Author results

6V35
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CRYO-EM STRUCTURE OF CA2+-FREE HSSLO1-BETA4 CHANNEL COMPLEX
Descriptor:Calcium-activated potassium channel subunit alpha-1, Calcium-activated potassium channel subunit beta-4, (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, ...
Authors:Tao, X., MacKinnon, R.
Deposit date:2019-11-25
Release date:2019-12-25
Last modified:2020-03-25
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Molecular structures of the human Slo1 K+channel in complex with beta 4.
Elife, 8, 2019
6V38
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CRYO-EM STRUCTURE OF CA2+-BOUND HSSLO1 CHANNEL
Descriptor:Calcium-activated potassium channel subunit alpha-1, MAGNESIUM ION, CALCIUM ION, ...
Authors:Tao, X., MacKinnon, R.
Deposit date:2019-11-25
Release date:2019-12-25
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Molecular structures of the human Slo1 K+channel in complex with beta 4.
Elife, 8, 2019
6V3G
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CRYO-EM STRUCTURE OF CA2+-FREE HSSLO1 CHANNEL
Descriptor:Calcium-activated potassium channel subunit alpha-1
Authors:Tao, X., MacKinnon, R.
Deposit date:2019-11-25
Release date:2019-12-25
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Molecular structures of the human Slo1 K+channel in complex with beta 4.
Elife, 8, 2019
6V22
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CRYO-EM STRUCTURE OF CA2+-BOUND HSSLO1-BETA4 CHANNEL COMPLEX
Descriptor:Calcium-activated potassium channel subunit alpha-1, Calcium-activated potassium channel subunit beta-4, MAGNESIUM ION, ...
Authors:Tao, X., MacKinnon, R.
Deposit date:2019-11-22
Release date:2019-12-25
Last modified:2020-03-25
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Molecular structures of the human Slo1 K+channel in complex with beta 4.
Elife, 8, 2019
6UWM
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SINGLE PARTICLE CRYO-EM STRUCTURE OF KVAP
Descriptor:Voltage-gated potassium channel
Authors:Tao, X., MacKinnon, R.
Deposit date:2019-11-05
Release date:2019-12-04
Last modified:2020-01-08
Method:ELECTRON MICROSCOPY (5.9 Å)
Cite:Cryo-EM structure of the KvAP channel reveals a non-domain-swapped voltage sensor topology.
Elife, 8, 2019
6K0Z
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SUBSTRATE BOUND STATE OF STAPHYLOCOCCUS AUREUS ALDH
Descriptor:Aldehyde dehydrogenase, GLYCEROL, 1,2-ETHANEDIOL
Authors:Zhang, Z., Tao, X.
Deposit date:2019-05-08
Release date:2020-05-20
Method:X-RAY DIFFRACTION (2.496726 Å)
Cite:Substrate bound state of Staphylococcus Aureus AldH
To Be Published
6K10
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NON SUBSTRATE BOUND STATE OF STAPHYLOCOCCUS AUREUS ALDH
Descriptor:Aldehyde dehydrogenase, 1,2-ETHANEDIOL
Authors:Zhang, Z., Tao, X.
Deposit date:2019-05-08
Release date:2020-05-20
Method:X-RAY DIFFRACTION (1.789622 Å)
Cite:Non substrate bound state of Staphylococcus Aureus AldH
To Be Published
5Y2D
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CRYSTAL STRUCTURE OF H. PYLORI HTRA
Descriptor:Periplasmic serine endoprotease DegP-like, UNK-UNK-UNK, UNK-UNK-UNK-UNK-UNK, ...
Authors:Zhang, Z., Huang, Q., Tao, X.
Deposit date:2017-07-25
Release date:2018-08-15
Last modified:2019-08-28
Method:X-RAY DIFFRACTION (3.700099 Å)
Cite:The unique trimeric assembly of the virulence factor HtrA fromHelicobacter pylorioccurs via N-terminal domain swapping.
J.Biol.Chem., 294, 2019
5Y28
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CRYSTAL STRUCTURE OF H. PYLORI HTRA WITH PDZ2 DELETION
Descriptor:Periplasmic serine endoprotease DegP-like, UNK-UNK-UNK-UNK, 1,2-ETHANEDIOL
Authors:Zhang, Z., Huang, Q., Tao, X.
Deposit date:2017-07-24
Release date:2018-08-15
Last modified:2019-08-28
Method:X-RAY DIFFRACTION (3.086068 Å)
Cite:The unique trimeric assembly of the virulence factor HtrA fromHelicobacter pylorioccurs via N-terminal domain swapping.
J.Biol.Chem., 294, 2019
5TJI
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CA2+ BOUND APLYSIA SLO1
Descriptor:High conductance calcium-activated potassium channel, (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate
Authors:MacKinnon, R., Tao, X., Hite, R.K.
Deposit date:2016-10-04
Release date:2016-12-28
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structural basis for gating the high-conductance Ca(2+)-activated K(+) channel.
Nature, 541, 2017
5TJ6
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CA2+ BOUND APLYSIA SLO1
Descriptor:High conductance calcium-activated potassium channel, POTASSIUM ION, MAGNESIUM ION, ...
Authors:MacKinnon, R., Tao, X., Hite, R.K.
Deposit date:2016-10-03
Release date:2016-12-14
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Cryo-EM structure of the open high-conductance Ca(2+)-activated K(+) channel.
Nature, 541, 2017
5BXJ
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COMPLEX OF THE FK1 DOMAIN MUTANT A19T OF FKBP51 WITH 4-NITROPHENOL
Descriptor:Peptidyl-prolyl cis-trans isomerase FKBP5, P-NITROPHENOL
Authors:Wu, D., Tao, X., Chen, Z., Han, J., Jia, W., Li, X., Wang, Z., He, Y.X.
Deposit date:2015-06-09
Release date:2016-05-25
Method:X-RAY DIFFRACTION (1.24 Å)
Cite:The environmental endocrine disruptor p-nitrophenol interacts with FKBP51, a positive regulator of androgen receptor and inhibits androgen receptor signaling in human cells
J. Hazard. Mater., 307, 2016
4IJS
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CRYSTAL STRUCTURE OF NUCLEOCAPSID PROTEIN ENCODED BY THE PROTOTYPIC MEMBER OF ORTHOBUNYAVIRUS
Descriptor:Nucleoprotein, RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3')
Authors:Li, B.B., Wang, Q., Lou, Z.Y.
Deposit date:2012-12-23
Release date:2013-04-24
Last modified:2013-07-10
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Bunyamwera virus possesses a distinct nucleocapsid protein to facilitate genome encapsidation
Proc.Natl.Acad.Sci.USA, 110, 2013
4DXW
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CRYSTAL STRUCTURE OF NAVRH, A VOLTAGE-GATED SODIUM CHANNEL
Descriptor:Ion transport protein, B-NONYLGLUCOSIDE, CALCIUM ION, ...
Authors:Zhang, X., Ren, W.L., Yan, C.Y., Wang, J.W., Yan, N.
Deposit date:2012-02-28
Release date:2012-05-23
Last modified:2013-07-10
Method:X-RAY DIFFRACTION (3.052 Å)
Cite:Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel
Nature, 486, 2012
3SPC
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INWARD RECTIFIER POTASSIUM CHANNEL KIR2.2 IN COMPLEX WITH DIOCTANOYLGLYCEROL PYROPHOSPHATE (DGPP)
Descriptor:Inward-rectifier K+ channel Kir2.2, POTASSIUM ION, (2R)-3-{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}propane-1,2-diyl dioctanoate
Authors:Hansen, S.B., Tao, X., MacKinnon, R.
Deposit date:2011-07-01
Release date:2011-08-24
Last modified:2011-09-21
Method:X-RAY DIFFRACTION (2.454 Å)
Cite:Structural basis of PIP(2) activation of the classical inward rectifier K(+) channel Kir2.2.
Nature, 477, 2011
3SPG
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INWARD RECTIFIER POTASSIUM CHANNEL KIR2.2 R186A MUTANT IN COMPLEX WITH PIP2
Descriptor:Inward-rectifier K+ channel Kir2.2, POTASSIUM ION, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
Authors:Hansen, S.B., Tao, X., MacKinnon, R.
Deposit date:2011-07-01
Release date:2011-08-24
Last modified:2011-09-21
Method:X-RAY DIFFRACTION (2.613 Å)
Cite:Structural basis of PIP(2) activation of the classical inward rectifier K(+) channel Kir2.2.
Nature, 477, 2011
3SPH
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INWARD RECTIFIER POTASSIUM CHANNEL KIR2.2 I223L MUTANT IN COMPLEX WITH PIP2
Descriptor:Inward-rectifier K+ channel Kir2.2, POTASSIUM ION, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
Authors:Hansen, S.B., Tao, X., MacKinnon, R.
Deposit date:2011-07-01
Release date:2011-08-24
Last modified:2011-09-21
Method:X-RAY DIFFRACTION (3.003 Å)
Cite:Structural basis of PIP(2) activation of the classical inward rectifier K(+) channel Kir2.2.
Nature, 477, 2011
3SPI
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INWARD RECTIFIER POTASSIUM CHANNEL KIR2.2 IN COMPLEX WITH PIP2
Descriptor:Inward-rectifier K+ channel Kir2.2, POTASSIUM ION, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
Authors:Hansen, S.B., Tao, X., MacKinnon, R.
Deposit date:2011-07-01
Release date:2011-08-24
Last modified:2011-09-21
Method:X-RAY DIFFRACTION (3.307 Å)
Cite:Structural basis of PIP(2) activation of the classical inward rectifier K(+) channel Kir2.2.
Nature, 477, 2011
3SPJ
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APO INWARD RECTIFIER POTASSIUM CHANNEL KIR2.2 I223L MUTANT
Descriptor:Inward-rectifier K+ channel Kir2.2, POTASSIUM ION
Authors:Hansen, S.B., Tao, X., MacKinnon, R.
Deposit date:2011-07-01
Release date:2011-08-24
Last modified:2011-09-21
Method:X-RAY DIFFRACTION (3.307 Å)
Cite:Structural basis of PIP(2) activation of the classical inward rectifier K(+) channel Kir2.2.
Nature, 477, 2011
3LUT
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A STRUCTURAL MODEL FOR THE FULL-LENGTH SHAKER POTASSIUM CHANNEL KV1.2
Descriptor:Voltage-gated potassium channel subunit beta-2, Potassium voltage-gated channel subfamily A member 2, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Chen, X., Ni, F., Wang, Q., Ma, J.
Deposit date:2010-02-18
Release date:2010-06-23
Last modified:2011-10-26
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of the full-length Shaker potassium channel Kv1.2 by normal-mode-based X-ray crystallographic refinement.
Proc.Natl.Acad.Sci.USA, 107, 2010
3LNM
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F233W MUTANT OF THE KV2.1 PADDLE-KV1.2 CHIMERA CHANNEL
Descriptor:Voltage-gated potassium channel subunit beta-2, F233W mutant of the Kv2.1 paddle-Kv1.2 chimera, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Tao, X., Lee, A., Limapichat, W., Dougherty, D.A., MacKinnon, R.
Deposit date:2010-02-02
Release date:2010-04-14
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A gating charge transfer center in voltage sensors.
Science, 328, 2010
3JYC
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CRYSTAL STRUCTURE OF THE EUKARYOTIC STRONG INWARD-RECTIFIER K+ CHANNEL KIR2.2 AT 3.1 ANGSTROM RESOLUTION
Descriptor:Inward-rectifier K+ channel Kir2.2, POTASSIUM ION
Authors:Tao, X.
Deposit date:2009-09-21
Release date:2010-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.11 Å)
Cite:Crystal structure of the eukaryotic strong inward-rectifier K+ channel Kir2.2 at 3.1 A resolution.
Science, 326, 2009
2R9R
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SHAKER FAMILY VOLTAGE DEPENDENT POTASSIUM CHANNEL (KV1.2-KV2.1 PADDLE CHIMERA CHANNEL) IN ASSOCIATION WITH BETA SUBUNIT
Descriptor:Voltage-gated potassium channel subunit beta-2, Paddle chimera voltage gated potassium channel Kv1.2-Kv2.1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Long, S.B., Tao, X., Campbell, E.B., Mackinnon, R.
Deposit date:2007-09-13
Release date:2007-11-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment.
Nature, 450, 2007
2JS7
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SOLUTION NMR STRUCTURE OF HUMAN MYELOID DIFFERENTIATION PRIMARY RESPONSE (MYD88). NORTHEAST STRUCTURAL GENOMICS TARGET HR2869A
Descriptor:Myeloid differentiation primary response protein MyD88
Authors:Rossi, P., Ramelot, T.A., Tao, X., Ciano, M., Ho, C., Ma, L.-C., Xiao, R., Acton, T.B., Kennedy, M.A., Tong, L., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2007-06-29
Release date:2007-10-23
Last modified:2020-02-19
Method:SOLUTION NMR
Cite:Solution NMR Structure of Human Myeloid Differentiation Primary Response (MyD88).
To be Published
2OUC
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CRYSTAL STRUCTURE OF THE MAP KINASE BINDING DOMAIN OF MKP5
Descriptor:Dual specificity protein phosphatase 10
Authors:Tao, X., Tong, L.
Deposit date:2007-02-10
Release date:2007-08-07
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of the MAP kinase binding domain and the catalytic domain of human MKP5.
Protein Sci., 16, 2007
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