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1HCF
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CRYSTAL STRUCTURE OF TRKB-D5 BOUND TO NEUROTROPHIN-4/5
Descriptor:NEUROTROPHIN-4, BDNF/NT-3 GROWTH FACTORS RECEPTOR, SULFATE ION
Authors:Banfield, M.J., Naylor, R.L., Robertson, A.G.S., Allen, S.J., Dawbarn, D., Brady, R.L.
Deposit date:2001-05-03
Release date:2001-12-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Specificity in Trk-Receptor:Neurotrophin Interaction: The Crystal Structure of Trkb-D5 in Complex with Neurotrophin-4/5
Structure, 9, 2001
6HAL
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HUMAN CARBONMONOXY HEMOGLOBIN SFX DATASET
Descriptor:Hemoglobin subunit alpha, Hemoglobin subunit beta, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Doak, B., Gorel, A., Foucar, L., Barends, T.R.M., Gruenbein, M.L., Hilpert, M., Kloos, M., Nass Kovacs, G., Roome, C.M., Shoeman, R.L., Stricker, M., Tono, K., You, D., Ueda, K., Sherrell, D.A., Owen, R.L., Schlichting, I.
Deposit date:2018-08-07
Release date:2018-10-17
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystallography on a chip - without the chip: sheet-on-sheet sandwich.
Acta Crystallogr D Struct Biol, 74, 2018
1HDS
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MACROMOLECULAR STRUCTURE REFINEMENT BY RESTRAINED LEAST-SQUARES AND INTERACTIVE GRAPHICS AS APPLIED TO SICKLING DEER TYPE III HEMOGLOBIN
Descriptor:HEMOGLOBIN S (DEOXY) (ALPHA CHAIN), HEMOGLOBIN S (DEOXY) (BETA CHAIN), PROTOPORPHYRIN IX CONTAINING FE
Authors:Amma, E.L., Girling, R.L.
Deposit date:1979-10-01
Release date:1979-12-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Macromolecular Structure Refinement by Restrained Least-Squares and Interactive Graphics as Applied to Sickling Deer Type III Hemoglobin
Acta Crystallogr.,Sect.A, 36, 1980
1HFP
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COMPARISON OF TERNARY CRYSTAL COMPLEXES OF HUMAN DIHYDROFOLATE REDUCTASE WITH NADPH AND A CLASSICAL ANTITUMOR FUROPYRIMDINE
Descriptor:DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N-[4-[(2,4-DIAMINOFURO[2,3D]PYRIMIDIN-5-YL)METHYL]METHYLAMINO]-BENZOYL]-L-GLUTAMATE
Authors:Cody, V., Galitsky, N., Luft, J.R., Pangborn, W., Blakley, R.L., Gangjee, A.
Deposit date:1997-11-04
Release date:1998-01-28
Last modified:2013-12-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Comparison of ternary crystal complexes of F31 variants of human dihydrofolate reductase with NADPH and a classical antitumor furopyrimidine.
Anti-Cancer Drug Des., 13, 1998
1HFQ
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COMPARISON OF TERNARY CRYSTAL COMPLEXES OF HUMAN DIHYDROFOLATE REDUCTASE WITH NADPH AND A CLASSICAL ANTITUMOR FUROPYRIMDINE
Descriptor:DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N-[4-[(2,4-DIAMINOFURO[2,3D]PYRIMIDIN-5-YL)METHYL]METHYLAMINO]-BENZOYL]-L-GLUTAMATE
Authors:Cody, V., Galitsky, N., Luft, J.R., Pangborn, W., Blakley, R.L., Gangjee, A.
Deposit date:1997-11-04
Release date:1998-01-28
Last modified:2013-12-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Comparison of ternary crystal complexes of F31 variants of human dihydrofolate reductase with NADPH and a classical antitumor furopyrimidine.
Anti-Cancer Drug Des., 13, 1998
1HFR
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COMPARISON OF TERNARY CRYSTAL COMPLEXES OF HUMAN DIHYDROFOLATE REDUCTASE WITH NADPH AND A CLASSICAL ANTITUMOR FUROPYRIMDINE
Descriptor:DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N-[4-[(2,4-DIAMINOFURO[2,3D]PYRIMIDIN-5-YL)METHYL]METHYLAMINO]-BENZOYL]-L-GLUTAMATE
Authors:Cody, V., Galitsky, N., Luft, J.R., Pangborn, W., Blakley, R.L., Gangjee, A.
Deposit date:1997-11-04
Release date:1998-01-28
Last modified:2013-12-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Comparison of ternary crystal complexes of F31 variants of human dihydrofolate reductase with NADPH and a classical antitumor furopyrimidine.
Anti-Cancer Drug Des., 13, 1998
1BOZ
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STRUCTURE-BASED DESIGN AND SYNTHESIS OF LIPOPHILIC 2,4-DIAMINO-6-SUBSTITUTED QUINAZOLINES AND THEIR EVALUATION AS INHIBITORS OF DIHYDROFOLATE REDUCTASE AND POTENTIAL ANTITUMOR AGENTS
Descriptor:PROTEIN (DIHYDROFOLATE REDUCTASE), NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N6-(2,5-DIMETHOXY-BENZYL)-N6-METHYL-PYRIDO[2,3-D]PYRIMIDINE-2,4,6-TRIAMINE
Authors:Gangjee, A., Vidwans, A.P., Vasudevan, A., Queener, S.F., Kisliuk, R.L., Cody, V., Li, R., Galitsky, N., Luft, J.R., Pangborn, W.
Deposit date:1998-08-06
Release date:1998-08-12
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-based design and synthesis of lipophilic 2,4-diamino-6-substituted quinazolines and their evaluation as inhibitors of dihydrofolate reductases and potential antitumor agents.
J.Med.Chem., 41, 1998
1D2A
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CRYSTAL STRUCTURE OF A YEAST LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE (LTP1) COMPLEXED WITH THE ACTIVATOR ADENINE
Descriptor:TYROSINE PHOSPHATASE, PHOSPHATE ION, CHLORIDE ION, ...
Authors:Wang, S., Stauffacher, C.V., Van Etten, R.L.
Deposit date:1999-09-22
Release date:2000-03-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and mechanistic basis for the activation of a low-molecular weight protein tyrosine phosphatase by adenine.
Biochemistry, 39, 2000
1GGI
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CRYSTAL STRUCTURE OF AN HIV-1 NEUTRALIZING ANTIBODY 50.1 IN COMPLEX WITH ITS V3 LOOP PEPTIDE ANTIGEN
Descriptor:IGG2A 50.1 FAB (LIGHT CHAIN), IGG2A 50.1 FAB (HEAVY CHAIN), HIV-1 V3 LOOP PEPTIDE ANTIGEN
Authors:Stanfield, R.L., Rini, J.M., Wilson, I.A.
Deposit date:1993-04-02
Release date:1993-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of a human immunodeficiency virus type 1 neutralizing antibody, 50.1, in complex with its V3 loop peptide antigen.
Proc.Natl.Acad.Sci.USA, 90, 1993
1IF0
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PSEUDO-ATOMIC MODEL OF BACTERIOPHAGE HK97 PROCAPSID (PROHEAD II)
Descriptor:PROTEIN (MAJOR CAPSID PROTEIN GP5)
Authors:Conway, J.F., Wikoff, W.R., Cheng, N., Duda, R.L., Hendrix, R.W., Johnson, J.E., Steven, A.C.
Deposit date:2001-04-11
Release date:2001-05-02
Last modified:2011-07-13
Method:ELECTRON MICROSCOPY (12 Å)
Cite:Virus maturation involving large subunit rotations and local refolding.
Science, 292, 2001
1OHG
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STRUCTURE OF THE DSDNA BACTERIOPHAGE HK97 MATURE EMPTY CAPSID
Descriptor:MAJOR CAPSID PROTEIN, SULFATE ION, CHLORIDE ION
Authors:Helgstrand, C., Wikoff, W.R., Duda, R.L., Hendrix, R.W., Johnson, J.E., Liljas, L.
Deposit date:2003-05-26
Release date:2003-12-11
Last modified:2012-01-11
Method:X-RAY DIFFRACTION (3.45 Å)
Cite:The Refined Structure of a Protein Catenane: The Hk97 Bacteriophage Capsid at 3.44A Resolution
J.Mol.Biol., 334, 2003
2AJL
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X-RAY STRUCTURE OF NOVEL BIARYL-BASED DIPEPTIDYL PEPTIDASE IV INHIBITOR
Descriptor:Dipeptidyl peptidase 4, N-ACETYL-D-GLUCOSAMINE, 1-[2-(S)-AMINO-3-BIPHENYL-4-YL-PROPIONYL]-PYRROLIDINE-2-(S)-CARBONITRILE
Authors:Qiao, L., Baumann, C.A., Crysler, C.S., Ninan, N.S., Abad, M.C., Spurlino, J.C., DesJarlais, R.L., Kervinen, J., Neeper, M.P., Bayoumy, S.S.
Deposit date:2005-08-02
Release date:2005-11-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Discovery, SAR, and X-ray structure of novel biaryl-based dipeptidyl peptidase IV inhibitors
Bioorg.Med.Chem.Lett., 16, 2006
2HKX
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STRUCTURE OF COOA MUTANT (N127L/S128L) FROM CARBOXYDOTHERMUS HYDROGENOFORMANS
Descriptor:Carbon monoxide oxidation system transcription regulator CooA-1, PROTOPORPHYRIN IX CONTAINING FE, CARBON MONOXIDE
Authors:Lanz, N.D., Borjigin, M., Li, H., Kerby, R.L., Poulos, T.L., Roberts, G.P.
Deposit date:2006-07-05
Release date:2007-03-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure-based hypothesis on the activation of the CO-sensing transcription factor CooA.
Acta Crystallogr.,Sect.D, 63, 2007
6GF0
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LYSOZYME STRUCTURE DETERMINED FROM SFX DATA USING A SHEET-ON-SHEET CHIPLESS CHIP
Descriptor:Lysozyme C
Authors:Doak, R.B., Gorel, A., Foucar, L., Gruenbein, M.L., Hilpert, M., Kloos, M., Nass Kovacs, G., Roome, C., Shoeman, R.L., Stricker, M., Tono, K., You, D., Ueda, K., Sherrel, D., Owen, R., Barends, T.R.M., Schlichting, I.
Deposit date:2018-04-27
Release date:2018-10-17
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Crystallography on a chip - without the chip: sheet-on-sheet sandwich.
Acta Crystallogr D Struct Biol, 74, 2018
1A14
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COMPLEX BETWEEN NC10 ANTI-INFLUENZA VIRUS NEURAMINIDASE SINGLE CHAIN ANTIBODY WITH A 5 RESIDUE LINKER AND INFLUENZA VIRUS NEURAMINIDASE
Descriptor:NEURAMINIDASE, NC10 FV (HEAVY CHAIN), NC10 FV (LIGHT CHAIN), ...
Authors:Malby, R.L., Mccoy, A.J., Kortt, A.A., Hudson, P.J., Colman, P.M.
Deposit date:1997-12-21
Release date:1998-05-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Three-dimensional structures of single-chain Fv-neuraminidase complexes.
J.Mol.Biol., 279, 1998
1AM5
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THE CRYSTAL STRUCTURE AND PROPOSED AMINO ACID SEQUENCE OF A PEPSIN FROM ATLANTIC COD (GADUS MORHUA)
Descriptor:PEPSIN
Authors:Karlsen, S., Hough, E., Olsen, R.L.
Deposit date:1997-06-23
Release date:1997-12-24
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Structure and proposed amino-acid sequence of a pepsin from atlantic cod (Gadus morhua).
Acta Crystallogr.,Sect.D, 54, 1998
1BBJ
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CRYSTAL STRUCTURE OF A CHIMERIC FAB' FRAGMENT OF AN ANTIBODY BINDING TUMOUR CELLS
Descriptor:IGG4-KAPPA B72.3 FAB (LIGHT CHAIN), IGG4-KAPPA B72.3 FAB (HEAVY CHAIN)
Authors:Brady, R.L., Hubbard, R.E., Todd, R.J.
Deposit date:1992-04-30
Release date:1994-01-31
Last modified:2014-02-05
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal structure of a chimeric Fab' fragment of an antibody binding tumour cells.
J.Mol.Biol., 227, 1992
1BVH
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SOLUTION STRUCTURE OF A LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE
Descriptor:ACID PHOSPHATASE
Authors:Logan, T.M., Zhou, M.-M., Nettesheim, D.G., Meadows, R.P., Van Etten, R.L., Fesik, S.W.
Deposit date:1994-05-03
Release date:1994-07-31
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of a low molecular weight protein tyrosine phosphatase.
Biochemistry, 33, 1994
1BWC
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STRUCTURE OF HUMAN GLUTATHIONE REDUCTASE COMPLEXED WITH AJOENE INHIBITOR AND SUBVERSIVE SUBSTRATE
Descriptor:PROTEIN (GLUTATHIONE REDUCTASE), CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Gallwitz, H., Bonse, S., Martinez-Cruz, A., Schlichting, I., Schumacher, K., Krauth-Siegel, R.L.
Deposit date:1998-09-23
Release date:1999-07-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Ajoene is an inhibitor and subversive substrate of human glutathione reductase and Trypanosoma cruzi trypanothione reductase: crystallographic, kinetic, and spectroscopic studies.
J.Med.Chem., 42, 1999
1C0E
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ACTIVE SITE S19A MUTANT OF BOVINE HEART PHOSPHOTYROSYL PHOSPHATASE
Descriptor:PROTEIN (TYROSINE PHOSPHATASE (ORTHOPHOSPHORIC MONOESTER PHOSPHOHYDROLASE)), PHOSPHATE ION
Authors:Tabernero, L., Evans, B.N., Tishmack, P.A., Van Etten, R.L., Stauffacher, C.V.
Deposit date:1999-07-15
Release date:1999-09-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The structure of the bovine protein tyrosine phosphatase dimer reveals a potential self-regulation mechanism.
Biochemistry, 38, 1999
1CD2
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LIGAND INDUCED CONFORMATIONAL CHANGES IN THE CRYSTAL STRUCTURES OF PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE COMPLEXES WITH FOLATE AND NADP+
Descriptor:DIHYDROFOLATE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, FOLIC ACID
Authors:Cody, V., Galitsky, N., Luft, J.R., Pangborn, W., Blakley, R.L., Gangjee, A.
Deposit date:1999-03-05
Release date:2000-03-06
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Ligand-induced conformational changes in the crystal structures of Pneumocystis carinii dihydrofolate reductase complexes with folate and NADP+.
Biochemistry, 38, 1999
1CEQ
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CHLOROQUINE BINDS IN THE COFACTOR BINDING SITE OF PLASMODIUM FALCIPARUM LACTATE DEHYDROGENASE.
Descriptor:PROTEIN (L-LACTATE DEHYDROGENASE)
Authors:Read, J.A., Wilkinson, K.W., Tranter, R., Sessions, R.B., Brady, R.L.
Deposit date:1999-03-10
Release date:1999-03-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Chloroquine binds in the cofactor binding site of Plasmodium falciparum lactate dehydrogenase.
J.Biol.Chem., 274, 1999
1CET
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CHLOROQUINE BINDS IN THE COFACTOR BINDING SITE OF PLASMODIUM FALCIPARUM LACTATE DEHYDROGENASE.
Descriptor:PROTEIN (L-LACTATE DEHYDROGENASE), N4-(7-CHLORO-QUINOLIN-4-YL)-N1,N1-DIETHYL-PENTANE-1,4-DIAMINE
Authors:Read, J.A., Wilkinson, K.W., Tranter, R., Sessions, R.B., Brady, R.L.
Deposit date:1999-03-10
Release date:1999-03-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Chloroquine binds in the cofactor binding site of Plasmodium falciparum lactate dehydrogenase.
J.Biol.Chem., 274, 1999
1CLO
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ANTI-CARCINOEMBRYONIC ANTIGEN MONOCLONAL ANTIBODY A5B7
Descriptor:A5B7 MONOCLONAL ANTIBODY
Authors:Banfield, M.J., King, D.J., Mountain, A., Brady, R.L.
Deposit date:1996-05-01
Release date:1997-05-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:VL:VH domain rotations in engineered antibodies: crystal structures of the Fab fragments from two murine antitumor antibodies and their engineered human constructs.
Proteins, 29, 1997
1D1P
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CRYSTAL STRUCTURE OF A YEAST LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE (LTP1)
Descriptor:TYROSINE PHOSPHATASE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Wang, S., Tabernero, L., Zhang, M., Harms, E., Van Etten, R.L., Stauffacher, C.V.
Deposit date:1999-09-20
Release date:2000-03-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of a low-molecular weight protein tyrosine phosphatase from Saccharomyces cerevisiae and its complex with the substrate p-nitrophenyl phosphate.
Biochemistry, 39, 2000