1PJ4

Crystal structure of human mitochondrial NAD(P)+-dependent malic enzyme in a pentary complex with natural substrate malate, ATP, Mn++, and allosteric activator fumarate.

Summary for 1PJ4

• Entry DOI: 10.2210/pdb1pj4/pdb
• Related: 1PJ2 1PJ3
• Descriptor: NAD-dependent malic enzyme, mitochondrial, D-MALATE, MANGANESE (II) ION, ... (6 entities in total)
• Functional Keywords: oxidative decarboxylase, oxidoreductase
• Biological source: Homo sapiens (human)
• Cellular location: Mitochondrion matrix: P23368
• Total number of polymer chains: 4
• Total formula weight: 260850.51

Authors

Tao, X.,Yang, Z.,Tong, L. (deposition date: 2003-05-31, release date: 2003-09-30, Last modification date: 2023-11-15)

• Primary citation: Tao, X.,Yang, Z.,Tong, L.; Crystal structures of substrate complexes of malic enzyme and insights into the catalytic mechanism.; Structure, 11:1141-1150, 2003; PubMed: 12962632; DOI: 10.1016/S0969-2126(03)00168-0

Experimental method

X-RAY DIFFRACTION (2.3 Å)