1MBT

OXIDOREDUCTASE

Summary for 1MBT

• Entry DOI: 10.2210/pdb1mbt/pdb
• Descriptor: URIDINE DIPHOSPHO-N-ACETYLENOLPYRUVYLGLUCOSAMINE REDUCTASE, SULFATE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... (4 entities in total)
• Functional Keywords: flavoenzyme, oxidoreductase
• Biological source: Escherichia coli
• Cellular location: Cytoplasm (Probable): P08373
• Total number of polymer chains: 1
• Total formula weight: 38773.52

Authors

Benson, T.E.,Walsh, C.T.,Hogle, J.M. (deposition date: 1995-11-28, release date: 1996-10-14, Last modification date: 2024-02-14)

Primary citation

Benson, T.E.,Walsh, C.T.,Hogle, J.M.
The structure of the substrate-free form of MurB, an essential enzyme for the synthesis of bacterial cell walls.
Structure, 4:47-54, 1996

PubMed Abstract: The repeating disaccharide and pentapeptide units of the bacterial peptidoglycan layer are connected by a lactyl ether bridge biosynthesized from UDP-N-acetylglucosamine and phosphoenolpyruvate in sequential enol ether transfer and reduction steps catalyzed by MurA and MurB respectively. Knowledge of the structure and mechanism of the MurB enzyme will permit analysis of this unusual enol ether reduction reaction and may facilitate the design of inhibitors as candidate next-generation antimicrobial agents.

PubMed: 8805513
DOI: 10.1016/S0969-2126(96)00008-1

Experimental method

X-RAY DIFFRACTION (3 Å)