3OMQ

Fragment-Based Design of novel Estrogen Receptor Ligands

Summary for 3OMQ

Entry DOI	10.2210/pdb3omq/pdb
Related	3OLM 3OLS 3OMO 3OMP
Descriptor	Estrogen receptor beta, Nuclear receptor coactivator 1, 2-[(trifluoromethyl)sulfonyl]-1,2,3,4-tetrahydroisoquinolin-6-ol, ... (4 entities in total)
Functional Keywords	steroid binding, protein binding
Biological source	Homo sapiens (human) More
Cellular location	Nucleus: Q92731 Nucleus (By similarity): Q15788
Total number of polymer chains	4
Total formula weight	59249.86
Authors	Moecklinghoff, S.,van Otterlo, W.A.,Rose, R.,Fuchs, S.,Dominguez Seoane, M.,Waldmann, H.,Ottmann, C.,Brunsveld, L. (deposition date: 2010-08-27, release date: 2011-03-16, Last modification date: 2024-02-21)
Primary citation	van Otterlo, W.A.,Rose, R.,Fuchs, S.,Zimmermann, T.J.,Dominguez Seoane, M.,Waldmann, H.,Ottmann, C.,Brunsveld, L. Design and Evaluation of Fragment-Like Estrogen Receptor Tetrahydroisoquinoline Ligands from a Scaffold-Detection Approach. J.Med.Chem., 54:2005-2011, 2011 Cited by PubMed: 21381753 DOI: 10.1021/jm1011116 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.97 Å)

Structure validation