Author results

4GFT
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MALARIA INVASION MACHINERY PROTEIN-NANOBODY COMPLEX
Descriptor:Myosin A tail domain interacting protein, Nanobody, 1,2-ETHANEDIOL
Authors:Khamrui, S., Turley, S., Pardon, E., Steyaert, J., Verlinde, C., Fan, E., Bergman, L.W., Hol, W.G.J.
Deposit date:2012-08-03
Release date:2013-07-03
Last modified:2015-12-09
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The structure of the D3 domain of Plasmodium falciparum myosin tail interacting protein MTIP in complex with a nanobody.
Mol.Biochem.Parasitol., 190, 2013
4I0C
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THE STRUCTURE OF THE CAMELID ANTIBODY CABHUL5 IN COMPLEX WITH HUMAN LYSOZYME
Descriptor:Lysozyme C, cAbHuL5 antibody, CHLORIDE ION, ...
Authors:De Genst, E., Chan, P.H., Pardon, E., Kumita, J.R., Christodoulou, J., Menzer, L., Chirgadze, D.Y., Robinson, C.V., Muyldermans, S., Matagne, A., Wyns, L., Dobson, C.M., Dumoulin, M.
Deposit date:2012-11-16
Release date:2013-10-09
Last modified:2013-11-06
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A nanobody binding to non-amyloidogenic regions of the protein human lysozyme enhances partial unfolding but inhibits amyloid fibril formation.
J.Phys.Chem.B, 117, 2013
4W6W
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CO-COMPLEX STRUCTURE OF THE LECTIN DOMAIN OF F18 FIMBRIAL ADHESIN FEDF WITH INHIBITORY NANOBODY NBFEDF6
Descriptor:F18 fimbrial adhesin AC, NbFedF6
Authors:Moonens, K., De Kerpel, M., Annelies, C., Cox, E., Pardon, E., Remaut, H., De Greve, H.
Deposit date:2014-08-21
Release date:2014-12-17
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Nanobody Mediated Inhibition of Attachment of F18 Fimbriae Expressing Escherichia coli.
Plos One, 9, 2014
4W6X
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CO-COMPLEX STRUCTURE OF THE LECTIN DOMAIN OF F18 FIMBRIAL ADHESIN FEDF WITH INHIBITORY NANOBODY NBFEDF7
Descriptor:F18 fimbrial adhesin AC, Nanobody NbFedF7
Authors:Moonens, K., De Kerpel, M., Coddens, A., Cox, E., Pardon, E., Remaut, H., De Greve, H.
Deposit date:2014-08-21
Release date:2014-12-17
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Nanobody Mediated Inhibition of Attachment of F18 Fimbriae Expressing Escherichia coli.
Plos One, 9, 2014
4W6Y
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CO-COMPLEX STRUCTURE OF THE LECTIN DOMAIN OF F18 FIMBRIAL ADHESIN FEDF WITH INHIBITORY NANOBODY NBFEDF9
Descriptor:F18 fimbrial adhesin AC, Nanobody NbFedF9, SULFATE ION
Authors:Moonens, K., De Kerpel, M., Coddens, A., Cox, E., Pardon, E., Remaut, H., De Greve, H.
Deposit date:2014-08-21
Release date:2014-12-17
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Nanobody Mediated Inhibition of Attachment of F18 Fimbriae Expressing Escherichia coli.
Plos One, 9, 2014
6B73
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CRYSTAL STRUCTURE OF A NANOBODY-STABILIZED ACTIVE STATE OF THE KAPPA-OPIOID RECEPTOR
Descriptor:Soluble cytochrome b562, kappa-type opioid receptor, Nanobody, ...
Authors:Che, T., Majumdar, S., Zaidi, S.A., Kormos, C., McCorvy, J.D., Wang, S., Mosier, P.D., Uprety, R., Vardy, E., Krumm, B.E., Han, G.W., Lee, M.Y., Pardon, E., Steyaert, J., Huang, X.P., Strachan, R.T., Tribo, A.R., Pasternak, G.W., Carroll, I.F., Stevens, R.C., Cherezov, V., Katritch, V., Wacker, D., Roth, B.L.
Deposit date:2017-10-03
Release date:2018-01-17
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor.
Cell, 172, 2018
6MXT
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CRYSTAL STRUCTURE OF HUMAN BETA2 ADRENERGIC RECEPTOR BOUND TO SALMETEROL AND NB71
Descriptor:Endolysin, Beta-2 adrenergic receptor chimera, nanobody Nb71, ...
Authors:Masureel, M., Zou, Y., Picard, L.P., van der Westhuizen, E., Mahoney, J.P., Rodrigues, J.P.G.L.M., Mildorf, T.J., Dror, R.O., Shaw, D.E., Bouvier, M., Pardon, E., Steyaert, J., Sunahara, R.K., Weis, W.I., Zhang, C., Kobilka, B.K.
Deposit date:2018-10-31
Release date:2018-11-14
Method:X-RAY DIFFRACTION (2.959342 Å)
Cite:Structural insights into binding specificity, efficacy and bias of a beta2AR partial agonist.
Nat. Chem. Biol., 14, 2018
2X6M
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STRUCTURE OF A SINGLE DOMAIN CAMELID ANTIBODY FRAGMENT IN COMPLEX WITH A C-TERMINAL PEPTIDE OF ALPHA-SYNUCLEIN
Descriptor:HEAVY CHAIN VARIABLE DOMAIN FROM DROMEDARY, ALPHA-SYNUCLEIN PEPTIDE
Authors:DeGenst, E., Guilliams, T., Wellens, J., O'Day, E.M., Waudby, C.A., Meehan, S., Dumoulin, M., Hsu, S.-T.D., Cremades, N., Verschueren, K.H.G., Pardon, E., Wyns, L., Steyaert, J., Christodoulou, J., Dobson, C.M.
Deposit date:2010-02-18
Release date:2010-06-23
Last modified:2017-03-29
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Structure and Properties of a Complex of Alpha-Synuclein and a Single-Domain Camelid Antibody.
J.Mol.Biol., 402, 2010
4WEM
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CO-COMPLEX STRUCTURE OF THE F4 FIMBRIAL ADHESIN FAEG VARIANT AC WITH LLAMA SINGLE DOMAIN ANTIBODY V1
Descriptor:K88 fimbrial protein AC, Anti-F4+ETEC bacteria VHH variable region, PHOSPHATE ION
Authors:Moonens, K., Van den Broeck, I., Pardon, E., De Kerpel, M., Remaut, H., De Greve, H.
Deposit date:2014-09-10
Release date:2015-02-04
Last modified:2015-04-15
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural insight in the inhibition of adherence of F4 fimbriae producing enterotoxigenic Escherichia coli by llama single domain antibodies.
Vet. Res., 46, 2015
4WEN
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CO-COMPLEX STRUCTURE OF THE F4 FIMBRIAL ADHESIN FAEG VARIANT AC WITH LLAMA SINGLE DOMAIN ANTIBODY V2
Descriptor:K88 fimbrial protein AC, Anti-F4+ETEC bacteria VHH variable region
Authors:Moonens, K., Van den Broeck, I., Pardon, E., De Kerpel, M., Remaut, H., De Greve, H.
Deposit date:2014-09-10
Release date:2015-02-04
Last modified:2015-04-15
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Structural insight in the inhibition of adherence of F4 fimbriae producing enterotoxigenic Escherichia coli by llama single domain antibodies.
Vet. Res., 46, 2015
4WEU
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CO-COMPLEX STRUCTURE OF THE F4 FIMBRIAL ADHESIN FAEG VARIANT AD WITH LLAMA SINGLE DOMAIN ANTIBODY V3
Descriptor:Anti-F4+ETEC bacteria VHH variable region, K88 fimbrial protein AD
Authors:Moonens, K., Van den Broeck, I., Pardon, E., De Kerpel, M., Remaut, H., De Greve, H.
Deposit date:2014-09-11
Release date:2015-02-04
Last modified:2015-04-15
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Structural insight in the inhibition of adherence of F4 fimbriae producing enterotoxigenic Escherichia coli by llama single domain antibodies.
Vet. Res., 46, 2015
5BOP
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CRYSTAL STRUCTURE OF THE ARTIFICIAL NANOBODY OCTARELLINV.1 COMPLEX
Descriptor:Nanobody, Octarellin V.1
Authors:Figueroa, M., Sleutel, M., Pardon, E., Steyaert, J., Martial, J.A., van de Weerdt, C.
Deposit date:2015-05-27
Release date:2016-05-25
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The unexpected structure of the designed protein Octarellin V.1 forms a challenge for protein structure prediction tools.
J.Struct.Biol., 195, 2016
2YPW
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ATOMIC MODEL FOR THE N-TERMINUS OF TRAO FITTED IN THE FULL-LENGTH STRUCTURE OF THE BACTERIAL PKM101 TYPE IV SECRETION SYSTEM CORE COMPLEX
Descriptor:TRAO
Authors:Rivera-Calzada, A., Fronzes, R., Savva, C.G., Chandran, V., Lian, P.W., Laeremans, T., Pardon, E., Steyaert, J., Remaut, H., Waksman, G., Orlova, E.V.
Deposit date:2012-11-02
Release date:2013-04-03
Last modified:2017-08-23
Method:ELECTRON MICROSCOPY (12.4 Å)
Cite:Structure of a Bacterial Type Iv Secretion Core Complex at Subnanometre Resolution.
Embo J., 32, 2013
3ZBI
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FITTING RESULT IN THE O-LAYER OF THE SUBNANOMETER STRUCTURE OF THE BACTERIAL PKM101 TYPE IV SECRETION SYSTEM CORE COMPLEX DIGESTED WITH ELASTASE
Descriptor:TRAF PROTEIN, TRAO PROTEIN, TRAN PROTEIN
Authors:Rivera-Calzada, A., Fronzes, R., Savva, C.G., Chandran, V., Lian, P.W., Laeremans, T., Pardon, E., Steyaert, J., Remaut, H., Waksman, G., Orlova, E.V.
Deposit date:2012-11-10
Release date:2013-04-03
Last modified:2017-08-23
Method:ELECTRON MICROSCOPY (8.5 Å)
Cite:Structure of a Bacterial Type Iv Secretion Core Complex at Subnanometre Resolution.
Embo J., 32, 2013
1ZMY
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CABBCII-10 VHH FRAMEWORK WITH CDR LOOPS OF CABLYS3 GRAFTED ON IT AND IN COMPLEX WITH HEN EGG WHITE LYSOZYME
Descriptor:Antibody cabbcII-10:lys3, Lysozyme C
Authors:Saerens, D., Pellis, M., Loris, R., Pardon, E., Dumoulin, M., Matagne, A., Wyns, L., Muyldermans, S., Conrath, K.
Deposit date:2005-05-11
Release date:2005-10-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Identification of a universal VHH framework to graft non-canonical antigen-binding loops of camel single-domain antibodies
J.Mol.Biol., 352, 2005
2X89
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STRUCTURE OF THE BETA2_MICROGLOBULIN INVOLVED IN AMYLOIDOGENESIS
Descriptor:ANTIBODY, BETA-2-MICROGLOBULIN
Authors:Domanska, K., Srinivasan, V., Vanderhaegen, S., Pardon, E., Marquez, J.A., Bellotti, V., Wyns, L., Steyaert, J.
Deposit date:2010-03-07
Release date:2011-01-19
Last modified:2013-09-04
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Atomic Structure of a Nanobody-Trapped Domain-Swapped Dimer of an Amyloidogenic {Beta}2-Microglobulin Variant.
Proc.Natl.Acad.Sci.USA, 108, 2011
3CFI
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NANOBODY-AIDED STRUCTURE DETERMINATION OF THE EPSI:EPSJ PSEUDOPILIN HETERDIMER FROM VIBRIO VULNIFICUS
Descriptor:Type II secretory pathway, pseudopilin EpsI, PSEUDOPILIN EpsJ, ...
Authors:Lam, A.Y., Pardon, E., Korotkov, K.V., Steyaert, J., Hol, W.G.J.
Deposit date:2008-03-03
Release date:2009-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Nanobody-aided structure determination of the EpsI:EpsJ pseudopilin heterodimer from Vibrio vulnificus.
J.Struct.Biol., 166, 2009
3EZJ
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CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF THE SECRETIN GSPD FROM ETEC DETERMINED WITH THE ASSISTANCE OF A NANOBODY
Descriptor:General secretion pathway protein GspD, NANOBODY NBGSPD_7, PHOSPHATE ION, ...
Authors:Korotkov, K.V., Pardon, E., Steyaert, J., Hol, W.G.
Deposit date:2008-10-22
Release date:2009-02-17
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the N-terminal domain of the secretin GspD from ETEC determined with the assistance of a nanobody.
Structure, 17, 2009
3P0G
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STRUCTURE OF A NANOBODY-STABILIZED ACTIVE STATE OF THE BETA2 ADRENOCEPTOR
Descriptor:Beta-2 adrenergic receptor, Lysozyme, Camelid Antibody Fragment, ...
Authors:Rasmussen, S.G.F., Choi, H.-J., Fung, J.J., Pardon, E., Casarosa, P., Chae, P.S., DeVree, B.T., Rosenbaum, D.M., Thian, F.S., Kobilka, T.S., Schnapp, A., Konetzki, I., Sunahara, R.K., Gellman, S.H., Pautsch, A., Steyaert, J., Weis, W.I., Kobilka, B.K.
Deposit date:2010-09-28
Release date:2011-01-19
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structure of a nanobody-stabilized active state of the b2 adrenoceptor
Nature, 469, 2011
3SN6
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CRYSTAL STRUCTURE OF THE BETA2 ADRENERGIC RECEPTOR-GS PROTEIN COMPLEX
Descriptor:Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Rasmussen, S.G.F., DeVree, B.T., Zou, Y., Kruse, A.C., Chung, K.Y., Kobilka, T.S., Thian, F.S., Chae, P.S., Pardon, E., Calinski, D., Mathiesen, J.M., Shah, S.T.A., Lyons, J.A., Caffrey, M., Gellman, S.H., Steyaert, J., Skiniotis, G., Weis, W.I., Sunahara, R.K., Kobilka, B.K.
Deposit date:2011-06-28
Release date:2011-07-20
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of the beta2 adrenergic receptor-Gs protein complex
Nature, 477, 2011
3ZBJ
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FITTING RESULTS IN THE I-LAYER OF THE SUBNANOMETER STRUCTURE OF THE BACTERIAL PKM101 TYPE IV SECRETION SYSTEM CORE COMPLEX DIGESTED WITH ELASTASE
Descriptor:TRAO PROTEIN
Authors:Rivera-Calzada, A., Fronzes, R., Savva, C.G., Chandran, V., Lian, P.W., Laeremans, T., Pardon, E., Steyaert, J., Remaut, H., Waksman, G., Orlova, E.V.
Deposit date:2012-11-10
Release date:2013-04-03
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY (8.5 Å)
Cite:Structure of a Bacterial Type Iv Secretion Core Complex at Subnanometre Resolution.
Embo J., 32, 2013
4CDG
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CRYSTAL STRUCTURE OF THE BLOOM'S SYNDROME HELICASE BLM IN COMPLEX WITH NANOBODY
Descriptor:BLOOM SYNDROME PROTEIN, NANOBODY, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Newman, J.A., Savitsky, P., Allerston, C.K., Pike, A.C.W., Pardon, E., Steyaert, J., Arrowsmith, C.H., von Delft, F., Bountra, C., Edwards, A., Gileadi, O.
Deposit date:2013-10-31
Release date:2013-11-13
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.794 Å)
Cite:Crystal Structure of the Bloom'S Syndrome Helicase Indicates a Role for the Hrdc Domain in Conformational Changes.
Nucleic Acids Res., 43, 2015
4KDT
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STRUCTURE OF AN EARLY NATIVE-LIKE INTERMEDIATE OF BETA2-MICROGLOBULIN AMYLOIDOSIS
Descriptor:Nanobody24, Beta-2-microglobulin, SULFATE ION, ...
Authors:Vanderhaegen, S., Fislage, M., Pardon, E., Versees, W., Steyaert, J.
Deposit date:2013-04-25
Release date:2013-08-28
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of an early native-like intermediate of beta 2-microglobulin amyloidogenesis.
Protein Sci., 22, 2013
4KML
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PROBING THE N-TERMINAL BETA-SHEET CONVERSION IN THE CRYSTAL STRUCTURE OF THE FULL-LENGTH HUMAN PRION PROTEIN BOUND TO A NANOBODY
Descriptor:Major prion protein, Nanobody
Authors:Abskharon, R.N.N., Giachin, G., Wohlkonig, A., Soror, S.H., Pardon, E., Legname, G., Steyaert, J.
Deposit date:2013-05-08
Release date:2014-02-19
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Probing the N-Terminal beta-Sheet Conversion in the Crystal Structure of the Human Prion Protein Bound to a Nanobody.
J.Am.Chem.Soc., 136, 2014
4KSB
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STRUCTURES OF P-GLYCOPROTEIN REVEAL ITS CONFORMATIONAL FLEXIBILITY AND AN EPITOPE ON THE NUCLEOTIDE-BINDING DOMAIN
Descriptor:Multidrug resistance protein 1A
Authors:Ward, A., Szewczyk, P., Grimard, V., Lee, C.-W., Martinez, L., Doshi, R., Caya, A., Villaluz, M., Pardon, E., Cregger, C., Swartz, D.J., Falson, P., Urbatsch, I., Govaerts, C., Steyaert, J., Chang, G.
Deposit date:2013-05-17
Release date:2013-07-31
Last modified:2015-09-09
Method:X-RAY DIFFRACTION (3.8001 Å)
Cite:Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain.
Proc.Natl.Acad.Sci.USA, 110, 2013