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6I8A
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BU of 6i8a by Molmil
The crystal structure of the Pol2 catalytic domain of DNA polymerase epsilon carrying a P301R substitution.
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA polymerase epsilon catalytic subunit A, ...
Authors:Parkash, V, Johansson, E.
Deposit date:2018-11-19
Release date:2019-01-30
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.652 Å)
Cite:Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase epsilon.
Nat Commun, 10, 2019
3FUB
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BU of 3fub by Molmil
Crystal structure of GDNF-GFRalpha1 complex
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Parkash, V, Goldman, A.
Deposit date:2009-01-14
Release date:2009-06-02
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Comparison of GFL-GFRalpha complexes: further evidence relating GFL bend angle to RET signalling
Acta Crystallogr.,Sect.F, 65, 2009
6FWK
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BU of 6fwk by Molmil
The crystal structure of Pol2CORE-M644G in complex with DNA and an incoming nucleotide
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(P*TP*AP*AP*CP*CP*GP*CP*GP*TP*TP*(DOC))-3'), ...
Authors:Parkash, V, Johansson, E.
Deposit date:2018-03-06
Release date:2019-01-30
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.503 Å)
Cite:Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase epsilon.
Nat Commun, 10, 2019
6G0A
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BU of 6g0a by Molmil
The crystal structure of the Pol2 catalytic domain of DNA polymerase epsilon carrying a P301R substitution.
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(P*TP*AP*AP*CP*CP*GP*CP*GP*TP*TP*DC)-3'), ...
Authors:Parkash, V, Johansson, E.
Deposit date:2018-03-16
Release date:2019-01-30
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase epsilon.
Nat Commun, 10, 2019
8B67
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BU of 8b67 by Molmil
The crystal structure of M644G variant of DNA Pol Epsilon containing CTP in the polymerase active site
Descriptor: ACETATE ION, CALCIUM ION, CYTIDINE-5'-TRIPHOSPHATE, ...
Authors:Parkash, V, Johansson, E.
Deposit date:2022-09-26
Release date:2023-10-25
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides.
Nucleic Acids Res., 2023
8B6K
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BU of 8b6k by Molmil
The crystal structure of M644G variant of DNA Pol Epsilon containing dCTP in the polymerase active site
Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA polymerase epsilon catalytic subunit A, ...
Authors:Parkash, V, Johansson, E.
Deposit date:2022-09-27
Release date:2023-10-25
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides.
Nucleic Acids Res., 2023
8B7E
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BU of 8b7e by Molmil
The crystal structure of N828V variant of DNA Pol Epsilon containing UTP in the polymerase active site
Descriptor: CALCIUM ION, DNA polymerase epsilon catalytic subunit A, GLYCEROL, ...
Authors:Parkash, V, Johansson, E.
Deposit date:2022-09-29
Release date:2023-10-25
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides.
Nucleic Acids Res., 2023
8B77
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BU of 8b77 by Molmil
The crystal structure of N828V variant of DNA Pol Epsilon containing dATP in the polymerase active site
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA polymerase epsilon catalytic subunit A, ...
Authors:Parkash, V, Johansson, E.
Deposit date:2022-09-29
Release date:2023-10-25
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides.
Nucleic Acids Res., 2023
8B76
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BU of 8b76 by Molmil
The crystal structure of M644G variant of DNA Pol Epsilon containing dTTP in the polymerase active site
Descriptor: ACETATE ION, CALCIUM ION, DNA polymerase epsilon catalytic subunit A, ...
Authors:Parkash, V, Johansson, E.
Deposit date:2022-09-28
Release date:2023-11-01
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides.
Nucleic Acids Res., 2023
8B79
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BU of 8b79 by Molmil
The crystal structure of M644G variant of DNA Pol Epsilon containing UTP in the polymerase active site
Descriptor: ACETATE ION, CALCIUM ION, DNA polymerase epsilon catalytic subunit A, ...
Authors:Parkash, V, Johansson, E.
Deposit date:2022-09-29
Release date:2023-10-25
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides.
Nucleic Acids Res., 2023
2V5E
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BU of 2v5e by Molmil
The structure of the GDNF:Coreceptor complex: Insights into RET signalling and heparin binding.
Descriptor: 1,2-ETHANEDIOL, 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Parkash, V, Leppanen, V.-M, Virtanen, H, Jurvansuu, J.-M, Bespalov, M.M, Sidorova, Y.A, Runeberg-Roos, P, Saarma, M, Goldman, A.
Deposit date:2008-10-03
Release date:2008-10-21
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:The Structure of the Glial Cell Line-Derived Neurotrophic Factor-Coreceptor Complex: Insights Into Ret Signaling and Heparin Binding.
J.Biol.Chem., 283, 2008
2W50
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BU of 2w50 by Molmil
N-terminal domain of human conserved dopamine neurotrophic factor (CDNF)
Descriptor: ARMET-LIKE PROTEIN 1, PHOSPHATE ION
Authors:Parkash, V, Lindholm, P, Peranen, J, Kalkkinen, N, Oksanen, E, Saarma, M, Leppanen, V.M, Goldman, A.
Deposit date:2008-12-03
Release date:2009-03-17
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The Structure of the Conserved Neurotrophic Factors Manf and Cdnf Explains Why They are Bifunctional.
Protein Eng.Des.Sel., 22, 2009
2W51
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BU of 2w51 by Molmil
Human mesencephalic astrocyte-derived neurotrophic factor (MANF)
Descriptor: PROTEIN ARMET
Authors:Parkash, V, Lindholm, P, Peranen, J, Kalkkinen, N, Oksanen, E, Saarma, M, Leppanen, V.M, Goldman, A.
Deposit date:2008-12-03
Release date:2009-03-17
Last modified:2019-04-10
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The Structure of the Conserved Neurotrophic Factors Manf and Cdnf Explains Why They are Bifunctional.
Protein Eng.Des.Sel., 22, 2009
6QIB
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BU of 6qib by Molmil
The crystal structure of Pol2CORE in complex with DNA and an incoming nucleotide, carrying an Fe-S cluster
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA polymerase epsilon catalytic subunit A, ...
Authors:Parkash, V, Johansson, E.
Deposit date:2019-01-18
Release date:2019-04-17
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural evidence for an essential Fe-S cluster in the catalytic core domain of DNA polymerase ε.
Nucleic Acids Res., 47, 2019
6H1V
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BU of 6h1v by Molmil
The crystal structure of Pol2CORE in complex with DNA and an incoming nucleotide, carrying an Fe-S cluster
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(P*AP*AP*TP*TP*GP*AP*AP*CP*GP*CP*GP*GP*TP*TP*A)-3'), DNA (5'-D(P*TP*AP*AP*CP*CP*GP*CP*GP*TP*TP*(DOC))-3'), ...
Authors:Parkash, V, Johansson, E.
Deposit date:2018-07-12
Release date:2019-04-24
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural evidence for an essential Fe-S cluster in the catalytic core domain of DNA polymerase ε.
Nucleic Acids Res., 47, 2019
4A0Q
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BU of 4a0q by Molmil
Activated Conformation of Integrin alpha1 I-Domain mutant
Descriptor: INTEGRIN ALPHA-1, MAGNESIUM ION
Authors:Lahti, M, Bligt, E, Niskanen, H, Parkash, V, Brandt, A.-M, Jokinen, J, Patrikainen, P, Kapyla, J, Heino, J, Salminen, T.A.
Deposit date:2011-09-12
Release date:2011-10-26
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of Collagen Receptor Integrin Aplha1I Domain Carrying the Activating Mutation E317A.
J.Biol.Chem., 286, 2011
7R3Y
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BU of 7r3y by Molmil
The crystal structure of the V426L variant of Pol2CORE in complex with DNA and an incoming nucleotide
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA Primer, ...
Authors:Barbari, S.R, Beach, A.K, Markgren, J.G, Parkash, V, Johansson, E, Shcherbakova, P.V.
Deposit date:2022-02-08
Release date:2022-07-27
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Enhanced polymerase activity permits efficient synthesis by cancer-associated DNA polymerase ε variants at low dNTP levels.
Nucleic Acids Res., 50, 2022
7R3X
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BU of 7r3x by Molmil
The crystal structure of the L439V variant of Pol2CORE in complex with DNA and an incoming nucleotide
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, ACETATE ION, CALCIUM ION, ...
Authors:Barbari, S.R, Beach, A.K, Markgren, J.G, Parkash, V, Johansson, E, Shcherbakova, P.V.
Deposit date:2022-02-08
Release date:2022-07-27
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Enhanced polymerase activity permits efficient synthesis by cancer-associated DNA polymerase ε variants at low dNTP levels.
Nucleic Acids Res., 50, 2022
2Y74
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BU of 2y74 by Molmil
THE CRYSTAL STRUCTURE OF HUMAN SOLUBLE PRIMARY AMINE OXIDASE AOC3 IN THE OFF-COPPER CONFORMATION
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Elovaara, H, Kidron, H, Parkash, V, Nymalm, Y, Bligt, E, Ollikka, P, Smith, D.J, Pihlavisto, M, Salmi, M, Jalkanen, S, Salminen, T.A.
Deposit date:2011-01-28
Release date:2011-06-15
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Identification of Two Imidazole Binding Sites and Key Residues for Substrate Specificity in Human Primary Amine Oxidase Aoc3.
Biochemistry, 50, 2011
2Y73
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BU of 2y73 by Molmil
THE NATIVE STRUCTURES OF SOLUBLE HUMAN PRIMARY AMINE OXIDASE AOC3
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Elovaara, H, Kidron, H, Parkash, V, Nymalm, Y, Bligt, E, Ollikka, P, Smith, D.J, Pihlavisto, M, Salmi, M, Jalkanen, S, Salminen, T.A.
Deposit date:2011-01-28
Release date:2011-06-15
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Identification of Two Imidazole Binding Sites and Key Residues for Substrate Specificity in Human Primary Amine Oxidase Aoc3.
Biochemistry, 50, 2011

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