Author results

1KKQ
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CRYSTAL STRUCTURE OF THE HUMAN PPAR-ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH AN ANTAGONIST GW6471 AND A SMRT COREPRESSOR MOTIF
Descriptor:PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR, NUCLEAR RECEPTOR CO-REPRESSOR 2, N-((2S)-2-({(1Z)-1-METHYL-3-OXO-3-[4-(TRIFLUOROMETHYL) PHENYL]PROP-1-ENYL}AMINO)-3-{4-[2-(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)ETHOXY]PHENYL}PROPYL)PROPANAMIDE
Authors:Xu, H.E., Stanley, T.B., Montana, V.G., Lambert, M.H., Shearer, B.G., Cobb, J.E., McKee, D.D., Galardi, C.M., Nolte, R.T., Parks, D.J.
Deposit date:2001-12-10
Release date:2002-02-20
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha.
Nature, 415, 2002
1M2Z
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CRYSTAL STRUCTURE OF A DIMER COMPLEX OF THE HUMAN GLUCOCORTICOID RECEPTOR LIGAND-BINDING DOMAIN BOUND TO DEXAMETHASONE AND A TIF2 COACTIVATOR MOTIF
Descriptor:glucocorticoid receptor, nuclear receptor coactivator 2, B-OCTYLGLUCOSIDE, ...
Authors:Bledsoe, R.B., Montana, V.G., Stanley, T.B., Delves, C.J., Apolito, C.J., Mckee, D.D., Consler, T.G., Parks, D.J., Stewart, E.L., Willson, T.M., Lambert, M.H., Moore, J.T., Pearce, K.H., Xu, H.E.
Deposit date:2002-06-26
Release date:2003-07-15
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of the Glucocorticoid Receptor Ligand Binding Domain Reveals a Novel Mode of Receptor Dimerization and Coactivator Recognition
Cell(Cambridge,Mass.), 110, 2002
1XOW
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CRYSTAL STRUCTURE OF THE HUMAN ANDROGEN RECEPTOR LIGAND BINDING DOMAIN BOUND WITH AN ANDROGEN RECEPTOR NH2-TERMINAL PEPTIDE, AR20-30, AND R1881
Descriptor:androgen receptor, decamer fragment of androgen receptor, (17BETA)-17-HYDROXY-17-METHYLESTRA-4,9,11-TRIEN-3-ONE
Authors:He, B., Gampe Jr., R.T., Kole, A.J., Hnat, A.T., Stanley, T.B., An, G., Stewart, E.L., Kalman, R.I., Minges, J.T., Wilson, E.M.
Deposit date:2004-10-07
Release date:2004-11-16
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for androgen receptor interdomain and coactivator interactions suggests a transition in nuclear receptor activation function dominance
Mol.Cell, 16, 2004
1XQ3
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CRYSTAL STRUCTURE OF THE HUMAN ANDROGEN RECEPTOR LIGAND BINDING DOMAIN BOUND WITH R1881
Descriptor:androgen receptor, (17BETA)-17-HYDROXY-17-METHYLESTRA-4,9,11-TRIEN-3-ONE
Authors:He, B., Gampe Jr., R.T., Kole, A.J., Hnat, A.T., Stanley, T.B., An, G., Stewart, E.L., Kalman, R.I., Minges, J.T., Wilson, E.M.
Deposit date:2004-10-11
Release date:2004-11-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural basis for androgen receptor interdomain and coactivator interactions suggests a transition in nuclear receptor activation function dominance
Mol.Cell, 16, 2004
2AA2
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MINERALOCORTICOID RECEPTOR WITH BOUND ALDOSTERONE
Descriptor:Mineralocorticoid receptor, B-OCTYLGLUCOSIDE, SULFATE ION, ...
Authors:Bledsoe, R.K., Madauss, K.P., Holt, J.A., Apolito, C.J., Lambert, M.H., Pearce, K.H., Stanley, T.B., Stewart, E.L., Trump, R.P., Willson, T.M., Williams, S.P.
Deposit date:2005-07-13
Release date:2005-07-26
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A Ligand-mediated Hydrogen Bond Network Required for the Activation of the Mineralocorticoid Receptor
J.Biol.Chem., 280, 2005
2AA5
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MINERALOCORTICOID RECEPTOR WITH BOUND PROGESTERONE
Descriptor:Mineralocorticoid receptor, PROGESTERONE
Authors:Bledsoe, R.K., Madauss, K.P., Holt, J.A., Apolito, C.J., Lambert, M.H., Pearce, K.H., Stanley, T.B., Stewart, E.L., Trump, R.P., Willson, T.M., Williams, S.P.
Deposit date:2005-07-13
Release date:2005-07-26
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A Ligand-mediated Hydrogen Bond Network Required for the Activation of the Mineralocorticoid Receptor
J.Biol.Chem., 280, 2005
2AA6
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MINERALOCORTICOID RECEPTOR S810L MUTANT WITH BOUND PROGESTERONE
Descriptor:Mineralocorticoid receptor, PROGESTERONE
Authors:Bledsoe, R.K., Madauss, K.P., Holt, J.A., Apolito, C.J., Lambert, M.H., Pearce, K.H., Stanley, T.B., Stewart, E.L., Trump, R.P., Willson, T.M., Williams, S.P.
Deposit date:2005-07-13
Release date:2005-07-26
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A Ligand-mediated Hydrogen Bond Network Required for the Activation of the Mineralocorticoid Receptor
J.Biol.Chem., 280, 2005
2AA7
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MINERALOCORTICOID RECEPTOR WITH BOUND DEOXYCORTICOSTERONE
Descriptor:Mineralocorticoid receptor, SULFATE ION, DESOXYCORTICOSTERONE, ...
Authors:Bledsoe, R.K., Madauss, K.P., Holt, J.A., Apolito, C.J., Lambert, M.H., Pearce, K.H., Stanley, T.B., Stewart, E.L., Trump, R.P., Willson, T.M., Williams, S.P.
Deposit date:2005-07-13
Release date:2005-07-26
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A Ligand-mediated Hydrogen Bond Network Required for the Activation of the Mineralocorticoid Receptor
J.Biol.Chem., 280, 2005
2AAX
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MINERALOCORTICOID RECEPTOR DOUBLE MUTANT WITH BOUND CORTISONE
Descriptor:Mineralocorticoid receptor, SULFATE ION, 17,21-DIHYDROXYPREGNA-1,4-DIENE-3,11,20-TRIONE
Authors:Bledsoe, R.K., Madauss, K.P., Holt, J.A., Apolito, C.J., Lambert, M.H., Pearce, K.H., Stanley, T.B., Stewart, E.L., Trump, R.P., Willson, T.M., Williams, S.P.
Deposit date:2005-07-14
Release date:2005-07-26
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:A Ligand-mediated Hydrogen Bond Network Required for the Activation of the Mineralocorticoid Receptor
J.Biol.Chem., 280, 2005
2AB2
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MINERALOCORTICOID RECEPTOR DOUBLE MUTANT WITH BOUND SPIRONOLACTONE
Descriptor:Mineralocorticoid receptor, SPIRONOLACTONE, SULFATE ION
Authors:Bledsoe, R.K., Madauss, K.P., Holt, J.A., Apolito, C.J., Lambert, M.H., Pearce, K.H., Stanley, T.B., Stewart, E.L., Trump, R.P., Willson, T.M., Williams, S.P.
Deposit date:2005-07-14
Release date:2005-07-26
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:A Ligand-mediated Hydrogen Bond Network Required for the Activation of the Mineralocorticoid Receptor
J.Biol.Chem., 280, 2005
2AO6
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CRYSTAL STRUCTURE OF THE HUMAN ANDROGEN RECEPTOR LIGAND BINDING DOMAIN BOUND WITH TIF2(III) 740-753 PEPTIDE AND R1881
Descriptor:androgen receptor, 14-mer fragment of Nuclear receptor coactivator 2, (17BETA)-17-HYDROXY-17-METHYLESTRA-4,9,11-TRIEN-3-ONE
Authors:He, B., Gampe Jr., R.T., Kole, A.J., Hnat, A.T., Stanley, T.B., An, G., Stewart, E.L., Kalman, R.I., Minges, J.T., Wilson, E.M.
Deposit date:2005-08-12
Release date:2005-08-30
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Structural basis for androgen receptor interdomain and coactivator interactions suggests a transition in nuclear receptor activation function dominance
Mol.Cell, 16, 2004
2OVH
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PROGESTERONE RECEPTOR WITH BOUND ASOPRISNIL AND A PEPTIDE FROM THE CO-REPRESSOR SMRT
Descriptor:Progesterone receptor, SMRT peptide, 4-[(11BETA,17BETA)-17-METHOXY-17-(METHOXYMETHYL)-3-OXOESTRA-4,9-DIEN-11-YL]BENZALDEHYDE OXIME
Authors:Madauss, K.P., Deng, S.-J., Short, S.A., Stewart, E.L., Williams, S.P.
Deposit date:2007-02-13
Release date:2007-03-20
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:A structural and in vitro characterization of asoprisnil: a selective progesterone receptor modulator.
Mol.Endocrinol., 21, 2007
2OVM
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PROGESTERONE RECEPTOR WITH BOUND ASOPRISNIL AND A PEPTIDE FROM THE CO-REPRESSOR NCOR
Descriptor:Progesterone receptor, NCoR, 4-[(11BETA,17BETA)-17-METHOXY-17-(METHOXYMETHYL)-3-OXOESTRA-4,9-DIEN-11-YL]BENZALDEHYDE OXIME
Authors:Madauss, K.P., Deng, S.-J., Short, S.A., Stewart, E.L., Williams, S.P.
Deposit date:2007-02-14
Release date:2007-03-20
Last modified:2019-09-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A structural and in vitro characterization of asoprisnil: a selective progesterone receptor modulator.
Mol.Endocrinol., 21, 2007
2Q7I
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THE WILD TYPE ANDROGEN RECEPTOR LIGAND BINDING DOMAIN BOUND WITH TESTOSTERONE AND AN AR 20-30 PEPTIDE
Descriptor:Androgen receptor, SULFATE ION, TESTOSTERONE, ...
Authors:Gampe, R.T.
Deposit date:2007-06-06
Release date:2007-07-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Modulation of androgen receptor activation function 2 by testosterone and dihydrotestosterone.
J.Biol.Chem., 282, 2007
2Q7J
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THE WILD TYPE ANDROGEN RECEPTOR LIGAND BINDING DOMAIN BOUND WITH TESTOSTERONE AND A TIF2 BOX 3 COACTIVATOR PEPTIDE 740-753
Descriptor:Androgen receptor, Nuclear receptor coactivator 2, SULFATE ION, ...
Authors:Gampe, R.T.
Deposit date:2007-06-07
Release date:2007-07-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Modulation of androgen receptor activation function 2 by testosterone and dihydrotestosterone.
J.Biol.Chem., 282, 2007
2Q7K
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THE ANDROGEN RECEPTOR PROSTATE CANCER MUTANT H874Y LIGAND BINDING DOMAIN BOUND WITH TESTOSTERONE AND AN AR 20-30 PEPTIDE
Descriptor:Androgen receptor, SULFATE ION, TESTOSTERONE, ...
Authors:Gampe, R.T.
Deposit date:2007-06-07
Release date:2007-07-24
Last modified:2013-05-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Modulation of androgen receptor activation function 2 by testosterone and dihydrotestosterone.
J.Biol.Chem., 282, 2007
2Q7L
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THE ANDROGEN RECEPTOR PROSTATE CANCER MUTANT H874Y LIGAND BINDING DOMAIN BOUND WITH TESTOSTERONE AND A TIF2 BOX3 COACTIVATOR PEPTIDE 740-753
Descriptor:Androgen receptor, Nuclear receptor coactivator 2, TESTOSTERONE, ...
Authors:Gampe, R.T.
Deposit date:2007-06-07
Release date:2007-07-24
Last modified:2013-05-08
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Modulation of androgen receptor activation function 2 by testosterone and dihydrotestosterone.
J.Biol.Chem., 282, 2007
3L0E
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X-RAY CRYSTAL STRUCTURE OF A POTENT LIVER X RECEPTOR MODULATOR
Descriptor:Oxysterols receptor LXR-beta, Nuclear receptor coactivator 2, N-(2-chloro-6-fluorobenzyl)-1-methyl-N-{[3'-(methylsulfonyl)biphenyl-4-yl]methyl}-1H-imidazole-4-sulfonamide
Authors:Gampe Jr., R.T.
Deposit date:2009-12-09
Release date:2010-04-07
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery of tertiary sulfonamides as potent liver X receptor antagonists.
J.Med.Chem., 53, 2010