1K4Q
 
 | | Human Glutathione Reductase Inactivated by Peroxynitrite | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Glutathione Reductase | | Authors: | Savvides, S.N, Scheiwein, M, Boehme, C.C, Arteel, G.E, Karplus, P.A, Becker, K, Schirmer, R.H. | | Deposit date: | 2001-10-08 | | Release date: | 2002-01-30 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structure of the antioxidant enzyme glutathione reductase inactivated by peroxynitrite.
J.Biol.Chem., 277, 2002
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1ETE
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1NLY
 | | Crystal structure of the traffic ATPase of the Helicobacter pylori type IV secretion system in complex with ATPgammaS | | Descriptor: | MAGNESIUM ION, NONAETHYLENE GLYCOL, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | | Authors: | Savvides, S.N, Yeo, H.J, Beck, M.R, Blaesing, F, Lurz, R, Lanka, E, Buhrdorf, R, Fischer, W, Haas, R, Waksman, G. | | Deposit date: | 2003-01-08 | | Release date: | 2003-05-06 | | Last modified: | 2012-03-07 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | VirB11 ATPases are dynamic hexameric assemblies: New insights into bacterial type IV secretion
Embo J., 22, 2003
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1OPX
 | | Crystal structure of the traffic ATPase (HP0525) of the Helicobacter pylori type IV secretion system bound by sulfate | | Descriptor: | NONAETHYLENE GLYCOL, SULFATE ION, virB11 homolog | | Authors: | Savvides, S.N, Yeo, H.J, Beck, M.R, Blaesing, F, Lurz, R, Lanka, E, Buhrdorf, R, Fischer, W, Haas, R, Waksman, G. | | Deposit date: | 2003-03-06 | | Release date: | 2003-05-06 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | VirB11 ATPases are dynamic hexameric assemblies: New insights into bacterial type IV secretion
Embo J., 22, 2003
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1NLZ
 | | Crystal structure of unliganded traffic ATPase of the type IV secretion system of helicobacter pylori | | Descriptor: | virB11 homolog | | Authors: | Savvides, S.N, Yeo, H.J, Beck, M.R, Blaesing, F, Lurz, R, Lanka, E, Buhrdorf, R, Fischer, W, Haas, R, Waksman, G. | | Deposit date: | 2003-01-08 | | Release date: | 2003-05-06 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | VirB11 ATPases are dynamic hexameric assemblies: New insights into bacterial type IV secretion
Embo J., 22, 2003
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1SRU
 | | Crystal structure of full length E. coli SSB protein | | Descriptor: | Single-strand binding protein | | Authors: | Savvides, S.N, Raghunathan, S, Fuetterer, K, Kozlov, A.G, Lohman, T.M, Waksman, G. | | Deposit date: | 2004-03-23 | | Release date: | 2004-08-03 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | The C-terminal domain of full-length E. coli SSB is disordered even when bound to DNA.
Protein Sci., 13, 2004
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1XAN
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2I9V
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2GQ9
 | | Structure of SYE1, an OYE homologue from S. oneidensis, in complex with p-hydroxybenzaldehyde | | Descriptor: | FLAVIN MONONUCLEOTIDE, P-HYDROXYBENZALDEHYDE, SULFATE ION, ... | | Authors: | Savvides, S.N, van den Hemel, D. | | Deposit date: | 2006-04-20 | | Release date: | 2006-07-25 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Ligand-induced conformational changes in the capping subdomain of a bacterial old yellow enzyme homologue and conserved sequence fingerprints provide new insights into substrate binding.
J.Biol.Chem., 281, 2006
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2GQ8
 | | Structure of SYE1, an OYE homologue from S. ondeidensis, in complex with p-hydroxyacetophenone | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FLAVIN MONONUCLEOTIDE, P-HYDROXYACETOPHENONE, ... | | Authors: | Savvides, S.N, van den Hemel, D. | | Deposit date: | 2006-04-20 | | Release date: | 2006-07-25 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Ligand-induced conformational changes in the capping subdomain of a bacterial old yellow enzyme homologue and conserved sequence fingerprints provide new insights into substrate binding.
J.Biol.Chem., 281, 2006
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2GOU
 | | Structure of wild type, oxidized SYE1, an OYE homologue from S. oneidensis | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, FLAVIN MONONUCLEOTIDE, ... | | Authors: | Savvides, S.N, van den Hemel, D. | | Deposit date: | 2006-04-14 | | Release date: | 2006-07-25 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Ligand-induced conformational changes in the capping subdomain of a bacterial old yellow enzyme homologue and conserved sequence fingerprints provide new insights into substrate binding.
J.Biol.Chem., 281, 2006
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2GQA
 | | Structure of NADH-reduced SYE1, an OYE homologue from S. oneidensis | | Descriptor: | FLAVIN MONONUCLEOTIDE, SULFATE ION, oxidoreductase, ... | | Authors: | Savvides, S.N, van den Hemel, D. | | Deposit date: | 2006-04-20 | | Release date: | 2006-07-25 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Ligand-induced conformational changes in the capping subdomain of a bacterial old yellow enzyme homologue and conserved sequence fingerprints provide new insights into substrate binding.
J.Biol.Chem., 281, 2006
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7OX6
 | | Solution structure of human interleukin-9 | | Descriptor: | Interleukin-9 | | Authors: | Savvides, S.N, Tripsianes, K, De Vos, T, Papageorgiou, A, Evangelidis, T. | | Deposit date: | 2021-06-22 | | Release date: | 2022-12-28 | | Last modified: | 2023-01-11 | | Method: | SOLUTION NMR | | Cite: | Structural basis for the mechanism and antagonism of receptor signaling mediated by Interleukin-9 (IL-9)
Biorxiv, 2022
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8C7L
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8C7E
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8C6Z
 | | necrotic enteritis associated Clostridium p. chitinase F8UNI4 in complex with inhibitor bisdionin C | | Descriptor: | 1,1'-PROPANE-1,3-DIYLBIS(3,7-DIMETHYL-3,7-DIHYDRO-1H-PURINE-2,6-DIONE), CADMIUM ION, COBALT (II) ION, ... | | Authors: | Bloch, Y, Savvides, S.N. | | Deposit date: | 2023-01-12 | | Release date: | 2023-05-31 | | Last modified: | 2024-06-19 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Contribution and structural characterization of Chitinases to Clostridium perfringens Pathogenesis in Broilers
To Be Published
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7R3N
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7AL7
 | | The Crystal Structure of Human IL-18 in Complex With Human IL-18 Binding Protein | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutathione S-transferase class-mu 26 kDa isozyme,Interleukin-18, Interleukin-18-binding protein | | Authors: | Detry, S, Andries, J, Bloch, Y, Clancy, D, Savvides, S.N. | | Deposit date: | 2020-10-05 | | Release date: | 2022-04-20 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.801 Å) | | Cite: | Structural basis of human IL-18 sequestration by the decoy receptor IL-18 binding protein in inflammation and tumor immunity.
J.Biol.Chem., 298, 2022
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2A8Z
 | | Structure Of A Cold-Adapted Family 8 Xylanase | | Descriptor: | endo-1,4-beta-xylanase | | Authors: | Collins, T, De Vos, D, Hoyoux, A, Savvides, S.N, Gerday, C, Van Beeumen, J, Feller, G. | | Deposit date: | 2005-07-10 | | Release date: | 2005-12-20 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Study of the active site residues of a glycoside hydrolase family 8 xylanase.
J.Mol.Biol., 354, 2005
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1ZZH
 | | Structure of the fully oxidized di-heme cytochrome c peroxidase from R. capsulatus | | Descriptor: | CALCIUM ION, HEME C, ZINC ION, ... | | Authors: | De Smet, L, Savvides, S.N, Van Horen, E, Pettigrew, G, Van Beeumen, J.J. | | Deposit date: | 2005-06-14 | | Release date: | 2005-11-29 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural and mutagenesis studies on the cytochrome c peroxidase from Rhodobacter capsulatus provide new insights into structure-function relationships of bacterial di-heme peroxidases
J.Biol.Chem., 281, 2006
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2B4F
 | | Structure Of A Cold-Adapted Family 8 Xylanase in complex with substrate | | Descriptor: | beta-D-xylopyranose-(1-4)-beta-D-xylopyranose-(1-4)-beta-D-xylopyranose-(1-4)-beta-D-xylopyranose-(1-4)-beta-D-xylopyranose, endo-1,4-beta-xylanase | | Authors: | De Vos, D, Collins, T, Savvides, S.N, Feller, G, Van Beeumen, J.J. | | Deposit date: | 2005-09-23 | | Release date: | 2006-09-05 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Oligosaccharide binding in family 8 glycosidases: crystal structures of active-site mutants of the beta-1,4-xylanase pXyl from Pseudoaltermonas haloplanktis TAH3a in complex with substrate and product.
Biochemistry, 45, 2006
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4WRL
 | | Structure of the human CSF-1:CSF-1R complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Macrophage colony-stimulating factor 1, Macrophage colony-stimulating factor 1 receptor, ... | | Authors: | Felix, J, De Munck, S, Elegheert, J, Savvides, S.N. | | Deposit date: | 2014-10-24 | | Release date: | 2015-08-12 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.802 Å) | | Cite: | Structure and Assembly Mechanism of the Signaling Complex Mediated by Human CSF-1.
Structure, 23, 2015
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4WRM
 | | Structure of the human CSF-1:CSF-1R complex | | Descriptor: | Macrophage colony-stimulating factor 1, Macrophage colony-stimulating factor 1 receptor | | Authors: | Felix, J, De Munck, S, Elegheert, J, Savvides, S.N. | | Deposit date: | 2014-10-24 | | Release date: | 2015-08-12 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (6.853 Å) | | Cite: | Structure and Assembly Mechanism of the Signaling Complex Mediated by Human CSF-1.
Structure, 23, 2015
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3QS9
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3QS7
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