Author results

2WLS
  • Download 2wls
  • View 2wls
Molmil generated image of 2wls
CRYSTAL STRUCTURE OF MUS MUSCULUS ACETYLCHOLINESTERASE IN COMPLEX WITH AMTS13
Descriptor:ACETYLCHOLINESTERASE, N-ACETYL-D-GLUCOSAMINE, N,N,N-trimethyl-13-[(methylsulfonyl)sulfanyl]tridecan-1-aminium, ...
Authors:Pang, Y.P., Ekstrom, F., Polsinelli, G.A., Gao, Y., Rana, S., Hua, D.H., Andersson, B., Andersson, P.O., Peng, L., Singh, S.K., Mishra, R.K., Zhu, K.Y., Fallon, A.M., Ragsdale, D.W., Brimijoin, S.
Deposit date:2009-06-25
Release date:2009-09-08
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Selective and Irreversible Inhibitors of Mosquito Acetylcholinesterases for Controlling Malaria and Other Mosquito-Borne Diseases.
Plos One, 4, 2009
2GYU
  • Download 2gyu
  • View 2gyu
Molmil generated image of 2gyu
CRYSTAL STRUCTURE OF MUS MUSCULUS ACETYLCHOLINESTERASE IN COMPLEX WITH HI-6
Descriptor:Acetylcholinesterase, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
Authors:Pang, Y.P., Boman, M., Artursson, E., Akfur, C., Lundberg, S.
Deposit date:2006-05-10
Release date:2006-08-15
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of acetylcholinesterase in complex with HI-6, Ortho-7 and obidoxime: Structural basis for differences in the ability to reactivate tabun conjugates.
Biochem.Pharm., 72, 2006
2GYV
  • Download 2gyv
  • View 2gyv
Molmil generated image of 2gyv
CRYSTAL STRUCTURE OF MUS MUSCULUS ACETYLCHOLINESTERASE IN COMPLEX WITH ORTHO-7
Descriptor:Acetylcholinesterase, N-ACETYL-D-GLUCOSAMINE, CARBONATE ION, ...
Authors:Pang, Y.P., Boman, M., Artursson, E., Akfur, C., Lundberg, S.
Deposit date:2006-05-10
Release date:2006-08-15
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of acetylcholinesterase in complex with HI-6, Ortho-7 and obidoxime: Structural basis for differences in the ability to reactivate tabun conjugates.
Biochem.Pharm., 72, 2006
2GYW
  • Download 2gyw
  • View 2gyw
Molmil generated image of 2gyw
CRYSTAL STRUCTURE OF MUS MUSCULUS ACETYLCHOLINESTERASE IN COMPLEX WITH OBIDOXIME
Descriptor:Acetylcholinesterase, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
Authors:Pang, Y.P., Boman, M., Artursson, E., Akfur, C., Lundberg, S.
Deposit date:2006-05-10
Release date:2006-08-15
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structures of acetylcholinesterase in complex with HI-6, Ortho-7 and obidoxime: Structural basis for differences in the ability to reactivate tabun conjugates.
Biochem.Pharm., 72, 2006
1H23
  • Download 1h23
  • View 1h23
Molmil generated image of 1h23
STRUCTURE OF ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH (S,S)-(-)-BIS(12)-HUPYRIDONE AT 2.15A RESOLUTION
Descriptor:ACETYLCHOLINESTERASE, (S,S)-(-)-N,N'-DI-5'-[5',6',7',8'-TETRAHYDRO- 2'(1'H)-QUINOLYNYL]-1,12-DIAMINODODECANE DIHYDROCHLORIDE, N-ACETYL-D-GLUCOSAMINE
Authors:Wong, D.M., Greenblatt, H.M., Carlier, P.R., Han, Y.F., Pang, Y.P., Silman, I., Sussman, J.L.
Deposit date:2002-07-30
Release date:2002-12-23
Last modified:2014-01-22
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Acetylcholinesterase Complexed with Bivalent Ligands Related to Huperzine A: Experimental Evidence for Species-Dependent Protein-Ligand Complementarity
J.Am.Chem.Soc., 125, 2003
1ZGB
  • Download 1zgb
  • View 1zgb
Molmil generated image of 1zgb
CRYSTAL STRUCTURE OF TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH AN (R)-TACRINE(10)-HUPYRIDONE INHIBITOR.
Descriptor:Acetylcholinesterase, N-ACETYL-D-GLUCOSAMINE, (5R)-5-{[10-(1,2,3,4-TETRAHYDROACRIDIN-9-YLAMINO)DECYL]AMINO}-5,6,7,8-TETRAHYDROQUINOLIN-2(1H)-ONE
Authors:Haviv, H., Wong, D.M., Greenblatt, H.M., Carlier, P.R., Pang, Y.P., Silman, I., Sussman, J.L., Israel Structural Proteomics Center (ISPC)
Deposit date:2005-04-21
Release date:2005-08-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Packing Mediates Enantioselective Ligand Recognition at the Peripheral Site of Acetylcholinesterase
J.Am.Chem.Soc., 127, 2005
1ZGC
  • Download 1zgc
  • View 1zgc
Molmil generated image of 1zgc
CRYSTAL STRUCTURE OF TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH AN (RS)-TACRINE(10)-HUPYRIDONE INHIBITOR.
Descriptor:Acetylcholinesterase, N-ACETYL-D-GLUCOSAMINE, (5S)-5-{[10-(1,2,3,4-TETRAHYDROACRIDIN-9-YLAMINO)DECYL]AMINO}-5,6,7,8-TETRAHYDROQUINOLIN-2(1H)-ONE
Authors:Haviv, H., Wong, D.M., Greenblatt, H.M., Carlier, P.R., Pang, Y.P., Silman, I., Sussman, J.L., Israel Structural Proteomics Center (ISPC)
Deposit date:2005-04-21
Release date:2005-08-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Packing Mediates Enantioselective Ligand Recognition at the Peripheral Site of Acetylcholinesterase
J.Am.Chem.Soc., 127, 2005
2CKM
  • Download 2ckm
  • View 2ckm
Molmil generated image of 2ckm
TORPEDO CALIFORNICA ACETYLCHOLINESTERASE COMPLEXED WITH ALKYLENE- LINKED BIS-TACRINE DIMER (7 CARBON LINKER)
Descriptor:ACETYLCHOLINESTERASE, N,N'-DI-1,2,3,4-TETRAHYDROACRIDIN-9-YLHEPTANE-1,7-DIAMINE, N-ACETYL-D-GLUCOSAMINE
Authors:Brumshtein, B., Rydberg, E.H., Greenblatt, H.M., Wong, D.M., Shaya, D., Williams, L.D., Carlier, P.R., Pang, Y.P., Silman, I., Sussman, J.L.
Deposit date:2006-04-20
Release date:2006-09-04
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge.
J. Med. Chem., 49, 2006
2CMF
  • Download 2cmf
  • View 2cmf
Molmil generated image of 2cmf
TORPEDO CALIFORNICA ACETYLCHOLINESTERASE COMPLEXED WITH ALKYLENE- LINKED BIS-TACRINE DIMER (5 CARBON LINKER)
Descriptor:ACETYLCHOLINESTERASE, N,N'-DI-1,2,3,4-TETRAHYDROACRIDIN-9-YLPENTANE-1,5-DIAMINE, N-ACETYL-D-GLUCOSAMINE
Authors:Rydberg, E.H., Brumshtein, B., Greenblatt, H.M., Wong, D.M., Pang, Y.P., Silman, I., Sussman, J.L.
Deposit date:2006-05-08
Release date:2006-09-04
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge.
J. Med. Chem., 49, 2006
2WHP
  • Download 2whp
  • View 2whp
Molmil generated image of 2whp
CRYSTAL STRUCTURE OF ACETYLCHOLINESTERASE, PHOSPHONYLATED BY SARIN AND IN COMPLEX WITH HI-6
Descriptor:ACETYLCHOLINESTERASE, N-ACETYL-D-GLUCOSAMINE, 4-(AMINOCARBONYL)-1-[({2-[(E)-(HYDROXYIMINO)METHYL]PYRIDINIUM-1-YL}METHOXY)METHYL]PYRIDINIUM, ...
Authors:Ekstrom, F., Hornberg, A., Artursson, E., Hammarstrom, L.G., Schneider, G., Pang, Y.P.
Deposit date:2009-05-06
Release date:2009-06-30
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of Hi-6Sarin-Acetylcholinesterase Determined by X-Ray Crystallography and Molecular Dynamics Simulation: Reactivator Mechanism and Design.
Plos One, 4, 2009
2WHQ
  • Download 2whq
  • View 2whq
Molmil generated image of 2whq
CRYSTAL STRUCTURE OF ACETYLCHOLINESTERASE, PHOSPHONYLATED BY SARIN (AGED) IN COMPLEX WITH HI-6
Descriptor:ACETYLCHOLINESTERASE, N-ACETYL-D-GLUCOSAMINE, 4-(AMINOCARBONYL)-1-[({2-[(E)-(HYDROXYIMINO)METHYL]PYRIDINIUM-1-YL}METHOXY)METHYL]PYRIDINIUM, ...
Authors:Ekstrom, F., Hornberg, A., Artursson, E., Hammarstrom, L.G., Schneider, G., Pang, Y.P.
Deposit date:2009-05-06
Release date:2009-06-30
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structure of Hi-6Sarin-Acetylcholinesterase Determined by X-Ray Crystallography and Molecular Dynamics Simulation: Reactivator Mechanism and Design.
Plos One, 4, 2009
2JEY
  • Download 2jey
  • View 2jey
Molmil generated image of 2jey
MUS MUSCULUS ACETYLCHOLINESTERASE IN COMPLEX WITH HLO-7
Descriptor:ACETYLCHOLINESTERASE, 1-[({2,4-BIS[(E)-(HYDROXYIMINO)METHYL]PYRIDINIUM-1-YL}METHOXY)METHYL]-4-CARBAMOYLPYRIDINIUM, HEXAETHYLENE GLYCOL
Authors:Ekstrom, F., Astot, C., Pang, Y.P.
Deposit date:2007-01-25
Release date:2007-07-03
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Novel Nerve-Agent Antidote Design Based on Crystallographic and Mass Spectrometric Analyses of Tabun-Conjugated Acetylcholinesterase in Complex with Antidotes.
Clin.Pharmacol.Ther., 82, 2007
2JEZ
  • Download 2jez
  • View 2jez
Molmil generated image of 2jez
MUS MUSCULUS ACETYLCHOLINESTERASE IN COMPLEX WITH TABUN AND HLO-7
Descriptor:ACETYLCHOLINESTERASE, 1-[({2,4-BIS[(E)-(HYDROXYIMINO)METHYL]PYRIDINIUM-1-YL}METHOXY)METHYL]-4-CARBAMOYLPYRIDINIUM, HEXAETHYLENE GLYCOL
Authors:Ekstrom, F., Astot, C., Pang, Y.P.
Deposit date:2007-01-25
Release date:2007-07-03
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Novel Nerve-Agent Antidote Design Based on Crystallographic and Mass Spectrometric Analyses of Tabun-Conjugated Acetylcholinesterase in Complex with Antidotes.
Clin.Pharmacol.Ther., 82, 2007
2JF0
  • Download 2jf0
  • View 2jf0
Molmil generated image of 2jf0
MUS MUSCULUS ACETYLCHOLINESTERASE IN COMPLEX WITH TABUN AND ORTHO-7
Descriptor:ACETYLCHOLINESTERASE, HEXAETHYLENE GLYCOL, 1,7-HEPTYLENE-BIS-N,N'-SYN-2-PYRIDINIUMALDOXIME
Authors:Ekstrom, F., Astot, C., Pang, Y.P.
Deposit date:2007-01-25
Release date:2007-07-03
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Novel Nerve-Agent Antidote Design Based on Crystallographic and Mass Spectrometric Analyses of Tabun-Conjugated Acetylcholinesterase in Complex with Antidotes.
Clin.Pharmacol.Ther., 82, 2007
1VOT
  • Download 1vot
  • View 1vot
Molmil generated image of 1vot
ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH HUPERZINE A
Descriptor:ACETYLCHOLINESTERASE, Huperzine A
Authors:Raves, M.L., Harel, M., Silman, I., Sussman, J.L.
Deposit date:1996-06-23
Release date:1997-06-16
Last modified:2013-10-23
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A.
Nat.Struct.Biol., 4, 1997