3V9B

Crystal structure of the catalytic domain of PDE4D2 with (S)-N-(3-{1-[1-(3-Cyclopropylmethoxy-4-difluoromethoxyphenyl)-2-(1-oxypyridin-4-yl)-ethyl]-1H-pyrazl-3-yl}phenyl)acetamide

Summary for 3V9B

Entry DOI	10.2210/pdb3v9b/pdb
Descriptor	cAMP-specific 3',5'-cyclic phosphodiesterase 4D, N-(3-{1-[(1S)-1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(1-oxidopyridin-4-yl)ethyl]-1H-pyrazol-3-yl}phenyl)acetamide, ZINC ION, ... (4 entities in total)
Functional Keywords	hydrolase, 3', 5'-cyclic-amp phosphodiesterases, cyclic nucleotide, phosphodiesterases, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm (By similarity): Q08499
Total number of polymer chains	4
Total formula weight	168240.58
Authors	Kim, H.T.,Chang, H.J. (deposition date: 2011-12-25, release date: 2012-01-18, Last modification date: 2023-11-08)
Primary citation	Park, C.M.,Jeon, D.J. Stereoselective synthesis of novel pyrazole derivatives using tert-butansulfonamide as a chiral auxiliary Org.Biomol.Chem., 10:2613-2620, 2012 Cited by PubMed: 22371117 DOI: 10.1039/c2ob06495b PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation