1UN8
| Crystal structure of the dihydroxyacetone kinase of C. freundii (native form) | Descriptor: | (2R)-3-(PHOSPHONOOXY)-2-(TETRADECANOYLOXY)PROPYL PALMITATE, DIHYDROXYACETONE KINASE | Authors: | Siebold, C, Arnold, I, Garcia-Alles, L.F, Baumann, U, Erni, B. | Deposit date: | 2003-09-08 | Release date: | 2003-10-10 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal Structure of the Citrobacter Freundii Dihydroxyacetone Kinase Reveals an Eight-Stranded Alpha-Helical Barrel ATP-Binding Domain J.Biol.Chem., 278, 2003
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1UN9
| Crystal structure of the dihydroxyacetone kinase from C. freundii in complex with AMP-PNP and Mg2+ | Descriptor: | DIHYDROXYACETONE, DIHYDROXYACETONE KINASE, MAGNESIUM ION, ... | Authors: | Siebold, C, Arnold, I, Garcia-Alles, L.F, Baumann, U, Erni, B. | Deposit date: | 2003-09-08 | Release date: | 2003-10-30 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Crystal Structure of the Citrobacter Freundii Dihydroxyacetone Kinase Reveals an Eight-Stranded Alpha-Helical Barrel ATP-Binding Domain J.Biol.Chem., 278, 2003
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1OI2
| X-ray structure of the dihydroxyacetone kinase from Escherichia coli | Descriptor: | GLYCEROL, HYPOTHETICAL PROTEIN YCGT, SULFATE ION | Authors: | Siebold, C, Garcia-Alles, L.-F, Erni, B, Baumann, U. | Deposit date: | 2003-06-04 | Release date: | 2003-06-26 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | A Mechanism of Covalent Substrate Binding in the X-Ray Structure of Subunit K of the Escherichia Coli Dihydroxyacetone Kinase Proc.Natl.Acad.Sci.USA, 100, 2003
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1OI3
| X-ray structure of the dihydroxyacetone kinase from Escherichia coli | Descriptor: | HYPOTHETICAL PROTEIN YCGT, SULFATE ION | Authors: | Siebold, C, Garcia-Alles, L.-F, Erni, B, Baumann, U. | Deposit date: | 2003-06-04 | Release date: | 2003-07-14 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A Mechanism of Covalent Substrate Binding in the X-Ray Structure of Subunit K of the Escherichia Coli Dihydroxyacetone Kinase Proc.Natl.Acad.Sci.USA, 100, 2003
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1UVQ
| Crystal structure of HLA-DQ0602 in complex with a hypocretin peptide | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETIC ACID, GLYCINE, ... | Authors: | Siebold, C, Hansen, B.E, Wyer, J.R, Harlos, K, Esnouf, R.E, Svejgaard, A, Bell, J.I, Strominger, J.L, Jones, E.Y, Fugger, L. | Deposit date: | 2004-01-22 | Release date: | 2004-02-05 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal Structure of Hla-Dq0602 that Protects Against Type 1 Diabetes and Confers Strong Susceptibility to Narcolepsy Proc.Natl.Acad.Sci.USA, 101, 2004
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2BRY
| Crystal structure of the native monooxygenase domain of MICAL at 1.45 A resolution | Descriptor: | CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... | Authors: | Siebold, C, Berrow, N, Walter, T.S, Harlos, K, Owens, R.J, Terman, J.R, Stuart, D.I, Kolodkin, A.L, Pasterkamp, R.J, Jones, E.Y. | Deposit date: | 2005-05-13 | Release date: | 2005-10-26 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | High-Resolution Structure of the Catalytic Region of Mical (Molecule Interacting with Casl), a Multidomain Flavoenzyme-Signaling Molecule. Proc.Natl.Acad.Sci.USA, 102, 2005
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2C4C
| Crystal structure of the NADPH-treated monooxygenase domain of MICAL | Descriptor: | CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, NEDD9-INTERACTING PROTEIN WITH CALPONIN HOMOLOGY AND LIM DOMAINS | Authors: | Siebold, C, Berrow, N, Walter, T.S, Harlos, K, Owens, R.J, Terman, J.R, Stuart, D.I, Kolodkin, A.L, Pasterkamp, R.J, Jones, E.Y. | Deposit date: | 2005-10-18 | Release date: | 2005-10-26 | Last modified: | 2017-06-28 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | High-Resolution Structure of the Catalytic Region of Mical (Molecule Interacting with Casl), a Multidomain Flavoenzyme-Signaling Molecule. Proc.Natl.Acad.Sci.USA, 102, 2005
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2UUX
| Structure of the tryptase inhibitor TdPI from a tick | Descriptor: | SULFATE ION, TRYPTASE INHIBITOR | Authors: | Siebold, C, Paesen, G.C, Harlos, K, Peacey, M.F, Nuttall, P.A, Stuart, D.I. | Deposit date: | 2007-03-08 | Release date: | 2007-04-03 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | A Tick Protein with a Modified Kunitz Fold Inhibits Human Tryptase. J.Mol.Biol., 368, 2007
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2UUY
| Structure of a tick tryptase inhibitor in complex with bovine trypsin | Descriptor: | CALCIUM ION, CATIONIC TRYPSIN, CHLORIDE ION, ... | Authors: | Siebold, C, Paesen, G.C, Harlos, K, Peacey, M.F, Nuttall, P.A, Stuart, D.I. | Deposit date: | 2007-03-08 | Release date: | 2007-04-10 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.15 Å) | Cite: | A Tick Protein with a Modified Kunitz Fold Inhibits Human Tryptase. J.Mol.Biol., 368, 2007
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1UOD
| Crystal structure of the dihydroxyacetone kinase from E. coli in complex with dihydroxyacetone-phosphate | Descriptor: | DIHYDROXYACETONE KINASE, GLYCERALDEHYDE-3-PHOSPHATE, SULFATE ION | Authors: | Siebold, C, Garcia-Alles, L.F, Luthi-Nyffeler, T, Flukiger-Bruhwiler, K, Burgi, H.-B, Baumann, U, Erni, B. | Deposit date: | 2003-09-16 | Release date: | 2004-09-24 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Phosphoenolpyruvate- and ATP-Dependent Dihydroxyacetone Kinases: Covalent Substrate-Binding and Kinetic Mechanism Biochemistry, 43, 2004
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1UOE
| Crystal structure of the dihydroxyacetone kinase from E. coli in complex with glyceraldehyde | Descriptor: | DIHYDROXYACETONE KINASE, GLYCEROL, SULFATE ION | Authors: | Siebold, C, Garcia-Alles, L.F, Luthi-Nyffeler, T, Flukiger-Bruhwiler, K, Burgi, H.-B, Baumann, U, Erni, B. | Deposit date: | 2003-09-16 | Release date: | 2004-09-24 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Phosphoenolpyruvate- and ATP-Dependent Dihydroxyacetone Kinases: Covalent Substrate-Binding and Kinetic Mechanism Biochemistry, 43, 2004
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7ZI0
| Structure of human Smoothened in complex with cholesterol and SAG | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-chloro-N-[trans-4-(methylamino)cyclohexyl]-N-{[3-(pyridin-4-yl)phenyl]methyl}-1-benzothiophene-2-carboxamide, CHOLESTEROL, ... | Authors: | Byrne, E.F.X, Woolley, R.E, Ansell, B, Sansom, M.S.P, Newstead, S, Siebold, C. | Deposit date: | 2022-04-07 | Release date: | 2022-06-15 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Patched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain. Sci Adv, 8, 2022
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7Q6Z
| Structure of Hedgehog acyltransferase (HHAT) in complex with megabody 177 bound to IMP-1575 | Descriptor: | 2-(2-methylpropylamino)-1-[(4R)-4-(6-methylpyridin-2-yl)-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl]ethanone, CHOLESTEROL, Megabody 177, ... | Authors: | Coupland, C, Carrique, L, Siebold, C. | Deposit date: | 2021-11-09 | Release date: | 2022-01-26 | Method: | ELECTRON MICROSCOPY (3.59 Å) | Cite: | Structure, mechanism, and inhibition of Hedgehog acyltransferase. Mol.Cell, 81, 2021
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7Q1U
| Structure of Hedgehog acyltransferase (HHAT) in complex with megabody 177 bound to non-hydrolysable palmitoyl-CoA (Composite Map) | Descriptor: | CHOLESTEROL, MAGNESIUM ION, Megabody 177, ... | Authors: | Coupland, C, Carrique, L, Siebold, C. | Deposit date: | 2021-10-21 | Release date: | 2022-06-08 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structure, mechanism, and inhibition of Hedgehog acyltransferase. Mol.Cell, 81, 2021
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2V5P
| COMPLEX STRUCTURE OF HUMAN IGF2R DOMAINS 11-13 BOUND TO IGF-II | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR, INSULIN-LIKE GROWTH FACTOR II, ... | Authors: | Brown, J, Delaine, C, Zaccheo, O.J, Siebold, C, Gilbert, R.J, van Boxel, G, Denley, A, Wallace, J.C, Hassan, A.B, Forbes, B.E, Jones, E.Y. | Deposit date: | 2007-07-06 | Release date: | 2007-12-11 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (4.1 Å) | Cite: | Structure and Functional Analysis of the Igf-II/Igf2R Interaction Embo J., 27, 2008
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3SUA
| Crystal structure of the intracellular domain of Plexin-B1 in complex with Rac1 | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Plexin-B1, ... | Authors: | Bell, C.H, Aricescu, A.R, Jones, E.Y, Siebold, C. | Deposit date: | 2011-07-11 | Release date: | 2011-09-07 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (4.39 Å) | Cite: | A Dual Binding Mode for RhoGTPases in Plexin Signalling. Plos Biol., 9, 2011
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3SU8
| Crystal structure of a truncated intracellular domain of Plexin-B1 in complex with Rac1 | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Plexin-B1, ... | Authors: | Bell, C.H, Aricescu, A.R, Jones, E.Y, Siebold, C. | Deposit date: | 2011-07-11 | Release date: | 2011-09-28 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | A Dual Binding Mode for RhoGTPases in Plexin Signalling. Plos Biol., 9, 2011
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7NDG
| Cryo-EM structure of the ternary complex between Netrin-1, Neogenin and Repulsive Guidance Molecule B | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Neogenin, ... | Authors: | Robinson, R.A, Griffiths, S.C, van de Haar, L.L, Malinauskas, T, van Battum, E.Y, Zelina, P, Schwab, R.A, Karia, D, Malinauskaite, L, Brignani, S, van den Munkhof, M, Dudukcu, O, De Ruiter, A.A, Van den Heuvel, D.M.A, Bishop, B, Elegheert, J, Aricescu, A.R, Pasterkamp, R.J, Siebold, C. | Deposit date: | 2021-02-01 | Release date: | 2021-03-31 | Last modified: | 2021-04-28 | Method: | ELECTRON MICROSCOPY (5.98 Å) | Cite: | Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling. Cell, 184, 2021
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7NE0
| Structure of the ternary complex between Netrin-1, Repulsive-Guidance Molecule-B (RGMB) and Neogenin | Descriptor: | 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Robinson, R.A, Griffiths, S.C, van de Haar, L.L, Malinauskas, T, van Battum, E.Y, Zelina, P, Schwab, R.A, Karia, D, Malinauskaite, L, Brignani, S, van den Munkhof, M, Dudukcu, O, De Ruiter, A.A, Van den Heuvel, D.M.A, Bishop, B, Elegheert, J, Aricescu, A.R, Pasterkamp, R.J, Siebold, C. | Deposit date: | 2021-02-02 | Release date: | 2021-03-31 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling. Cell, 184, 2021
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7NE1
| Structure of the complex between Netrin-1 and its receptor Neogenin | Descriptor: | 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Robinson, R.A, Griffiths, S.C, van de Haar, L.L, Malinauskas, T, van Battum, E.Y, Zelina, P, Schwab, R.A, Karia, D, Malinauskaite, L, Brignani, S, van den Munkhof, M, Dudukcu, O, De Ruiter, A.A, Van den Heuvel, D.M.A, Bishop, B, Elegheert, J, Aricescu, A.R, Pasterkamp, R.J, Siebold, C. | Deposit date: | 2021-02-02 | Release date: | 2021-03-31 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling. Cell, 184, 2021
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4GZA
| Complex of mouse Plexin A2 - Semaphorin 3A - Neuropilin-1 | Descriptor: | CALCIUM ION, Neuropilin-1, Plexin-A2, ... | Authors: | Janssen, B.J.C, Malinauskas, T, Siebold, C, Jones, E.Y. | Deposit date: | 2012-09-06 | Release date: | 2012-10-17 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (7 Å) | Cite: | Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex. Nat.Struct.Mol.Biol., 19, 2012
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4GZ8
| Mouse Semaphorin 3A, domains Sema-PSI-IG | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... | Authors: | Janssen, B.J.C, Malinauskas, T, Siebold, C, Jones, E.Y. | Deposit date: | 2012-09-06 | Release date: | 2012-10-17 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex. Nat.Struct.Mol.Biol., 19, 2012
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4GZ9
| Mouse Neuropilin-1, extracellular domains 1-4 (a1a2b1b2) | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Janssen, B.J.C, Malinauskas, T, Siebold, C, Jones, E.Y. | Deposit date: | 2012-09-06 | Release date: | 2012-10-17 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex. Nat.Struct.Mol.Biol., 19, 2012
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4UI1
| Crystal structure of the human RGMC-BMP2 complex | Descriptor: | 1,2-ETHANEDIOL, BONE MORPHOGENETIC PROTEIN 2, CHLORIDE ION, ... | Authors: | Healey, E.G, Bishop, B, Elegheert, J, Bell, C.H, Padilla-Parra, S, Siebold, C. | Deposit date: | 2015-03-27 | Release date: | 2015-05-06 | Last modified: | 2015-06-17 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Repulsive Guidance Molecule is a Structural Bridge between Neogenin and Bone Morphogenetic Protein. Nat.Struct.Mol.Biol., 22, 2015
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4UHY
| Crystal structure of the human RGMA-BMP2 complex | Descriptor: | BONE MORPHOGENETIC PROTEIN 2, REPULSIVE GUIDANCE MOLECULE A | Authors: | Healey, E.G, Bishop, B, Elegheert, J, Bell, C.H, Padilla-Parra, S, Siebold, C. | Deposit date: | 2015-03-27 | Release date: | 2015-05-06 | Last modified: | 2015-06-17 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Repulsive Guidance Molecule is a Structural Bridge between Neogenin and Bone Morphogenetic Protein. Nat.Struct.Mol.Biol., 22, 2015
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