2V5Q

CRYSTAL STRUCTURE OF WILD-TYPE PLK-1 KINASE DOMAIN IN COMPLEX WITH A SELECTIVE DARPIN

Summary for 2V5Q

Related1Q4K 1Q4O 1UMW
DescriptorSERINE/THREONINE-PROTEIN KINASE PLK1, DESIGN ANKYRIN REPEAT PROTEIN (3 entities in total)
Functional Keywordsdesign ankyrin repeat protein, transferase complex, phosphorylation, nucleotide-binding, serine/threonine-protein kinase, kinase, nucleus, transferase, atp-binding, serine/threonine protein kinase
Biological sourceHOMO SAPIENS (HUMAN)
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Total number of polymer chains4
Total molecular weight107617.68
Authors
Primary citation
Bandeiras, T.M.,Hillig, R.C.,Matias, P.M.,Eberspaecher, U.,Fanghanel, J.,Thomaz, M.,Miranda, S.,Crusius, K.,Putter, V.,Amstutz, P.,Gulotti-Georgieva, M.,Binz, H.K.,Holz, C.,Schmitz, A.A.,Lang, C.,Donner, P.,Egner, U.,Carrondo, M.A.,Muller-Tiemann, B.
Structure of wild-type Plk-1 kinase domain in complex with a selective DARPin.
Acta Crystallogr. D Biol. Crystallogr., 64:339-353, 2008
PubMed: 18391401 (PDB entries with the same primary citation)
DOI: 10.1107/S0907444907068217
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.3 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers4 0.2% 3.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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More Biological unit images

Molmil generated image of 2v5q
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Molmil generated image of 2v5q
rotated about x axis by 90°
Molmil generated image of 2v5q
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (2v5q.pdb1.gz [71.17 KB])
Coordinate files for Biological unit (2v5q.pdb2.gz [71.1 KB])