Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

6ECH

Pyruvate Kinase Isoform L-type with phosphorylated Ser12 (pS12) in complex with FBP

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0001666biological_processresponse to hypoxia
A0003824molecular_functioncatalytic activity
A0004743molecular_functionpyruvate kinase activity
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006096biological_processglycolytic process
A0007584biological_processresponse to nutrient
A0009749biological_processresponse to glucose
A0010038biological_processresponse to metal ion
A0016301molecular_functionkinase activity
A0016310biological_processphosphorylation
A0030955molecular_functionpotassium ion binding
A0032869biological_processcellular response to insulin stimulus
A0033198biological_processresponse to ATP
A0042866biological_processpyruvate biosynthetic process
A0046872molecular_functionmetal ion binding
A0048029molecular_functionmonosaccharide binding
A0051591biological_processresponse to cAMP
A0051707biological_processresponse to other organism
A0071872biological_processcellular response to epinephrine stimulus
B0000287molecular_functionmagnesium ion binding
B0001666biological_processresponse to hypoxia
B0003824molecular_functioncatalytic activity
B0004743molecular_functionpyruvate kinase activity
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006096biological_processglycolytic process
B0007584biological_processresponse to nutrient
B0009749biological_processresponse to glucose
B0010038biological_processresponse to metal ion
B0016301molecular_functionkinase activity
B0016310biological_processphosphorylation
B0030955molecular_functionpotassium ion binding
B0032869biological_processcellular response to insulin stimulus
B0033198biological_processresponse to ATP
B0042866biological_processpyruvate biosynthetic process
B0046872molecular_functionmetal ion binding
B0048029molecular_functionmonosaccharide binding
B0051591biological_processresponse to cAMP
B0051707biological_processresponse to other organism
B0071872biological_processcellular response to epinephrine stimulus
C0000287molecular_functionmagnesium ion binding
C0001666biological_processresponse to hypoxia
C0003824molecular_functioncatalytic activity
C0004743molecular_functionpyruvate kinase activity
C0005524molecular_functionATP binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006096biological_processglycolytic process
C0007584biological_processresponse to nutrient
C0009749biological_processresponse to glucose
C0010038biological_processresponse to metal ion
C0016301molecular_functionkinase activity
C0016310biological_processphosphorylation
C0030955molecular_functionpotassium ion binding
C0032869biological_processcellular response to insulin stimulus
C0033198biological_processresponse to ATP
C0042866biological_processpyruvate biosynthetic process
C0046872molecular_functionmetal ion binding
C0048029molecular_functionmonosaccharide binding
C0051591biological_processresponse to cAMP
C0051707biological_processresponse to other organism
C0071872biological_processcellular response to epinephrine stimulus
D0000287molecular_functionmagnesium ion binding
D0001666biological_processresponse to hypoxia
D0003824molecular_functioncatalytic activity
D0004743molecular_functionpyruvate kinase activity
D0005524molecular_functionATP binding
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006096biological_processglycolytic process
D0007584biological_processresponse to nutrient
D0009749biological_processresponse to glucose
D0010038biological_processresponse to metal ion
D0016301molecular_functionkinase activity
D0016310biological_processphosphorylation
D0030955molecular_functionpotassium ion binding
D0032869biological_processcellular response to insulin stimulus
D0033198biological_processresponse to ATP
D0042866biological_processpyruvate biosynthetic process
D0046872molecular_functionmetal ion binding
D0048029molecular_functionmonosaccharide binding
D0051591biological_processresponse to cAMP
D0051707biological_processresponse to other organism
D0071872biological_processcellular response to epinephrine stimulus
Functional Information from PROSITE/UniProt
site_idPS00110
Number of Residues13
DetailsPYRUVATE_KINASE Pyruvate kinase active site signature. IkIISKIENhEGV
ChainResidueDetails
AILE277-VAL289

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues56
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P30613
ChainResidueDetails
AARG85
ATHR340
ATHR444
ATRP494
AARG501
AARG528
BARG85
BASN87
BSER89
BASP125
BTHR126
AASN87
BLYS282
BGLU284
BGLY307
BASP308
BTHR340
BTHR444
BTRP494
BARG501
BARG528
CARG85
ASER89
CASN87
CSER89
CASP125
CTHR126
CLYS282
CGLU284
CGLY307
CASP308
CTHR340
CTHR444
AASP125
CTRP494
CARG501
CARG528
DARG85
DASN87
DSER89
DASP125
DTHR126
DLYS282
DGLU284
ATHR126
DGLY307
DASP308
DTHR340
DTHR444
DTRP494
DARG501
DARG528
ALYS282
AGLU284
AGLY307
AASP308

site_idSWS_FT_FI2
Number of Residues8
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P14618
ChainResidueDetails
AARG132
ALYS219
BARG132
BLYS219
CARG132
CLYS219
DARG132
DLYS219

site_idSWS_FT_FI3
Number of Residues4
DetailsSITE: Transition state stabilizer => ECO:0000250|UniProtKB:P00549
ChainResidueDetails
ALYS282
BLYS282
CLYS282
DLYS282

site_idSWS_FT_FI4
Number of Residues20
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P30613
ChainResidueDetails
AGLU2
BSER261
CGLU2
CGLU19
CGLN26
CSEP12
CSER261
DGLU2
DGLU19
DGLN26
DSEP12
AGLU19
DSER261
AGLN26
ASEP12
ASER261
BGLU2
BGLU19
BGLN26
BSEP12

224572

PDB entries from 2024-09-04

PDB statisticsPDBj update infoContact PDBjnumon