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1QOL
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STRUCTURE OF THE FMDV LEADER PROTEASE
Descriptor:PROTEASE (NONSTRUCTURAL PROTEIN P20A), 1,2-ETHANEDIOL, CHLORIDE ION
Authors:Guarne, A., Tormo, J., Kirchweger, R., Pfistermueller, D., Skern, T., Fita, I.
Deposit date:1999-11-13
Release date:2000-11-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the Foot-and-Mouth Disease Virus Leader Protease: A Papain-Like Fold Adapted for Self-Processing and Eif4G Recognition.
Embo J., 17, 1998
1QMY
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FMDV LEADER PROTEASE (LBSHORT-C51A-C133S)
Descriptor:PROTEASE, 1,2-ETHANEDIOL
Authors:Guarne, A., Tormo, J., Glaser, W., Skern, T., Fita, I.
Deposit date:1999-10-08
Release date:2000-10-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure and Biochemical Features Distinguish the Foot-and-Mouth Disease Virus Leader Proteinase from Other Papain-Like Enzymes
J.Mol.Biol., 302, 2000
1Z8R
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2A CYSTEINE PROTEINASE FROM HUMAN COXSACKIEVIRUS B4 (STRAIN JVB / BENSCHOTEN / NEW YORK / 51)
Descriptor:Coxsackievirus B4 polyprotein, ZINC ION
Authors:Baxter, N.J., Roetzer, A., Liebig, H.D., Sedelnikova, S.E., Hounslow, A.M., Skern, T., Waltho, J.P.
Deposit date:2005-03-31
Release date:2006-02-14
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure and dynamics of coxsackievirus B4 2A proteinase, an enyzme involved in the etiology of heart disease.
J.Virol., 80, 2006
2HRV
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2A CYSTEINE PROTEINASE FROM HUMAN RHINOVIRUS 2
Descriptor:2A CYSTEINE PROTEINASE, ZINC ION
Authors:Petersen, J.F.W., Cherney, M.M., Liebig, H.-D., Skern, T., Kuechler, E., James, M.N.G.
Deposit date:1999-04-29
Release date:2000-05-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The structure of the 2A proteinase from a common cold virus: a proteinase responsible for the shut-off of host-cell protein synthesis.
EMBO J., 18, 1999
2JQF
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FULL LENGTH LEADER PROTEASE OF FOOT AND MOUTH DISEASE VIRUS C51A MUTANT
Descriptor:Genome polyprotein
Authors:Cencic, R., Mayer, C., Juliano, M.A., Juliano, L., Konrat, R., Kontaxis, G., Skern, T.
Deposit date:2007-06-01
Release date:2007-07-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Investigating the Substrate Specificity and Oligomerisation of the Leader Protease of Foot and Mouth Disease Virus using NMR
J.Mol.Biol., 373, 2007
2JQG
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LEADER PROTEASE
Descriptor:Genome polyprotein
Authors:Cencic, R., Mayer, C., Juliano, M.A., Juliano, L., Konrat, R., Kontaxis, G., Skern, T.
Deposit date:2007-06-01
Release date:2007-07-24
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Investigating the Substrate Specificity and Oligomerisation of the Leader Protease of Foot and Mouth Disease Virus using NMR
J.Mol.Biol., 373, 2007
4LQK
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STRUCTURE OF THE VACCINIA VIRUS NF- B ANTAGONIST A46
Descriptor:Protein A46, SODIUM ION, BROMIDE ION
Authors:Grishkovskaya, I., Fedosyuk, S., Skern, T., Djinovic-Carugo, K.
Deposit date:2013-07-18
Release date:2013-12-25
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Characterization and Structure of the Vaccinia Virus NF-kappa B Antagonist A46.
J.Biol.Chem., 289, 2014
4QBB
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STRUCTURE OF THE FOOT-AND-MOUTH DISEASE VIRUS LEADER PROTEINASE IN COMPLEX WITH INHIBITOR (N~2~-[(3S)-4-({(2R)-1-[(4-CARBAMIMIDAMIDOBUTYL)AMINO]-4-METHYL-1-OXOPENTAN-2-YL}AMINO)-3-HYDROXY-4-OXOBUTANOYL]-L-ARGINYL-L-PROLINAMIDE)
Descriptor:Leader protease, POTASSIUM ION, N~2~-[(3S)-4-({(2R)-1-[(4-carbamimidamidobutyl)amino]-4-methyl-1-oxopentan-2-yl}amino)-3-hydroxy-4-oxobutanoyl]-L-arginyl-L-prolinamide, ...
Authors:Grishkovskaya, I., Steinberger, J., Cencic, R., Juliano, M.A., Juliano, L., Skern, T.
Deposit date:2014-05-07
Release date:2014-11-05
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Foot-and-mouth disease virus leader proteinase: Structural insights into the mechanism of intermolecular cleavage.
Virology, 468-470C, 2014
5EZU
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CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF VACCINIA VIRUS IMMUNOMODULATOR A46 IN COMPLEX WITH MYRISTIC ACID.
Descriptor:Protein A46, MYRISTIC ACID
Authors:Fedosyuk, S., Bezerra, G.A., Sammito, M., Uson, I., Skern, T.
Deposit date:2015-11-26
Release date:2016-11-30
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Vaccinia Virus Immunomodulator A46: A Lipid and Protein-Binding Scaffold for Sequestering Host TIR-Domain Proteins.
PLoS Pathog., 12, 2016
1BBD
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THREE DIMENSIONAL STRUCTURE OF THE FAB FRAGMENT OF A NEUTRALIZING ANTIBODY TO HUMAN RHINOVIRUS SEROTYPE 2
Descriptor:IGG2A-KAPPA 8F5 FAB (LIGHT CHAIN), IGG2A-KAPPA 8F5 FAB (HEAVY CHAIN), SULFATE ION
Authors:Tormo, J., Blaas, D., Fita, I.
Deposit date:1992-05-05
Release date:1994-01-31
Last modified:2014-02-05
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Three-dimensional structure of the Fab fragment of a neutralizing antibody to human rhinovirus serotype 2.
Protein Sci., 1, 1992
6FFA
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FMDV LEADER PROTEASE BOUND TO SUBSTRATE ISG15
Descriptor:Lbpro, Ubiquitin-like protein ISG15, GLYCEROL, ...
Authors:Swatek, K.N., Pruneda, J.N., Komander, D.
Deposit date:2018-01-05
Release date:2018-02-21
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
1A3R
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FAB FRAGMENT (ANTIBODY 8F5) COMPLEXED WITH PEPTIDE FROM HUMAN RHINOVIRUS (SEROTYPE 2) VIRAL CAPSID PROTEIN VP2 (RESIDUES 156-170)
Descriptor:IGG2A 8F5 FAB (LIGHT CHAIN), IGG2A 8F5 FAB (HEAVY CHAIN), HUMAN RHINOVIRUS CAPSID PROTEIN VP2
Authors:Tormo, J., Blaas, D., Fita, I.
Deposit date:1998-01-23
Release date:1998-04-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of a human rhinovirus neutralizing antibody complexed with a peptide derived from viral capsid protein VP2.
EMBO J., 13, 1994