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2AM9
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CRYSTAL STRUCTURE OF HUMAN ANDROGEN RECEPTOR LIGAND BINDING DOMAIN IN COMPLEX WITH TESTOSTERONE
Descriptor:Androgen receptor, SULFATE ION, TESTOSTERONE, ...
Authors:Pereira de Jesus-Tran, K., Cote, P.-L., Cantin, L., Blanchet, J., Labrie, F., Breton, R.
Deposit date:2005-08-09
Release date:2006-05-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Comparison of crystal structures of human androgen receptor ligand-binding domain complexed with various agonists reveals molecular determinants responsible for binding affinity.
Protein Sci., 15, 2006
2AMA
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CRYSTAL STRUCTURE OF HUMAN ANDROGEN RECEPTOR LIGAND BINDING DOMAIN IN COMPLEX WITH DIHYDROTESTOSTERONE
Descriptor:Androgen receptor, SULFATE ION, 5-ALPHA-DIHYDROTESTOSTERONE
Authors:Pereira de Jesus-Tran, K., Cote, P.-L., Cantin, L., Blanchet, J., Labrie, F., Breton, R.
Deposit date:2005-08-09
Release date:2006-05-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Comparison of crystal structures of human androgen receptor ligand-binding domain complexed with various agonists reveals molecular determinants responsible for binding affinity.
Protein Sci., 15, 2006
2AMB
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CRYSTAL STRUCTURE OF HUMAN ANDROGEN RECEPTOR LIGAND BINDING DOMAIN IN COMPLEX WITH TETRAHYDROGESTRINONE
Descriptor:Androgen receptor, SULFATE ION, 17-HYDROXY-18A-HOMO-19-NOR-17ALPHA-PREGNA-4,9,11-TRIEN-3-ONE, ...
Authors:Pereira de Jesus-Tran, K., Cote, P.-L., Cantin, L., Blanchet, J., Labrie, F., Breton, R.
Deposit date:2005-08-09
Release date:2006-05-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Comparison of crystal structures of human androgen receptor ligand-binding domain complexed with various agonists reveals molecular determinants responsible for binding affinity.
Protein Sci., 15, 2006
2HDJ
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CRYSTAL STRUCTURE OF HUMAN TYPE 3 3ALPHA-HYDROXYSTEROID DEHYDROGENASE IN COMPLEX WITH NADP(H)
Descriptor:Aldo-keto reductase family 1 member C2, SULFATE ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Faucher, F., Pereira de Jesus-Tran, K., Cantin, L., Luu-the, V., Labrie, F., Breton, R.
Deposit date:2006-06-20
Release date:2006-12-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structures of Mouse 17alpha-Hydroxysteroid Dehydrogenase (Apoenzyme and Enzyme-NADP(H) Binary Complex): Identification of Molecular Determinants Responsible for the Unique 17alpha-reductive Activity of this Enzyme.
J.Mol.Biol., 364, 2006
2HE5
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CRYSTAL STRUCTURE OF 17ALPHA-HYDROXYSTEROID DEHYDROGENASE IN BINARY COMPLEX WITH NADP(H) IN AN OPEN CONFORMATION
Descriptor:Aldo-keto reductase family 1, member C21, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Faucher, F., Pereira de Jesus-Tran, K., Cantin, L., Luu-the, V., Labrie, F., Breton, R.
Deposit date:2006-06-21
Release date:2006-12-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal Structures of Mouse 17alpha-Hydroxysteroid Dehydrogenase (Apoenzyme and Enzyme-NADP(H) Binary Complex): Identification of Molecular Determinants Responsible for the Unique 17alpha-reductive Activity of this Enzyme.
J.Mol.Biol., 364, 2006
2HE8
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CRYSTAL STRUCTURE OF 17ALPHA-HYDROXYSTEROID DEHYDROGENASE IN ITS APO-FORM
Descriptor:Aldo-keto reductase family 1, member C21, ACETATE ION, ...
Authors:Faucher, F., Pereira de Jesus-Tran, K., Cantin, L., Luu-the, V., Labrie, F., Breton, R.
Deposit date:2006-06-21
Release date:2006-12-05
Last modified:2011-10-05
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structures of Mouse 17alpha-Hydroxysteroid Dehydrogenase (Apoenzyme and Enzyme-NADP(H) Binary Complex): Identification of Molecular Determinants Responsible for the Unique 17alpha-reductive Activity of this Enzyme.
J.Mol.Biol., 364, 2006
2HEJ
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CRYSTAL STRUCTURE OF 17ALPHA-HYDROXYSTEROID DEHYDROGENASE IN COMPLEX WITH NADP(H) IN A CLOSED CONFORMATION
Descriptor:Aldo-keto reductase family 1, member C21, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Faucher, F., Pereira de Jesus-Tran, K., Cantin, L., Luu-the, V., Labrie, F., Breton, R.
Deposit date:2006-06-21
Release date:2006-12-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Crystal Structures of Mouse 17alpha-Hydroxysteroid Dehydrogenase (Apoenzyme and Enzyme-NADP(H) Binary Complex): Identification of Molecular Determinants Responsible for the Unique 17alpha-reductive Activity of this Enzyme.
J.Mol.Biol., 364, 2006
2IPF
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CRYSTAL STRUCTURE OF 17ALPHA-HYDROXYSTEROID DEHYDROGENASE IN COMPLEX WITH NADP+ AND EPI-TESTOSTERONE
Descriptor:(3(17)alpha-hydroxysteroid dehydrogenase), NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (10ALPHA,13ALPHA,14BETA,17ALPHA)-17-HYDROXYANDROST-4-EN-3-ONE, ...
Authors:Faucher, F., Cantin, L., Pereira de Jesus-Tran, K., Luu-the, V., Labrie, F., Breton, R.
Deposit date:2006-10-12
Release date:2007-06-19
Last modified:2012-05-16
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Mouse 17alpha-Hydroxysteroid Dehydrogenase (AKR1C21) Binds Steroids Differently from other Aldo-keto Reductases: Identification and Characterization of Amino Acid Residues Critical for Substrate Binding.
J.Mol.Biol., 369, 2007
2IPG
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CRYSTAL STRUCTURE OF 17ALPHA-HYDROXYSTEROID DEHYDROGENASE MUTANT K31A IN COMPLEX WITH NADP+ AND EPI-TESTOSTERONE
Descriptor:3(17)alpha-hydroxysteroid dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (10ALPHA,13ALPHA,14BETA,17ALPHA)-17-HYDROXYANDROST-4-EN-3-ONE, ...
Authors:Faucher, F., Cantin, L., Pereira de Jesus-Tran, K., Lemieux, M., Luu-the, V., Labrie, F., Breton, R.
Deposit date:2006-10-12
Release date:2007-06-19
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mouse 17alpha-Hydroxysteroid Dehydrogenase (AKR1C21) Binds Steroids Differently from other Aldo-keto Reductases: Identification and Characterization of Amino Acid Residues Critical for Substrate Binding.
J.Mol.Biol., 369, 2007
2IPJ
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CRYSTAL STRUCTURE OF H3ALPHA-HYDROXYSTEROID DEHYDROGENASE TYPE 3 MUTANT Y24A IN COMPLEX WITH NADP+ AND EPI-TESTOSTERONE
Descriptor:Aldo-keto reductase family 1 member C2, SULFATE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Faucher, F., Cantin, L., Pereira de Jesus-Tran, K., Luu-the, V., Labrie, F., Breton, R.
Deposit date:2006-10-12
Release date:2007-06-19
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mouse 17alpha-Hydroxysteroid Dehydrogenase (AKR1C21) Binds Steroids Differently from other Aldo-keto Reductases: Identification and Characterization of Amino Acid Residues Critical for Substrate Binding.
J.Mol.Biol., 369, 2007
1PM5
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CRYSTAL STRUCTURE OF WILD TYPE LACTOCOCCUS LACTIS FPG COMPLEXED TO A TETRAHYDROFURAN CONTAINING DNA
Descriptor:DNA (5'-D(*CP*TP*CP*TP*TP*TP*(3DR)P*TP*TP*TP*CP*TP*CP*G)-3'), DNA (5'-D(*GP*CP*GP*AP*GP*AP*AP*AP*CP*AP*AP*AP*GP*A)-3'), Formamidopyrimidine-DNA glycosylase, ...
Authors:Pereira de Jesus-Tran, K., Serre, L., Zelwer, C., Castaing, B.
Deposit date:2003-06-10
Release date:2004-07-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural insights into abasic site for Fpg specific binding and catalysis: comparative high-resolution crystallographic studies of Fpg bound to various models of abasic site analogues-containing DNA.
Nucleic Acids Res., 33, 2005
2PNU
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CRYSTAL STRUCTURE OF HUMAN ANDROGEN RECEPTOR LIGAND-BINDING DOMAIN IN COMPLEX WITH EM-5744
Descriptor:Androgen receptor, SULFATE ION, (5S,8R,9S,10S,13R,14S,17S)-13-{2-[(3,5-DIFLUOROBENZYL)OXY]ETHYL}-17-HYDROXY-10-METHYLHEXADECAHYDRO-3H-CYCLOPENTA[A]PHENANTHREN-3-ONE, ...
Authors:Cantin, L., Faucher, F., Couture, J.F., Pereira de Jesus-Tran, K., Legrand, P., Ciobanu, C.L., Singh, S.M., Labrie, F., Breton, R.
Deposit date:2007-04-25
Release date:2007-09-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural Characterization of the Human Androgen Receptor Ligand-binding Domain Complexed with EM5744, a Rationally Designed Steroidal Ligand Bearing a Bulky Chain Directed toward Helix 12.
J.Biol.Chem., 282, 2007
1XJB
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CRYSTAL STRUCTURE OF HUMAN TYPE 3 3ALPHA-HYDROXYSTEROID DEHYDROGENASE IN COMPLEX WITH NADP(H), CITRATE AND ACETATE MOLECULES
Descriptor:Aldo-keto reductase family 1 member C2, ACETATE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Couture, J.-F., Pereira de Jesus-Tran, K., Roy, A.-M., Legrand, P., Cantin, L., Cote, P.-L., Luu-The, V., Labrie, F., Breton, R.
Deposit date:2004-09-23
Release date:2005-06-21
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Comparison of crystal structures of human type 3 3alpha-hydroxysteroid dehydrogenase reveals an "induced-fit" mechanism and a conserved basic motif involved in the binding of androgen
Protein Sci., 14, 2005