3OOI
| Crystal Structure of Human Histone-Lysine N-methyltransferase NSD1 SET domain in Complex with S-adenosyl-L-methionine | Descriptor: | Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, S-ADENOSYLMETHIONINE, ... | Authors: | Qiao, Q, Wang, M, Xu, R.M. | Deposit date: | 2010-08-31 | Release date: | 2010-12-22 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | The structure of NSD1 reveals an autoregulatory mechanism underlying histone H3K36 methylation J.Biol.Chem., 286, 2010
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5W0Z
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5W0R
| Crystal structure of MBP fused activation-induced cytidine deaminase (AID) in complex with cacodylic acid | Descriptor: | CACODYLATE ION, CALCIUM ION, MBP fused activation-induced cytidine deaminase, ... | Authors: | Qiao, Q, Wang, L, Wu, H. | Deposit date: | 2017-05-31 | Release date: | 2017-08-16 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | AID Recognizes Structured DNA for Class Switch Recombination. Mol. Cell, 67, 2017
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5W1C
| Crystal structure of MBP fused activation-induced cytidine deaminase (AID) in complex with cytidine | Descriptor: | 4-AMINO-1-BETA-D-RIBOFURANOSYL-2(1H)-PYRIMIDINONE, CALCIUM ION, DNA (5'-D(*CP*TP*GP*GP*CP*CP*TP*TP*GP*AP*AP*C)-3'), ... | Authors: | Qiao, Q, Wang, L, Wu, H. | Deposit date: | 2017-06-02 | Release date: | 2017-08-16 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.18 Å) | Cite: | AID Recognizes Structured DNA for Class Switch Recombination. Mol. Cell, 67, 2017
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5W0U
| Crystal structure of MBP fused activation-induced cytidine deaminase (AID) in complex with dCMP | Descriptor: | 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE, CALCIUM ION, DNA (5'-D(*CP*TP*GP*GP*CP*CP*TP*TP*GP*AP*AP*C)-3'), ... | Authors: | Qiao, Q, Wang, L, Wu, H. | Deposit date: | 2017-05-31 | Release date: | 2017-08-16 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | AID Recognizes Structured DNA for Class Switch Recombination. Mol. Cell, 67, 2017
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5EX3
| Crystal structure of human SMYD3 in complex with a VEGFR1 peptide | Descriptor: | ACETIC ACID, Histone-lysine N-methyltransferase SMYD3, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Qiao, Q, Fu, W, Liu, N, Wang, M, Min, J, Zhu, B, Xu, R.M, Yang, N. | Deposit date: | 2015-11-23 | Release date: | 2016-03-09 | Last modified: | 2017-10-18 | Method: | X-RAY DIFFRACTION (2.408 Å) | Cite: | Structural Basis for Substrate Preference of SMYD3, a SET Domain-containing Protein Lysine Methyltransferase J.Biol.Chem., 291, 2016
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5EX0
| Crystal structure of human SMYD3 in complex with a MAP3K2 peptide | Descriptor: | ACETIC ACID, Histone-lysine N-methyltransferase SMYD3, MAP3K2 peptide, ... | Authors: | Fu, W, Liu, N, Qiao, Q, Wang, M, Min, J, Zhu, B, Xu, R.M, Yang, N. | Deposit date: | 2015-11-23 | Release date: | 2016-03-09 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural Basis for Substrate Preference of SMYD3, a SET Domain-containing Protein Lysine Methyltransferase J.Biol.Chem., 291, 2016
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6BFN
| Crystal structure of human IRAK1 | Descriptor: | Interleukin-1 receptor-associated kinase 1, N-[2-methoxy-4-(morpholin-4-yl)phenyl]-6-(1H-pyrazol-5-yl)pyridine-2-carboxamide | Authors: | Wang, L, Qiao, Q, Wu, H. | Deposit date: | 2017-10-26 | Release date: | 2017-12-06 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.26 Å) | Cite: | Crystal structure of human IRAK1. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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2MB9
| Human Bcl10 CARD | Descriptor: | B-cell lymphoma/leukemia 10 | Authors: | Zheng, C, Bracken, C, Wu, H. | Deposit date: | 2013-07-26 | Release date: | 2013-10-16 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural Architecture of the CARMA1/Bcl10/MALT1 Signalosome: Nucleation-Induced Filamentous Assembly. Mol.Cell, 51, 2013
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4LWD
| Human CARMA1 CARD domain | Descriptor: | Caspase recruitment domain-containing protein 11, MAGNESIUM ION, SULFATE ION | Authors: | Zheng, C, Wu, H. | Deposit date: | 2013-07-26 | Release date: | 2013-10-16 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.792 Å) | Cite: | Structural Architecture of the CARMA1/Bcl10/MALT1 Signalosome: Nucleation-Induced Filamentous Assembly. Mol.Cell, 51, 2013
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4D2K
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6NPY
| Cryo-EM structure of NLRP3 bound to NEK7 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, NACHT, LRR and PYD domains-containing protein 3, ... | Authors: | Sharif, H, Wang, L, Wang, W.L, Wu, H. | Deposit date: | 2019-01-18 | Release date: | 2019-06-19 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome. Nature, 570, 2019
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4MQ2
| The crystal structure of DYRK1a with a bound pyrido[2,3-d]pyrimidine inhibitor | Descriptor: | Dual specificity tyrosine-phosphorylation-regulated kinase 1A, PENTAETHYLENE GLYCOL, SULFATE ION, ... | Authors: | Lukacs, C.M, Janson, C.A, Garvie, C, Liang, L. | Deposit date: | 2013-09-15 | Release date: | 2013-12-11 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Pyrido[2,3-d]pyrimidines: Discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors. Bioorg.Med.Chem.Lett., 23, 2013
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4MQ1
| The crystal structure of DYRK1a with a bound pyrido[2,3-d]pyrimidine inhibitor | Descriptor: | Dual specificity tyrosine-phosphorylation-regulated kinase 1A, N-(5-{[(1R)-3-amino-1-(3-chlorophenyl)propyl]carbamoyl}-2-chlorophenyl)-2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide, PENTAETHYLENE GLYCOL, ... | Authors: | Lukacs, C.M, Janson, C.A, Garvie, C, Liang, L. | Deposit date: | 2013-09-15 | Release date: | 2013-12-11 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Pyrido[2,3-d]pyrimidines: Discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors. Bioorg.Med.Chem.Lett., 23, 2013
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5XPC
| Crystal Structure of Drep4 CIDE domain | Descriptor: | DNAation factor-related protein 4, GLYCEROL | Authors: | Park, H.H, Jeong, J.H. | Deposit date: | 2017-06-01 | Release date: | 2017-07-26 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.902 Å) | Cite: | CIDE domains form functionally important higher-order assemblies for DNA fragmentation. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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