6ECH

Pyruvate Kinase Isoform L-type with phosphorylated Ser12 (pS12) in complex with FBP

Summary for 6ECH

Entry DOI	10.2210/pdb6ech/pdb
Related	6ECK
Descriptor	Pyruvate kinase PKLR, CHLORIDE ION, 1,6-di-O-phosphono-beta-D-fructofuranose, ... (11 entities in total)
Functional Keywords	pkl, pyruvate kinase, glycolysis, transferase
Biological source	Rattus norvegicus (Rat)
Total number of polymer chains	4
Total formula weight	245832.23
Authors	Padyana, A.,Tong, S. (deposition date: 2018-08-07, release date: 2019-12-04, Last modification date: 2023-10-11)
Primary citation	Gassaway, B.M.,Cardone, R.L.,Padyana, A.K.,Petersen, M.C.,Judd, E.T.,Hayes, S.,Tong, S.,Barber, K.W.,Apostolidi, M.,Abulizi, A.,Sheetz, J.B.,Aerni, H.R.,Gross, S.,Kung, C.,Samuel, V.T.,Shulman, G.I.,Kibbey, R.G.,Rinehart, J. Distinct Hepatic PKA and CDK Signaling Pathways Control Activity-Independent Pyruvate Kinase Phosphorylation and Hepatic Glucose Production. Cell Rep, 29:3394-3404.e9, 2019 Cited by PubMed: 31825824 DOI: 10.1016/j.celrep.2019.11.009 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.19 Å)

Structure validation