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2KYK
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BU of 2kyk by Molmil
The sandwich region between two LMP2A PY motif regulates the interaction between AIP4WW2domain and PY motif
Descriptor: E3 ubiquitin-protein ligase Itchy homolog
Authors:Seo, M, Park, S, Seok, S, Kim, J, Cha, M, Lee, B.
Deposit date:2010-05-28
Release date:2011-06-01
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:The sandwich region between two LMP2A PY motif regulates the interaction between AIP4WW2domain and PY motif
To be Published
3OMP
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BU of 3omp by Molmil
Fragment-Based Design of novel Estrogen Receptor Ligands
Descriptor: 2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinolin-7-ol, Estrogen receptor beta, Nuclear receptor coactivator 1
Authors:Moecklinghoff, S, van Otterlo, W.A, Rose, R, Fuchs, S, Dominguez Seoane, M, Waldmann, H, Ottmann, C, Brunsveld, L.
Deposit date:2010-08-27
Release date:2011-03-16
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Design and Evaluation of Fragment-Like Estrogen Receptor Tetrahydroisoquinoline Ligands from a Scaffold-Detection Approach.
J.Med.Chem., 54, 2011
3OMO
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BU of 3omo by Molmil
Fragment-Based Design of novel Estrogen Receptor Ligands
Descriptor: 2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinolin-6-ol, Estrogen receptor beta, Nuclear receptor coactivator 1
Authors:Moecklinghoff, S, van Otterlo, W.A, Rose, R, Fuchs, S, Dominguez Seoane, M, Waldmann, H, Ottmann, C, Brunsveld, L.
Deposit date:2010-08-27
Release date:2011-03-16
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Design and Evaluation of Fragment-Like Estrogen Receptor Tetrahydroisoquinoline Ligands from a Scaffold-Detection Approach.
J.Med.Chem., 54, 2011
3OMQ
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BU of 3omq by Molmil
Fragment-Based Design of novel Estrogen Receptor Ligands
Descriptor: 2-[(trifluoromethyl)sulfonyl]-1,2,3,4-tetrahydroisoquinolin-6-ol, Estrogen receptor beta, Nuclear receptor coactivator 1
Authors:Moecklinghoff, S, van Otterlo, W.A, Rose, R, Fuchs, S, Dominguez Seoane, M, Waldmann, H, Ottmann, C, Brunsveld, L.
Deposit date:2010-08-27
Release date:2011-03-16
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Design and Evaluation of Fragment-Like Estrogen Receptor Tetrahydroisoquinoline Ligands from a Scaffold-Detection Approach.
J.Med.Chem., 54, 2011
4MA4
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BU of 4ma4 by Molmil
S-glutathionylated PFKFB3
Descriptor: 6-O-phosphono-beta-D-fructofuranose, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3, ACETIC ACID, ...
Authors:Lee, Y.-H, Seo, M.-S.
Deposit date:2013-08-15
Release date:2013-12-11
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:PFKFB3 Regulates Oxidative Stress Homeostasis via Its S-Glutathionylation in Cancer.
J.Mol.Biol., 426, 2014
3WG8
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BU of 3wg8 by Molmil
Crystal structure of the abscisic acid receptor PYR1 in complex with an antagonist AS6
Descriptor: (2Z,4E)-5-[(1S)-3-(hexylsulfanyl)-1-hydroxy-2,6,6-trimethyl-4-oxocyclohex-2-en-1-yl]-3-methylpenta-2,4-dienoic acid, Abscisic acid receptor PYR1
Authors:Akiyama, T, Sue, M, Takeuchi, J, Okamoto, M, Muto, T, Endo, A, Nambara, E, Hirai, N, Ohnishi, T, Cutler, S.R, Todoroki, Y, Yajima, S.
Deposit date:2013-07-31
Release date:2014-05-07
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Designed abscisic acid analogs as antagonists of PYL-PP2C receptor interactions
Nat.Chem.Biol., 10, 2014
7Y28
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BU of 7y28 by Molmil
Controlling fibrosis using compound with novel binding mode to prolyl-tRNA synthetase 1
Descriptor: 1-[6-(3-fluorophenyl)benzimidazol-1-yl]-3-[(2R,3S)-3-oxidanylpiperidin-2-yl]propan-2-one, ADENOSINE-5'-TRIPHOSPHATE, Bifunctional glutamate/proline--tRNA ligase, ...
Authors:Kim, S, Yoon, I, Son, J, Park, S, Hwang, K.Y.
Deposit date:2022-06-09
Release date:2023-07-05
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Control of fibrosis with enhanced safety via asymmetric inhibition of prolyl-tRNA synthetase 1.
Embo Mol Med, 15, 2023
7Y1H
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BU of 7y1h by Molmil
Controlling fibrosis using compound with novel binding mode to prolyl-tRNA synthetase 1
Descriptor: 1-(5-chloranyl-4-methyl-benzimidazol-1-yl)-3-[(2R,3S)-3-oxidanylpiperidin-2-yl]propan-2-one, ADENOSINE-5'-TRIPHOSPHATE, Bifunctional glutamate/proline--tRNA ligase, ...
Authors:Kim, S, Yoon, I, Son, J, Park, S, Hwang, K.Y.
Deposit date:2022-06-08
Release date:2023-07-05
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Control of fibrosis with enhanced safety via asymmetric inhibition of prolyl-tRNA synthetase 1.
Embo Mol Med, 15, 2023
7Y1W
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BU of 7y1w by Molmil
Controlling fibrosis using compound with novel binding mode to prolyl-tRNA synthetase 1
Descriptor: (2R,3S)-2-[3-[4,5-bis(chloranyl)benzimidazol-1-yl]propyl]piperidin-3-ol, ADENOSINE-5'-TRIPHOSPHATE, Bifunctional glutamate/proline--tRNA ligase, ...
Authors:Kim, S, Yoon, I, Son, J, Park, S, Hwang, K.Y.
Deposit date:2022-06-09
Release date:2023-07-05
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Control of fibrosis with enhanced safety via asymmetric inhibition of prolyl-tRNA synthetase 1.
Embo Mol Med, 15, 2023
7Y3S
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BU of 7y3s by Molmil
Controlling fibrosis using compound with novel binding mode to prolyl-tRNA synthetase 1
Descriptor: 1-(6-bromanyl-7-methyl-imidazo[4,5-b]pyridin-3-yl)-3-[(2R,3S)-3-oxidanylpiperidin-2-yl]propan-2-one, ADENOSINE-5'-TRIPHOSPHATE, Bifunctional glutamate/proline--tRNA ligase, ...
Authors:Kim, S, Yoon, I, Son, J, Park, S, Hwang, K.Y.
Deposit date:2022-06-12
Release date:2023-07-05
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Control of fibrosis with enhanced safety via asymmetric inhibition of prolyl-tRNA synthetase 1.
Embo Mol Med, 15, 2023
6JMF
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BU of 6jmf by Molmil
Crystal structure of human tyrosine-protein kinase Fes/Fps in complex with compound 4
Descriptor: 6-{[(1R,2S)-2-aminocyclohexyl]amino}-5-cyano-2-[(3-methylphenyl)amino]pyridine-3-carboxamide, SULFATE ION, Tyrosine-protein kinase Fes/Fps
Authors:Baba, D, Hanzawa, H.
Deposit date:2019-03-08
Release date:2019-06-12
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of Novel Pyrido-pyridazinone Derivatives as FER Tyrosine Kinase Inhibitors with Antitumor Activity.
Acs Med.Chem.Lett., 10, 2019

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PDB entries from 2024-09-18

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