Author results

6HTY
  • Download 6hty
  • View 6hty
Molmil generated image of 6hty
PXR IN COMPLEX WITH P2X4 INHIBITOR COMPOUND 25
Descriptor:Nuclear receptor subfamily 1 group I member 2,Nuclear receptor coactivator 1, GLYCEROL, DIMETHYL SULFOXIDE, ...
Authors:Hillig, R.C., Puetter, V., Werner, S., Mesch, S., Laux-Biehlmann, A., Braeuer, N., Dahloef, H., Klint, J., ter Laak, A., Pook, E., Neagoe, I., Nubbemeyer, R., Schulz, S.
Deposit date:2018-10-05
Release date:2019-12-04
Last modified:2020-01-08
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Discovery and Characterization of the Potent and Selective P2X4 InhibitorN-[4-(3-Chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide (BAY-1797) and Structure-Guided Amelioration of Its CYP3A4 Induction Profile.
J.Med.Chem., 62, 2019
2V5Q
  • Download 2v5q
  • View 2v5q
Molmil generated image of 2v5q
CRYSTAL STRUCTURE OF WILD-TYPE PLK-1 KINASE DOMAIN IN COMPLEX WITH A SELECTIVE DARPIN
Descriptor:SERINE/THREONINE-PROTEIN KINASE PLK1, DESIGN ANKYRIN REPEAT PROTEIN
Authors:Bandeiras, T.M., Hillig, R.C., Matias, P.M., Eberspaecher, U., Fanghaenel, J., Thomaz, M., Miranda, S., Crusius, K., Puetter, V., Amstutz, P., Gulotti-Georgieva, M., Binz, H.K., Holz, C., Schmitz, A.A.P., Lang, C., Donner, P., Egner, U., Carrondo, M.A., Mueller-Tiemann, B.
Deposit date:2007-07-08
Release date:2008-04-01
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of wild-type Plk-1 kinase domain in complex with a selective DARPin.
Acta Crystallogr. D Biol. Crystallogr., 64, 2008
5N49
  • Download 5n49
  • View 5n49
Molmil generated image of 5n49
BRPF2 IN COMPLEX WITH COMPOUND 7
Descriptor:Bromodomain-containing protein 1, 2-(1,3,6-trimethyl-2-oxidanylidene-benzimidazol-5-yl)benzo[de]isoquinoline-1,3-dione
Authors:Bouche, L., Christ, C.D., Siegel, S., Fernandez-Montalvan, A.E., Holton, S.J., Fedorov, O., ter Laak, A., Sugawara, T., Stoeckigt, D., Tallant, C., Bennett, J., Monteiro, O., Saez, L.D., Siejka, P., Meier, J., Puetter, V., Weiske, J., Mueller, S., Huber, K.V.M., Hartung, I.V., Haendler, B.
Deposit date:2017-02-10
Release date:2017-05-03
Last modified:2017-05-24
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains.
J. Med. Chem., 60, 2017
6F7B
  • Download 6f7b
  • View 6f7b
Molmil generated image of 6f7b
CRYSTAL STRUCTURE OF THE HUMAN BUB1 KINASE DOMAIN IN COMPLEX WITH BAY 1816032
Descriptor:Mitotic checkpoint serine/threonine-protein kinase BUB1, 2-[3,5-bis(fluoranyl)-4-[[3-[5-methoxy-4-[(3-methoxypyridin-4-yl)amino]pyrimidin-2-yl]indazol-1-yl]methyl]phenoxy]ethanol, MAGNESIUM ION
Authors:Holton, S.J., Siemeister, G., Mengel, A., Bone, W., Schroeder, J., Zitzmann-Kolbe, S., Briem, H., Fernandez-Montalvan, A., Prechtl, S., Moenning, U., von Ahsen, O., Johanssen, J., Cleve, A., Puetter, V., Hitchcock, M., von Nussbaum, F., Brands, M., Mumberg, D., Ziegelbauer, K.
Deposit date:2017-12-08
Release date:2018-12-19
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Inhibition of BUB1 Kinase by BAY 1816032 Sensitizes Tumor Cells toward Taxanes, ATR, and PARP InhibitorsIn VitroandIn Vivo.
Clin.Cancer Res., 25, 2019