAMINE
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, URIDINE DIPHOSPHO-N-ACETYLENOLPYRUVYLGLUCOSAMINE REDUCTASE, URIDINE-DIPHOSPHATE-2(N-ACETYLGLUCOSAMINYL) BUTYRIC ACID
Authors:Benson, T.E, Walsh, C.T, Hogle, J.M.
Deposit date:1996-11-08
Release date:1997-04-01
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:X-ray crystal structures of the S229A mutant and wild-type MurB in the presence of the substrate enolpyruvyl-UDP-N-acetylglucosamine at 1.8-A resolution.
Biochemistry, 36, 1997
2WK1
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BU of 2wk1 by Molmil
Structure of the O-methyltransferase NovP
Descriptor: 1,2-ETHANEDIOL, NOVP, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Gomez Garcia, I, Stevenson, C.E.M, Uson, I, Freel Meyers, C.L, Walsh, C.T, Lawson, D.M.
Deposit date:2009-06-03
Release date:2009-12-15
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:The Crystal Structure of the Novobiocin Biosynthetic Enzyme Novp: The First Representative Structure for the Tylf O-Methyltransferase Superfamily.
J.Mol.Biol., 395, 2010
4GRT
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BU of 4grt by Molmil
HUMAN GLUTATHIONE REDUCTASE A34E, R37W MUTANT, MIXED DISULFIDE BETWEEN TRYPANOTHIONE AND THE ENZYME
Descriptor: BIS(GAMMA-GLUTAMYL-CYSTEINYL-GLYCINYL)SPERMIDINE, FLAVIN-ADENINE DINUCLEOTIDE, GLUTATHIONE REDUCTASE
Authors:Stoll, V.S, Simpson, S.J, Krauth-Siegel, R.L, Walsh, C.T, Pai, E.F.
Deposit date:1997-02-12
Release date:1997-08-12
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity.
Biochemistry, 36, 1997
2MBR
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BU of 2mbr by Molmil
MURB WILD TYPE, COMPLEX WITH ENOLPYRUVYL-UDP-N-ACETYLGLUCOSAMINE
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, URIDINE DIPHOSPHO-N-ACETYLENOLPYRUVYLGLUCOSAMINE REDUCTASE, URIDINE-DIPHOSPHATE-2(N-ACETYLGLUCOSAMINYL) BUTYRIC ACID
Authors:Benson, T.E, Walsh, C.T, Hogle, J.M.
Deposit date:1996-11-08
Release date:1997-04-01
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:X-ray crystal structures of the S229A mutant and wild-type MurB in the presence of the substrate enolpyruvyl-UDP-N-acetylglucosamine at 1.8-A resolution.
Biochemistry, 36, 1997
2C0Z
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BU of 2c0z by Molmil
The 1.6 A resolution crystal structure of NovW: a 4-keto-6-deoxy sugar epimerase from the novobiocin biosynthetic gene cluster of Streptomyces spheroides
Descriptor: 1,2-ETHANEDIOL, NOVW, SULFATE ION
Authors:Jakimowicz, P, Tello, M, Freel-Meyers, C.L, Walsh, C.T, Buttner, M.J, Field, R.A, Lawson, D.M.
Deposit date:2005-09-09
Release date:2006-01-25
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The 1.6 A Resolution Crystal Structure of Novw: A 4-Keto-6-Deoxy Sugar Epimerase from the Novobiocin Biosynthetic Gene Cluster of Streptomyces Spheroides
Proteins, 63, 2006
1EHI
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BU of 1ehi by Molmil
D-ALANINE:D-LACTATE LIGASE (LMDDL2) OF VANCOMYCIN-RESISTANT LEUCONOSTOC MESENTEROIDES
Descriptor: 1(S)-AMINOETHYL-(2-CARBOXYPROPYL)PHOSPHORYL-PHOSPHINIC ACID, ADENOSINE-5'-DIPHOSPHATE, D-ALANINE:D-LACTATE LIGASE, ...
Authors:Kuzin, A.P, Sun, T, Jorczak-Baillass, J, Healy, V.L, Walsh, C.T, Knox, J.R.
Deposit date:2000-02-21
Release date:2000-05-23
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Enzymes of vancomycin resistance: the structure of D-alanine-D-lactate ligase of naturally resistant Leuconostoc mesenteroides.
Structure Fold.Des., 8, 2000
3GRT
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BU of 3grt by Molmil
HUMAN GLUTATHIONE REDUCTASE A34E, R37W MUTANT, OXIDIZED TRYPANOTHIONE COMPLEX
Descriptor: 2-AMINO-4-[4-(4-AMINO-4-CARBOXY-BUTYRYLAMINO)-5,8,19,22-TETRAOXO-1,2-DITHIA-6,9,13,18,21-PENTAAZA-CYCLOTETRACOS-23-YLCARBAMOYL]-BUTYRIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, GLUTATHIONE REDUCTASE
Authors:Stoll, V.S, Simpson, S.J, Krauth-Siegel, R.L, Walsh, C.T, Pai, E.F.
Deposit date:1997-02-12
Release date:1997-08-12
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity.
Biochemistry, 36, 1997
5T81
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BU of 5t81 by Molmil
Rhombohedral crystal form of the EpoB NRPS cyclization-docking bidomain from Sorangium cellulosum
Descriptor: EpoB, GLYCEROL
Authors:Dowling, D.P, Kung, Y, Croft, A.K, Taghizadeh, K, Kelly, W.L, Walsh, C.T, Drennan, C.L.
Deposit date:2016-09-06
Release date:2016-11-09
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.604 Å)
Cite:Structural elements of an NRPS cyclization domain and its intermodule docking domain.
Proc.Natl.Acad.Sci.USA, 113, 2016
5T7Z
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BU of 5t7z by Molmil
Monoclinic crystal form of the EpoB NRPS cyclization-docking bidomain from Sorangium cellulosum
Descriptor: EpoB
Authors:Dowling, D.P, Kung, Y, Croft, A.K, Taghizadeh, K, Kelly, W.L, Walsh, C.T, Drennan, C.L.
Deposit date:2016-09-06
Release date:2016-11-09
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Structural elements of an NRPS cyclization domain and its intermodule docking domain.
Proc.Natl.Acad.Sci.USA, 113, 2016
1CSA
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BU of 1csa by Molmil
THE MUTANT E.COLI F112W CYCLOPHILIN BINDS CYCLOSPORIN A IN NEARLY IDENTICAL CONFORMATION AS HUMAN CYCLOPHILIN
Descriptor: CYCLOSPORIN A
Authors:Fejzo, J, Walsh, C.T, Wagner, G.
Deposit date:1992-02-24
Release date:1994-04-30
Last modified:2012-12-12
Method:SOLUTION NMR
Cite:The Mutant Escherichia Coli F112W Cyclophilin Binds Cyclosporin a in Nearly Identical Conformation as Human Cyclophilin.
Biochemistry, 33, 1994
3H5N
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BU of 3h5n by Molmil
Crystal structure of E. coli MccB + ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, MccB protein, ...
Authors:Regni, C.A, Roush, R.F, Miller, D, Nourse, A, Walsh, C.T, Schulman, B.A.
Deposit date:2009-04-22
Release date:2009-06-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:How the MccB bacterial ancestor of ubiquitin E1 initiates biosynthesis of the microcin C7 antibiotic.
Embo J., 28, 2009
3H5R
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BU of 3h5r by Molmil
Crystal structure of E. coli MccB + Succinimide
Descriptor: MccB protein, Microcin C7 analog, SULFATE ION, ...
Authors:Regni, C.A, Roush, R.F, Miller, D, Nourse, A, Walsh, C.T, Schulman, B.A.
Deposit date:2009-04-22
Release date:2009-06-16
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:How the MccB bacterial ancestor of ubiquitin E1 initiates biosynthesis of the microcin C7 antibiotic.
Embo J., 28, 2009
3H5A
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BU of 3h5a by Molmil
Crystal structure of E. coli MccB
Descriptor: MccB protein, ZINC ION
Authors:Regni, C.A, Roush, R.F, Miller, D, Nourse, A, Walsh, C.T, Schulman, B.A.
Deposit date:2009-04-21
Release date:2009-06-16
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:How the MccB bacterial ancestor of ubiquitin E1 initiates biosynthesis of the microcin C7 antibiotic.
Embo J., 28, 2009
3H9G
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BU of 3h9g by Molmil
Crystal structure of E. coli MccB + MccA-N7isoASN
Descriptor: MccB protein, Microcin C7 analog, SULFATE ION, ...
Authors:Regni, C.A, Roush, R.F, Miller, D, Nourse, A, Walsh, C.T, Schulman, B.A.
Deposit date:2009-04-30
Release date:2009-06-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:How the MccB bacterial ancestor of ubiquitin E1 initiates biosynthesis of the microcin C7 antibiotic.
Embo J., 28, 2009
3H9Q
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BU of 3h9q by Molmil
Crystal structure of E. coli MccB + SeMet MccA
Descriptor: MccB protein, Microcin C7 ANALOG, SULFATE ION, ...
Authors:Regni, C.A, Roush, R.F, Miller, D, Nourse, A, Walsh, C.T, Schulman, B.A.
Deposit date:2009-04-30
Release date:2009-06-16
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:How the MccB bacterial ancestor of ubiquitin E1 initiates biosynthesis of the microcin C7 antibiotic.
Embo J., 28, 2009
3H9J
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BU of 3h9j by Molmil
Crystal structure of E. coli MccB + AMPCPP + SeMeT MccA
Descriptor: DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, MccB protein, Microcin C7 ANALOG, ...
Authors:Regni, C.A, Roush, R.F, Miller, D, Nourse, A, Walsh, C.T, Schulman, B.A.
Deposit date:2009-04-30
Release date:2009-06-16
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:How the MccB bacterial ancestor of ubiquitin E1 initiates biosynthesis of the microcin C7 antibiotic.
Embo J., 28, 2009
1MBB
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BU of 1mbb by Molmil
OXIDOREDUCTASE
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, URIDINE DIPHOSPHO-N-ACETYLENOLPYRUVYLGLUCOSAMINE REDUCTASE, URIDINE-DIPHOSPHATE-3(N-ACETYLGLUCOSAMINYL)BUTYRIC ACID
Authors:Benson, T.E, Lees, W.J, Walsh, C.T, Hogle, J.M.
Deposit date:1995-11-07
Release date:1996-10-14
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:(E)-enolbutyryl-UDP-N-acetylglucosamine as a mechanistic probe of UDP-N-acetylenolpyruvylglucosamine reductase (MurB).
Biochemistry, 35, 1996
1MBT
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BU of 1mbt by Molmil
OXIDOREDUCTASE
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION, URIDINE DIPHOSPHO-N-ACETYLENOLPYRUVYLGLUCOSAMINE REDUCTASE
Authors:Benson, T.E, Walsh, C.T, Hogle, J.M.
Deposit date:1995-11-28
Release date:1996-10-14
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:The structure of the substrate-free form of MurB, an essential enzyme for the synthesis of bacterial cell walls.
Structure, 4, 1996
1PNV
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BU of 1pnv by Molmil
Crystal Structure of TDP-epi-Vancosaminyltransferase GtfA in complexes with TDP and Vancomycin
Descriptor: GLYCOSYLTRANSFERASE GTFA, THYMIDINE-5'-DIPHOSPHATE, VANCOMYCIN, ...
Authors:Mulichak, A.M, Losey, H.C, Lu, W, Wawrzak, Z, Walsh, C.T, Garavito, R.M.
Deposit date:2003-06-13
Release date:2003-08-12
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of the Tdp-Epi-Vancosaminyltransferase Gtfa from the Chloroeremomycin Biosynthetic Pathway.
Proc.Natl.Acad.Sci.USA, 100, 2003
1PN3
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BU of 1pn3 by Molmil
Crystal Structure of TDP-epi-Vancosaminyltransferase GtfA in complexes with TDP and the acceptor substrate DVV.
Descriptor: DESVANCOSAMINYL VANCOMYCIN, GLYCOSYLTRANSFERASE GTFA, THYMIDINE-5'-DIPHOSPHATE, ...
Authors:Mulichak, A.M, Losey, H.C, Lu, W, Wawrzak, Z, Walsh, C.T, Garavito, R.M.
Deposit date:2003-06-12
Release date:2003-08-12
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of the Tdp-Epi-Vancosaminyltransferase Gtfa from the Chloroeremomycin Biosynthetic Pathway.
Proc.Natl.Acad.Sci.USA, 100, 2003
1RRV
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BU of 1rrv by Molmil
X-ray crystal structure of TDP-vancosaminyltransferase GtfD as a complex with TDP and the natural substrate, desvancosaminyl vancomycin.
Descriptor: DESVANCOSAMINYL VANCOMYCIN, GLYCEROL, GLYCOSYLTRANSFERASE GTFD, ...
Authors:Mulichak, A.M, Lu, W, Losey, H.C, Walsh, C.T, Garavito, R.M.
Deposit date:2003-12-09
Release date:2004-05-18
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of Vancosaminyltransferase Gtfd from the Vancomycin Biosynthetic Pathway: Interactions with Acceptor and Nucleotide Ligands
Biochemistry, 43, 2004
2GRT
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BU of 2grt by Molmil
HUMAN GLUTATHIONE REDUCTASE A34E, R37W MUTANT, OXIDIZED GLUTATHIONE COMPLEX
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, GLUTATHIONE REDUCTASE, OXIDIZED GLUTATHIONE DISULFIDE
Authors:Stoll, V.S, Simpson, S.J, Krauth-Siegel, R.L, Walsh, C.T, Pai, E.F.
Deposit date:1997-02-12
Release date:1997-08-12
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity.
Biochemistry, 36, 1997
1GRT
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BU of 1grt by Molmil
HUMAN GLUTATHIONE REDUCTASE A34E/R37W MUTANT
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, GLUTATHIONE REDUCTASE
Authors:Stoll, V.S, Simpson, S.J, Krauth-Siegel, R.L, Walsh, C.T, Pai, E.F.
Deposit date:1996-12-17
Release date:1997-06-16
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity.
Biochemistry, 36, 1997
4EIP
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BU of 4eip by Molmil
Native and K252c bound RebC-10x
Descriptor: 6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one, FLAVIN-ADENINE DINUCLEOTIDE, Putative FAD-monooxygenase
Authors:Goldman, P.J, Ryan, K.S, Howard-Jones, A.R, Hamill, M.J, Elliott, S.J, Walsh, C.T, Drennan, C.L.
Deposit date:2012-04-05
Release date:2012-08-08
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.332 Å)
Cite:An Unusual Role for a Mobile Flavin in StaC-like Indolocarbazole Biosynthetic Enzymes.
Chem.Biol., 19, 2012

 

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