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3WZZ
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CRYSTAL STRUCTURE OF PIP4KIIBETA
Descriptor:Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
Authors:Takeuchi, K., Lo, Y.H., Sumita, K., Senda, M., Terakawa, J., Dimitoris, A., Locasale, J.W., Sasaki, M., Yoshino, H., Zhang, Y., Kahoud, E.R., Takano, T., Yokota, T., Emerling, B., Asara, J.A., Ishida, T., Shimada, I., Daikoku, T., Cantley, L.C., Senda, T., Sasaki, A.T.
Deposit date:2014-10-08
Release date:2015-10-14
Last modified:2016-02-03
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The Lipid Kinase PI5P4K beta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis
Mol.Cell, 61, 2016
3X01
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CRYSTAL STRUCTURE OF PIP4KIIBETA COMPLEX WITH AMP
Descriptor:Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, ADENOSINE MONOPHOSPHATE
Authors:Takeuchi, K., Lo, Y.H., Sumita, K., Senda, M., Terakawa, J., Dimitoris, A., Locasale, J.W., Sasaki, M., Yoshino, H., Zhang, Y., Kahoud, E.R., Takano, T., Yokota, T., Emerling, B., Asara, J.A., Ishida, T., Shimada, I., Daikoku, T., Cantley, L.C., Senda, T., Sasaki, A.T.
Deposit date:2014-10-09
Release date:2015-10-14
Last modified:2016-02-03
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:The Lipid Kinase PI5P4K beta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis
Mol.Cell, 61, 2016
3X02
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CRYSTAL STRUCTURE OF PIP4KIIBETA COMPLEX WITH GMP
Descriptor:Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, GUANOSINE-5'-MONOPHOSPHATE
Authors:Takeuchi, K., Lo, Y.H., Sumita, K., Senda, M., Terakawa, J., Dimitoris, A., Locasale, J.W., Sasaki, M., Yoshino, H., Zhang, Y., Kahoud, E.R., Takano, T., Yokota, T., Emerling, B., Asara, J.A., Ishida, T., Shimada, I., Daikoku, T., Cantley, L.C., Senda, T., Sasaki, A.T.
Deposit date:2014-10-09
Release date:2015-10-14
Last modified:2016-02-03
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:The Lipid Kinase PI5P4K beta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis
Mol.Cell, 61, 2016
3X03
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CRYSTAL STRUCTURE OF PIP4KIIBETA COMPLEX WITH AMPPNP
Descriptor:Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Takeuchi, K., Lo, Y.H., Sumita, K., Senda, M., Terakawa, J., Dimitoris, A., Locasale, J.W., Sasaki, M., Yoshino, H., Zhang, Y., Kahoud, E.R., Takano, T., Yokota, T., Emerling, B., Asara, J.A., Ishida, T., Shimada, I., Daikoku, T., Cantley, L.C., Senda, T., Sasaki, A.T.
Deposit date:2014-10-09
Release date:2015-10-14
Last modified:2016-02-03
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The Lipid Kinase PI5P4K beta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis
Mol.Cell, 61, 2016
3X04
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CRYSTAL STRUCTURE OF PIP4KIIBETA COMPLEX WITH GMPPNP
Descriptor:Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Takeuchi, K., Lo, Y.H., Sumita, K., Senda, M., Terakawa, J., Dimitoris, A., Locasale, J.W., Sasaki, M., Yoshino, H., Zhang, Y., Kahoud, E.R., Takano, T., Yokota, T., Emerling, B., Asara, J.A., Ishida, T., Shimada, I., Daikoku, T., Cantley, L.C., Senda, T., Sasaki, A.T.
Deposit date:2014-10-09
Release date:2015-10-14
Last modified:2016-02-03
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The Lipid Kinase PI5P4K beta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis
Mol.Cell, 61, 2016
3X05
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CRYSTAL STRUCTURE OF PIP4KIIBETA T201M COMPLEX WITH AMP
Descriptor:Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, ADENOSINE MONOPHOSPHATE
Authors:Takeuchi, K., Lo, Y.H., Sumita, K., Senda, M., Terakawa, J., Dimitoris, A., Locasale, J.W., Sasaki, M., Yoshino, H., Zhang, Y., Kahoud, E.R., Takano, T., Yokota, T., Emerling, B., Asara, J.A., Ishida, T., Shimada, I., Daikoku, T., Cantley, L.C., Senda, T., Sasaki, A.T.
Deposit date:2014-10-09
Release date:2015-10-14
Last modified:2016-02-03
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The Lipid Kinase PI5P4K beta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis
Mol.Cell, 61, 2016
3X06
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CRYSTAL STRUCTURE OF PIP4KIIBETA T201M COMPLEX WITH GMP
Descriptor:Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, GUANOSINE-5'-MONOPHOSPHATE
Authors:Takeuchi, K., Lo, Y.H., Sumita, K., Senda, M., Terakawa, J., Dimitoris, A., Locasale, J.W., Sasaki, M., Yoshino, H., Zhang, Y., Kahoud, E.R., Takano, T., Yokota, T., Emerling, B., Asara, J.A., Ishida, T., Shimada, I., Daikoku, T., Cantley, L.C., Senda, T., Sasaki, A.T.
Deposit date:2014-10-09
Release date:2015-10-14
Last modified:2016-02-03
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:The Lipid Kinase PI5P4K beta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis
Mol.Cell, 61, 2016
3X07
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CRYSTAL STRUCTURE OF PIP4KIIBETA N203A COMPLEX WITH AMP
Descriptor:Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, ADENOSINE MONOPHOSPHATE
Authors:Takeuchi, K., Lo, Y.H., Sumita, K., Senda, M., Terakawa, J., Dimitoris, A., Locasale, J.W., Sasaki, M., Yoshino, H., Zhang, Y., Kahoud, E.R., Takano, T., Yokota, T., Emerling, B., Asara, J.A., Ishida, T., Shimada, I., Daikoku, T., Cantley, L.C., Senda, T., Sasaki, A.T.
Deposit date:2014-10-09
Release date:2015-10-14
Last modified:2016-02-03
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The Lipid Kinase PI5P4K beta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis
Mol.Cell, 61, 2016
3X08
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CRYSTAL STRUCTURE OF PIP4KIIBETA N203A COMPLEX WITH GMP
Descriptor:Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, GUANOSINE-5'-MONOPHOSPHATE
Authors:Takeuchi, K., Lo, Y.H., Sumita, K., Senda, M., Terakawa, J., Dimitoris, A., Locasale, J.W., Sasaki, M., Yoshino, H., Zhang, Y., Kahoud, E.R., Takano, T., Yokota, T., Emerling, B., Asara, J.A., Ishida, T., Shimada, I., Daikoku, T., Cantley, L.C., Senda, T., Sasaki, A.T.
Deposit date:2014-10-09
Release date:2015-10-14
Last modified:2016-02-03
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:The Lipid Kinase PI5P4K beta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis
Mol.Cell, 61, 2016
3X09
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CRYSTAL STRUCTURE OF PIP4KIIBETA F205L COMPLEX WITH AMP
Descriptor:Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, ADENOSINE MONOPHOSPHATE
Authors:Takeuchi, K., Lo, Y.H., Sumita, K., Senda, M., Terakawa, J., Dimitoris, A., Locasale, J.W., Sasaki, M., Yoshino, H., Zhang, Y., Kahoud, E.R., Takano, T., Yokota, T., Emerling, B., Asara, J.A., Ishida, T., Shimada, I., Daikoku, T., Cantley, L.C., Senda, T., Sasaki, A.T.
Deposit date:2014-10-09
Release date:2015-10-14
Last modified:2016-02-03
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The Lipid Kinase PI5P4K beta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis
Mol.Cell, 61, 2016
3X0A
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CRYSTAL STRUCTURE OF PIP4KIIBETA F205L COMPLEX WITH GMP
Descriptor:Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, GUANOSINE-5'-MONOPHOSPHATE
Authors:Takeuchi, K., Lo, Y.H., Sumita, K., Senda, M., Terakawa, J., Dimitoris, A., Locasale, J.W., Sasaki, M., Yoshino, H., Zhang, Y., Kahoud, E.R., Takano, T., Yokota, T., Emerling, B., Asara, J.A., Ishida, T., Shimada, I., Daikoku, T., Cantley, L.C., Senda, T., Sasaki, A.T.
Deposit date:2014-10-09
Release date:2015-10-14
Last modified:2016-02-03
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The Lipid Kinase PI5P4K beta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis
Mol.Cell, 61, 2016
3X0B
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CRYSTAL STRUCTURE OF PIP4KIIBETA I368A COMPLEX WITH AMP
Descriptor:Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, ADENOSINE MONOPHOSPHATE
Authors:Takeuchi, K., Lo, Y.H., Sumita, K., Senda, M., Terakawa, J., Dimitoris, A., Locasale, J.W., Sasaki, M., Yoshino, H., Zhang, Y., Kahoud, E.R., Takano, T., Yokota, T., Emerling, B., Asara, J.A., Ishida, T., Shimada, I., Daikoku, T., Cantley, L.C., Senda, T., Sasaki, A.T.
Deposit date:2014-10-09
Release date:2015-10-14
Last modified:2016-02-03
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The Lipid Kinase PI5P4K beta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis
Mol.Cell, 61, 2016
3X0C
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CRYSTAL STRUCTURE OF PIP4KIIBETA I368A COMPLEX WITH GMP
Descriptor:Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, GUANOSINE-5'-MONOPHOSPHATE
Authors:Takeuchi, K., Lo, Y.H., Sumita, K., Senda, M., Terakawa, J., Dimitoris, A., Locasale, J.W., Sasaki, M., Yoshino, H., Zhang, Y., Kahoud, E.R., Takano, T., Yokota, T., Emerling, B., Asara, J.A., Ishida, T., Shimada, I., Daikoku, T., Cantley, L.C., Senda, T., Sasaki, A.T.
Deposit date:2014-10-09
Release date:2015-10-14
Last modified:2016-02-03
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:The Lipid Kinase PI5P4K beta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis
Mol.Cell, 61, 2016
1IPB
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CRYSTAL STRUCTURE OF EUKARYOTIC INITIATION FACTOR 4E COMPLEXED WITH 7-METHYL GPPPA
Descriptor:EUKARYOTIC TRANSLATION INITIATION FACTOR 4E, P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE
Authors:Tomoo, K., Shen, X., Okabe, K., Nozoe, Y., Fukuhara, S., Morino, S., Ishida, T., Taniguchi, T., Hasegawa, H., Terashima, A., Sasaki, M., Katsuya, Y., Kitamura, K., Miyoshi, H., Ishikawa, M., Miura, K.
Deposit date:2001-05-08
Release date:2002-05-08
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of 7-methylguanosine 5'-triphosphate (m(7)GTP)- and P(1)-7-methylguanosine-P(3)-adenosine-5',5'-triphosphate (m(7)GpppA)-bound human full-length eukaryotic initiation factor 4E: biological importance of the C-terminal flexible region
BIOCHEM.J., 362, 2002
1IPC
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CRYSTAL STRUCTURE OF EUKARYOTIC INITIATION FACTOR 4E COMPLEXED WITH 7-METHYL GTP
Descriptor:EUKARYOTIC TRANSLATION INITIATION FACTOR 4E, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE
Authors:Tomoo, K., Shen, X., Okabe, K., Nozoe, Y., Fukuhara, S., Morino, S., Ishida, T., Taniguchi, T., Hasegawa, H., Terashima, A., Sasaki, M., Katsuya, Y., Kitamura, K., Miyoshi, H., Ishikawa, M., Miura, K.
Deposit date:2001-05-08
Release date:2002-05-08
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of 7-methylguanosine 5'-triphosphate (m(7)GTP)- and P(1)-7-methylguanosine-P(3)-adenosine-5',5'-triphosphate (m(7)GpppA)-bound human full-length eukaryotic initiation factor 4E: biological importance of the C-terminal flexible region
BIOCHEM.J., 362, 2002
2ZNS
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CRYSTAL STRUCTURE OF THE LIGAND-BINDING CORE OF THE HUMAN IONOTROPIC GLUTAMATE RECEPTOR, GLUR5, IN COMPLEX WITH GLUTAMATE
Descriptor:Glutamate receptor, ionotropic kainate 1, GLUTAMIC ACID
Authors:Unno, M., Sasaki, M., Ikeda-Saito, M.
Deposit date:2008-05-01
Release date:2009-05-05
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Binding and Selectivity of the Marine Toxin Neodysiherbaine A and Its Synthetic Analogues to GluK1 and GluK2 Kainate Receptors.
J.Mol.Biol., 413, 2011
2ZNT
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CRYSTAL STRUCTURE OF THE LIGAND-BINDING CORE OF THE HUMAN IONOTROPIC GLUTAMATE RECEPTOR, GLUR5, IN COMPLEX WITH A NOVEL SELECTIVE AGONIST, DYSIHERBAINE
Descriptor:Glutamate receptor, ionotropic kainate 1, (2R,3aR,6S,7R,7aR)-2-[(2S)-2-amino-2-carboxyethyl]-6-hydroxy-7-(methylamino)hexahydro-2H-furo[3,2-b]pyran-2-carboxylic acid, ...
Authors:Unno, M., Sasaki, M., Ikeda-Saito, M.
Deposit date:2008-05-01
Release date:2009-05-05
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Binding and Selectivity of the Marine Toxin Neodysiherbaine A and Its Synthetic Analogues to GluK1 and GluK2 Kainate Receptors.
J.Mol.Biol., 413, 2011
2ZNU
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CRYSTAL STRUCTURE OF THE LIGAND-BINDING CORE OF THE HUMAN IONOTROPIC GLUTAMATE RECEPTOR, GLUR5, IN COMPLEX WITH A NOVEL SELECTIVE AGONIST, NEODYSIHERBAINE A
Descriptor:Glutamate receptor, ionotropic kainate 1, (2R,3aR,6R,7R,7aR)-2-[(2S)-2-amino-2-carboxyethyl]-6,7-dihydroxyhexahydro-2H-furo[3,2-b]pyran-2-carboxylic acid, ...
Authors:Unno, M., Sasaki, M., Ikeda-Saito, M.
Deposit date:2008-05-01
Release date:2009-05-05
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Binding and Selectivity of the Marine Toxin Neodysiherbaine A and Its Synthetic Analogues to GluK1 and GluK2 Kainate Receptors.
J.Mol.Biol., 413, 2011
3FUZ
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CRYSTAL STRUCTURE OF THE HUMAN GLUTAMATE RECEPTOR, GLUR5, LIGAND-BINDING CORE IN COMPLEX WITH L-GLUTAMATE IN SPACE GROUP P1
Descriptor:Glutamate receptor, ionotropic kainate 1, GLUTAMIC ACID, ...
Authors:Unno, M., Sasaki, M., Ikeda-Saito, M.
Deposit date:2009-01-15
Release date:2010-01-19
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Binding and Selectivity of the Marine Toxin Neodysiherbaine A and Its Synthetic Analogues to GluK1 and GluK2 Kainate Receptors.
J.Mol.Biol., 413, 2011
3FV1
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CRYSTAL STRUCTURE OF THE HUMAN GLUTAMATE RECEPTOR, GLUR5, LIGAND-BINDING CORE IN COMPLEX WITH DYSIHERBAINE IN SPACE GROUP P1
Descriptor:Glutamate receptor, ionotropic kainate 1, (2R,3aR,6S,7R,7aR)-2-[(2S)-2-amino-2-carboxyethyl]-6-hydroxy-7-(methylamino)hexahydro-2H-furo[3,2-b]pyran-2-carboxylic acid, ...
Authors:Unno, M., Sasaki, M., Ikeda-Saito, M.
Deposit date:2009-01-15
Release date:2010-01-19
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Binding and Selectivity of the Marine Toxin Neodysiherbaine A and Its Synthetic Analogues to GluK1 and GluK2 Kainate Receptors.
J.Mol.Biol., 413, 2011
3FV2
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CRYSTAL STRUCTURE OF THE HUMAN GLUTAMATE RECEPTOR, GLUR5, LIGAND-BINDING CORE IN COMPLEX WITH NEODYSIHERBAINE A IN SPACE GROUP P1
Descriptor:Glutamate receptor, ionotropic kainate 1, GLYCEROL, ...
Authors:Unno, M., Sasaki, M., Ikeda-Saito, M.
Deposit date:2009-01-15
Release date:2010-01-19
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Binding and Selectivity of the Marine Toxin Neodysiherbaine A and Its Synthetic Analogues to GluK1 and GluK2 Kainate Receptors.
J.Mol.Biol., 413, 2011
3FVG
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CRYSTAL STRUCTURE OF THE HUMAN GLUTAMATE RECEPTOR, GLUR5, LIGAND-BINDING CORE IN COMPLEX WITH MSVIII-19 IN SPACE GROUP P1
Descriptor:Glutamate receptor, ionotropic kainate 1, GLYCEROL, ...
Authors:Unno, M., Sasaki, M., Ikeda-Saito, M.
Deposit date:2009-01-15
Release date:2010-01-19
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Binding and Selectivity of the Marine Toxin Neodysiherbaine A and Its Synthetic Analogues to GluK1 and GluK2 Kainate Receptors.
J.Mol.Biol., 413, 2011
3FVK
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CRYSTAL STRUCTURE OF THE HUMAN GLUTAMATE RECEPTOR, GLUR5, LIGAND-BINDING CORE IN COMPLEX WITH 8-DEOXY-NEODYSIHERBAINE A IN SPACE GROUP P1
Descriptor:Glutamate receptor, ionotropic kainate 1, GLYCEROL, ...
Authors:Unno, M., Sasaki, M., Ikeda-Saito, M.
Deposit date:2009-01-15
Release date:2010-01-19
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Binding and Selectivity of the Marine Toxin Neodysiherbaine A and Its Synthetic Analogues to GluK1 and GluK2 Kainate Receptors.
J.Mol.Biol., 413, 2011
3FVN
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CRYSTAL STRUCTURE OF THE HUMAN GLUTAMATE RECEPTOR, GLUR5, LIGAND-BINDING CORE IN COMPLEX WITH 9-DEOXY-NEODYSIHERBAINE A IN SPACE GROUP P1
Descriptor:Glutamate receptor, ionotropic kainate 1, GLYCEROL, ...
Authors:Unno, M., Sasaki, M., Ikeda-Saito, M.
Deposit date:2009-01-16
Release date:2010-01-19
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Binding and Selectivity of the Marine Toxin Neodysiherbaine A and Its Synthetic Analogues to GluK1 and GluK2 Kainate Receptors.
J.Mol.Biol., 413, 2011
3FVO
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CRYSTAL STRUCTURE OF THE HUMAN GLUTAMATE RECEPTOR, GLUR5, LIGAND-BINDING CORE IN COMPLEX WITH 8-EPI-NEODYSIHERBAINE A IN SPACE GROUP P1
Descriptor:Glutamate receptor, ionotropic kainate 1, GLYCEROL, ...
Authors:Unno, M., Sasaki, M., Ikeda-Saito, M.
Deposit date:2009-01-16
Release date:2010-01-19
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal Structures of Human GluR5 Ligand-Binding Core in Complexes with Novel Marine-Derived Toxins, Dysiherbaine and Neodysiherbaine A, and Their Analogues
To be Published
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