Author results

5JWY
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STRUCTURE OF LIPID PHOSPHATE PHOSPHATASE PGPB COMPLEX WITH PE
Descriptor:Phosphatidylglycerophosphatase B, (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl tetradecanoate
Authors:Tong, S., Wang, M., Zheng, L.
Deposit date:2016-05-12
Release date:2016-07-20
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural Insight into Substrate Selection and Catalysis of Lipid Phosphate Phosphatase PgpB in the Cell Membrane.
J.Biol.Chem., 291, 2016
3EHQ
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CRYSTAL STRUCTURE OF HUMAN OSTEOCLAST STIMULATING FACTOR
Descriptor:Osteoclast-stimulating factor 1, 1,2-ETHANEDIOL
Authors:Tong, S., Zhou, H., Gao, Y., Zhu, Z., Zhang, X., Teng, M., Niu, L.
Deposit date:2008-09-14
Release date:2009-08-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:Crystal structure of human osteoclast stimulating factor
Proteins, 75, 2009
3EHR
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CRYSTAL STRUCTURE OF HUMAN OSTEOCLAST STIMULATING FACTOR
Descriptor:Osteoclast-stimulating factor 1
Authors:Tong, S., Zhou, H., Gao, Y., Zhu, Z., Zhang, X., Teng, M., Niu, L.
Deposit date:2008-09-14
Release date:2009-08-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of human osteoclast stimulating factor
Proteins, 75, 2009
6K1S
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DISCOVERY OF POTENT AND SELECTIVE COVALENT PROTEIN ARGININE METHYLTRANSFERASE (PRMT5) INHIBITORS
Descriptor:Protein arginine N-methyltransferase 5, Methylosome protein 50, 2-[[7-[(2~{R},3~{R},4~{S},5~{R})-5-[(~{R})-(4-chlorophenyl)-oxidanyl-methyl]-3,4-bis(oxidanyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidin-4-yl]amino]ethanal, ...
Authors:Tong, S., Lin, H.
Deposit date:2019-05-12
Release date:2019-06-19
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors.
Acs Med.Chem.Lett., 2019
3DTO
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CRYSTAL STRUCTURE OF THE METAL-DEPENDENT HD DOMAIN-CONTAINING HYDROLASE BH2835 FROM BACILLUS HALODURANS, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET BHR130.
Descriptor:BH2835 protein
Authors:Forouhar, F., Su, M., Seetharaman, J., Janjua, H., Fang, Y., Xiao, R., Cunningham, K., Ma, L.-C., Owen, L.A., Wang, D., Tong, S., Everett, J.K., Acton, T.B., Montelione, G.T., Tong, L., Hunt, J.F., Northeast Structural Genomics Consortium (NESG)
Deposit date:2008-07-15
Release date:2008-09-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Crystal structure of the metal-dependent HD domain-containing hydrolase BH2835 from Bacillus halodurans, Northeast Structural Genomics Consortium Target BhR130.
To be Published
3E23
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CRYSTAL STRUCTURE OF THE RPA2492 PROTEIN IN COMPLEX WITH SAM FROM RHODOPSEUDOMONAS PALUSTRIS, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET RPR299
Descriptor:uncharacterized protein RPA2492, SULFATE ION, S-ADENOSYLMETHIONINE
Authors:Forouhar, F., Chen, Y., Seetharaman, J., Mao, L., Xiao, R., Foote, E.L., Ciccosanti, C., Wang, H., Tong, S., Everett, J.K., Acton, T.B., Montelione, G.T., Tong, L., Hunt, J.F., Northeast Structural Genomics Consortium (NESG)
Deposit date:2008-08-05
Release date:2008-09-30
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of the RPA2492 protein in complex with SAM from Rhodopseudomonas palustris, Northeast Structural Genomics Consortium Target RpR299
To be Published
3ELI
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CRYSTAL STRUCTURE OF THE AHSA1 (SPO3351) PROTEIN FROM SILICIBACTER POMEROYI, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET SIR160
Descriptor:Aha1 domain protein
Authors:Forouhar, F., Su, M., Seetharaman, J., Janjua, H., Xiao, R., Ciccosanti, C., Foote, E.L., Wang, D., Tong, S., Everett, J.K., Acton, T.B., Montelione, G.T., Hunt, J.F., Tong, L., Northeast Structural Genomics Consortium (NESG)
Deposit date:2008-09-22
Release date:2008-09-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the AHSA1 (SPO3351) protein from Silicibacter pomeroyi, Northeast Structural Genomics Consortium Target SiR160
To be Published
4KJR
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CRYSTAL STRUCTURE OF SELENIUM SUBSTITUTED CA2+/H+ ANTIPORTER PROTEINYFKE
Descriptor:cation exchanger YfkE
Authors:Wu, M., Tong, S., Zheng, L.
Deposit date:2013-05-03
Release date:2013-07-03
Last modified:2013-08-07
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of Ca2+/H+ antiporter protein YfkE reveals the mechanisms of Ca2+ efflux and its pH regulation.
Proc.Natl.Acad.Sci.USA, 110, 2013
4KJS
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STRUCTURE OF NATIVE YFKE
Descriptor:cation exchanger YfkE
Authors:Wu, M., Tong, S., Zheng, L.
Deposit date:2013-05-03
Release date:2013-06-26
Last modified:2013-08-07
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Crystal structure of Ca2+/H+ antiporter protein YfkE reveals the mechanisms of Ca2+ efflux and its pH regulation.
Proc.Natl.Acad.Sci.USA, 110, 2013
2KZ5
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SOLUTION NMR STRUCTURE OF TRANSCRIPTION FACTOR NF-E2 SUBUNIT'S DNA BINDING DOMAIN FROM HOMO SAPIENS, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET HR4653B
Descriptor:Transcription factor NF-E2 45 kDa subunit
Authors:Liu, G., Janjua, H., Xiao, R., Ciccosanti, C., Shastry, R., Acton, T.B., Tong, S., Everett, J.K., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2010-06-11
Release date:2010-07-07
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Northeast Structural Genomics Consortium Target HR4653B
To be Published
2L0B
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SOLUTION NMR STRUCTURE OF ZINC FINGER DOMAIN OF E3 UBIQUITIN-PROTEIN LIGASE PRAJA-1 FROM HOMO SAPIENS, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET HR4710B
Descriptor:E3 ubiquitin-protein ligase Praja-1, ZINC ION
Authors:Liu, G., Tong, S., Hamilton, K., Ciccosanti, C., Shastry, R., Acton, T.B., Xiao, R., Everett, J.K., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2010-06-30
Release date:2010-08-25
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of zinc finger domain of E3 ubiquitin-protein ligase protein praja-1 from Homo sapiens, northeast structural genomics consortium (NESG) target HR4710B
To be Published
2L81
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SOLUTION NMR STRUCTURE OF THE SERINE-RICH DOMAIN OF HEF1 (ENHANCER OF FILAMENTATION 1) FROM HOMO SAPIENS, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET HR5554A
Descriptor:Enhancer of filamentation 1
Authors:Liu, G., Xiao, R., Huang, Y.J., Patel, D., Ciccosanti, C.T., Acton, T.B., Tong, S., Everett, J.T., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2010-12-31
Release date:2011-02-09
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Northeast Structural Genomics Consortium Target HR5554A
To be Published
2L82
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SOLUTION NMR STRUCTURE OF DE NOVO DESIGNED PROTEIN, P-LOOP NTPASE FOLD, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET OR32
Descriptor:DESIGNED PROTEIN OR32
Authors:Liu, G., Koga, N., Koga, R., Xiao, R., Hamilton, K., Janjua, H., Tong, S., Acton, T.B., Everett, J., Baker, D., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2010-12-31
Release date:2011-02-09
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Northeast Structural Genomics Consortium Target OR32
To be Published
3B4D
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CRYSTAL STRUCTURE OF HUMAN PABPN1 RRM
Descriptor:Polyadenylate-binding protein 2
Authors:Ge, H., Tong, S., Teng, M., Niu, L.
Deposit date:2007-10-24
Release date:2008-01-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:Crystal structure and possible dimerization of the single RRM of human PABPN1
Proteins, 71, 2008
3P5T
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CFIM25-CFIM68 COMPLEX
Descriptor:Cleavage and polyadenylation specificity factor subunit 5, Cleavage and polyadenylation specificity factor subunit 6
Authors:Li, H., Tong, S., Li, X., Shi, H., Gao, Y., Ge, H., Niu, L., Teng, M.
Deposit date:2010-10-11
Release date:2010-11-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis of pre-mRNA recognition by the human cleavage factor Im complex
To be Published
3P6Y
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CF IM25-CF IM68-UGUAA COMPLEX
Descriptor:Cleavage and polyadenylation specificity factor subunit 5, Cleavage and polyadenylation specificity factor subunit 6, 5'-R(*UP*GP*UP*AP*A)-3'
Authors:Li, H., Tong, S., Li, X., Shi, H., Gao, Y., Ge, H., Niu, L., Teng, M.
Deposit date:2010-10-11
Release date:2010-11-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis of pre-mRNA recognition by the human cleavage factor Im complex
To be Published
4K3X
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CRYSTAL STRUCTURE OF A SUBTYPE H18 HEMAGGLUTININ HOMOLOGUE FROM A/FLAT-FACED BAT/PERU/033/2010 (H18N11)
Descriptor:Hemagglutinin HA1, Hemagglutinin HA2, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Zhu, X., Wilson, I.A.
Deposit date:2013-04-11
Release date:2013-10-23
Last modified:2013-11-20
Method:X-RAY DIFFRACTION (2.149 Å)
Cite:New world bats harbor diverse influenza a viruses.
Plos Pathog., 9, 2013
4K3Y
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CRYSTAL STRUCTURE OF A SUBTYPE N11 NEURAMINIDASE-LIKE PROTEIN OF A/FLAT-FACED BAT/PERU/033/2010 (H18N11)
Descriptor:neuraminidase, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Zhu, X., Wilson, I.A.
Deposit date:2013-04-11
Release date:2013-10-23
Last modified:2013-11-20
Method:X-RAY DIFFRACTION (2.682 Å)
Cite:New world bats harbor diverse influenza a viruses.
Plos Pathog., 9, 2013
4MC5
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CRYSTAL STRUCTURE OF A SUBTYPE H18 HEMAGGLUTININ HOMOLOGUE FROM A/FLAT-FACED BAT/PERU/033/2010 (H18N11)
Descriptor:Hemagglutinin, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Yang, H., Carney, P.J., Chang, J.C., Guo, Z., Stevens, J.
Deposit date:2013-08-21
Release date:2013-10-23
Last modified:2013-11-20
Method:X-RAY DIFFRACTION (2.238 Å)
Cite:New world bats harbor diverse influenza a viruses.
Plos Pathog., 9, 2013
4MC7
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CRYSTAL STRUCTURE OF A SUBTYPE N11 NEURAMINIDASE-LIKE PROTEIN OF A/FLAT-FACED BAT/PERU/033/2010 (H18N11)
Descriptor:NEURAMINIDASE, N-ACETYL-D-GLUCOSAMINE, CALCIUM ION
Authors:Yang, H., Carney, P.J., Chang, J.C., Guo, Z., Stevens, J.
Deposit date:2013-08-21
Release date:2013-10-23
Last modified:2013-11-20
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:New world bats harbor diverse influenza a viruses.
Plos Pathog., 9, 2013
4JCA
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CRYSTAL STRUCTURE OF THE APO FORM OF THE EVOLVED VARIANT OF THE COMPUTATIONALLY DESIGNED SERINE HYDROLASE, OSH55.4_H1. NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET OR273
Descriptor:serine hydrolase, RUBIDIUM ION, CITRIC ACID
Authors:Kuzin, A.P., Lew, S., Rajagopalan, S., Seetharaman, J., Tong, S., Everett, J.K., Acton, T.B., Baker, D., Montelione, G.T., Tong, L., Hunt, J.F., Northeast Structural Genomics Consortium (NESG)
Deposit date:2013-02-21
Release date:2013-03-20
Last modified:2014-10-08
Method:X-RAY DIFFRACTION (2.411 Å)
Cite:Design of activated serine-containing catalytic triads with atomic-level accuracy.
Nat.Chem.Biol., 10, 2014
4JLL
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CRYSTAL STRUCTURE OF THE EVOLVED VARIANT OF THE COMPUTATIONALLY DESIGNED SERINE HYDROLASE, OSH55.4_H1 COVALENTLY BOUND WITH FP-ALKYNE, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET OR273
Descriptor:Evolved variant of computationally designed serine hydrolase OSH55.4_H1, ethyl (R)-{10-[(hept-6-yn-1-ylcarbamoyl)oxy]decyl}phosphonofluoridate, CHLORIDE ION, ...
Authors:Kuzin, A., Lew, S., Rajagopalan, S., Seetharaman, J., Tong, S., Everett, J.K., Acton, T.B., Baker, D., Montelione, G.T., Tong, L., Hunt, J.F., Northeast Structural Genomics Consortium (NESG)
Deposit date:2013-03-12
Release date:2013-04-10
Last modified:2014-05-14
Method:X-RAY DIFFRACTION (1.36 Å)
Cite:Design of activated serine-containing catalytic triads with atomic-level accuracy.
Nat.Chem.Biol., 10, 2014
4JVV
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CRYSTAL STRUCTURE OF THE EVOLVED VARIANT OF THE COMPUTATIONALLY DESIGNED SERINE HYDROLASE, OSH55.4_H1, COVALENTLY BOUND WITH DIISOPROPYL FLUOROPHOSPHATE (DFP), NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET OR273
Descriptor:evolved variant of the computationally designed serine hydrolase
Authors:Kuzin, A., Lew, S., Rajagopalan, S., Seetharaman, J., Tong, S., Everett, J.K., Acton, T.B., Baker, D., Montelione, G.T., Tong, L., Hunt, J.F., Northeast Structural Genomics Consortium (NESG)
Deposit date:2013-03-26
Release date:2013-04-24
Last modified:2014-05-14
Method:X-RAY DIFFRACTION (2.288 Å)
Cite:Design of activated serine-containing catalytic triads with atomic-level accuracy.
Nat.Chem.Biol., 10, 2014
3E17
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CRYSTAL STRUCTURE OF THE SECOND PDZ DOMAIN FROM HUMAN ZONA OCCLUDENS-2
Descriptor:Tight junction protein ZO-2
Authors:Chen, H., Tong, S.L., Teng, M.K., Niu, L.W.
Deposit date:2008-08-01
Release date:2009-07-21
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structure of the second PDZ domain from human zonula occludens 2
Acta Crystallogr.,Sect.F, 65, 2009
3E48
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CRYSTAL STRUCTURE OF A NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE (SAV0421) FROM STAPHYLOCOCCUS AUREUS, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET ZR319
Descriptor:Putative nucleoside-diphosphate-sugar epimerase, MAGNESIUM ION
Authors:Forouhar, F., Abashidze, M., Seetharaman, J., Mao, L., Janjua, H., Xiao, R., Ciccosanti, C., Foote, E.L., Wang, D., Tong, S., Everett, J.K., Acton, T.B., Montelione, G.T., Tong, L., Hunt, J.F., Northeast Structural Genomics Consortium (NESG)
Deposit date:2008-08-11
Release date:2008-08-19
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:

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