Author results

1JAN
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COMPLEX OF PRO-LEU-GLY-HYDROXYLAMINE WITH THE CATALYTIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (PHE79 FORM)
Descriptor:MATRIX METALLO PROTEINASE-8 (PHE79 FORM), PRO-LEU-GLY-HYDROXYLAMINE INHIBITOR, CALCIUM ION, ...
Authors:Reinemer, P., Grams, F., Huber, R., Kleine, T., Schnierer, S., Pieper, M., Tschesche, H., Bode, W.
Deposit date:1996-03-11
Release date:1996-07-11
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural implications for the role of the N terminus in the 'superactivation' of collagenases. A crystallographic study.
FEBS Lett., 338, 1994
1GNW
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STRUCTURE OF GLUTATHIONE S-TRANSFERASE
Descriptor:GLUTATHIONE S-TRANSFERASE, S-HEXYLGLUTATHIONE
Authors:Reinemer, P., Prade, L., Hof, P., Neuefeind, T., Huber, R., Palme, K., Bartunik, H.D., Bieseler, B.
Deposit date:1996-09-15
Release date:1997-09-17
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Three-dimensional structure of glutathione S-transferase from Arabidopsis thaliana at 2.2 A resolution: structural characterization of herbicide-conjugating plant glutathione S-transferases and a novel active site architecture.
J.Mol.Biol., 255, 1996
1GSS
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THREE-DIMENSIONAL STRUCTURE OF CLASS PI GLUTATHIONE S-TRANSFERASE FROM HUMAN PLACENTA IN COMPLEX WITH S-HEXYLGLUTATHIONE AT 2.8 ANGSTROMS RESOLUTION
Descriptor:GLUTATHIONE S-TRANSFERASE, L-gamma-glutamyl-S-hexyl-L-cysteinylglycine
Authors:Reinemer, P., Dirr, H.W., Ladenstein, R., Lobello, M., Federici, G., Huber, R., Parker, M.W.
Deposit date:1992-05-28
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Three-dimensional structure of class pi glutathione S-transferase from human placenta in complex with S-hexylglutathione at 2.8 A resolution.
J.Mol.Biol., 227, 1992
2GSR
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STRUCTURE OF PORCINE CLASS PI GLUTATHIONE S-TRANSFERASE
Descriptor:CLASS PI GST GLUTATHIONE S-TRANSFERASE, GLUTATHIONE SULFONIC ACID
Authors:Reinemer, P., Dirr, H.W., Huber, R.
Deposit date:1996-03-21
Release date:1996-11-08
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Refined crystal structure of porcine class Pi glutathione S-transferase (pGST P1-1) at 2.1 A resolution.
J.Mol.Biol., 243, 1994
1JAO
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COMPLEX OF 3-MERCAPTO-2-BENZYLPROPANOYL-ALA-GLY-NH2 WITH THE CATALYTIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM)
Descriptor:MATRIX METALLO PROTEINASE-8 (MET80 FORM), N-[(2S)-2-benzyl-3-sulfanylpropanoyl]-L-alanylglycinamide, CALCIUM ION, ...
Authors:Grams, F., Reinemer, P., Powers, J.C., Kleine, T., Piper, M., Tschesche, H., Huber, R., Bode, W.
Deposit date:1996-03-11
Release date:1996-07-11
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:X-ray structures of human neutrophil collagenase complexed with peptide hydroxamate and peptide thiol inhibitors. Implications for substrate binding and rational drug design.
Eur.J.Biochem., 228, 1995
1JAP
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COMPLEX OF PRO-LEU-GLY-HYDROXYLAMINE WITH THE CATALYTIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM)
Descriptor:MATRIX METALLO PROTEINASE-8 (MET80 FORM), PRO-LEU-GLY-HYDROXYLAMINE, CALCIUM ION, ...
Authors:Bode, W., Reinemer, P., Huber, R., Kleine, T., Schnierer, S., Tschesche, H.
Deposit date:1996-03-11
Release date:1996-07-11
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:The X-ray crystal structure of the catalytic domain of human neutrophil collagenase inhibited by a substrate analogue reveals the essentials for catalysis and specificity.
EMBO J., 13, 1994
1JAQ
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COMPLEX OF 1-HYDROXYLAMINE-2-ISOBUTYLMALONYL-ALA-GLY-NH2 WITH THE CATALYTIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM)
Descriptor:MATRIX METALLO PROTEINASE-8 (MET80 FORM), CALCIUM ION, N-[(2R)-2-(hydroxycarbamoyl)-4-methylpentanoyl]-L-alanylglycinamide, ...
Authors:Grams, F., Reinemer, P., Powers, J.C., Kleine, T., Piper, M., Tschesche, H., Huber, R., Bode, W.
Deposit date:1996-03-11
Release date:1996-07-11
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:X-ray structures of human neutrophil collagenase complexed with peptide hydroxamate and peptide thiol inhibitors. Implications for substrate binding and rational drug design.
Eur.J.Biochem., 228, 1995
1IAR
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INTERLEUKIN-4 / RECEPTOR ALPHA CHAIN COMPLEX
Descriptor:PROTEIN (INTERLEUKIN-4), PROTEIN (INTERLEUKIN-4 RECEPTOR ALPHA CHAIN)
Authors:Hage, T., Sebald, W., Reinemer, P.
Deposit date:1999-02-25
Release date:2000-03-03
Last modified:2019-11-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface.
Cell(Cambridge,Mass.), 97, 1999
1AW9
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STRUCTURE OF GLUTATHIONE S-TRANSFERASE III IN APO FORM
Descriptor:GLUTATHIONE S-TRANSFERASE III, CADMIUM ION
Authors:Neuefeind, T., Huber, R., Reinemer, P., Knaeblein, J.
Deposit date:1997-10-13
Release date:1998-10-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Cloning, sequencing, crystallization and X-ray structure of glutathione S-transferase-III from Zea mays var. mutin: a leading enzyme in detoxification of maize herbicides.
J.Mol.Biol., 274, 1997
1TSP
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CRYSTAL STRUCTURE OF P22 TAILSPIKE PROTEIN: INTERDIGITATED SUBUNITS IN A THERMOSTABLE TRIMER
Descriptor:TAILSPIKE-PROTEIN
Authors:Steinbacher, S., Seckler, R., Miller, S., Steipe, B., Huber, R., Reinemer, P.
Deposit date:1994-06-16
Release date:1995-09-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of P22 tailspike protein: interdigitated subunits in a thermostable trimer.
Science, 265, 1994
2W26
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FACTOR XA IN COMPLEX WITH BAY59-7939
Descriptor:ACTIVATED FACTOR XA HEAVY CHAIN, 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide, CALCIUM ION
Authors:Roehrig, S., Straub, A., Pohlmann, J., Lampe, T., Pernerstorfer, J., Schlemmer, K., Reinemer, P., Perzborn, E., Schaefer, M.
Deposit date:2008-10-24
Release date:2008-11-11
Last modified:2017-03-22
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Discovery of the Novel Antithrombotic Agent 5-Chloro-N-({(5S)-2-Oxo-3- [4-(3-Oxomorpholin-4-Yl)Phenyl]-1,3-Oxazolidin-5-Yl}Methyl)Thiophene-2- Carboxamide (Bay 59-7939): An Oral, Direct Factor Xa Inhibitor.
J.Med.Chem., 48, 2005
1MMB
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COMPLEX OF BB94 WITH THE CATALYTIC DOMAIN OF MATRIX METALLOPROTEINASE-8
Descriptor:MATRIX METALLOPROTEINASE-8, CALCIUM ION, ZINC ION, ...
Authors:Bode, W., Grams, F.
Deposit date:1995-08-23
Release date:1996-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure determination and analysis of human neutrophil collagenase complexed with a hydroxamate inhibitor.
Biochemistry, 34, 1995
1GNE
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THE THREE-DIMENSIONAL STRUCTURE OF GLUTATHIONE S-TRANSFERASE OF SCHISTOSOMA JAPONICUM FUSED WITH A CONSERVED NEUTRALIZING EPITOPE ON GP41 OF HUMAN IMMUNODEFICIENCY VIRUS TYPE 1
Descriptor:GLUTATHIONE S-TRANSFERASE, GLUTATHIONE
Authors:Lim, K., Ho, J.X., Keeling, K., Gilliland, G.L., Ji, X., Ruker, F., Carter, D.C.
Deposit date:1994-06-16
Release date:1994-11-30
Last modified:2019-08-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Three-dimensional structure of Schistosoma japonicum glutathione S-transferase fused with a six-amino acid conserved neutralizing epitope of gp41 from HIV.
Protein Sci., 3, 1994
5IWG
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HDAC2 WITH LIGAND BRD4884
Descriptor:Histone deacetylase 2, ZINC ION, CALCIUM ION, ...
Authors:Steinbacher, S.
Deposit date:2016-03-22
Release date:2016-08-31
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors.
Bioorg.Med.Chem., 24, 2016
5IX0
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HDAC2 WITH LIGAND BRD7232
Descriptor:Histone deacetylase 2, ZINC ION, CALCIUM ION, ...
Authors:Steinbacher, S.
Deposit date:2016-03-23
Release date:2016-08-31
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors.
Bioorg.Med.Chem., 24, 2016
1GUH
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STRUCTURE DETERMINATION AND REFINEMENT OF HUMAN ALPHA CLASS GLUTATHIONE TRANSFERASE A1-1, AND A COMPARISON WITH THE MU AND PI CLASS ENZYMES
Descriptor:GLUTATHIONE S-TRANSFERASE A1-1, S-BENZYL-GLUTATHIONE
Authors:Sinning, I., Kleywegt, G.J., Jones, T.A.
Deposit date:1993-02-24
Release date:1993-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure determination and refinement of human alpha class glutathione transferase A1-1, and a comparison with the Mu and Pi class enzymes.
J.Mol.Biol., 232, 1993
1IAG
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FIRST STRUCTURE OF A SNAKE VENOM METALLOPROTEINASE: A PROTOTYPE FOR MATRIX METALLOPROTEINASES(SLASH)COLLAGENASES
Descriptor:ADAMALYSIN II, ZINC ION, CALCIUM ION, ...
Authors:Gomis-Rueth, F.-X., Bode, W.
Deposit date:1994-05-09
Release date:1994-08-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:First structure of a snake venom metalloproteinase: a prototype for matrix metalloproteinases/collagenases.
EMBO J., 12, 1993
2GAI
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STRUCTURE OF FULL LENGTH TOPOISOMERASE I FROM THERMOTOGA MARITIMA IN TRICLINIC CRYSTAL FORM
Descriptor:DNA topoisomerase I
Authors:Hansen, G.
Deposit date:2006-03-08
Release date:2006-04-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structure of Full Length Topoisomerase I from Thermotoga maritima
J.Mol.Biol., 358, 2006
2GAJ
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STRUCTURE OF FULL LENGTH TOPOISOMERASE I FROM THERMOTOGA MARITIMA IN MONOCLINIC CRYSTAL FORM
Descriptor:DNA topoisomerase I
Authors:Hansen, G.
Deposit date:2006-03-09
Release date:2006-04-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal Structure of Full Length Topoisomerase I from Thermotoga maritima
J.Mol.Biol., 358, 2006
3Q76
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STRUCTURE OF HUMAN NEUTROPHIL ELASTASE (UNCOMPLEXED)
Descriptor:Neutrophil elastase, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
Authors:Hansen, G., Niefind, K.
Deposit date:2011-01-04
Release date:2011-05-11
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.861 Å)
Cite:Unexpected active-site flexibility in the structure of human neutrophil elastase in complex with a new dihydropyrimidone inhibitor.
J.Mol.Biol., 409, 2011
3Q77
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STRUCTURE OF HUMAN NEUTROPHIL ELASTASE IN COMPLEX WITH A DIHYDROPYRIMIDONE INHIBITOR
Descriptor:Neutrophil elastase, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
Authors:Hansen, G., Niefind, K.
Deposit date:2011-01-04
Release date:2011-05-11
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.998 Å)
Cite:Unexpected active-site flexibility in the structure of human neutrophil elastase in complex with a new dihydropyrimidone inhibitor.
J.Mol.Biol., 409, 2011
1PMA
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PROTEASOME FROM THERMOPLASMA ACIDOPHILUM
Descriptor:PROTEASOME
Authors:Loewe, J., Stock, D., Jap, B., Zwickl, P., Baumeister, W., Huber, R.
Deposit date:1994-12-19
Release date:1996-06-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Crystal structure of the 20S proteasome from the archaeon T. acidophilum at 3.4 A resolution.
Science, 268, 1995
1ZS0
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CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN MMP-8 AND A PHOSPHONATE INHIBITOR (S-ENANTIOMER)
Descriptor:Neutrophil collagenase, CALCIUM ION, ZINC ION, ...
Authors:Pochetti, G., Gavuzzo, E., Campestre, C., Agamennone, M., Tortorella, P., Consalvi, V., Gallina, C., Hiller, O., Tschesche, H., Tucker, P.A., Mazza, F.
Deposit date:2005-05-23
Release date:2006-05-02
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Structural insight into the stereoselective inhibition of MMP-8 by enantiomeric sulfonamide phosphonates.
J.Med.Chem., 49, 2006
1ZVX
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CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN MMP-8 AND A PHOSPHONATE INHIBITOR (R-ENANTIOMER)
Descriptor:Neutrophil collagenase, CALCIUM ION, ZINC ION, ...
Authors:Pochetti, G., Gavuzzo, E., Campestre, C., Agamennone, M., Tortorella, P., Consalvi, V., Gallina, C., Hiller, O., Tschesche, H., Tucker, P.A., Mazza, F.
Deposit date:2005-06-03
Release date:2006-05-16
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Structural insight into the stereoselective inhibition of MMP-8 by enantiomeric sulfonamide phosphonates.
J.Med.Chem., 49, 2006
3PGT
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CRYSTAL STRUCTURE OF HGSTP1-1[I104] COMPLEXED WITH THE GSH CONJUGATE OF (+)-ANTI-BPDE
Descriptor:PROTEIN (GLUTATHIONE S-TRANSFERASE), SULFATE ION, 2-AMINO-4-[1-(CARBOXYMETHYL-CARBAMOYL)-2-(9-HYDROXY-7,8-DIOXO-7,8,9,10-TETRAHYDRO-BENZO[DEF]CHRYSEN-10-YLSULFANYL)-ETHYLCARBAMOYL]-BUTYRIC ACID, ...
Authors:Ji, X., Xiao, B.
Deposit date:1999-03-22
Release date:1999-09-01
Last modified:2019-11-13
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Structure and function of residue 104 and water molecules in the xenobiotic substrate-binding site in human glutathione S-transferase P1-1.
Biochemistry, 38, 1999
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