4K3X
Crystal structure of a subtype H18 hemagglutinin homologue from A/flat-faced bat/Peru/033/2010 (H18N11)
Summary for 4K3X
| Entry DOI | 10.2210/pdb4k3x/pdb |
| Related | 4K3Y |
| Descriptor | Hemagglutinin HA1, 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA2, ... (11 entities in total) |
| Functional Keywords | influenza virus, hemagglutinin homologue, h18, ectodomain, viral protein |
| Biological source | Influenza A virus More |
| Total number of polymer chains | 6 |
| Total formula weight | 183462.13 |
| Authors | Zhu, X.,Wilson, I.A. (deposition date: 2013-04-11, release date: 2013-10-23, Last modification date: 2024-11-06) |
| Primary citation | Tong, S.,Zhu, X.,Li, Y.,Shi, M.,Zhang, J.,Bourgeois, M.,Yang, H.,Chen, X.,Recuenco, S.,Gomez, J.,Chen, L.M.,Johnson, A.,Tao, Y.,Dreyfus, C.,Yu, W.,McBride, R.,Carney, P.J.,Gilbert, A.T.,Chang, J.,Guo, Z.,Davis, C.T.,Paulson, J.C.,Stevens, J.,Rupprecht, C.E.,Holmes, E.C.,Wilson, I.A.,Donis, R.O. New world bats harbor diverse influenza a viruses. Plos Pathog., 9:e1003657-e1003657, 2013 Cited by PubMed Abstract: Aquatic birds harbor diverse influenza A viruses and are a major viral reservoir in nature. The recent discovery of influenza viruses of a new H17N10 subtype in Central American fruit bats suggests that other New World species may similarly carry divergent influenza viruses. Using consensus degenerate RT-PCR, we identified a novel influenza A virus, designated as H18N11, in a flat-faced fruit bat (Artibeus planirostris) from Peru. Serologic studies with the recombinant H18 protein indicated that several Peruvian bat species were infected by this virus. Phylogenetic analyses demonstrate that, in some gene segments, New World bats harbor more influenza virus genetic diversity than all other mammalian and avian species combined, indicative of a long-standing host-virus association. Structural and functional analyses of the hemagglutinin and neuraminidase indicate that sialic acid is not a ligand for virus attachment nor a substrate for release, suggesting a unique mode of influenza A virus attachment and activation of membrane fusion for entry into host cells. Taken together, these findings indicate that bats constitute a potentially important and likely ancient reservoir for a diverse pool of influenza viruses. PubMed: 24130481DOI: 10.1371/journal.ppat.1003657 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.149 Å) |
Structure validation
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