Author results

5UBP
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TREX2 M-REGION
Descriptor:Leucine permease transcriptional regulator, Nuclear mRNA export protein THP1, 26S proteasome complex subunit SEM1
Authors:Stewart, M., Gordon, J.
Deposit date:2016-12-21
Release date:2017-04-05
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of the Sac3 RNA-binding M-region in the Saccharomyces cerevisiae TREX-2 complex.
Nucleic Acids Res., 45, 2017
5OWU
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KAP95:NUP1 COMPLEX
Descriptor:Importin subunit beta-1, Nucleoporin NUP1
Authors:Stewart, M.
Deposit date:2017-09-04
Release date:2017-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for the high-affinity binding of nucleoporin Nup1p to the Saccharomyces cerevisiae importin-beta homologue, Kap95p.
J. Mol. Biol., 349, 2005
5L3T
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STRUCTURE OF THE SACCHAROMYCES CEREVISIAE TREX-2 COMPLEX
Descriptor:Nuclear mRNA export protein SAC3, Nuclear mRNA export protein THP1, 26S proteasome complex subunit SEM1, ...
Authors:Stewart, M., Aibara, S.
Deposit date:2016-05-24
Release date:2016-07-27
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (4.927 Å)
Cite:The Sac3 TPR-like region in the Saccharomyces cerevisiae TREX-2 complex is more extensive but independent of the CID region.
J. Struct. Biol., 195, 2016
5L2L
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NAB2 ZN FINGERS 5-7 BOUND TO A11G RNA
Descriptor:Nab2p, RNA (5'-R(*AP*AP*AP*AP*AP*AP*AP*AP*AP*G)-3'), ZINC ION
Authors:Stewart, M., Aibara, S.
Deposit date:2016-08-02
Release date:2016-12-21
Last modified:2017-06-14
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural basis for the dimerization of Nab2 generated by RNA binding provides insight into its contribution to both poly(A) tail length determination and transcript compaction in Saccharomyces cerevisiae.
Nucleic Acids Res., 45, 2017
5K9S
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IMPORTIN-ALPHA IN COMPLEX WITH HNF1-BETA PEPTIDE
Descriptor:Importin subunit alpha-1, HNF1 beta A splice variant 2
Authors:Wiedmann, M.M., Aibara, S., Spring, D.R., Stewart, M., Brenton, J.
Deposit date:2016-06-01
Release date:2016-11-23
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Importin-alpha in complex with HNF1-beta peptide
To Be Published
5G5P
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STRUCTURE OF THE SACCHAROMYCES CEREVISIAE TREX-2 COMPLEX
Descriptor:NUCLEAR MRNA EXPORT PROTEIN SAC3, NUCLEAR MRNA EXPORT PROTEIN THP1, 26S PROTEASOME COMPLEX SUBUNIT SEM1
Authors:Aibara, S., Bai, X.C., Stewart, M.
Deposit date:2016-05-26
Release date:2016-11-23
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (5.3 Å)
Cite:The Sac3 Tpr-Like Region in the Saccharomyces Cerevisiae Trex-2 Complex is More Extensive But Independent of the Cid Region
J.Struct.Biol., 195, 2016
5C5W
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1.25 A RESOLUTION STRUCTURE OF AN RNA 20-MER
Descriptor:RNA (5'-R(P*CP*CP*UP*GP*AP*GP*UP*UP*CP*AP*AP*UP*UP*CP*UP*AP*GP*CP*G)-3')
Authors:Stewart, M., Valkov, E.
Deposit date:2015-06-22
Release date:2015-10-14
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:1.25 angstrom resolution structure of an RNA 20-mer that binds to the TREX2 complex.
Acta Crystallogr.,Sect.F, 71, 2015
5BXQ
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STRUCTURE OF THE NTF2:RANGDP COMPLEX
Descriptor:Nuclear transport factor 2, GTP-binding nuclear protein Ran, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Stewart, M.
Deposit date:2015-06-09
Release date:2015-07-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for molecular recognition between nuclear transport factor 2 (NTF2) and the GDP-bound form of the Ras-family GTPase Ran.
J. Mol. Biol., 277, 1998
4XM4
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STRUCTURE OF CHAETOMIUM MEX67:MTR2 SUBUNITS
Descriptor:Mex67
Authors:Aibara, S., Valkov, M., Stewart, M.
Deposit date:2015-01-14
Release date:2015-07-15
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structural characterization of the principal mRNA-export factor Mex67-Mtr2 from Chaetomium thermophilum.
Acta Crystallogr.,Sect.F, 71, 2015
4X2O
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SAC3N PEPTIDE BOUND TO MEX67:MTR2
Descriptor:Putative mRNA export protein, Putative uncharacterized protein, Putative SAC3 family protein
Authors:Aibara, S., Valkov, E., Stewart, M.
Deposit date:2014-11-26
Release date:2015-06-17
Last modified:2015-07-15
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural Characterization of the Chaetomium thermophilum TREX-2 Complex and its Interaction with the mRNA Nuclear Export Factor Mex67:Mtr2.
Structure, 23, 2015
4X2M
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STRUCTURE OF MTR2
Descriptor:Mtr2
Authors:Aibara, S., Valkov, E., Stewart, M.
Deposit date:2014-11-26
Release date:2015-07-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural characterization of the principal mRNA-export factor Mex67-Mtr2 from Chaetomium thermophilum.
Acta Crystallogr.,Sect.F, 71, 2015
4X2H
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SAC3N PEPTIDE BOUND TO MEX67:MTR2
Descriptor:Putative mRNA export protein, Putative uncharacterized protein, SER-SER-VAL-PHE-GLY-ALA-PRO-ALA
Authors:Aibara, S., Valkov, E., Stewart, M.
Deposit date:2014-11-26
Release date:2015-06-17
Last modified:2015-07-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Characterization of the Chaetomium thermophilum TREX-2 Complex and its Interaction with the mRNA Nuclear Export Factor Mex67:Mtr2.
Structure, 23, 2015
4WYK
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STRUCTURE OF THE LRR AND NTF2-LIKE DOMAINS OF NXF1 COMPLEXED WITH NXT1
Descriptor:Nuclear RNA export factor 1, NTF2-related export protein 1
Authors:Aibara, S., Valkov, E., Stewart, M.
Deposit date:2014-11-17
Release date:2015-02-04
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:The principal mRNA nuclear export factor NXF1:NXT1 forms a symmetric binding platform that facilitates export of retroviral CTE-RNA.
Nucleic Acids Res., 43, 2015
4WWU
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STRUCTURE OF MEX67:MTR2
Descriptor:mRNA export factor MEX67, mRNA transport regulator MTR2, ZINC ION
Authors:Aibara, S., Valkov, E., Stewart, M.
Deposit date:2014-11-12
Release date:2015-02-04
Last modified:2015-02-25
Method:X-RAY DIFFRACTION (3.301 Å)
Cite:Domain organization within the nuclear export factor Mex67:Mtr2 generates an extended mRNA binding surface.
Nucleic Acids Res., 43, 2015
4WPX
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CHAETOMIUM THEROMOPHILUM TREX2 CID DOMAIN COMPLEX
Descriptor:Cell division control protein 31-like protein, Putative SAC3 family protein, Putative uncharacterized protein
Authors:Valkov, E., Stewart, M.
Deposit date:2014-10-21
Release date:2015-06-17
Last modified:2015-07-15
Method:X-RAY DIFFRACTION (3.31 Å)
Cite:Structural Characterization of the Chaetomium thermophilum TREX-2 Complex and its Interaction with the mRNA Nuclear Export Factor Mex67:Mtr2.
Structure, 23, 2015
4WPM
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STRUCTURE OF THE CHAETOMIUM THERMOPHILUM MEX67:MTR2 COMPLEX
Descriptor:mRNA export protein, SULFATE ION
Authors:Aibara, S., Valkov, E., Stewart, M.
Deposit date:2014-10-20
Release date:2015-07-15
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural characterization of the principal mRNA-export factor Mex67-Mtr2 from Chaetomium thermophilum.
Acta Crystallogr.,Sect.F, 71, 2015
4WP6
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STRUCTURE OF THE MEX67 LRR DOMAIN FROM CHAETOMIUM THERMOPHILUM
Descriptor:mRNA export protein
Authors:Aibara, S., Valkov, E., Lamers, M., Stewart, M.
Deposit date:2014-10-17
Release date:2015-07-15
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural characterization of the principal mRNA-export factor Mex67-Mtr2 from Chaetomium thermophilum.
Acta Crystallogr.,Sect.F, 71, 2015
4WP5
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CHAETOMIUM THERMOPHILUM MEX67 NTF2-LIKE DOMAIN COMPLEXED WITH MTR2
Descriptor:mRNA export protein, Mtr2
Authors:Aibara, S., Valkov, E., Stewart, M.
Deposit date:2014-10-17
Release date:2015-07-15
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural characterization of the principal mRNA-export factor Mex67-Mtr2 from Chaetomium thermophilum.
Acta Crystallogr.,Sect.F, 71, 2015
4WP2
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CHAETOMIUM MEX67 UBA DOMAIN
Descriptor:Putative mRNA export protein
Authors:Aibara, S., Stewart, M.
Deposit date:2014-10-17
Release date:2015-07-15
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural characterization of the principal mRNA-export factor Mex67-Mtr2 from Chaetomium thermophilum.
Acta Crystallogr.,Sect.F, 71, 2015
4U5V
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IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR
Descriptor:Importin subunit alpha-1, N~2~-{[5-(pyridin-3-yl)thiophen-2-yl]methyl}-L-lysinamide
Authors:Stewart, M., Valkov, E., Holvey, R.S.
Deposit date:2014-07-25
Release date:2015-05-13
Last modified:2015-07-08
Method:X-RAY DIFFRACTION (1.968 Å)
Cite:Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design.
Chemmedchem, 10, 2015
4U5U
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IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR
Descriptor:Importin subunit alpha-1, N~2~-[3-(pyridin-3-yl)benzyl]-L-lysinamide
Authors:Stewart, M., Valkov, E., Holvey, R.S.
Deposit date:2014-07-25
Release date:2015-05-13
Last modified:2015-07-08
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design.
Chemmedchem, 10, 2015
4U5S
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IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR
Descriptor:Importin subunit alpha-1, N-[(2S)-2-[(N~2~-acetyl-D-lysyl)amino]-3-(pyridin-3-ylmethoxy)propyl]-L-allothreonyl-D-phenylalaninamide
Authors:Stewart, M., Valkov, E., Holvey, R.S.
Deposit date:2014-07-25
Release date:2015-05-13
Last modified:2017-06-21
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design.
Chemmedchem, 10, 2015
4U5O
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IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR
Descriptor:Importin subunit alpha-1, N~2~-[4-(pyridin-3-yl)benzyl]-D-lysinamide
Authors:Stewart, M., Valkov, E., Holvey, R.S.
Deposit date:2014-07-25
Release date:2015-05-13
Last modified:2015-07-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design.
Chemmedchem, 10, 2015
4U5N
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IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR
Descriptor:Importin subunit alpha-1, N~2~-[4-(pyridin-3-yl)benzyl]-L-lysyl-N-[(1R,2S,3R)-1-{[(2R)-1-amino-1-oxo-3-phenylpropan-2-yl]amino}-1,3-dihydroxybutan-2-yl]glycinamide
Authors:Stewart, M., Valkov, E., Holvey, R.S.
Deposit date:2014-07-25
Release date:2015-05-13
Last modified:2015-07-08
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design.
Chemmedchem, 10, 2015
4U5L
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IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR
Descriptor:Importin subunit alpha-1, N~2~-[4-(pyridin-3-yl)benzyl]-L-lysinamide
Authors:Stewart, M., Valkov, E., Holvey, R.S.
Deposit date:2014-07-25
Release date:2015-05-13
Last modified:2015-07-08
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design.
Chemmedchem, 10, 2015