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4ZZ7
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CRYSTAL STRUCTURE OF METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE (DDDC) FROM OCEANIMONAS DOUDOROFFII
Descriptor:Methylmalonate-semialdehyde dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Do, H., Lee, C.W., Lee, S.G., Kang, H., Park, C.M., Kim, H.J., Park, H., Park, H., Lee, J.H.
Deposit date:2015-05-22
Release date:2016-04-06
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure and modeling of the tetrahedral intermediate state of methylmalonate-semialdehyde dehydrogenase (MMSDH) from Oceanimonas doudoroffii.
J. Microbiol., 54, 2016
2O1Y
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SOLUTION STRUCTURE OF THE ANTI-APOPTOTIC PROTEIN BCL-XL IN COMPLEX WITH AN ACYL-SULFONAMIDE-BASED LIGAND
Descriptor:Apoptosis regulator Bcl-X, 3-NITRO-N-{4-[2-(2-PHENYLETHYL)-1,3-BENZOTHIAZOL-5-YL]BENZOYL}-4-{[2-(PHENYLSULFANYL)ETHYL]AMINO}BENZENESULFONAMIDE
Authors:Bruncko, M., Oost, T.K., Belli, B.A., Ding, H., Joseph, M.K., Kunzer, A., Martineau, D., McClellan, W.J., Mitten, M., Ng, S.C., Nimmer, P.M., Oltersdorf, T., Park, C.M., Petros, A.M., Shoemaker, A.R., Song, X., Wang, X., Wendt, M.D., Zhang, H., Fesik, S.W., Rosenberg, S.H., Elmore, S.W.
Deposit date:2006-11-29
Release date:2007-02-27
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL.
J.Med.Chem., 50, 2007
2O21
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SOLUTION STRUCTURE OF THE ANTI-APOPTOTIC PROTEIN BCL-2 IN COMPLEX WITH AN ACYL-SULFONAMIDE-BASED LIGAND
Descriptor:Apoptosis regulator Bcl-2, 3-NITRO-N-{4-[2-(2-PHENYLETHYL)-1,3-BENZOTHIAZOL-5-YL]BENZOYL}-4-{[2-(PHENYLSULFANYL)ETHYL]AMINO}BENZENESULFONAMIDE
Authors:Bruncko, M., Oost, T.K., Belli, B.A., Ding, H., Joseph, M.K., Kunzer, A., Martineau, D., McClellan, W.J., Mitten, M., Ng, S.C., Nimmer, P.M., Oltersdorf, T., Park, C.M., Petros, A.M., Shoemaker, A.R., Song, X., Wang, X., Wendt, M.D., Zhang, H., Fesik, S.W., Rosenberg, S.H., Elmore, S.W.
Deposit date:2006-11-29
Release date:2007-02-27
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL.
J.Med.Chem., 50, 2007
2O22
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SOLUTION STRUCTURE OF THE ANTI-APOPTOTIC PROTEIN BCL-2 IN COMPLEX WITH AN ACYL-SULFONAMIDE-BASED LIGAND
Descriptor:Apoptosis regulator Bcl-2, N-[(4-{[1,1-dimethyl-2-(phenylthio)ethyl]amino}-3-nitrophenyl)sulfonyl]-4-(4,4-dimethylpiperidin-1-yl)benzamide
Authors:Bruncko, M., Oost, T.K., Belli, B.A., Ding, H., Joseph, M.K., Kunzer, A., Martineau, D., McClellan, W.J., Mitten, M., Ng, S.C., Nimmer, P.M., Oltersdorf, T., Park, C.M., Petros, A.M., Shoemaker, A.R., Song, X., Wang, X., Wendt, M.D., Zhang, H., Fesik, S.W., Rosenberg, S.H., Elmore, S.W.
Deposit date:2006-11-29
Release date:2007-02-27
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL.
J.Med.Chem., 50, 2007
2O2F
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SOLUTION STRUCTURE OF THE ANTI-APOPTOTIC PROTEIN BCL-2 IN COMPLEX WITH AN ACYL-SULFONAMIDE-BASED LIGAND
Descriptor:Apoptosis regulator Bcl-2, 4-(4-BENZYL-4-METHOXYPIPERIDIN-1-YL)-N-[(4-{[1,1-DIMETHYL-2-(PHENYLTHIO)ETHYL]AMINO}-3-NITROPHENYL)SULFONYL]BENZAMIDE
Authors:Bruncko, M., Oost, T.K., Belli, B.A., Ding, H., Joseph, M.K., Kunzer, A., Martineau, D., McClellan, W.J., Mitten, M., Ng, S.C., Nimmer, P.M., Oltersdorf, T., Park, C.M., Petros, A.M., Shoemaker, A.R., Song, X., Wang, X., Wendt, M.D., Zhang, H., Fesik, S.W., Rosenberg, S.H., Elmore, S.W.
Deposit date:2006-11-29
Release date:2007-02-27
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL.
J.Med.Chem., 50, 2007
2O2M
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SOLUTION STRUCTURE OF THE ANTI-APOPTOTIC PROTEIN BCL-XL IN COMPLEX WITH AN ACYL-SULFONAMIDE-BASED LIGAND
Descriptor:Apoptosis regulator Bcl-X, 4-(4-BENZYL-4-METHOXYPIPERIDIN-1-YL)-N-[(4-{[1,1-DIMETHYL-2-(PHENYLTHIO)ETHYL]AMINO}-3-NITROPHENYL)SULFONYL]BENZAMIDE
Authors:Bruncko, M., Oost, T.K., Belli, B.A., Ding, H., Joseph, M.K., Kunzer, A., Martineau, D., McClellan, W.J., Mitten, M., Ng, S.C., Nimmer, P.M., Oltersdorf, T., Park, C.M., Petros, A.M., Shoemaker, A.R., Song, X., Wang, X., Wendt, M.D., Zhang, H., Fesik, S.W., Rosenberg, S.H., Elmore, S.W.
Deposit date:2006-11-30
Release date:2007-02-27
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL.
J.Med.Chem., 50, 2007
2O2N
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SOLUTION STRUCTURE OF THE ANTI-APOPTOTIC PROTEIN BCL-XL IN COMPLEX WITH AN ACYL-SULFONAMIDE-BASED LIGAND
Descriptor:Apoptosis regulator Bcl-X, 4-[4-(BIPHENYL-2-YLMETHYL)PIPERAZIN-1-YL]-N-[(4-{[1,1-DIMETHYL-2-(PHENYLTHIO)ETHYL]AMINO}-3-NITROPHENYL)SULFONYL]BENZAMIDE
Authors:Bruncko, M., Oost, T.K., Belli, B.A., Ding, H., Joseph, M.K., Kunzer, A., Martineau, D., McClellan, W.J., Mitten, M., Ng, S.C., Nimmer, P.M., Oltersdorf, T., Park, C.M., Petros, A.M., Shoemaker, A.R., Song, X., Wang, X., Wendt, M.D., Zhang, H., Fesik, S.W., Rosenberg, S.H., Elmore, S.W.
Deposit date:2006-11-30
Release date:2007-02-27
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL.
J.Med.Chem., 50, 2007
3V9B
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PDE4D2 WITH (S)-N-(3-{1-[1-(3-CYCLOPROPYLMETHOXY-4-DIFLUOROMETHOXYPHENYL)-2-(1-OXYPYRIDIN-4-YL)-ETHYL]-1H-PYRAZL-3-YL}PHENYL)ACETAMIDE
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4D, N-(3-{1-[(1S)-1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(1-oxidopyridin-4-yl)ethyl]-1H-pyrazol-3-yl}phenyl)acetamide, ZINC ION
Authors:Kim, H.T., Chang, H.J.
Deposit date:2011-12-25
Release date:2012-01-18
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Stereoselective synthesis of novel pyrazole derivatives using tert-butansulfonamide as a chiral auxiliary
Org.Biomol.Chem., 10, 2012
3OW6
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CRYSTAL STRUCTURE OF HSP90 WITH N-ARYL-BENZIMIDAZOLONE I
Descriptor:Heat shock protein HSP 90-alpha, 1-(2,4-dihydroxyphenyl)-1,3-dihydro-2H-benzimidazol-2-one
Authors:Park, C.H.
Deposit date:2010-09-17
Release date:2011-09-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:N-aryl-benzimidazolones as novel small molecule HSP90 inhibitors.
Bioorg.Med.Chem.Lett., 20, 2010
3OWB
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CRYSTAL STRUCTURE OF HSP90 WITH VER-49009
Descriptor:Heat shock protein HSP 90-alpha, 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXAMIDE
Authors:Park, C.H.
Deposit date:2010-09-17
Release date:2011-09-21
Last modified:2011-10-19
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:N-aryl-benzimidazolones as novel small molecule HSP90 inhibitors.
Bioorg.Med.Chem.Lett., 20, 2010
3OWD
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CRYSTAL STRUCTURE OF HSP90 WITH N-ARYL-BENZIMIDAZOLONE II
Descriptor:Heat shock protein HSP 90-alpha, N-{[1-(5-chloro-2,4-dihydroxyphenyl)-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl]methyl}naphthalene-1-sulfonamide
Authors:Park, C.H.
Deposit date:2010-09-17
Release date:2011-09-21
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:N-aryl-benzimidazolones as novel small molecule HSP90 inhibitors.
Bioorg.Med.Chem.Lett., 20, 2010
4LVT
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BCL_2-NAVITOCLAX (ABT-263) COMPLEX
Descriptor:Apoptosis regulator Bcl-2, 4-(4-{[2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(2R)-4-(morpholin-4-yl)-1-(phenylsulfanyl)butan-2-yl]amino}-3-[(trifluoromethyl)sulfonyl]phenyl)sulfonyl]benzamide
Authors:Park, C.H.
Deposit date:2013-07-26
Release date:2013-08-14
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets.
NAT.MED. (N.Y.), 19, 2013
4LXD
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BCL_2-NAVITOCLAX ANALOG (WITHOUT THIOPHENYL) COMPLEX
Descriptor:Apoptosis regulator Bcl-2, 4-(4-{[4-(4-chlorophenyl)-5,6-dihydro-2H-pyran-3-yl]methyl}piperazin-1-yl)-N-{[3-nitro-4-(tetrahydro-2H-pyran-4-ylamino)phenyl]sulfonyl}benzamide
Authors:Park, C.H.
Deposit date:2013-07-29
Release date:2013-08-14
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets.
NAT.MED. (N.Y.), 19, 2013
4MAN
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BCL_2-NAVITOCLAX ANALOG (WITH INDOLE) COMPLEX
Descriptor:Apoptosis regulator Bcl-2, 4-[4-({4'-chloro-3-[2-(dimethylamino)ethoxy]biphenyl-2-yl}methyl)piperazin-1-yl]-2-(1H-indol-5-yloxy)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)benzamide
Authors:Park, C.H.
Deposit date:2013-08-16
Release date:2014-01-29
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets.
NAT.MED. (N.Y.), 19, 2013
4Y46
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PYRIDOPYRIMIDINONE DERIVATIVES AS POTENT AND SELECTIVE C-JUN N-TERMINAL KINASE (JNK) INHIBITORS
Descriptor:Mitogen-activated protein kinase 10, 1-{trans-4-[(8-cyclopentyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino]cyclohexyl}-3-propan-2-ylurea
Authors:Park, H.
Deposit date:2015-02-10
Release date:2015-05-06
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) Inhibitors.
Acs Med.Chem.Lett., 6, 2015
4Y5H
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PYRIDOPYRIMIDINONE DERIVATIVES AS POTENT AND SELECTIVE C-JUN N-TERMINAL KINASE (JNK) INHIBITORS
Descriptor:Mitogen-activated protein kinase 10, 1-(trans-4-{[7-oxo-8-(propan-2-yl)-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]amino}cyclohexyl)-3-propan-2-ylurea
Authors:Park, H.
Deposit date:2015-02-11
Release date:2015-05-06
Method:X-RAY DIFFRACTION (2.055 Å)
Cite:Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) Inhibitors.
Acs Med.Chem.Lett., 6, 2015
1I3C
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RESPONSE REGULATOR FOR CYANOBACTERIAL PHYTOCHROME, RCP1
Descriptor:RESPONSE REGULATOR RCP1, SULFATE ION
Authors:Im, Y.J., Rho, S.-H., Park, C.-M., Yang, S.-S., Kang, J.-G., Lee, J.Y., Song, P.-S., Eom, S.H.
Deposit date:2001-02-14
Release date:2002-03-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of a cyanobacterial phytochrome response regulator.
Protein Sci., 11, 2002
1JLK
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CRYSTAL STRUCTURE OF THE MN(2+)-BOUND FORM OF RESPONSE REGULATOR RCP1
Descriptor:Response regulator RCP1, SULFATE ION, MANGANESE (II) ION
Authors:Im, Y.J., Rho, S.-H., Park, C.-M., Yang, S.-S., Kang, J.-G., Lee, J.Y., Song, P.-S., Eom, S.H.
Deposit date:2001-07-16
Release date:2002-03-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of a cyanobacterial phytochrome response regulator.
Protein Sci., 11, 2002
1KP6
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USTILAGO MAYDIS KILLER TOXIN KP6 ALPHA-SUBUNIT
Descriptor:PROTEIN (TOXIN), SULFATE ION
Authors:Li, N., Erman, M., Pangborn, W., Duax, W.L., Park, C.-M., Bruenn, J., Ghosh, D.
Deposit date:1999-05-28
Release date:1999-07-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of Ustilago maydis killer toxin KP6 alpha-subunit. A multimeric assembly with a central pore.
J.Biol.Chem., 274, 1999
2QI2
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CRYSTAL STRUCTURE OF THE THERMOPLASMA ACIDOPHILUM PELOTA PROTEIN
Descriptor:Cell division protein pelota related protein
Authors:Lee, H.H., Kim, Y.S., Kim, K.H., Heo, I.H., Kim, S.K., Kim, O., Suh, S.W.
Deposit date:2007-07-03
Release date:2007-10-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural and functional insights into dom34, a key component of no-go mRNA decay
Mol.Cell, 27, 2007
4YSB
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CRYSTAL STRUCTURE OF ETHE1 FROM MYXOCOCCUS XANTHUS
Descriptor:Metallo-beta-lactamase family protein, FE (III) ION
Authors:Sattler, S.A., Wang, X., DeHan, P.J., Xun, L., Kang, C.
Deposit date:2015-03-17
Release date:2015-06-24
Last modified:2015-08-12
Method:X-RAY DIFFRACTION (2.5015 Å)
Cite:Characterizations of Two Bacterial Persulfide Dioxygenases of the Metallo-beta-lactamase Superfamily.
J.Biol.Chem., 290, 2015
4YSK
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CRYSTAL STRUCTURE OF APO-FORM SDOA FROM PSEUDOMONAS PUTIDA
Descriptor:Beta-lactamase domain protein, FE (III) ION
Authors:Sattler, S.A., Wang, X., DeHan, P.J., Xun, L., Kang, C.
Deposit date:2015-03-17
Release date:2015-06-24
Last modified:2015-08-12
Method:X-RAY DIFFRACTION (2.466 Å)
Cite:Characterizations of Two Bacterial Persulfide Dioxygenases of the Metallo-beta-lactamase Superfamily.
J.Biol.Chem., 290, 2015
4YSL
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CRYSTAL STRUCTURE OF SDOA FROM PSEUDOMONAS PUTIDA IN COMPLEX WITH GLUTATHIONE
Descriptor:Beta-lactamase domain protein, FE (III) ION, GLUTATHIONE
Authors:Sattler, S.A., Wang, X., DeHan, P.J., Xun, L., Kang, C.
Deposit date:2015-03-17
Release date:2015-06-24
Last modified:2015-08-12
Method:X-RAY DIFFRACTION (1.4618 Å)
Cite:Characterizations of Two Bacterial Persulfide Dioxygenases of the Metallo-beta-lactamase Superfamily.
J.Biol.Chem., 290, 2015