4KYW
| Restriction endonuclease DPNI in complex with two DNA molecules | Descriptor: | 5'-(*DC*DTP*DGP*DGP*6MAP*DTP*DCP*DCP*DAP*DG)-3', CALCIUM ION, SODIUM ION, ... | Authors: | Mierzejewska, K, Siwek, W, Czapinska, H, Skowronek, K, Bujnicki, J.M, Bochtler, M. | Deposit date: | 2013-05-29 | Release date: | 2014-06-04 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structural basis of the methylation specificity of R.DpnI. Nucleic Acids Res., 42, 2014
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4ESJ
| RESTRICTION ENDONUCLEASE DpnI IN COMPLEX WITH TARGET DNA | Descriptor: | AZIDE ION, DNA (5'-D(*CP*TP*GP*GP*(6MA)P*TP*CP*CP*AP*G)-3'), GLYCEROL, ... | Authors: | Siwek, W, Czapinska, H, Bochtler, M, Bujnicki, J.M, Skowronek, K. | Deposit date: | 2012-04-23 | Release date: | 2012-06-13 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Crystal structure and mechanism of action of the N6-methyladenine-dependent type IIM restriction endonuclease R.DpnI. Nucleic Acids Res., 40, 2012
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1XJ0
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8A8J
| Complex of RecF and DNA from Thermus thermophilus. | Descriptor: | DNA replication and repair protein RecF, MAGNESIUM ION, Oligo1, ... | Authors: | Nirwal, S, Czarnocki-Cieciura, M, Chaudhary, A, Zajko, W, Skowronek, K, Chamera, S, Figiel, M, Nowotny, M. | Deposit date: | 2022-06-23 | Release date: | 2023-04-26 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Mechanism of RecF-RecO-RecR cooperation in bacterial homologous recombination. Nat.Struct.Mol.Biol., 30, 2023
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8A93
| Complex of RecF-RecR-DNA from Thermus thermophilus. | Descriptor: | DNA replication and repair protein RecF, MAGNESIUM ION, Oligo1, ... | Authors: | Nirwal, S, Czarnocki-Cieciura, M, Chaudhary, A, Zajko, W, Skowronek, K, Chamera, S, Figiel, M, Nowotny, M. | Deposit date: | 2022-06-27 | Release date: | 2023-04-26 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.05 Å) | Cite: | Mechanism of RecF-RecO-RecR cooperation in bacterial homologous recombination. Nat.Struct.Mol.Biol., 30, 2023
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8AB0
| Complex of RecO-RecR-DNA from Thermus thermophilus. | Descriptor: | DNA repair protein RecO, Oligo1, Oligo2, ... | Authors: | Nirwal, S, Czarnocki-Cieciura, M, Chaudhary, A, Zajko, W, Skowronek, K, Chamera, S, Figiel, M, Nowotny, M. | Deposit date: | 2022-07-04 | Release date: | 2023-04-26 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (6.09 Å) | Cite: | Mechanism of RecF-RecO-RecR cooperation in bacterial homologous recombination. Nat.Struct.Mol.Biol., 30, 2023
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7ZVX
| Crystal structure of human Annexin A2 in complex with full phosphorothioate 5-10 2'-methoxyethyl DNA gapmer antisense oligonucleotide solved at 2.4 A resolution | Descriptor: | 1,2-ETHANEDIOL, 2'-methoxyethyl DNA gapmer antisense oligonucleotide, Annexin A2, ... | Authors: | Hyjek-Skladanowska, M, Anderson, B, Mykhaylyk, V, Orr, C, Wagner, A, Skowronek, K, Seth, P, Nowotny, M. | Deposit date: | 2022-05-17 | Release date: | 2022-09-14 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structures of annexin A2-PS DNA complexes show dominance of hydrophobic interactions in phosphorothioate binding. Nucleic Acids Res., 51, 2023
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7ZVN
| Crystal structure of human Annexin A2 in complex with full phosphorothioate 5-10 2'-methoxyethyl DNA gapmer antisense oligonucleotide solved at 1.87 A resolution | Descriptor: | 2'-methoxyethyl DNA gapmer antisense oligonucleotide, Annexin A2, CALCIUM ION, ... | Authors: | Hyjek-Skladanowska, M, Anderson, B, Mykhaylyk, V, Orr, C, Wagner, A, Skowronek, K, Seth, P, Nowotny, M. | Deposit date: | 2022-05-16 | Release date: | 2022-09-14 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | Structures of annexin A2-PS DNA complexes show dominance of hydrophobic interactions in phosphorothioate binding. Nucleic Acids Res., 51, 2023
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8BPR
| Complex of RecF-RecO-RecR-DNA from Thermus thermophilus (low resolution reconstruction). | Descriptor: | DNA repair protein RecO, DNA replication and repair protein RecF, MAGNESIUM ION, ... | Authors: | Nirwal, S, Czarnocki-Cieciura, M, Chaudhary, A, Zajko, W, Skowronek, K, Chamera, S, Figiel, M, Nowotny, M. | Deposit date: | 2022-11-17 | Release date: | 2023-04-26 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.65 Å) | Cite: | Mechanism of RecF-RecO-RecR cooperation in bacterial homologous recombination. Nat.Struct.Mol.Biol., 30, 2023
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8BV8
| Crystal structure of the phage Mu protein Mom inactive mutant S124A | Descriptor: | Methylcarbamoylase mom | Authors: | Silva, R.M.B, Slyvka, A, Lee, Y.J, Guan, C, Lund, S.R, Raleigh, E.A, Skowronek, K, Bochtler, M, Weigele, P.R. | Deposit date: | 2022-12-08 | Release date: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Crystal structure of the phage Mu protein Mom catalytic mutant S124A To Be Published
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6QM2
| NlaIV restriction endonuclease | Descriptor: | POTASSIUM ION, SODIUM ION, Type-2 restriction enzyme NlaIV | Authors: | Czapinska, H, Siwek, W, Szczepanowski, R.H, Bujnicki, J.M, Bochtler, M, Skowronek, K. | Deposit date: | 2019-02-01 | Release date: | 2019-05-01 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal Structure and Directed Evolution of Specificity of NlaIV Restriction Endonuclease. J.Mol.Biol., 431, 2019
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4OUN
| Crystal Structure of Mini-ribonuclease 3 from Bacillus subtilis | Descriptor: | Mini-ribonuclease 3 | Authors: | Chojnowski, G, Czarnecka, J, Nowak, E, Pianka, D, Glow, D, Sabala, I, Skowronek, K, Nowotny, M, Bujnicki, J.M. | Deposit date: | 2014-02-18 | Release date: | 2015-02-04 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Sequence-specific cleavage of dsRNA by Mini-III RNase Nucleic Acids Res., 43, 2015
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7O24
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7O0H
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7O0G
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8R0S
| Structure of reverse transcriptase from Cauliflower Mosaic Virus in complex with RNA/DNA hybrid | Descriptor: | DNA (5'-D(*GP*CP*TP*AP*CP*GP*CP*AP*CP*TP*GP*CP*TP*GP*GP*A)-3'), Enzymatic polyprotein, RNA (5'-R(*GP*UP*CP*CP*AP*GP*CP*AP*GP*UP*GP*CP*GP*UP*AP*GP*C)-3') | Authors: | Prabaharan, C, Figiel, M, Chamera, S, Szczepanowski, R, Nowak, E, Nowotny, M. | Deposit date: | 2023-10-31 | Release date: | 2024-07-24 | Last modified: | 2024-08-21 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structural and biochemical characterization of cauliflower mosaic virus reverse transcriptase. J.Biol.Chem., 300, 2024
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8RPX
| NhoI restriction endonuclease in complex with quadruply methylated DNA target | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, DNA (5'-D(*CP*TP*GP*(5CM)P*AP*GP*(5CM)P*TP*C)-3'), ... | Authors: | Rafalski, D, Krakowska, K, Gilski, M, Bochtler, M. | Deposit date: | 2024-01-17 | Release date: | 2024-07-17 | Last modified: | 2024-09-04 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Structural analysis of the BisI family of modification dependent restriction endonucleases. Nucleic Acids Res., 52, 2024
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3PIH
| T. maritima UvrA in complex with fluorescein-modified DNA | Descriptor: | DNA (32-MER), PYROPHOSPHATE, UvrABC system protein A, ... | Authors: | Jaciuk, M, Nowak, E, Nowotny, M. | Deposit date: | 2010-11-06 | Release date: | 2011-01-19 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structure of UvrA nucleotide excision repair protein in complex with modified DNA. Nat.Struct.Mol.Biol., 18, 2011
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7Z0Z
| Abortive infection DNA polymerase AbiK from Lactococcus lactis, Y44F variant | Descriptor: | AbiK | Authors: | Figiel, M, Gapinska, M, Czarnocki-Cieciura, M, Zajko, W, Nowotny, M. | Deposit date: | 2022-02-24 | Release date: | 2022-09-07 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (2.68 Å) | Cite: | Mechanism of protein-primed template-independent DNA synthesis by Abi polymerases. Nucleic Acids Res., 50, 2022
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8Q5O
| N-terminal domain of restriction endonuclease Eco15I with tetra-methylated target DNA. | Descriptor: | CALCIUM ION, DNA (5'-D(*CP*TP*GP*(5CM)P*TP*GP*(5CM)P*TP*C)-3'), DNA (5'-D(*GP*AP*GP*(5CM)P*AP*GP*(5CM)P*AP*G)-3'), ... | Authors: | Rafalski, D, Krakowska, K, Bochtler, M. | Deposit date: | 2023-08-09 | Release date: | 2024-07-17 | Last modified: | 2024-09-04 | Method: | X-RAY DIFFRACTION (2.33 Å) | Cite: | Structural analysis of the BisI family of modification dependent restriction endonucleases. Nucleic Acids Res., 52, 2024
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8Q5M
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8Q5N
| Apo form of restriction endonuclease NhoI. | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, Restriction endonuclease (NhoI) | Authors: | Rafalski, D, Krakowska, A, Bochtler, M. | Deposit date: | 2023-08-09 | Release date: | 2024-07-17 | Last modified: | 2024-09-04 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Structural analysis of the BisI family of modification dependent restriction endonucleases. Nucleic Acids Res., 52, 2024
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8AUP
| Structure of hARG1 with a novel inhibitor. | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-[(1~{R},3~{R},4~{S})-3-azanyl-3-carboxy-4-[(dimethylamino)methyl]cyclohexyl]ethyl-$l^{3}-oxidanyl-bis(oxidanyl)boron, Arginase-1, ... | Authors: | Napiorkowska-Gromadzka, A, Nowak, E, Nowotny, M. | Deposit date: | 2022-08-25 | Release date: | 2023-03-29 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.17 Å) | Cite: | Arginase 1/2 Inhibitor OATD-02: From Discovery to First-in-man Setup in Cancer Immunotherapy. Mol.Cancer Ther., 22, 2023
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7R08
| Abortive infection DNA polymerase Abi-P2 | Descriptor: | Reverse transcriptase | Authors: | Gapinska, M.A, Figiel, M, Czarnocki Cieciura, M, Nowotny, M, Zajko, W. | Deposit date: | 2022-02-01 | Release date: | 2022-09-07 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Mechanism of protein-primed template-independent DNA synthesis by Abi polymerases. Nucleic Acids Res., 50, 2022
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7R06
| Abortive infection DNA polymerase AbiK from Lactococcus lactis | Descriptor: | AbiK, DNA (5'-D(*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*C)-3') | Authors: | Figiel, M, Nowotny, M, Gapinska, M, Czarnocki-Cieciura, M, Zajko, W. | Deposit date: | 2022-02-01 | Release date: | 2022-09-07 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (2.27 Å) | Cite: | Mechanism of protein-primed template-independent DNA synthesis by Abi polymerases. Nucleic Acids Res., 50, 2022
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