Author results

1KEQ
  • Download 1keq
  • View 1keq
Molmil generated image of 1keq
CRYSTAL STRUCTURE OF F65A/Y131C CARBONIC ANHYDRASE V, COVALENTLY MODIFIED WITH 4-CHLOROMETHYLIMIDAZOLE
Descriptor:F65A/Y131C-MI Carbonic Anhydrase V, POTASSIUM ION, ZINC ION, ...
Authors:Jude, K.M., Wright, S.K., Tu, C., Silverman, D.N., Viola, R.E., Christianson, D.W.
Deposit date:2001-11-16
Release date:2002-03-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Crystal structure of F65A/Y131C-methylimidazole carbonic anhydrase V reveals architectural features of an engineered proton shuttle.
Biochemistry, 41, 2002
1MOO
  • Download 1moo
  • View 1moo
Molmil generated image of 1moo
SITE SPECIFIC MUTANT (H64A) OF HUMAN CARBONIC ANHYDRASE II AT HIGH RESOLUTION
Descriptor:Carbonic Anhydrase II, ZINC ION, MERCURY (II) ION, ...
Authors:Duda, D.M., Govindasamy, L., Agbandje-McKenna, M., Tu, C.K., Silverman, D.N., McKenna, R.
Deposit date:2002-09-09
Release date:2002-09-18
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:The refined atomic structure of carbonic anhydrase II at 1.05 A resolution: implications of chemical rescue of proton transfer.
Acta Crystallogr.,Sect.D, 59, 2003
3OIK
  • Download 3oik
  • View 3oik
Molmil generated image of 3oik
HUMAN CARBONIC ANHYDRASE II MUTANT A65S, N67Q (CA IX MIMIC) BOUND BY 2-ETHYLESTRADIOL 3,17-O,O-BIS-SULFAMATE
Descriptor:Carbonic anhydrase 2, ZINC ION, (9BETA,13ALPHA,14BETA,17ALPHA)-2-ETHYLESTRA-1(10),2,4-TRIENE-3,17-DIYL DISULFAMATE, ...
Authors:Sippel, K.H., Stander, B.A., Robbins, A.H., Tu, C.K., Agbandje-McKenna, M., Silverman, D.N., Joubert, A.M., McKenna, R.
Deposit date:2010-08-19
Release date:2011-07-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Characterization of Carbonic Anhydrase Isozyme Specific Inhibition by Sulfamated 2-Ethylestra Compounds
LETT.DRUG DES.DISCOVERY, 8, 2011
3OIL
  • Download 3oil
  • View 3oil
Molmil generated image of 3oil
HUMAN CARBONIC ANHYDRASE II MUTANT A65S, N67Q (CA IX MIMIC) BOUND BY 2-ETHYLESTRADIOL 3-O-SULFAMATE
Descriptor:Carbonic anhydrase 2, ZINC ION, (14beta,17alpha)-2-ethyl-17-hydroxyestra-1(10),2,4-trien-3-yl sulfamate
Authors:Sippel, K.H., Stander, B.A., Robbins, A.H., Tu, C.K., Agbandje-McKenna, M., Silverman, D.N., Joubert, A.M., McKenna, R.
Deposit date:2010-08-19
Release date:2011-07-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Characterization of Carbonic Anhydrase Isozyme Specific Inhibition by Sulfamated 2-Ethylestra Compounds
LETT.DRUG DES.DISCOVERY, 8, 2011
3OIM
  • Download 3oim
  • View 3oim
Molmil generated image of 3oim
HUMAN CARBONIC ANHYDRASE II BOUND BY 2-ETHYLESTRADIOL 3-O-SULFAMATE
Descriptor:Carbonic anhydrase 2, ZINC ION, (14beta,17alpha)-2-ethyl-17-hydroxyestra-1(10),2,4-trien-3-yl sulfamate, ...
Authors:Sippel, K.H., Stander, B.A., Robbins, A.H., Tu, C.K., Agbandje-McKenna, M., Silverman, D.N., Joubert, A.M., McKenna, R.
Deposit date:2010-08-19
Release date:2011-07-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Characterization of Carbonic Anhydrase Isozyme Specific Inhibition by Sulfamated 2-Ethylestra Compounds
LETT.DRUG DES.DISCOVERY, 8, 2011
3OKU
  • Download 3oku
  • View 3oku
Molmil generated image of 3oku
HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH 2-ETHYLESTRONE-3-O-SULFAMATE
Descriptor:Carbonic anhydrase 2, ZINC ION, (9beta)-2-ethyl-17-oxoestra-1(10),2,4-trien-3-yl sulfamate, ...
Authors:Sippel, K.H., Stander, B.A., Robbins, A.H., Tu, C.K., Agbandje-McKenna, M., Silverman, D.N., Joubert, A.M., McKenna, R.
Deposit date:2010-08-25
Release date:2011-07-06
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Characterization of Carbonic Anhydrase Isozyme Specific Inhibition by Sulfamated 2-Ethylestra Compounds
LETT.DRUG DES.DISCOVERY, 8, 2011
3OKV
  • Download 3okv
  • View 3okv
Molmil generated image of 3okv
HUMAN CARBONIC ANHYDRASE II A65S, N67Q (CA IX MIMIC) BOUND WITH 2-ETHYLESTRONE 3-O-SULFAMATE
Descriptor:Carbonic anhydrase 2, ZINC ION, (9beta)-2-ethyl-17-oxoestra-1(10),2,4-trien-3-yl sulfamate, ...
Authors:Sippel, K.H., Stander, B.A., Robbins, A.H., Tu, C.K., Agbandje-McKenna, M., Silverman, D.N., Joubert, A.M., McKenna, R.
Deposit date:2010-08-25
Release date:2011-07-06
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Characterization of Carbonic Anhydrase Isozyme Specific Inhibition by Sulfamated 2-Ethylestra Compounds
LETT.DRUG DES.DISCOVERY, 8, 2011
1EM1
  • Download 1em1
  • View 1em1
Molmil generated image of 1em1
X-RAY CRYSTAL STRUCTURE FOR HUMAN MANGANESE SUPEROXIDE DISMUTASE, Q143A
Descriptor:MANGANESE SUPEROXIDE DISMUTASE, SULFATE ION, MANGANESE (II) ION
Authors:Leveque, V., Stroupe, M.E., Lepock, J.R., Cabelli, D.E., Tainer, J.A., Nick, H.S., Silverman, D.N.
Deposit date:2000-03-14
Release date:2000-03-24
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Multiple replacements of glutamine 143 in human manganese superoxide dismutase: effects on structure, stability, and catalysis.
Biochemistry, 39, 2000
1LUV
  • Download 1luv
  • View 1luv
Molmil generated image of 1luv
CATALYTIC AND STRUCTURAL EFFECTS OF AMINO-ACID SUBSTITUTION AT HIS 30 IN HUMAN MANGANESE SUPEROXIDE DISMUTASE: INSERTION OF VAL CGAMMA INTO THE SUBSTRATE ACCESS CHANNEL
Descriptor:Superoxide dismutase [Mn], MANGANESE (II) ION
Authors:Hearn, A.S., Stroupe, M.E., Ramilo, C.A., Luba, J.P., Cabelli, D.E., Tainer, J.A., Silverman, D.N.
Deposit date:2002-05-23
Release date:2002-06-19
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Catalytic and structural effects of amino acid substitution at histidine 30 in human manganese superoxide dismutase: insertion of valine C gamma into the substrate access channel
Biochemistry, 42, 2003
1LUW
  • Download 1luw
  • View 1luw
Molmil generated image of 1luw
CATALYTIC AND STRUCTURAL EFFECTS OF AMINO-ACID SUBSTITUTION AT HIS 30 IN HUMAN MANGANESE SUPEROXIDE DISMUTASE: INSERTION OF VAL CGAMMA INTO THE SUBSTRATE ACCESS CHANNEL
Descriptor:Superoxide dismutase [Mn], MANGANESE (II) ION, SULFATE ION
Authors:Hearn, A.S., Stroupe, M.E., Ramilo, C.A., Luba, J.P., Cabelli, D.E., Tainer, J.A., Silverman, D.N.
Deposit date:2002-05-23
Release date:2002-06-19
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Catalytic and structural effects of amino acid substitution at histidine 30 in human manganese superoxide dismutase: insertion of valine C gamma into the substrate access channel
Biochemistry, 42, 2003
1LZV
  • Download 1lzv
  • View 1lzv
Molmil generated image of 1lzv
SITE-SPECIFIC MUTANT (TYR7 REPLACED WITH HIS) OF HUMAN CARBONIC ANHYDRASE II
Descriptor:Carbonic Anhydrase II, ZINC ION
Authors:Tu, C.K., Qian, M., An, H., Wadhwa, N.R., Duda, D.M., Yoshioka, C., Pathak, Y., McKenna, R., Laipis, P.J., Silverman, D.N.
Deposit date:2002-06-11
Release date:2002-10-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Kinetic analysis of multiple proton shuttles in the active site of human carbonic anhydrase.
J.Biol.Chem., 277, 2002
1SZX
  • Download 1szx
  • View 1szx
Molmil generated image of 1szx
ROLE OF HYDROGEN BONDING IN THE ACTIVE SITE OF HUMAN MANGANESE SUPEROXIDE DISMUTASE
Descriptor:Superoxide dismutase [Mn], mitochondrial, MANGANESE (II) ION
Authors:Greenleaf, W.B., Perry, J.J., Hearn, A.S., Cabelli, D.E., Lepock, J.R., Stroupe, M.E., Tainer, J.A., Nick, H.S., Silverman, D.N.
Deposit date:2004-04-06
Release date:2004-04-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Role of hydrogen bonding in the active site of human manganese superoxide dismutase.
Biochemistry, 43, 2004
1T9N
  • Download 1t9n
  • View 1t9n
Molmil generated image of 1t9n
EFFECT OF SHUTTLE LOCATION AND PH ENVIRONMENT ON H+ TRANSFER IN HUMAN CARBONIC ANHYDRASE II
Descriptor:Carbonic anhydrase II, ZINC ION, SULFATE ION
Authors:Fisher, Z., Hernandez Prada, J., Tu, C.K., Duda, D., Yoshioka, C., An, H., Govindasamy, L., Silverman, D.N., McKenna, R.
Deposit date:2004-05-18
Release date:2005-01-25
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and Kinetic Characterization of Active-Site Histidine as a Proton Shuttle in Catalysis by Human Carbonic Anhydrase II
Biochemistry, 44, 2005
1TB0
  • Download 1tb0
  • View 1tb0
Molmil generated image of 1tb0
EFFECT OF SHUTTLE LOCATION AND PH ENVIRONMENT ON H+ TRANSFER IN HUMAN CARBONIC ANHYDRASE II
Descriptor:Carbonic anhydrase II, ZINC ION, CHLORIDE ION
Authors:Fisher, Z., Hernandez Prada, J.A., Tu, C., Duda, D., Yoshioka, C., An, H., Govindasamy, L., Silverman, D.N., McKenna, R.
Deposit date:2004-05-19
Release date:2005-01-25
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and kinetic characterization of active-site histidine as a proton shuttle in catalysis by human carbonic anhydrase II.
Biochemistry, 44, 2005
1TBT
  • Download 1tbt
  • View 1tbt
Molmil generated image of 1tbt
EFFECT OF SHUTTLE LOCATION AND PH ENVIRONMENT ON H+ TRANSFER IN HUMAN CARBONIC ANHYDRASE II
Descriptor:Carbonic anhydrase II, ZINC ION
Authors:Fisher, Z., Hernandez Prada, J.A., Tu, C.K., Duda, D., Yoshioka, C., An, H., Govindasamy, L., Silverman, D.N., McKenna, R.
Deposit date:2004-05-20
Release date:2005-01-25
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and Kinetic Characterization of Active-Site Histidine as a Proton Shuttle in Catalysis by Human Carbonic Anhydrase II.
Biochemistry, 44, 2005
1TE3
  • Download 1te3
  • View 1te3
Molmil generated image of 1te3
EFFECT OF SHUTTLE LOCATION AND PH ENVIRONMENT ON H+ TRANSFER IN HUMAN CARBONIC ANHYDRASE II
Descriptor:Carbonic anhydrase II, ZINC ION, CHLORIDE ION
Authors:Fisher, Z., Hernandez Prada, J.A., Tu, C.K., Duda, D., Yoshioka, C., An, H., Govindasamy, L., Silverman, D.N., McKenna, R.
Deposit date:2004-05-24
Release date:2005-01-25
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and Kinetic Characterization of Active-Site Histidine as a Proton Shuttle in Catalysis by Human Carbonic Anhydrase II
Biochemistry, 44, 2005
1TEQ
  • Download 1teq
  • View 1teq
Molmil generated image of 1teq
EFFECT OF SHUTTLE LOCATION AND PH ENVIRONMENT ON H+ TRANSFER IN HUMAN CARBONIC ANHYDRASE II
Descriptor:Carbonic anhydrase II, ZINC ION, HYDROXIDE ION
Authors:Fisher, Z., Hernandez Prada, J.A., Tu, C.K., Duda, D., Yoshioka, C., An, H., Govindasamy, L., Silverman, D.N., McKenna, R.
Deposit date:2004-05-25
Release date:2005-01-25
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and Kinetic Characterization of Active-Site Histidine as a Proton Shuttle in Catalysis by Human Carbonic Anhydrase II
Biochemistry, 44, 2005
1TEU
  • Download 1teu
  • View 1teu
Molmil generated image of 1teu
EFFECT OF SHUTTLE LOCATION AND PH ENVIRONMENT ON H+ TRANSFER IN HUMAN CARBONIC ANHYDRASE II
Descriptor:Carbonic anhydrase II, ZINC ION
Authors:Fisher, Z., Hernandez Prada, J.A., Tu, C.K., Duda, D., Yoshioka, C., An, H., Govindasamy, L., Silverman, D.N., McKenna, R.
Deposit date:2004-05-25
Release date:2005-01-25
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and Kinetic Characterization of Active-Site Histidine as a Proton Shuttle in Catalysis by Human Carbonic Anhydrase II
Biochemistry, 44, 2005
1TG3
  • Download 1tg3
  • View 1tg3
Molmil generated image of 1tg3
EFFECT OF SHUTTLE LOCATION AND PH ENVIRONMENT ON H+ TRANSFER IN HUMAN CARBONIC ANHYDRASE II
Descriptor:Carbonic anhydrase II, ZINC ION, SULFATE ION
Authors:Fisher, Z., Hernandez Prada, J.A., Tu, C.K., Duda, D., Yoshioka, C., An, H., Govindasamy, L., Silverman, D.N., McKenna, R.
Deposit date:2004-05-28
Release date:2005-01-25
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural and Kinetic Characterization of Active-Site Histidine as a Proton Shuttle in Catalysis by Human Carbonic Anhydrase II
Biochemistry, 44, 2005
1TG9
  • Download 1tg9
  • View 1tg9
Molmil generated image of 1tg9
EFFECT OF SHUTTLE LOCATION AND PH ENVIRONMENT ON H+ TRANSFER IN HUMAN CARBONIC ANHYDRASE II
Descriptor:Carbonic anhydrase II, ZINC ION
Authors:Fisher, Z., Hernandez Prada, J.A., Tu, C.K., Duda, D., Yoshioka, C., An, H., Govindasamy, L., Silverman, D.N., McKenna, R.
Deposit date:2004-05-28
Release date:2005-01-25
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and Kinetic Characterization of Active-Site Histidine as a Proton Shuttle in Catalysis by Human Carbonic Anhydrase II
Biochemistry, 44, 2005
1TH9
  • Download 1th9
  • View 1th9
Molmil generated image of 1th9
EFFECT OF SHUTTLE LOCATION AND PH ENVIRONMENT ON H+ TRANSFER IN HUMAN CARBONIC ANHYDRASE II
Descriptor:Carbonic anhydrase II, ZINC ION, SULFATE ION
Authors:Fisher, Z., Hernandez Prada, J.A., Tu, C.K., Duda, D., Yoshioka, C., An, H., Govindasamy, L., Silverman, D.N., McKenna, R.
Deposit date:2004-06-01
Release date:2005-01-25
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Structural and Kinetic Characterization of Active-Site Histidine as a Proton Shuttle in Catalysis by Human Carbonic Anhydrase II
Biochemistry, 44, 2005
1THK
  • Download 1thk
  • View 1thk
Molmil generated image of 1thk
EFFECT OF SHUTTLE LOCATION AND PH ENVIRONMENT ON H+ TRANSFER IN HUMAN CARBONIC ANHYDRASE II
Descriptor:Carbonic anhydrase II, ZINC ION
Authors:Fisher, Z., Hernandez Prada, J.A., Tu, C.K., Duda, D., Yoshioka, C., An, H., Govindasamy, L., Silverman, D.N., McKenna, R.
Deposit date:2004-06-01
Release date:2005-01-25
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural and Kinetic Characterization of Active-Site Histidine as a Proton Shuttle in Catalysis by Human Carbonic Anhydrase II
Biochemistry, 44, 2005
1XDC
  • Download 1xdc
  • View 1xdc
Molmil generated image of 1xdc
HYDROGEN BONDING IN HUMAN MANGANESE SUPEROXIDE DISMUTASE CONTAINING 3-FLUOROTYROSINE
Descriptor:Superoxide dismutase [Mn], mitochondrial, MANGANESE (II) ION
Authors:Ayala, I., Perry, J.J., Szczepanski, J., Cabelli, D.E., Tainer, J.A., Vala, M.T., Nick, H.S., Silverman, D.N.
Deposit date:2004-09-05
Release date:2005-03-22
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Hydrogen bonding in human manganese superoxide dismutase containing 3-fluorotyrosine
Biophys.J., 89, 2005
1XIL
  • Download 1xil
  • View 1xil
Molmil generated image of 1xil
HYDROGEN BONDING IN HUMAN MANGANESE SUPEROXIDE DISMUTASE CONTAINING 3-FLUOROTYROSINE
Descriptor:Superoxide dismutase [Mn], mitochondrial, MANGANESE (II) ION
Authors:Ayala, I., Perry, J.J., Szczepanski, J., Cabelli, D.E., Tainer, J.A., Vala, M.T., Nick, H.S., Silverman, D.N.
Deposit date:2004-09-21
Release date:2005-03-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Hydrogen bonding in human manganese superoxide dismutase containing 3-fluorotyrosine
Biophys.J., 89, 2005
1XV8
  • Download 1xv8
  • View 1xv8
Molmil generated image of 1xv8
CRYSTAL STRUCTURE OF HUMAN SALIVARY ALPHA-AMYLASE DIMER
Descriptor:Alpha-amylase, CALCIUM ION, CHLORIDE ION
Authors:Fisher, S.Z., Govindasamy, L., Tu, C.K., Silverman, D.N., Rajaniemi, H., McKenna, R.
Deposit date:2004-10-27
Release date:2005-10-11
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal Structure of Human Salivary Alpha-Amylase Dimer
To be Published