2O22
Solution structure of the anti-apoptotic protein Bcl-2 in complex with an acyl-sulfonamide-based ligand
Summary for 2O22
Entry DOI | 10.2210/pdb2o22/pdb |
Related | 2O1Y 2O21 |
Descriptor | Apoptosis regulator Bcl-2, N-[(4-{[1,1-dimethyl-2-(phenylthio)ethyl]amino}-3-nitrophenyl)sulfonyl]-4-(4,4-dimethylpiperidin-1-yl)benzamide (2 entities in total) |
Functional Keywords | apoptosis, complex, bcl |
Biological source | Homo sapiens (human) |
Cellular location | Mitochondrion outer membrane; Single-pass membrane protein: P10415 |
Total number of polymer chains | 1 |
Total formula weight | 19752.04 |
Authors | Bruncko, M.,Oost, T.K.,Belli, B.A.,Ding, H.,Joseph, M.K.,Kunzer, A.,Martineau, D.,McClellan, W.J.,Mitten, M.,Ng, S.C.,Nimmer, P.M.,Oltersdorf, T.,Park, C.M.,Petros, A.M.,Shoemaker, A.R.,Song, X.,Wang, X.,Wendt, M.D.,Zhang, H.,Fesik, S.W.,Rosenberg, S.H.,Elmore, S.W. (deposition date: 2006-11-29, release date: 2007-02-27, Last modification date: 2023-12-27) |
Primary citation | Bruncko, M.,Oost, T.K.,Belli, B.A.,Ding, H.,Joseph, M.K.,Kunzer, A.,Martineau, D.,McClellan, W.J.,Mitten, M.,Ng, S.C.,Nimmer, P.M.,Oltersdorf, T.,Park, C.M.,Petros, A.M.,Shoemaker, A.R.,Song, X.,Wang, X.,Wendt, M.D.,Zhang, H.,Fesik, S.W.,Rosenberg, S.H.,Elmore, S.W. Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL. J.Med.Chem., 50:641-662, 2007 Cited by PubMed: 17256834DOI: 10.1021/jm061152t PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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